Journal of Drug Delivery Science and Technology最新文献

{"title":"Biodegradable glutamic acid loaded polycaprolactone nanofibrous scaffold for controlled dentin mineralization","authors":"Aruna Krishnan ,&nbsp;Sandhya Raghu ,&nbsp;Rajalakshmanan Eswaramoorthy ,&nbsp;Govindaraj Perumal","doi":"10.1016/j.jddst.2024.106546","DOIUrl":"10.1016/j.jddst.2024.106546","url":null,"abstract":"<div><div>This study aims to develop glutamic acid (Glu) loaded nanofibrous scaffolds using polycaprolactone (PCL) and nanohydroxyapatite (nHA) for applications in dentin mineralization. The scaffolds were fabricated by electrospinning technique and characterized using Scanning Electron Microscopy with Energy Dispersive Spectroscopy (SEM-EDS), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and water contact angle measurements. The resulting PCL/nHA/Glu scaffolds showed bead-free, randomly aligned nanofibers with high hydrophilicity and controlled glutamic acid release. Furthermore, these scaffolds demonstrated excellent cell viability, adhesion, and proliferation with human dental pulp stem cells (hDPSCs). The scaffolds also exhibited excellent three-dimensional mineralization and controlled biodegradation in Simulated Body Fluid (SBF) duration with 14 and 21 days when compared to PCL and PCL/nHA nanofibers. These results suggest that PCL/nHA/Glu nanofibrous scaffolds can be a potential biomaterial for dentin remineralization applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106546"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does using oral medication lubricants to swallow whole or crushed tablets alter drug absorption in vivo? A randomised, single-dose crossover bioequivalence study in healthy adults","authors":"Marwa A. Malouh ,&nbsp;Julie A.Y. Cichero ,&nbsp;Stephanie E. Reuter ,&nbsp;Min-Tz Weng ,&nbsp;Esther T.L. Lau ,&nbsp;Lisa M. Nissen ,&nbsp;Kathryn J. Steadman","doi":"10.1016/j.jddst.2024.106552","DOIUrl":"10.1016/j.jddst.2024.106552","url":null,"abstract":"<div><div>Tablets are often crushed and mixed with thick vehicles such as thickened fluids or medication lubricants to help people with swallowing difficulties to take their medications. <em>In vitro</em> dissolution tests indicate a highly significant reduction in drug dissolution rate when crushed tablets are mixed with vehicles classified as extremely thick (Level 4) according to the International Dysphagia Diet Standardisation Initiative (IDDSI) framework, leading to concerns that this practice may be having substantial impact on drug bioavailability and therapeutic effect. The aim of this study was to determine whether swallowing whole or crushed tablets with an IDDSI Level 4 medication lubricant causes the rate and extent of drug absorption to be significantly different to swallowing whole tablets with water. An open-label, randomised, single-dose crossover study in 19 healthy adults was performed, in which a standard oral dose of immediate-release paracetamol tablets was administered. Whole or crushed tablets were swallowed with water, or with the medication lubricants Gloup Forte or Gloup Family. Passive unstimulated saliva was collected at regular intervals from 5 min to 8 h after swallowing and analysed using HPLC-UV. Pharmacokinetic parameters were estimated using a standard non-compartmental approach. Co-administering whole tablets with medication lubricant was considered to be bioequivalent to swallowing whole tablets with water in terms of absorption rate and extent, though there was a short delay in reaching the maximum concentration of 12–18 min. Crushing the tablets caused maximum concentration of paracetamol to increase by 36 %, a reminder to avoid crushing tablets if possible. Using a medication lubricant instead of water reduced the crushing-induced dose-dump by 9–18 %. Concerns based on <em>in vitro</em> dissolution test results are not substantiated when tested <em>in vivo</em>, and, for immediate-release paracetamol tablets, we find no evidence for concern regarding the impact of medication lubricants on drug absorption. Assessment of other medication swallowing products and medications is recommended to establish whether these findings can be more widely generalised.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106552"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in cells, nanoparticles, and cell membrane coated nanoparticles for acute myeloid leukemia treatment","authors":"Tong Wang ,&nbsp;Yingying Wang ,&nbsp;Youping Zhang ,&nbsp;Yingli Wu ,&nbsp;Li-Min Zhu","doi":"10.1016/j.jddst.2024.106507","DOIUrl":"10.1016/j.jddst.2024.106507","url":null,"abstract":"<div><div>Acute myeloid leukemia (AML) is a common malignant hematologic neoplasm that is difficult to cure with a high recurrence rate and poor prognosis. The main reasons are the low bioavailability of chemotherapy drugs and the therapeutic resistance to chemotherapeutic agents of leukemic stem cells (LSCs) due to their location and characteristics. A wide range of novel strategies has been investigated to address the relapse of AML. With the continuous development of nanobiotechnology, cell and cell-based drug delivery systems have provided a promising therapeutic approach to treat AML. This review summarizes recent research advances in using cells, nanoparticles, and cell membrane coated nanoparticles (CMCNPs) for target drug delivery and target therapeutic for AML. CMCNPs retain the biological properties of the cell membrane, combined with the multiple treatments of functionalized nanoparticles, which have been demonstrated to be effective in many preclinical studies. However, the safety, generalizability, clinical translatability, and efficacy of CMCNPs need further consideration and development.