Journal of Dental Research最新文献

{"title":"Statistical Heterogeneity in Oral Health Meta-Analyses","authors":"Z. Tatas, E. Kyriakou, J. Seehra, N. Pandis, L.M. Spineli","doi":"10.1177/00220345251316279","DOIUrl":"https://doi.org/10.1177/00220345251316279","url":null,"abstract":"Providing the summary effect size and its uncertainty, a prediction interval, and a measure of statistical heterogeneity constitute good reporting practices in meta-analyses. Popular statistical heterogeneity measures comprise the τ<jats:sup>2</jats:sup> and I<jats:sup>2</jats:sup> statistics. However, researchers often rely unduly on the I<jats:sup>2</jats:sup> statistic, using naive categorizations to gauge the extent of heterogeneity, leading to misuses of the meta-analysis models, deficiencies in reporting, and misleading conclusions. The present study aimed to provide empirical evidence on the reporting and interpretation of statistical heterogeneity in systematic reviews of oral health published between 2021 and 2023 in 21 leading specialty and general dental journals. Systematic reviews with at least 1 meta-analysis on binary or continuous outcomes with the most studies were identified. Characteristics were extracted at the systematic review and meta-analysis levels. In total, 313 systematic reviews with meta-analyses were analyzed. Within this cohort of meta-analyses, the random-effects model (89%, n = 278) was frequently applied. Almost all meta-analyses (98%, n = 308) reported the I<jats:sup>2</jats:sup> value, and 51% ( n = 160) reported the τ<jats:sup>2</jats:sup> value. For this sample, the median I<jats:sup>2</jats:sup> was 76% (range: 0%–100%), and the median τ<jats:sup>2</jats:sup> was 0.29 (range: 0–2,632), with 13% ( n = 20/160) of these meta-analyses reporting zero τ<jats:sup>2</jats:sup>. Most of the meta-analyses (96%, n = 299) based the heterogeneity interpretation on I<jats:sup>2</jats:sup> and only 21 (7%) on τ<jats:sup>2</jats:sup>. Although 49% ( n = 152) of the meta-analyses chose the meta-analysis model a priori, only 41% ( n = 63/152) justified this choice. Furthermore, 42% ( n = 131) of the 313 meta-analyses chose the meta-analysis model based on the I<jats:sup>2</jats:sup>. Within oral health meta-analyses, there is evidence of overreliance on I<jats:sup>2</jats:sup> when reporting and interpreting statistical heterogeneity and selecting the meta-analysis model. The inappropriate use of I<jats:sup>2</jats:sup> in meta-analysis model selection and interpretation of statistical heterogeneity may have implications for the quality of conclusions delivered to the end users of systematic reviews.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"33 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cuproptosis Aggravates Pulpitis by Inhibiting the Pentose Phosphate Pathway","authors":"L. Zhou, H.-Q. Mao, Y.-H. Wen, Z. Chen, L. Zhang","doi":"10.1177/00220345251313797","DOIUrl":"https://doi.org/10.1177/00220345251313797","url":null,"abstract":"Excessive copper becomes toxic, driving inflammation, and, when copper exceeds a certain threshold, it even leads to a novel programmed cell death termed cuproptosis. However, disordered copper metabolism and its mechanism in pulpitis remain unclear. In this work, we found that lipoteichoic acid (LTA) or lipopolysaccharides (LPS) triggered copper deposition in pulpitis and consequently intensified cuproptosis by impeding the pentose phosphate pathway (PPP). We initially assessed the copper content in pulpitis tissues via inductively coupled plasma mass spectrometry and observed significantly greater concentrations than in healthy pulp tissues. We found that a relatively high copper content was triggered by LTA or LPS, leading cells to cuproptosis. Stimulation of LTA or LPS induced copper deposition and cuproptosis, worsening the progression of pulpitis in vivo. Mechanistically, we found that copper detoxification is dependent on the PPP. We used a <jats:sup>13</jats:sup>C-glucose stable isotope-tracing experiment to assess the effect of glucose utilization on cuproptosis. Excessive copper hindered the PPP, resulting in an inadequate generation of nicotinamide adenine dinucleotide phosphate to replenish glutathione and counteract copper toxicity. The PPP regulates the phenotype, function, and survival of preodontoblast-like cells in