Journal of Dental Research最新文献

{"title":"Edentulousness and Frailty: A Study of Directionality and Pathways.","authors":"E Petrauskiene,P Zaninotto,A Heilmann,A Peasey,G Tsakos","doi":"10.1177/00220345251414409","DOIUrl":"https://doi.org/10.1177/00220345251414409","url":null,"abstract":"Associations between tooth loss and frailty have been reported, but longitudinal evidence on directionality and pathways of this association is lacking. We examined the direction and pathways of the association between edentulousness and frailty among older adults in England using a nationally representative sample of 6,800 adults aged ≥50 y who participated in the English Longitudinal Study of Ageing (ELSA) at wave 3. Edentulousness and frailty (determined using the Frailty Index) were assessed at waves 3 (2006/7), 5 (2010/11), and 7 (2014/15). The following mediators were assessed at waves 4 (2008/9) and 6 (2012/13): loneliness (UCLA Loneliness Scale), C-reactive protein (CRP), and consumption of fruit and vegetables. A cross-lagged longitudinal structural equation model with a Bayesian estimator using probit regression assessed the direction and pathways of the association between edentulousness and frailty at 2 time points (i.e., wave 3 to wave 5 and wave 5 to wave 7), after adjusting for sociodemographic factors and smoking. Being edentate at wave 3 was associated with an increased probability of frailty at wave 5, but the path was not significant between waves 5 and 7 (probit regression coefficient 0.05; 95% CI, -0.02 to 0.13). The paths from frailty to edentulousness were not significant at either time point (probit regression coefficients 0.09 [95% CI, -0.10 to 0.279] and 0.14 [95% CI, -0.03 to 0.31] for waves 3-5 and waves 5-7, respectively). The estimates of indirect paths via loneliness and CRP were of small magnitude but significant at both time points. No significant mediation was observed via the consumption of fruit and vegetables. Health promotion strategies aimed at preserving natural teeth and tackling loneliness in older people may have the potential to prevent frailty.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"34 1","pages":"220345251414409"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting of Animal Studies on Craniofacial Bone Repair: 2004, 2014, and 2024.","authors":"Y Liu,F Guo,J Botelho,Z Tao,T Zhao,M Degen,N Pandis,F Hua","doi":"10.1177/00220345261424229","DOIUrl":"https://doi.org/10.1177/00220345261424229","url":null,"abstract":"Clinical need and research activities on craniofacial bone repair/regeneration (CBR) have been increasing in dentistry, and animal research provides essential support for its advancement. However, inadequate reporting in animal research contributes to avoidable research waste and limits the validation and translation of research findings. Therefore, this research-on-research study aimed to assess the reporting quality of animal research on CBR and to identify its changes over the past 2 decades. Electronic and manual searches were conducted to identify animal research regarding CBR published in 2004, 2014, and 2024. The reporting quality of included studies was assessed using a modified ARRIVE (Animal Research: Reporting In Vivo Experiments) 2.0 checklist. A multivariable generalized linear model was used to explore changes in reporting quality over time. A total of 164 studies were included. The mean (standard deviation) overall quality score (OQS; calculated by summing the scores of all checklist items) improved over time: OQS2004 = 4.42 (1.29), OQS2014 = 5.70 (1.72), and OQS2024 = 6.79 (2.25). Among the included studies, \"study design,\" \"objectives,\" and \"generalizability\" were adequately reported. In contrast, less than 1.0% of the included studies sufficiently reported \"inclusion and exclusion criteria\" (0.6%; 1/164) and \"protocol registration\" (0.6%; 1/164). Despite the release and update of the ARRIVE guidelines, several methodological items, including \"sample size\" (8.5%; 14/164) and \"randomization\" (6.7%; 11/164), remained poorly reported. Only 18 of 164 studies (11.0%) specified the primary outcome measures, and none reported effect sizes with confidence intervals. Reporting of \"ethical statements,\" \"data access,\" and \"declaration of interests\" considerably improved but remained suboptimal. According to the multivariable analysis, publication year was a significant predictor of reporting quality (P < 0.01). The reporting of CBR animal research has improved significantly during the past 2 decades. However, concerted efforts toward more complete and transparent reporting, which facilitate validation and translation, are warranted.