Journal of Dental Research最新文献

{"title":"Infertility and Periodontitis: Are We Connecting the Right Dots?","authors":"C Wetzel,C V Bumm,J Becker,F Schwendicke,M Folwaczny,N Werner","doi":"10.1177/00220345261416502","DOIUrl":"https://doi.org/10.1177/00220345261416502","url":null,"abstract":"Infertility is an increasing global health concern. Growing evidence suggests that systemic inflammatory conditions, including periodontal disease, may contribute to impaired reproductive outcomes. This narrative review highlights recent conceptual advances linking periodontal disease with male and female infertility, focusing on biological mechanisms (i.e., microbial translocation, chronic inflammation, immune dysregulation, oxidative stress, and epigenetic modifications). The review critically examines available studies focusing on scientific quality, design, and clinical relevance. In females, periodontal disease has been associated with idiopathic infertility and polycystic ovary syndrome. These conditions are characterized by immune dysregulation and low-grade systemic inflammation. In males, impaired semen parameters and idiopathic infertility have been linked to poor periodontal status. Despite growing interest, existing studies are largely associative and limited by methodological heterogeneity, insufficient control for confounders, and a lack of standardized outcome measures. This review proposes a framework for improved future research strategies addressing these shortcomings to clarify causality and therapeutic potential.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"85 1","pages":"220345261416502"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O-GlcNAcylation Mediates BMP2-Induced Osteogenesis/Cementogenesis via NMIIA.","authors":"J Zhou,F Shen,C You,M Liu,X Xie,L Zhao,L Ye,J Wang,Y Shi","doi":"10.1177/00220345251411887","DOIUrl":"https://doi.org/10.1177/00220345251411887","url":null,"abstract":"The precise cellular origin and regulatory mechanisms underlying cementum development remain poorly understood, hindering progress toward ideal cementum regeneration. Bone morphogenetic protein 2 (BMP2), approved by the US Food and Drug Administration for clinical use due to its potent osteoinductive capacity, is a key candidate for such regulation. Activin receptor-like kinase 3 (Alk3)-mediated BMP signaling plays a crucial role in the development and structural maintenance of mineralized tissues, including teeth. However, the precise mechanism by which BMP signaling regulates periodontal tissue development mediated by periodontal ligament stem cells (PDLSCs), especially Gli1+ cells, remains unknown. Emerging evidence has indicated that O-GlcNAc glycosylation (O-GlcNAcylation), a dynamic posttranslational modification, modulates critical biological processes, such as transcription, translation, and cell fate determination. In this study, we demonstrate how BMP2 signaling enhances O-GlcNAcylation in a SMAD-dependent manner. Notably, we demonstrate that the lack of Alk3 in Gli1+ cells resulted in reduced O-GlcNAcylation levels in vivo. Nonetheless, O-GlcNAcylation is identified as indispensable for PDLSC-mediated osteogenesis and cementogenesis both in vivo and in vitro. Moreover, deleting O-β-N-acetylglucosaminyltransferase (Ogt) in Gli1+ cells suppresses BMP signaling, consequently impairing cellular cementum formation and delaying alveolar socket healing. Mechanistically, we further revealed that the cytoskeleton, especially MYH9 (nonmuscle myosin IIA, NMIIA), is O-GlcNAcylated and is essential for BMP2-induced osteogenic/cementogenic differentiation. These findings demonstrate that O-GlcNAcylation is essential for cellular cementum formation by modulating the BMP signaling pathway in PDLSC differentiation and Gli1+ periodontal progenitors, highlighting its critical role in both tooth root development and alveolar bone repair.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"58 1","pages":"220345251411887"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways Mediating Immigration and Utilization of Dental Care in Children.","authors":"N Z Bashir,C C K Chan,C McGrath","doi":"10.1177/00220345261416826","DOIUrl":"https://doi.org/10.1177/00220345261416826","url":null,"abstract":"Timely dental care is essential for children's health and development, yet disparities persist, particularly among immigrants and children of immigrants. This study examined how children's and their parents' immigration status affects dental care utilization, considering social capital and material hardship as mediators. Using 8 waves of the National Survey of Children's Health from 2016 through 2023, we analyzed a nationally representative, pooled, cross-sectional survey sample of 274,302 children in the United States aged 2 to 17 y. Latent variables for social capital, material hardship, and socioeconomic status (SES) were constructed from factor analysis of observable indicators. Multivariable structural equation models simultaneously included child and parental immigration status as exposures to assess pathways linking immigration to dental attendance and receipt of preventive dental care. We compared models with mediation versus confounding by SES. Results indicate that social capital is a primary pathway through which immigration status reduces dental attendance. Social capital mediated the effect of being a