cuproptosis. Our findings revealed the intricate interplay among bacteria, copper homeostasis, and metabolic reprogramming, providing potential strategies for host-targeted therapy in pulpitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"104 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Composite Performance Prediction Using Artificial Intelligence","authors":"K. Paniagua, K. Whang, K. Joshi, H. Son, Y.S. Kim, M. Flores","doi":"10.1177/00220345241311888","DOIUrl":"https://doi.org/10.1177/00220345241311888","url":null,"abstract":"There is a need to increase the performance and longevity of dental composites and accelerate the translation of novel composites to the market. This study explores the use of artificial intelligence (AI), specifically machine learning (ML) models, to predict the performance outcomes (POs) of dental composites from their composite attributes. A comprehensive dataset was carefully curated and refined from 200+ publications. Nine ML models were trained to predict discrete POs, and their performance was evaluated. Five models were used for regression analysis of continuous POs. Different ML models performed better on different POs. The k-nearest neighbors (KNN) model excelled in predicting flexural modulus (FlexMod), Decision Tree model in flexural strength (FlexStr) and volumetric shrinkage (ShrinkV), and Logistic Regression and Support Vector Machine models in shrinkage stress (ShrinkStr). Receiver-operating characteristic area under the curve analysis confirmed these results but found that Random Forest was more effective for FlexStr and ShrinkV, suggesting the possibility of Decision Tree overfitting the data. Regression analysis revealed that the voting regressor was superior for FlexMod and ShrinkV predictions, while Decision Tree Regression was optimal for FlexStr and ShrinkStr. Feature importance analysis indicated triethylene glycol dimethacrylate is a key contributor to FlexMod and ShrinkV, bisphenol A glycidyl dimethacrylate and urethane dimethacrylate to FlexStr, and depth of cure, degree of monomer-to-polymer conversion, and filler loading to ShrinkStr. There is a need to conduct a full analysis using multiple ML models because different models predict different POs better and for a large, comprehensive dataset to train robust AI models to facilitate the prediction and optimization of composite properties and support the development of new dental materials.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"17 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education, Tooth Loss, and Dental Visits: Evidence from Schooling Reforms","authors":"S.-E. Baumeister, S. Listl, G.G. Nascimento, M. Nolde","doi":"10.1177/00220345251316815","DOIUrl":"https://doi.org/10.1177/00220345251316815","url":null,"abstract":"Numerous studies have shown that education correlates with tooth loss and dental services use, but whether expanding educational opportunities would reduce tooth loss and improve dental attendance remains unclear given that prior studies lacked a study design to assess causality. We leveraged a policy reform, raising the school leaving age, as an instrumental variable (IV) to estimate the effect of education on edentulism and dental visits in the United States using the repeated cross-sectional data from the Behavioral Risk Factor Surveillance System (BRFSS; N = 463,878). We additionally examined the effect of education on dental visits using longitudinal data from the Survey of Health, Aging and Retirement in Europe (SHARE; N = 69,929). Applying IV probit models, we found 1 extra year of schooling reduced edentulism likelihood by 2.9 percentage points (95% confidence interval [CI]: −0.041; −0.017) and increased dental visit likelihood by 1.2 percentage points (95% CI: 0.01; 0.024) in the United States, with similar effects on dental visits in Europe. Estimates were robust to different model specifications and plausible amounts of imperfect exogeneity. Negative control analysis supported the validity of our findings. This study provides consistent evidence that extended schooling reduces edentulism risk and increases regular dental attendance.