Journal of Dental Research最新文献

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英文 中文
Chinese Division 中国的分裂
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/0022034502081si-b03
{"title":"Chinese Division","authors":"","doi":"10.1177/0022034502081si-b03","DOIUrl":"https://doi.org/10.1177/0022034502081si-b03","url":null,"abstract":"","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"11 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Israeli Division 以色列分部
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/0022034502081si-b06
{"title":"Israeli Division","authors":"","doi":"10.1177/0022034502081si-b06","DOIUrl":"https://doi.org/10.1177/0022034502081si-b06","url":null,"abstract":"","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"41 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peruvian Section 秘鲁分部
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/0022034502081si-b11
{"title":"Peruvian Section","authors":"","doi":"10.1177/0022034502081si-b11","DOIUrl":"https://doi.org/10.1177/0022034502081si-b11","url":null,"abstract":"","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"43 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Irish Division 爱尔兰分部
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/0022034502081si-b05
{"title":"Irish Division","authors":"","doi":"10.1177/0022034502081si-b05","DOIUrl":"https://doi.org/10.1177/0022034502081si-b05","url":null,"abstract":"","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"56 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Saudi Arabian Section 沙特阿拉伯科
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/0022034502081si-b12
{"title":"Saudi Arabian Section","authors":"","doi":"10.1177/0022034502081si-b12","DOIUrl":"https://doi.org/10.1177/0022034502081si-b12","url":null,"abstract":"","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"28 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Caries and Caries-Free Archaeome 龋齿和无龋齿古生菌群
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/00220345251329343
N. Dame-Teixeira, J. Lynch, X. Yu, J.A. Cena, T. Do
{"title":"The Caries and Caries-Free Archaeome","authors":"N. Dame-Teixeira, J. Lynch, X. Yu, J.A. Cena, T. Do","doi":"10.1177/00220345251329343","DOIUrl":"https://doi.org/10.1177/00220345251329343","url":null,"abstract":"The difficulty of establishing a relationship between archaea and oral diseases such as dental caries stems from the challenges of detecting, identifying, and isolating these microorganisms. This study aimed to detect archaea in publicly available datasets comprising caries and caries-free saliva and dental plaque by using a tailored bioinformatic pipeline for shotgun sequencing analysis. A systematic search was performed to identify studies using shotgun metagenomics or metatranscriptomics on samples obtained from individuals with dental caries. Two reviewers selected studies based on eligibility criteria. Sequencing and metadata from each study were retrieved from the SRA Bioproject. A count table was generated for each database by mapping reads against an archaea genome database, specifically tailored for this study, using stringent filtering parameters of greater than 97% similarity and 90% query coverage. Archaeal prevalence was determined using an arbitrary cutoff point (&gt;500 reads). An effect size meta-analysis was performed to determine the overall prevalence. Phyloseq and DESeq2 packages were used to determine alpha and beta diversities, differential abundance in different taxonomic levels, and differential expression comparing caries and caries-free samples. Spearman correlation was performed with the bacteriome. The search yielded 154 titles, from which a collection of 7 datasets from 8 studies was obtained. Of 397 samples, <jats:italic>N</jats:italic> = 63 were positive for archaea using postfiltering, comprising a putative prevalence of 20% (confidence interval = 0%–40%) and identifying <jats:italic>Euryarchaeota</jats:italic> , <jats:italic>Thermoplasmatota</jats:italic> , and <jats:italic>Nitrosphaeria</jats:italic> . Methanogens were present in both the caries and caries-free groups ( <jats:italic>Methanobrevibacter</jats:italic> spp., <jats:italic>Methanosarcina</jats:italic> , and <jats:italic>Methanosphaera</jats:italic> ) and positively correlated with <jats:italic>Stenotrophomonas</jats:italic> , <jats:italic>Streptococcus</jats:italic> , <jats:italic>Actinomyces</jats:italic> , <jats:italic>Abiotrophia</jats:italic> , <jats:italic>Gemella</jats:italic> , and <jats:italic>Corynebacterium</jats:italic> . Several methanogenesis genes, including methyl-coenzyme M reductase, which catalyzes the final step of methane production in methanogens, were underexpressed in caries-active samples compared with caries-free samples. Saliva and dental plaque emerged as sites of low-abundance archaea, with methanogenesis genes underexpressed in caries-active samples.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"5 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