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"4 1","pages":"220345261424229"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Average and Heterogeneous Associations between Secondhand Smoking and Tooth Loss.","authors":"Y Q Chen,J M Zheng,Y Z Chen,H Y Zhang,J Y Li,H Deng,Y Y Kong","doi":"10.1177/00220345261419027","DOIUrl":"https://doi.org/10.1177/00220345261419027","url":null,"abstract":"Secondhand smoke (SHS) is a pervasive health concern increasingly associated with tooth loss, yet studies assessing its population-level associations and potential heterogeneity are limited. This study aimed at estimating the average and subgroup-specific effects of SHS exposure on tooth loss among US adults using modern causal inference-based methods. This study analyzed cross-sectional data from 6,019 nonsmokers aged ≥20 y, representing 48.2 million individuals, in the National Health and Nutrition Examination Survey (2009 to 2018). SHS was defined by serum cotinine. This study quantified the association between SHS exposure and tooth loss using targeted minimum loss estimation, a doubly robust estimator that enhances confounding adjustment in observational data. Confidence intervals were obtained via bootstrap resampling. Heterogeneity of the association was evaluated by a data-adaptive causal forest method that identifies subgroup-specific variation. SHS exposure was associated with having 0.74 fewer teeth (average association, -0.739; 95% CI, -1.053 to -0.426) and with a 4.6-percentage higher probability of having <20 teeth (average association, 0.046; 95% CI, 0.027 to 0.065). Larger associations were observed among adults aged ≥45 y, those with lower socioeconomic position, individuals with higher sugar intake or medical comorbidities, and participants at the extremes of flossing frequency. This study found that SHS exposure was associated with greater tooth loss, with disproportionate burdens observed among adults facing socioeconomic disadvantages or chronic health conditions. These findings underscore the potential value of integrating oral health outcomes into tobacco control initiatives and guiding targeted prevention for groups at elevated risk.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"236 1","pages":"220345261419027"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of the Kynurenine Pathway in Irreversible Pulpitis.","authors":"J Coulter,C J Nile,H Lemos,P LoCoco,J Whitworth,R A Valentine,A Diogenes,C Chang,A Mellor,V Telezhkin,J Durham","doi":"10.1177/00220345261416437","DOIUrl":"https://doi.org/10.1177/00220345261416437","url":null,"abstract":"Current therapeutic practices have limited effectiveness at targeting acute pain locally. This is in part due to the lack of understanding of the neuroinflammatory pathways active within pulpitis. Increased activity of inadoleamine 2,3 dioxygenase (IDO) was linked to hypersensitivity and pain in several settings. IDO is the rate-limiting enzyme of the kynurenine pathway, but changes in IDO's activity and expression in pulpitis have not been investigated. Tooth samples with a diagnosis of symptomatic irreversible pulpitis (SIP) were collected, and levels and activity of IDO and other markers of the kynurenine (KYN) pathway were examined using high-performance liquid chromatography (HPLC), quantitative polymerase chain reaction (PCR), and immunocytochemistry (ICC). Subsequently, odontoblast-like cells (OLCs) derived from dental pulp stem cells were stimulated in vitro with bacterial lipopolysaccharide and a synthetic proxy for DNA cytosine-phosphate-guanine (CpG) oligonucleotide 2006 (ODN 2006). The effects of these compounds on KYN pathway marker levels and transcription were then analyzed using quantitative PCR and HPLC mass spectrometry. IDO activity was significantly raised in SIP compared with healthy controls. ICC fluorescent imaging showed that IDO and KYN were colocalized with the markers of macrophages and neuronal fibers. Quantitative PCR data of SIP indicated that increased IDO may direct the KYN pathway toward the generation of the neuroinflammatory catabolite quinolinic acid, a metabolite that is opposite to the production of neuroprotective kynurenic acid. Administration of OLCs with ODN 2006 in vitro induced changes similar to those developed in SIP induced by bacterial infection. To our knowledge, this article is the first to demonstrate links between IDO activity, neuroinflammation, and algogenic pathways in SIP and localize this process to neuronal fibers. These observations highlight the potential role of the kynurenine pathway in SIP, but further investigation is required to determine if these changes are mirrored in the levels of neuroexcitatory metabolites in vivo.