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"51 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Evaluation of Image Superimposition in Dentistry","authors":"S. Nada, M. Hasanin, R. ElNaghy","doi":"10.1177/00220345241311263","DOIUrl":"https://doi.org/10.1177/00220345241311263","url":null,"abstract":"Image superimposition currently serves as an essential tool for evaluating the effectiveness of treatment by overlaying 2 or more images taken at different time intervals. Superimposition has proved to be an integral diagnostic tool in terms of assessing procedural accuracy, growth patterns, possible changes in extraoral soft tissue, and overall direction of teeth displacement. Several superimposition protocols have been proposed in literature. Traditionally, superimposition was done on 2-dimensional lateral cephalometric radiographs. However, this approach has its limitations. The rise of 3-dimensional (3D) imaging, including computed tomography and cone beam computed tomography, has introduced more advanced diagnostic tools. These technologies enable the creation of volumetric 3D images, which can be used for 3D superimposition to evaluate changes in the dentocraniofacial area. The primary techniques for 3D superimposition include landmark-based methods, surface-based methods, and the more recent voxel-based superimposition. By incorporating soft tissue data, the development of a virtual 3D patient is possible, offering substantial benefits in the field of dental and craniofacial medicine. Moreover, 4-dimensional superimposition, which captures the dynamics of temporomandibular joint and mandibular movements, is shifting research toward the study of dynamic, rather than static, virtual patients. Additionally, the advent of artificial intelligence is revolutionizing superimposition by enabling automated processes, which are poised to transform clinical and research practices. Here, we explore the recent advancements in superimposition techniques and their potential implications in dentocraniofacial analysis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"184 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FSP1/S100A4-Expressing Stem/Progenitor Cells Are Essential for Temporomandibular Joint Growth and Homeostasis","authors":"T. Tuwatnawanit, W. Wessman, D. Belisova, Z. Sumbalova Koledova, A.S. Tucker, N. Anthwal","doi":"10.1177/00220345251313795","DOIUrl":"https://doi.org/10.1177/00220345251313795","url":null,"abstract":"The temporomandibular joint (TMJ) is one of the most used joints in the body. Defects and wear in the cartilage of the joint, condyle, and fibrocartilage disc lie at the heart of many common TMJ disorders. During postnatal development, the condyle acts as a growth center for the mandible, with cells moving as a conveyor belt away from the top of the condyle as they differentiate. The superficial layers of the condyle have been proposed to contain stem/progenitor populations to allow growth and maintain homeostasis. Here we have focused on the role of fibroblast-specific protein 1 (FSP1; also known as S100a4) as a key fibroblast stem/progenitor marker for the condyle. Lineage tracing with FSP1-Cre;R26RmTmG mice revealed that FSP1-expressing cells were restricted to the superficial fibroblast zone, giving rise to all layers of the condyle over time. The FSP1-expressing cells overlapped with other putative stem cell markers of the condyle, such as Gli1 and scleraxis. BrdU pulse chase experiments highlighted that a subset of FSP1 fibrocartilage was label retaining, suggesting that FSP1 labels a novel stem/progenitor cell population in the condyle. Destruction of FSP1-expressing cells by conditional diphtheria toxin activity in FSP1-Cre;R26RDTA mice resulted in severe TMJ osteoarthritis with loss of the cartilage structure. Lgr5-expressing cells in the superficial layer of the condyle have been shown to create a Wnt inhibitory niche. FSP1 expression postnatally was associated with a reduction in canonical Wnt activity in the condyle. Importantly, constitutive activation of Wnt/β catenin in FSP1-expressing cells led to a downregulation of FSP1 and progressive postnatal loss of TMJ condylar hyaline cartilage due to loss of the superficial stem/progenitor cells. These data demonstrate a novel role for FSP1-expressing cells in the superficial zone in growth and maintenance of the TMJ condylar cartilage and highlight the importance of regulating Wnt activity in this population.