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106507"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhaled combined antibacterials against biofilm-forming antibiotic-resistant bacteria for the management of pulmonary bacterial infections","authors":"Ruwani K. Suraweera ,&nbsp;Kirsten M. Spann ,&nbsp;Timothy J. Wells ,&nbsp;Nazrul Islam","doi":"10.1016/j.jddst.2024.106555","DOIUrl":"10.1016/j.jddst.2024.106555","url":null,"abstract":"<div><div>Pulmonary antibiotic delivery is a mainstay of treatment for severe pulmonary infections associated with cystic fibrosis, chronic obstructive pulmonary disease and non-CF bronchiectasis. However, abnormal or hypersecreted mucus, antibiotic resistance, and bacterial biofilms hinder the efficacy of conventional pulmonary drug delivery modalities in treating lung infections. Many different therapeutic drug delivery strategies have been developed to overcome these barriers and improve the performance of inhaled antibiotics against multi-drug resistant and biofilm-associated bacterial infections, including inhaled combined antibacterial agents. Apart from conventional or novel antibiotics, combination therapies may include adjunct agents with antibacterial activity, such as biofilm eradicating agents, biofilm dispersal agents, biofilm preventers, mucoactive agents, and quorum sensing inhibitors. Optimized synergistic formulations of combined antibacterials and effective inhalable delivery strategies are essential in the development of novel treatments for biofilm-forming and antibacterial-resistant respiratory infections. This review discusses the benefits and rationale for developing combined inhaled antibacterials for the effective management of lung infections.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106555"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of nanoparticle-based therapeutic strategies for pulmonary drug delivery","authors":"Prashant Anilkumar Singh ,&nbsp;Ramendra Pati Pandey ,&nbsp;Rajendra Awasthi","doi":"10.1016/j.jddst.2024.106558","DOIUrl":"10.1016/j.jddst.2024.106558","url":null,"abstract":"<div><div>Pulmonary diseases are severe clinical conditions marked by widespread inflammation in the lungs, leading to impaired gas exchange, respiratory failure, and significant mortality. Despite intensive research and advancements in critical care, treatment of pulmonary diseases remains difficult to manage due to the absence of specific pharmacological therapies. The complexity of its pathophysiology, which involves dysregulated immune responses, increased vascular permeability, and alveolar damage, poses challenges in developing effective treatments. In recent years, nanoparticle-based drug delivery systems have emerged as a promising solution for addressing these limitations, offering the potential to deliver drugs precisely to the affected lung tissue while minimizing systemic side effects. This review explores various nanoparticle platforms, including liposomes, nanoemulsions, nanostructured lipid carriers, solid lipid nanoparticles, polymeric nanoparticles, niosomes, phytosomes, bilosomes, and micelles. These nanocarriers have shown potential in enhancing stability, drug solubility, and bioavailability, and enabling controlled and targeted delivery, thereby improving therapeutic outcomes in pulmonary diseases. Each nanocarrier system is discussed in terms of its composition, mechanism of action, and suitability for pulmonary drug delivery. Moreover, the review delves into recent patents in the field, underscoring innovative advancements that have the potential to revolutionize pulmonary drug delivery. By providing a comprehensive overview of the current landscape of nanoparticle-based drug delivery systems, this paper aims to highlight their potential as novel therapeutic strategies and encourage further research and clinical exploration to improve patient outcomes in the management and treatment of pulmonary diseases.