South African Division 南非分部
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-21 DOI: 10.1177/0022034502081si-b09
{"title":"South African Division","authors":"","doi":"10.1177/0022034502081si-b09","DOIUrl":"https://doi.org/10.1177/0022034502081si-b09","url":null,"abstract":"","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"64 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EP2 Modulates Satellite Glial Cell Activation in Temporomandibular Joint Osteoarthritis Chronic Pain via p-ERK1/2 Signaling. EP2通过p-ERK1/2信号调节颞下颌关节骨关节炎慢性疼痛中卫星胶质细胞的活化。
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-20 DOI: 10.1177/00220345251328889
X Ma,Y Yuan,T Zhu,X Liu,R Chen,X Zhang,Z Qin,J Zhao,Y Feng,H Li,Y Liu,J Ke
{"title":"EP2 Modulates Satellite Glial Cell Activation in Temporomandibular Joint Osteoarthritis Chronic Pain via p-ERK1/2 Signaling.","authors":"X Ma,Y Yuan,T Zhu,X Liu,R Chen,X Zhang,Z Qin,J Zhao,Y Feng,H Li,Y Liu,J Ke","doi":"10.1177/00220345251328889","DOIUrl":"https://doi.org/10.1177/00220345251328889","url":null,"abstract":"The etiology of chronic pain in temporomandibular joint osteoarthritis (TMJOA) is still unclear, making its treatment challenging in clinical practice. Emerging evidence suggests that the activation of satellite glial cells (SGCs) exerts an important role in the development of pain. This study aims to investigate whether and which prostaglandin E receptor (EP) subtypes expressed on peripheral SGCs and how the corresponding EP subtypes modulate SGC activation during TMJOA chronic pain. Immunofluorescence double staining was applied to demonstrate that EP2 and EP3 expressed on the activated SGCs in the trigeminal ganglions of mice. In vitro studies on the cultivation of primary SGCs showed that EP2 antagonist PF-04418948 significantly attenuated SGC activation in a dose-dependent manner, while EP3 agonist sulprostone failed to affect SGC activation. Kyoto Encyclopedia of Genes and Genomes analysis of RNA sequencing and Western blot demonstrated that the EP2-mediated signaling pathways were associated with phosphorylated extracellular signal-regulated kinase 1 and 2 (p-ERK1/2) signaling of mitogen-activated protein kinases (MAPKs). In addition, to verify the involvement of EP2 on SGCs in the activation of SGCs in vivo, a recombinant adeno-associated virus vector containing glial fibrillary acidic protein-shRNA (EP2)-enhanced green fluorescent protein was injected into TMJOA mouse ganglion of the third branch of the trigeminal nerve to knockdown EP2 on the SGCs. Taken together, EP2 modulates SGC activation through MAPK/p-ERK1/2 signaling in the chronic pain of monosodium iodoacetate-induced TMJOA. This study reveals a new mechanism of SGC activation, providing new insights for the treatment of chronic pain in TMJOA.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"74 1","pages":"220345251328889"},"PeriodicalIF":7.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preconception Oral Health Is Associated with Modifiable Health Behaviors. 孕前口腔健康与可改变的健康行为有关。
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-20 DOI: 10.1177/00220345251325216
J C Bond,M A Simancas-Pallares,K Divaris,R I Garcia,M P Fox,L A Wise,B Heaton
{"title":"Preconception Oral Health Is Associated with Modifiable Health Behaviors.","authors":"J C Bond,M A Simancas-Pallares,K Divaris,R I Garcia,M P Fox,L A Wise,B Heaton","doi":"10.1177/00220345251325216","DOIUrl":"https://doi.org/10.1177/00220345251325216","url":null,"abstract":"The health of prospective parents before conception (i.e., preconception health) has important intergenerational consequences. Although oral health is associated with several reproductive outcomes, it is often absent from preconception health promotion. To generate insights that may inform preconception oral health interventions, we used cross-sectional data from 6,159 US-based participants enrolled in the Pregnancy Study Online, a prospective