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"78 2 1","pages":"220345261416437"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OralDB: A Transcriptomic Resource for Mechanistic Exploration in Oral Diseases.","authors":"H Cui,Y Lu,G Zhao,S Zuo,S Cheng,Y Lian,S Duan,Y Yang,X Luo,X Zeng,H Zhao,J Li,Q Chen,D Duan,T Li","doi":"10.1177/00220345251410498","DOIUrl":"https://doi.org/10.1177/00220345251410498","url":null,"abstract":"Oral diseases, including oral cancer, periodontitis, and oral mucosal disorders, pose major global public health challenges and are driven by complex molecular mechanisms. While recent advances in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have unraveled the heterogeneity of these diseases, integrative analyses remain hindered by severe batch effects, inconsistent metadata annotations, and the fragmentation of public datasets. To address these challenges, we present OralDB (https://compbio.cn/oraldb/), the first comprehensive, standardized, and interactive multimodal transcriptomic resource dedicated to oral diseases. OralDB integrates 73 high-quality datasets spanning 20 oral diseases and 4 omics types (microarray, RNA-seq, scRNA-seq, ST), covering 2,027 tissue-based samples. The platform applies rigorous processing pipelines, including quality control, dimensionality reduction, clustering, and cell-type annotation, and provides interactive analytical modules for gene expression visualization, differential expression, pathway enrichment, gene correlation, and cell-cell interaction analysis. OralDB enables efficient exploration of molecular and cellular features across disease contexts. We demonstrate the platform's utility through case studies of SERPINE2-driven epithelial-mesenchymal transition in oral squamous cell carcinoma and fibroblast-derived CXCL1-mediated myeloid cell recruitment in periodontitis. By facilitating mechanistic insights and supporting translational applications, OralDB offers a robust resource to advance precision research and therapeutic development in oral diseases.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"5 1","pages":"220345251410498"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of the Brief Diagnostic Criteria for Temporomandibular Disorders.","authors":"S Sharma,M Drangsholt,J Durham,P Alstergren,R Ohrbach","doi":"10.1177/00220345251414019","DOIUrl":"https://doi.org/10.1177/00220345251414019","url":null,"abstract":"Valid diagnostic criteria for classifying pain-related temporomandibular disorders (TMDs) exist and can be applied with high interexaminer reliability to patients. However, adoption in most clinical settings, generalist and specialist, remains limited due to the examination complexity and time constraints in clinics. To address this limitation, we created a simplified examination protocol, and we test it here against reference standards based on the Diagnostic Criteria for TMD (DC/TMD). DC/TMD assessments include multiple provocation tests, 5 range-of-motion tasks, and 40 palpation points, as well as imaging for definitive joint diagnoses. We tested the simplified protocol using data from 2 multicenter studies: the TMJ Impact Project (n = 401) and OPPERA (n = 547). Examiners were trained and assessed annually for reliability, supporting generalizability. Diagnostic validity was assessed by area under the curve, sensitivity, specificity, and likelihood ratios (positive and negative). By using 2-s palpation at the full muscle (bilateral temporalis, masseter) and TMJ lateral pole, results showed high diagnostic performance for identifying painful TMD: area under the curve = 0.93, sensitivity = 0.88, and specificity = 0.98. Targeted single-band palpation within each