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106558"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of Oleanolic Acid from Olea Europaea L. leaves using a Lipophilic Deep Eutectic Solvent for direct formulation of self-emulsifying drug delivery systems","authors":"Antonio Spennacchio,&nbsp;Giuseppe Francesco Racaniello,&nbsp;Gennaro Balenzano,&nbsp;Rosa Maria Iacobazzi,&nbsp;Angela Assunta Lopedota,&nbsp;Antonio Lopalco,&nbsp;Nunzio Denora","doi":"10.1016/j.jddst.2024.106519","DOIUrl":"10.1016/j.jddst.2024.106519","url":null,"abstract":"<div><div>In this work is presented for the first time a new approach to extract the triterpene oleanolic acid (OA) from Olea Europaea L. leaves by using a lipophilic deep eutectic solvent (LipoDES) constituted of caprylic and lauric acid, as an alternative to conventional solvents, and formulate self-emulsifying drug delivery systems (SEDDSs), exploiting directly OA-containing LipoDES extract, to potentially improve the bioavailability of this BCS class IV bioactive molecule. LipoDES extract was characterized by using a HPLC technique which assessed the presence of OA in the extract and allowed us to quantify it. Subsequently, several preconcentrates were realized mixing the LipoDES extract, used as oily phase, with different surfactants (Cremophor RH-40 and Cremophor EL) and co-surfactants (Labrasol ALF and ethanol) which are well known for their self-emulsifying properties. After self-emulsification, the formulations were characterized by dynamic light scattering in terms of size and polydispersity index (PDI) to select the ones with proper characteristics. Three possible formulations (S_A, S_F and S_I) containing different amounts of extract were selected due to their low size and PDI and further investigated in terms of physical-chemical stability to temperature variations (stability at temperatures higher than 37 °C) and to dispersion and dilution in simulated gastrointestinal fluids. <em>In vitro</em> cytotoxicity and permeation studies were performed on CaCo-2 cells monolayer to prove the safety of SEDDSs and the ability of these systems to increase the permeability of OA. Bodipy alkyne dye (BDP) was selected as tracer in permeability studies, which highlighted an apparent permeability increase up to 10-fold for S_A loaded with BDP (S_A-BDP) compared to BDP alone. Eventually, a one-month chemical stability study was conducted on S_A, which resulted in being stable at least for that period of time if stored at 4 and 25 °C. This research highlights the potential dual use of LipoDES for extraction and formulation of bioactive compounds such as OA, resulting in a novel approach to innovative extraction and oral delivery of plant extracts.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106519"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-ulcerogenic activity of Citrus medica var. sarcodactylis fruit extract nano-emulsion in gastric ulcer rat model through modulating HMBG1/TLR4/NF-κB and Nrf2/HSP70/PGE2 signaling pathways","authors":"Eman A.W. El-Abd ,&nbsp;Sara M. Baraka ,&nbsp;Iman A.A. Kassem ,&nbsp;Zeinab A. El-Gendy ,&nbsp;Ahmed F. El-Sayed ,&nbsp;Saber Ibrahim ,&nbsp;Reda M.S. Korany ,&nbsp;Marwa M. Elbatanony","doi":"10.1016/j.jddst.2024.106465","DOIUrl":"10.1016/j.jddst.2024.106465","url":null,"abstract":"<div><div>One of the most prevalent gastrointestinal multi-etiological diseases is gastric ulcer, with several consequences and serious side influences. Nowadays, nanotechnology is one of the advanced tools to enhance drug delivery and bioavailability. Hence, the prime goal of this study was to create safe gastro-protective therapy using methanol fruit extract of <em>Citrus medica</em> var. sarcodactylis (CMF) and its prepared nano formula (Nano-CMF). CMF or its nano form was given to rats at dose 600 mg/kg/day for a week along with a single oral administration of ethanol (5 ml/kg) at the 7th day. The particle size distribution of formulated CMF reflected the successful preparation of nano form, with average size 65 nm. Pretreatment with CMF or its nano formula to ethanol challenged rats significantly controlled the inflammatory response through down-regulated gastric HMBG1/TLR4/NF-κB signaling pathway and its downstream mediators at p &lt; 0.001. Moreover, CMF or nano-CMF lessened oxidative stress incidence via modulating Nrf2 signaling pathway, sustaining prostaglandin content, and reducing gastric juice acidity with a significant p value less than 0.001, as compared to the EtOH-intoxicated rats. In addition, nano form effectively preserved the gastric mucosal integrity and alleviated apoptosis in gastric cells as validated by ulcer index (p &lt; 0.001), and the histological and immunohistochemical findings, when matched to the EtOH-treated group. The metabolomics analysis revealed the characterization of 36 compounds. GC/MS of CH₂Cl₂ fraction led to the identification of 34 compounds, the major category was fatty acid esters amounting 43.92 %. The TLC technique for methanol extract led to isolation of 8 compounds<del>:</del> (4,5-O-Dicaffeoylquinic acid, ferulic acid, hesperidin, limettin, 5-demethylsinensetin, brassicasterol, campesterol and β-sitosterol). Brassicasterol is newly reported from species while 5-demethylsinensetin was newly reported from the Citrus genus. Furthermore, the docking experiments revealed strong binding affinity interactions of these compounds with TLR-4, Nrf2-Keap1 complex, and pNF-κBp65. In conclusion, mechanism of action of CMF or its nano formula exerting anti-ulcer effect was postulated based on the synergistic action of its reported compounds which possesses anti-inflammatory, antioxidant, and anti-apoptotic activities. To be noted, nano CMF showed a superior potent anti-ulcer activity than CMF and conventional therapy, omeprazole.