foreign-born child in both the mediation-by-SES and confounding-by-SES models (odds ratio [OR], 0.74; 95% confidence intervals [CI], 0.64-0.86). Similarly, social capital mediated the effect of having foreign-born parents in both models (OR, 0.59; 95% CI, 0.46-0.76). Comparing the pathways of the 2 exposures revealed heterogeneity: direct effects (i.e., those not mediated by social capital or material hardship) were stronger than mediated effects for the child's immigrant status, whereas mediated effects were stronger for parental immigrant status. Our findings remained consistent when assessing receipt of preventive care as an outcome and also when carrying out sensitivity analyses comparing the pre- and post-COVID-19 periods. These results highlight social capital as a potential target for future research into reducing dental care disparities among immigrant children. Improving social networks, community engagement, and access to supportive resources may potentially be a viable way to promote equitable utilization of dental care.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"298 1","pages":"220345261416826"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VEGF-C-Driven Lymphatic Survival Signaling Promotes Periodontal Repair.","authors":"S Matsumoto,T Iwayama,P Bhongsatiern,Y Yoshida,Y Koketsu,E Tsuboi,S Takashiba,Y Sato,S Murakami,M Takedachi","doi":"10.1177/00220345261421161","DOIUrl":"https://doi.org/10.1177/00220345261421161","url":null,"abstract":"Lymphatic vessels play a pivotal role in tissue homeostasis and repair, yet their function in periodontal healing remains poorly defined. In this study, we investigated the spatial dynamics and functional significance of lymphatics during periodontal wound repair using a mouse model of ligature-induced periodontitis. By combining Prox1-tdTomato transgenic reporter mice with advanced tissue clearing and light sheet microscopy, we generated high-resolution 3-dimensional images of gingival lymphatic networks under both physiological and repair conditions. Our observations revealed that lymphatic vessels undergo active and spatially organized reassembly during the healing phase. Notably, we found a region-specific increase in lymphatic branching and density in the marginal gingiva, suggesting localized lymphangiogenesis. Time course analysis confirmed that this lymphatic remodeling peaks during the granulation tissue formation phase. We further identified epithelial upregulation of Vegfc during the repair phase and demonstrated that local administration of vascular endothelial growth factor C (VEGF-C) C156S, a VEGFR-3-specific agonist, enhanced lymphatic vessel function and alveolar bone repair. To explore the underlying molecular mechanisms, we successfully established, for the first time, primary cultures of gingiva-derived lymphatic endothelial cells (LECs). Comparative transcriptomic analysis revealed distinct signatures of gingival LECs compared to lymph node or dermal LECs. These cells maintained typical LEC characteristics in vitro and responded robustly to VEGF-C stimulation. RNA sequencing and functional apoptosis assays revealed significant modulation of apoptosis-related genes, including downregulation of Ell3 and upregulation of Siah1b, suggesting a survival-promoting role for VEGF-C signaling in LECs. Collectively, our findings highlight a previously underappreciated regenerative role of lymphatic vessels in the periodontium and establish lymphangiogenic activation as a potential therapeutic strategy for enhancing periodontal repair. The successful culture of primary gingival LECs further provides a novel platform for mechanistic studies in oral lymphatic biology.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"47 1","pages":"220345261421161"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Network Silk Fibroin/Quercetin Hydrogel for Periodontitis Treatment.","authors":"H Zhang,X Mao,S Ge,B Ma","doi":"10.1177/00220345261416506","DOIUrl":"https://doi.org/10.1177/00220345261416506","url":null,"abstract":"Periodontitis is characterized by bacterial infection, elevated reactive oxygen species (ROS), excessive inflammation, and immune imbalance. Consequently, there is an urgent need to devise promising strategies capable of simultaneously combating infection, alleviating oxidative stress, suppressing inflammation, and regulating immunity in periodontitis management. Herein, an injectable silk fibroin/quercetin (SFQ) natural hydrogel was developed through self-assembly. The quercetin-silk fibroin interaction and the quercetin-enhanced β-sheet formed the self-assembled dual-network structure, bringing good injectability and mechanical stability. SFQ hydrogel with high biocompatibility promoted cell migration, scavenged ROS, relieved mitochondrial damage, and prevented cellular apoptosis. Meanwhile, SFQ hydrogel possessed a satisfactory anti-inflammatory ability and regulated immune response by inhibiting M1 polarization and promoting M2 polarization of macrophages. In addition, SFQ hydrogel can efficiently kill free bacteria and inhibit biofilm formation. In vivo experiments revealed that SFQ hydrogel significantly ameliorated inflammation, reduced collagen destruction, and regulated the immune micro milieu for tissue remodeling. Overall, self-assembled SFQ natural hydrogel offers a promising therapeutic option for improving the