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"17 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Textured Intaglio Micropores Improve the Properties of 3D-Printed Zirconia Crowns","authors":"H. Zhu, J. Jiang, S. Wang, Y. Zhou, Y. Ma, X. Chen, F. He","doi":"10.1177/00220345241307912","DOIUrl":"https://doi.org/10.1177/00220345241307912","url":null,"abstract":"Monolithic zirconia crowns fabricated using computer-aided design and computer-aided manufacturing (CAD-CAM) via subtractive manufacturing (SM) exhibit limited bonding properties compared with other ceramics. Traditional methods such as air abrasion can improve bonding but may negatively affect the mechanical stability of zirconia. Nanoparticle jetting (NPJ), an emerging 3-dimensional–printing technology for zirconia restorations, offers the potential to create intricate structures, such as porous surfaces, with high precision. This study aimed to demonstrate that NPJ-manufactured monolithic zirconia crowns with an intaglio porous design can enhance bonding properties while maintaining mechanical strength. Standard NPJ zirconia crowns and commercially available SM zirconia crowns (SZC) were used as control groups. The surface roughness, fracture load, 2-body wear, and shear bond strength (SBS) were evaluated. The NPJ intaglio porous crowns (NIPC) with an intaglio porous design exhibited satisfactory and comparable fracture strength to SZC (within 1-mm occlusal thickness). Although the NIPC retained a relatively high original surface roughness, it demonstrated similar occlusal surface roughness, 2-body wear, and aging resistance to SZC after thorough polishing. Furthermore, the NIPC showed significantly superior intaglio surface roughness and SBS compared with conventionally air-abraded zirconia. Overall, this study successfully demonstrated the potential of NIPC as a viable restorative option, offering robust bonding and reliable mechanical properties.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"1 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enamel-like Polymer-Infiltrated Ceramic Materials for Dental Applications","authors":"X. Zhou, S. Liu, J. Chen, L. Zhu, X. Tong, Z. Chen, Y. Li, J. Lin, C. Wen, J. Ma","doi":"10.1177/00220345251313998","DOIUrl":"https://doi.org/10.1177/00220345251313998","url":null,"abstract":"Polymer-infiltrated ceramic network (PICN) composites are recognized for their mechanical properties, closely resembling natural tooth enamel. However, the low fracture toughness of current PICN materials limits their broader use. This study draws inspiration from the natural enamel rod–sheath architecture to develop bionic PICN composites with an enamel-like structure, enhancing their fracture toughness for dental restorations. By simulating the morphology and arrangement of enamel rods, 3 types of zirconia ceramic scaffolds were designed and manufactured by digital light processing technology, which featured a straight-rod structure, a gnarled-rod structure, or a natural rod distribution structure. The scaffolds were surface treated and resin infiltrated to obtain enamel-structured PICN material, wherein the infiltrated resin formed a rod-sheath structure. With VITA Enamic (VE) as control, the enamel-like composites were characterized in detail for their microstructure, flexural strength, fracture toughness, flexural modulus, friction and wear properties, adhesive properties, and cell compatibility. Results show that the PICN with the natural rod distribution structure had the highest flexural strength and fracture toughness among the 3 PICN composites, but there was no significant difference in their moduli. Its strength and modulus were slightly lower than those of VE, but its toughness was 7.0 ± 0.6 MPa·m<jats:sup>1/2</jats:sup>, around 7 times that of VE. The fracture mode in the ceramic phase was mainly transgranular, while ductile fracturing of the resin phase contributed to toughening. Furthermore, it exhibited superior wear resistance when compared with VE and bovine enamel. After sandblasting and priming, its bond strength to bovine dentin was comparable to that of VE after standardized treatment. Cytotoxicity assays confirmed high cell viability and healthy morphology. Overall, these results indicate that the newly developed PICN composites offer significant improvement over current dental materials, making them promising candidates for bonded prosthetic applications.