muscle yielded comparable results. Adding other joint pain provocation procedures to the index test did not improve diagnostic accuracy. For acute closed lock, other disc-based TMDs, and degenerative joint disease, sensitivity remained ≤0.12 while specificity was ≥0.92. For subluxation, sensitivity/specificity was 0.81/0.97. Based on the likelihood ratios, clinical decision-making guidelines were developed for brief DC diagnoses. In conclusion, a simplified and shortened version of the DC/TMD protocol demonstrates excellent validity for identifying painful TMDs and is feasible for clinical practice. This approach reduces examination time while maintaining diagnostic accuracy, potentially improving patient care across broader clinical settings.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"29 1","pages":"220345251414019"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and Transcriptomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes.","authors":"L Liu,Y Zhang,M Hao,Y Lou,L Liu,Z Zhou,Y Cui,J Bai,J Zhang,J Wang,C-X Zhou,T Li","doi":"10.1177/00220345261416398","DOIUrl":"https://doi.org/10.1177/00220345261416398","url":null,"abstract":"Adenoid cystic carcinoma (ACC) is a rare malignancy with 3 components (tubular, cribriform, and solid), and these components often coexist in the same patient. In the past few decades, great strides have been made in the pathological classification of ACC. However, due to the complexity of the pathological morphology, establishing a unified grading/assessment standard for clinical implementation process remains challenging. This study aimed to develop improved prognostic biomarkers to assist clinical pathological assessment at the molecular level. We used laser capture microdissection to isolate tumor microsamples with specific pathological features (solid, cribriform, and tubular component) and paracancerous normal glands from 100 patients, then performed DNA sequencing (n = 955) and RNA sequencing (n = 723) to obtain the genome and transcriptome profile, including copy number variation (CNV) type, gene fusion, and transcriptional expression. We found that CNV and gene fusion patterns differed among the 3 pathological subtypes and correlated with clinical outcome. We also found a mutually exclusive relationship between MYBL1::NFIB fusion and 6q-loss, and they displayed distinct different transcriptional profiles. We discovered that molecular markers 6q-loss and 14q-loss were strongly associated with poor prognosis in ACC. Patients with 6q-loss or 14q-loss had a higher risk of tumor metastasis and recurrence, whereas MYB::NFIB and MYBL1::NFIB fusions showed no adverse prognostic impact. Based on these findings, we propose a new CNV-based molecular classification that stratifies patients into the subgroups of 6q-loss, 14q-loss, and others. The molecular classification method increased the prognostic accuracy from 74.49% (the pathological method) to now 82.65%, especially in cribriform patients (increased from 64% to 80%). Fluorescence in situ hybridization-based detection of 6q-loss and 14q-loss by probe ESR1-6q25 and FOS-14q24 provided a rapid and clinically feasible validation in ACC prognostic assessment. Further multicohort and multifactor analysis demonstrated the robustness and independence of the prognostic value in overall survival and metastasis-free survival of the molecular classification method.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"47 1","pages":"220345261416398"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Method to Target Apical Periodontitis Worsened by Inflammatory Bowel Disease","authors":"M. Nakano, Y. Tanaka, M.S. Kyaw, W. Shuai, Y. Kamano, F. Toyama, T. Noguchi, F. Harada, V.V. Suresh, K. Handa, K. Mizuta, Y. Yahata, M. Saito","doi":"10.1177/00220345251412776","DOIUrl":"https://doi.org/10.1177/00220345251412776","url":null,"abstract":"Patients with inflammatory bowel disease (IBD) have a higher prevalence of apical periodontitis (AP), which is often associated with accelerated jawbone destruction. However, the mechanisms underlying this exacerbation remain unclear. In this study, we established a colitis+AP model and demonstrated that colitis exacerbates alveolar bone destruction. The upregulation of genes related to inflammation and neutrophils was also observed in the colitis+AP model compared with the AP-only model. In