treatment of periodontitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"40 1","pages":"220345261416506"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.","authors":"R A Kamath,A Phanrungsuwan,C Ge,S Shahid,F F Mohamed,J Chung,Y Han,M Killian,V Kaartinen,B L Foster,R T Franceschi","doi":"10.1177/00220345261423834","DOIUrl":"https://doi.org/10.1177/00220345261423834","url":null,"abstract":"Discoidin Domain Receptor 2 (DDR2) is a collagen-activated tyrosine kinase required for bone and tooth development as well as regeneration of calvarial and long bones. Although DDR2 is expressed in alveolar bone, its functions in this site have not been previously examined. The present study used global and conditional knockout approaches and lineage tracing to examine the functions of DDR2 in alveolar bone formation during tooth socket healing. First molars were extracted from the maxillae of wild-type and globally Ddr2-deficient (Ddr2LacZ/LacZ) mice, and socket healing was measured after 1, 2, or 4 wk. At all times, Ddr2 inactivation significantly reduced socket healing. These changes were associated with decreased cell proliferation 3 d after extraction without any detectable changes in apoptosis. In addition, collagen fibril orientation, measured using Picrosirius Red staining under polarized light, was disrupted in tooth sockets from Ddr2-deficient mice. For lineage tracing, 4-wk-old Ddr2mer-cre-mer; R26RtdTomato and Gli1CreERT2; R26RtdTomato mice were induced with tamoxifen, first molars were extracted, and socket healing was examined after 1, 3, or 7 d. In both cases, tdTomato+ cells migrated into sockets, where they sequentially co-localized with preosteoblast and osteoblast markers. Thus, both DDR2+ and GLI1+ cells contribute to socket healing. The considerable overlap observed between DDR2+ and GLI1+ cells suggested that DDR2 functioned in GLI1+ cells, which are known to have skeletal progenitor properties. Consistent with localization data, conditional knockout (Gli1CreERT2; Ddr2fl/fl) mice exhibited reductions in socket healing 1 wk postextraction, although the inhibition of socket repair was less than that seen in global Ddr2 knockouts. In summary, this work demonstrates a role for DDR2 in alveolar bone repair, a finding that may have therapeutic implications for the treatment of alveolar bone loss associated with periodontal disease and other disorders.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"9 1","pages":"220345261423834"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metacognition and Contested Science: The Case of Water Fluoridation.","authors":"H Fischer,S Listl","doi":"10.1177/00220345261425669","DOIUrl":"https://doi.org/10.1177/00220345261425669","url":null,"abstract":"Community water fluoridation (CWF) has become one of the most contested public health interventions despite a robust evidence base supporting its effectiveness, safety, and equity. Drawing on a recent comprehensive review, this perspective argues that persistent controversies revolve not only around the effectiveness, safety, and implementation of CWF but also around a \"fourth controversy\": how people evaluate and hold confidence in what they think they know. We discuss CWF as a case of contested science in which polarization and misinformation undermine belief updating. Using insights from metacognition research, we suggest that improving public reasoning requires communication and policy approaches that foster epistemic humility, iterative learning, and evidence-informed revision rather than reliance on evidence accumulation alone.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"82 1","pages":"220345261425669"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edentulousness and Frailty: A Study of Directionality and Pathways.","authors":"E Petrauskiene,P Zaninotto,A Heilmann,A Peasey,G Tsakos","doi":"10.1177/00220345251414409","DOIUrl":"https://doi.org/10.1177/00220345251414409","url":null,"abstract":"Associations between tooth loss and frailty have been reported, but longitudinal evidence on directionality and pathways of this association is lacking. We examined the direction and pathways of the association between edentulousness and frailty among older adults in England using a nationally representative sample of 6,800 adults aged ≥50 y who participated in the English Longitudinal Study of Ageing (ELSA) at wave 3. Edentulousness and frailty (determined using the Frailty Index) were assessed at waves 3 (2006/7), 5 (2010/11), and 7 (2014/15). The following mediators were assessed at waves 4 (2008/9) and 6 (2012/13): loneliness (UCLA Loneliness Scale), C-reactive protein (CRP), and consumption of fruit and vegetables. A cross-lagged longitudinal structural equation model with a Bayesian estimator using probit regression assessed the direction and pathways of the association between edentulousness and frailty at 2 time points (i.e., wave 3 to wave 5 and wave 5 to wave 7), after adjusting for sociodemographic factors and smoking. Being edentate at wave 3 was associated with an increased probability of frailty at wave 5, but the path was not significant between waves 5 and 7 (probit regression coefficient 0.05; 95% CI, -0.02 to 0.13). The paths from frailty to edentulousness were not significant at either time point (probit regression coefficients 0.09 [95% CI, -0.10 to 0.279] and 0.14 [95% CI, -0.03 to 0.31] for waves 3-5 and waves 5-7, respectively). The estimates of indirect paths via loneliness and CRP were of small magnitude but significant at both time points. No significant mediation was observed via the consumption of fruit and vegetables. Health promotion strategies aimed at preserving natural teeth and tackling loneliness in older people may have the potential to prevent frailty.