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"11 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyromonas gingivalis Impairs Microglial Aβ Clearance in a Mouse Model","authors":"M. Xie, X. Huang, Q. Tang, S. Yu, K. Zhang, X. Lu, Y. Zhang, J. Wang, L. Zhang, L. Chen","doi":"10.1177/00220345241294009","DOIUrl":"https://doi.org/10.1177/00220345241294009","url":null,"abstract":"Porphyromonas gingivalis ( Pg), a keystone pathogen in chronic periodontitis, has been identified as an emerging risk factor for Alzheimer’s disease (AD). Pg can promote the accumulation of amyloid β protein (Aβ), a characteristic feature of AD pathology. However, the underlying mechanism, particularly in Aβ clearance, remains poorly understood. Here, by using 3 different strains of Pg, ATCC33277, W50, and W83, we discovered that APP/PS1 mice infected with all 3 Pg strains showed decreased microglial Aβ internalization, increased Aβ deposition in the brain, and impaired cognitive function. Using in vitro experiments, we further demonstrated that all 3 Pg strains inhibited microglial Aβ clearance, where gingipains, a group of toxic proteases derived from Pg, were involved. Gingipains were shown to hydrolyze CD14, subsequently impeding the CD14-mediated Vav-Rac/Cdc42 signaling cascade, which ultimately suppressed phagocytosis. Gingipain inhibitor could effectively restore microglial Aβ clearance and diminish Aβ deposition, leading to improved cognitive function in Pg-infected APP/PS1 mice. These findings may provide new insights into the mechanism through which Pg impairs microglial Aβ clearance to aggravate AD phenotypes, suggesting that gingipain inhibitors could be potential therapeutics for treating Pg-associated AD.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"65 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"γδ17T Cells Aggravate Carcinogen-Induced Oral Squamous Cell Carcinoma","authors":"Y. Saba, S. Yacoub, Y. Netanely, Y. Jaber, R. Naamneh, K. Zubeidat, A. Meyer, Y.E. Shlomovitz, L. Eli-Berchoer, A. Wilensky, I. Prinz, A. Hovav","doi":"10.1177/00220345241305564","DOIUrl":"https://doi.org/10.1177/00220345241305564","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy, with a low 5-y survival rate and frequent local recurrence or metastasis. This study explores the role of γδT cells in the development and progression of OSCC. γδT cells, which exhibit innate and adaptive immune characteristics, are known for their dual role in cancer, acting as anti- and protumor agents depending on the context. Using a murine model of OSCC induced by the carcinogen 4-nitroquinoline-1-oxide (4NQO), which adequately mimics the progression of human OSCC, we investigated the impact of γδT cells on tumor growth and the tumor microenvironment. We first characterized the γδT cells of the tongue epithelium, the primary site for cancer development in this model. The results indicate that γδT cells are predominantly of the Vγ6<jats:sup>+</jats:sup> subset, expanding postnatally in a microbiota-dependent manner. Upon 4NQO administration, depletion of γδT cells did not significantly alter the kinetics of OSCC progression but did result in a reduction in tumor size and number, suggesting a role in promoting tumor growth. Interestingly, the absence of IL-17, a key cytokine produced by the Vγ6<jats:sup>+</jats:sup> subset, also resulted in reduced tumor volume without affecting disease progression, corroborating the protumor role of these cells in OSCC. Further analysis revealed that IL-17–producing γδT cells facilitate angiogenesis within the tumor microenvironment by promoting the expression of angiogenic factors. Of note, while 4NQO treatment increased the oral microbial load and altered its composition, IL-17 deficiency did not affect the oral microbiota, indicating that the effects of IL-17–producing γδT cells on OSCC are independent of microbial changes. This study highlights the pathologic role of IL-17–producing γδT cells in OSCC, particularly in promoting tumor growth through angiogenesis. This underscores the importance of γδT cells in OSCC and the need for further research into therapeutic strategies targeting these cells.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"20 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}