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106465"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of berberine hydrochloride ion-exchange resin complex by β-cyclodextrin inclusion","authors":"Tianyi Zhang,&nbsp;Sanmei Zhang,&nbsp;Fei Wu,&nbsp;Yi Feng","doi":"10.1016/j.jddst.2024.106472","DOIUrl":"10.1016/j.jddst.2024.106472","url":null,"abstract":"<div><div>In this study, berberine hydrochloride was combined with ion exchange resin to mask the unpleasant taste of berberine hydrochloride. The research uncovered the equation of berberine hydrochloride solubility in different β-cyclodextrin concentrations at different temperatures, providing a foundation for selecting binding parameters. The effects of various factors on the reaction process were then investigated. Following that, the characteristics and taste evaluation were studied to verify the formation. at last, the <em>in vitro</em> release studies of chosen complexes were determined in solution mediums with pH values of 1.0, 4.5, and 6.8. The results revealed that Amberlite IRP69, which has a higher drug availability and a better taste-masking effect, was selected as the drug carrier. The optimal combined conditions are that the β-cyclodextrin concentration is 0.06 mol·L⁻¹, the temperature is 65 °C, and the berberine hydrochloride concentration is 15 mg·mL⁻¹. Finally, <em>in vitro</em> release experiments of berberine hydrochloride and Amberlite IRP69 complex showed that the drug could be released more than 90 % in a medium with pH values of 1.0, 4.5, and 6.8. The research provided a method for preparing the berberine hydrochloride and resin complex, and the well-tasting complex was successfully prepared.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106472"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Platelet directed lectin-conjugated lipid nanocarriers for ticagrelor oral delivery: Development and evaluation” [J. Drug Deliv. Sci. Tech. 103 (2025) 106433]","authors":"Mohamed Nabil Abdel-Azeem ,&nbsp;Magdy Ibrahim Mohamed ,&nbsp;Mohamed A. Akl","doi":"10.1016/j.jddst.2024.106517","DOIUrl":"10.1016/j.jddst.2024.106517","url":null,"abstract":"","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106517"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of a novel biodegradable Poly(amidoamine) with Bis(guanidinium) and benzene ring structures for enhanced gene delivery","authors":"Yucen Luo ,&nbsp;Yichen Wang ,&nbsp;Yongfeng Chen ,&nbsp;Bao Li ,&nbsp;Tianzhi Yang ,&nbsp;Xiaoyun Zhao ,&nbsp;Pingtian Ding","doi":"10.1016/j.jddst.2024.106452","DOIUrl":"10.1016/j.jddst.2024.106452","url":null,"abstract":"<div><div>Cationic polymer carriers have shown promise in non-viral gene delivery but face challenges such as low transfection efficiency and high toxicity. To address these issues, we synthesized a novel biodegradable poly(amidoamine) (PAA) cationic polymer, 4-(4-biguanide benzoylamino)butylamine-N,N′-bis(acryloyl)cystamine (PDAB-CBA). This polymer incorporates bis(guanidinium) groups and a hydrophobic benzene ring to enhance membrane affinity and hydrophobic interactions, respectively, thereby improving gene delivery performance. The inclusion of disulfide bonds in the polymer's backbone imparts reductive response properties, allowing for degradation into small molecular weight fragments within cellular environments and reducing cytotoxicity. Our studies demonstrated that PDAB-CBA formed stable, uniform nanoparticles with plasmid DNA (pDNA), achieving an encapsulation efficiency of approximately 85 % at a 6:1 wt ratio. The polyplexes had the average particle size of around 100 nm and the zeta potential between 25 and 35 mV, ensuring effective cellular uptake. PDAB-CBA/pDNA polyplexes exhibited higher transfection efficiency, with relative light units (RLU) greater than 1 × 10⁵ at weight ratios of 6:1 to 24:1, compared to PEI/pDNA. Furthermore, PDAB-CBA demonstrated low cytotoxicity, maintaining cell viability above 80 % at weight ratios below 24:1, and effectively protected genes against DNaseI degradation and heparin replacement. The primary endocytosis pathway for these polyplexes was clathrin-mediated endocytosis. Overall, PDAB-CBA exhibited superior gene delivery capabilities and a favorable safety profile, providing a new strategy for the design of efficient and low-toxicity gene delivery vectors.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"104 ","pages":"Article 106452"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143180142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}