cohort study of pregnancy planners, to characterize preconception oral health care engagement and self-rated oral health. We used latent class analysis to identify homogenous subgroups (i.e., latent classes) of participants with respect to modifiable risk behaviors and quantified associations between class membership and 3 outcomes-reporting no dental visit within the past year, reporting no dental cleaning within the past year, and self-rated oral health-using log binomial regression models. We identified 3 distinct groups of participants: healthy behavior, high prevalence of healthy behaviors; some risk behavior, higher sugar-sweetened beverage consumption and lower vaccine uptake and multivitamin use; and most risk behavior, high probability of most risk behaviors, including current or former cigarette smoking. The some risk behavior class was more likely to report no dental visit within the past year as compared with the healthy behavior class (prevalence difference [PD] 0.17; 95% confidence interval [95% CI], 0.14 to 0.19). This association strengthened when most risk behavior was compared with healthy behavior (PD, 0.32; 95% CI, 0.28 to 0.36). Similarly, reporting no dental cleaning within the past year was more prevalent among some risk behavior (PD, 0.19; 95% CI, 0.16 to 0.21) and most risk behavior (PD, 0.38; 95% CI, 0.34 to 0.42) as compared with healthy behavior. The pattern was similar for self-rated oral health. Our findings suggest that oral health care engagement and self-rated oral health are associated with other modifiable behaviors in the preconception period. Health promotion efforts in the preconception period must consider oral health care engagement alongside other modifiable health behaviors.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"35 1","pages":"220345251325216"},"PeriodicalIF":7.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial and Antioxidant GelMA/CeO 2 Hydrogel Promotes Oral Mucosal Healing 抗菌和抗氧化凝胶促进口腔黏膜愈合
IF 7.6 1区 医学
Journal of Dental Research Pub Date : 2025-04-19 DOI: 10.1177/00220345251323264
F. Yang, Y. He, F. Wang, X. Zhao, Y. Hsu, F. Yan, X. Zhou, W. Hu, D. Xia, Y. Liu
{"title":"Antibacterial and Antioxidant GelMA/CeO 2 Hydrogel Promotes Oral Mucosal Healing","authors":"F. Yang, Y. He, F. Wang, X. Zhao, Y. Hsu, F. Yan, X. Zhou, W. Hu, D. Xia, Y. Liu","doi":"10.1177/00220345251323264","DOIUrl":"https://doi.org/10.1177/00220345251323264","url":null,"abstract":"Oral mucosal wounds can greatly affect overall patient health and interfere with eating and speech functions. The intraoral environment provides an ideal milieu for bacterial growth and proliferation, thereby increasing the risk of infection in oral mucosal wounds. In the event of wound infection, immune cells undergo a respiratory burst, leading to the production of a substantial amount of reactive oxygen species. Bacterial colonization and excessive reactive oxygen species can induce adverse inflammatory responses, resulting in delayed healing of oral mucosal wounds. Cerium oxide (CeO <jats:sub>2</jats:sub> ) nanoparticles were chosen for their high antibacterial and antioxidant capacities. Gelatin methacrylate (GelMA) is an excellent carrier of CeO <jats:sub>2</jats:sub> nanoparticles, which has good injectivity after precrosslinking and is suitable for deep oral wounds. In this study, GelMA/CeO <jats:sub>2</jats:sub> hydrogels with antibacterial and antioxidant functionalities were engineered to enhance the healing of oral mucosal wounds. The GelMA/CeO <jats:sub>2</jats:sub> hydrogels demonstrated excellent biocompatibility, promoted gingival fibroblast migration, and upregulated the expression of genes involved in wound healing. In addition to their significant antioxidant activity, the GelMA/CeO <jats:sub>2</jats:sub> hydrogels exhibited strong antibacterial properties, as evidenced by the inhibition of <jats:italic>Streptococcus mutans</jats:italic> and <jats:italic>Porphyromonas gingivalis</jats:italic> growth. The GelMA/CeO <jats:sub>2</jats:sub> hydrogels also significantly accelerated the healing of infected mucosal wounds in a rabbit model, achieving a 100% wound closure rate by day 7. In summary, the use of these novel GelMA/CeO <jats:sub>2</jats:sub> hydrogels represents an effective strategy for the treatment of oral wounds.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"10 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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