addition, colitis-induced local neutrophil infiltration was observed in the alveolar bone, which was further amplified by bacterial infection originating from the root canal. To address the exacerbated bone destruction in colitis+AP, we used a novel laser-induced cavitation system to locally deliver the immunosuppressant tacrolimus into the jawbone. This targeted approach effectively suppressed alveolar bone loss in the colitis+AP model. Our findings highlight the importance of the inflammatory interplay between IBD and AP. Systemic inflammation caused by IBD weakens local neutrophil function, leading to increased bone destruction and treatment-resistant AP. Furthermore, laser-activated local administration of tacrolimus significantly ameliorated bone destruction in AP associated with colitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"51 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147274327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil S100a9 Deficiency Protects against Periodontal Bone Loss","authors":"Y.Y. Wei, J.Q. Zheng, Y.L. Zhou, H.L. Wu, X.Z. Liu, H.Y. Yang, F.F. Song, C. Huang","doi":"10.1177/00220345251413516","DOIUrl":"https://doi.org/10.1177/00220345251413516","url":null,"abstract":"Periodontitis is an inflammatory disease driven by microbial dysbiosis, characterized by immune dysregulation and alveolar bone resorption. Although upregulation of S100A8/A9 levels was found in human periodontitis, its mechanism of regulating osteoimmunological homeostasis during periodontitis progression remains elusive. To investigate this, we constructed a ligature-induced periodontitis model using <jats:italic toggle=\"yes\">S100a9</jats:italic> knockout mice. Further studies showed that <jats:italic toggle=\"yes\">S100a9</jats:italic> knockout mice exhibited impaired neutrophil extracellular trap (NET) formation and ameliorated bone resorption. Mechanistic studies demonstrated that <jats:italic toggle=\"yes\">S100a9</jats:italic> deficiency inhibits neutrophil autophagy, resulting in diminished NET formation (NETosis), which consequently suppressed osteoclast differentiation. This effect was reversible in <jats:italic toggle=\"yes\">S100a9</jats:italic> deficiency mice upon rapamycin-induced autophagy restoration. Therapeutic intervention with the S100A9-specific inhibitor tasquinimod effectively inhibited osteoclastic differentiation of macrophages and mitigated bone loss. In conclusion, our findings reveal the mechanism by which S100A9 regulates osteoclast differentiation via NETosis, providing insights into osteoimmunological regulation in the pathogenesis of periodontitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"338 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147274323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Uses of Optical Coherence Tomography in Periodontology","authors":"G. Kang, D. Chen, Y.-Y. Juo, A. Lloyd, R. Reichelt, N. Soldatos, S.L. Sousa Melo, D. Huang, S. Chen, G.C.-Y. Hsu","doi":"10.1177/00220345251410056","DOIUrl":"https://doi.org/10.1177/00220345251410056","url":null,"abstract":"Optical coherence tomography (OCT) is a noninvasive imaging technology that provides high-resolution, cross-sectional views of biological tissues using near-infrared light. Since its introduction in the early 1990s, OCT has expanded from ophthalmology into dentistry. With micrometer-level resolution and no ionizing radiation, dental OCT offers significant advantages over conventional x-ray–based imaging modalities such as intraoral radiography and cone beam computed tomography, particularly for detecting early or subtle changes in hard and soft tissues. In this article, we review the evolution of OCT in periodontology and share 3 novel applications: assessment of postorthodontic fenestrations, preoperative planning for periapical lesions, and gingival revascularization after gingivectomy. These advances go beyond the reach of standard imaging tools and support the adoption of OCT for improving diagnosis, guiding treatment, and monitoring treatment response. As imaging protocols become increasingly sophisticated and targeted, OCT promises great advances in periodontal diagnostics and patient care.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"12 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147274346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}