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"34 1","pages":"220345251414409"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting of Animal Studies on Craniofacial Bone Repair: 2004, 2014, and 2024.","authors":"Y Liu,F Guo,J Botelho,Z Tao,T Zhao,M Degen,N Pandis,F Hua","doi":"10.1177/00220345261424229","DOIUrl":"https://doi.org/10.1177/00220345261424229","url":null,"abstract":"Clinical need and research activities on craniofacial bone repair/regeneration (CBR) have been increasing in dentistry, and animal research provides essential support for its advancement. However, inadequate reporting in animal research contributes to avoidable research waste and limits the validation and translation of research findings. Therefore, this research-on-research study aimed to assess the reporting quality of animal research on CBR and to identify its changes over the past 2 decades. Electronic and manual searches were conducted to identify animal research regarding CBR published in 2004, 2014, and 2024. The reporting quality of included studies was assessed using a modified ARRIVE (Animal Research: Reporting In Vivo Experiments) 2.0 checklist. A multivariable generalized linear model was used to explore changes in reporting quality over time. A total of 164 studies were included. The mean (standard deviation) overall quality score (OQS; calculated by summing the scores of all checklist items) improved over time: OQS2004 = 4.42 (1.29), OQS2014 = 5.70 (1.72), and OQS2024 = 6.79 (2.25). Among the included studies, \"study design,\" \"objectives,\" and \"generalizability\" were adequately reported. In contrast, less than 1.0% of the included studies sufficiently reported \"inclusion and exclusion criteria\" (0.6%; 1/164) and \"protocol registration\" (0.6%; 1/164). Despite the release and update of the ARRIVE guidelines, several methodological items, including \"sample size\" (8.5%; 14/164) and \"randomization\" (6.7%; 11/164), remained poorly reported. Only 18 of 164 studies (11.0%) specified the primary outcome measures, and none reported effect sizes with confidence intervals. Reporting of \"ethical statements,\" \"data access,\" and \"declaration of interests\" considerably improved but remained suboptimal. According to the multivariable analysis, publication year was a significant predictor of reporting quality (P < 0.01). The reporting of CBR animal research has improved significantly during the past 2 decades. However, concerted efforts toward more complete and transparent reporting, which facilitate validation and translation, are warranted.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"4 1","pages":"220345261424229"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Average and Heterogeneous Associations between Secondhand Smoking and Tooth Loss.","authors":"Y Q Chen,J M Zheng,Y Z Chen,H Y Zhang,J Y Li,H Deng,Y Y Kong","doi":"10.1177/00220345261419027","DOIUrl":"https://doi.org/10.1177/00220345261419027","url":null,"abstract":"Secondhand smoke (SHS) is a pervasive health concern increasingly associated with tooth loss, yet studies assessing its population-level associations and potential heterogeneity are limited. This study aimed at estimating the average and subgroup-specific effects of SHS exposure on tooth loss among US adults using modern causal inference-based methods. This study analyzed cross-sectional data from 6,019 nonsmokers aged ≥20 y, representing 48.2 million individuals, in the National Health and Nutrition Examination Survey (2009 to 2018). SHS was defined by serum cotinine. This study quantified the association between SHS exposure and tooth loss using targeted minimum loss estimation, a doubly robust estimator that enhances confounding adjustment in observational data. Confidence intervals were obtained via bootstrap resampling. Heterogeneity of the association was evaluated by a data-adaptive causal forest method that identifies subgroup-specific variation. SHS exposure was associated with having 0.74 fewer teeth (average association, -0.739; 95% CI, -1.053 to -0.426) and with a 4.6-percentage higher probability of having <20 teeth (average association, 0.046; 95% CI, 0.027 to 0.065). Larger associations were observed among adults aged ≥45 y, those with lower socioeconomic position, individuals with higher sugar intake or medical comorbidities, and participants at the extremes of flossing frequency. This study found that SHS exposure was associated with greater tooth loss, with disproportionate burdens observed among adults facing socioeconomic disadvantages or chronic health conditions. These findings underscore the potential value of integrating oral health outcomes into tobacco control initiatives and guiding targeted prevention for groups at elevated risk.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"236 1","pages":"220345261419027"},"PeriodicalIF":7.6,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147374025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}