Journal of Dental Research最新文献

{"title":"The Functional Impact of the Noncoding SNP rs3741442 on Orofacial Clefting.","authors":"N Funato,S R F Twigg","doi":"10.1177/00220345251334385","DOIUrl":"https://doi.org/10.1177/00220345251334385","url":null,"abstract":"Orofacial cleft (OFC) is a common congenital anomaly in humans with variable birth prevalence in different ethnic groups. Although genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with nonsyndromic OFC (nsOFC), understanding of the underlying biological mechanisms of causative SNPs and genes in nsOFC remains limited. Here, we report that the noncoding SNP, rs3741442, has an expression quantitative trait locus (eQTL) effect on epithelial genes associated with periderm differentiation. Using a combination of epigenetic markers and in silico analysis, we prioritized the intergenic SNP rs3741442 as a potential causal factor in nsOFC. The risk allele of rs3741442 is prevalent in East Asian populations, and its presence in CRISPR-edited cells leads to reduced expression of neighboring KRT18 and EIF4B. The transcription factor SP1 differentially binds the risk versus nonrisk alleles of rs3741442. Alongside this cis-eQTL impact, rs3741442 has a trans-eQTL effect on the epithelial gene TP63 that is associated with syndromic forms of OFC and psoriasis. These findings provide insights into the mechanism by which an intergenic SNP can affect palatogenesis through the modulation of gene expression.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"13 1","pages":"220345251334385"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health Characteristics 2 Years following Allogeneic Cell Transplant.","authors":"L I Leinbach,S Boroumand,L R Masuch,J T Nguyen,S M Ganesan,J W Mays","doi":"10.1177/00220345251329351","DOIUrl":"https://doi.org/10.1177/00220345251329351","url":null,"abstract":"Allogeneic hematopoietic cell transplantation (allo-HCT) is a treatment modality for cancers and hematopoietic disorders. The number of allo-HCT survivors is increasing in the United States. Allo-HCT is associated with oral health problems that can affect the quality of posttransplantation life. We characterize clinical and patient-reported oral health outcomes from the time of allo-HCT through 2 y following transplantation among a contemporary cohort of patients transplanted between 2019 and 2022. This prospective cohort study analyzed data from participants enrolled in a contemporary allo-HCT natural history study (ClinicalTrials.gov ID: NCT03602599). Clinical characteristics and patient-reported outcomes were captured at 3, 6, 12, 18, and 24 mo post-HCT. Descriptive and bivariable statistics were calculated. Sixty HCT participants were included in the final analysis. Differences were observed in oral pain, oral dryness, diet quality, difficulty swallowing, taste disturbances, and feelings of embarrassment from time of transplantation through the follow-up period. At 2 y, 47.5% of participants reported oral pain, and 44.1% reported xerostomia. Quality-of-life reductions related to taste, pain, and uncomfortable chewing were also observed after 2 y. Oral health problems and reductions in oral health-related quality of life were reported 2 y after allo-HCT. These findings support a tailored approach to oral health care among recipients of allo-HCT. Providing comprehensive and sustained oral health care for this patient population is essential.Knowledge Transfer StatementThis study found time-specific changes in patient-reported symptoms, oral health status, and quality of life that persisted 2 y after allo-HCT. It also suggests that specific attention to long-term oral health care among this patient population remains warranted.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"2 1","pages":"220345251329351"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durable Dentin Bonding with Multifunctional Methacrylated Proanthocyanidins.","authors":"V Hass,N Wickerhauser,N Desch,Y Li,R Wang,Z Peng,Y Wang","doi":"10.1177/00220345251332271","DOIUrl":"https://doi.org/10.1177/00220345251332271","url":null,"abstract":"The degradation of dentin bonding interfaces by enzymes, either originating from the dentin matrix or produced by oral biofilms, contributes to the failure of composite restorations. Proanthocyanidins (PAs) are effective collagen crosslinkers that help preserve collagen, but their interference with adhesive polymerization impairs clinical applications. Methacrylate-functionalized PA (MAPA) was developed as a polymerizable collagen crosslinker, designed to strengthen collagen while copolymerizing with adhesives. This study evaluated the effects of MAPA-containing adhesives on dentin-bonding properties, including collagen crosslinking within bonding interfaces (via sodium dodecyl sulfate-collagen hybridizing peptide assay), microtensile bond strength (µTBS), and collagenolytic activity (in situ zymography) at 24 h and after 2 y (2Y), as well as on biofilm inhibition. Two adhesives, Scotchbond Universal and Prime&Bond Elect, were modified with MAPA or PA at 0%, 5%, and 10% concentrations. Human molar dentin surfaces were bonded and restored using composite resin, then sectioned into sticks or slabs for µTBS and in situ zymography at 24 h or 2Y. Additional specimens were evaluated for biofilm formation (Streptococcus mutans) using live/dead staining, MTT assay, and colony-forming unit counts. Data were analyzed using 2-way analysis of variance and Games-Howell set at 5%. Results showed that MAPA effectively enhanced chemical crosslinking within bonding interfaces without affecting µTBS at 24 h (P > 0.05). Notably, 5%MAPA significantly stabilized bonding interfaces over 2Y (P > 0.05) compared with other groups. All MAPA groups demonstrated a significant reduction in collagenolytic activity (P < 0.05), with 5%MAPA maintaining this effect after 2Y (P > 0.05). In addition, MAPA reduced biofilm formation. MAPA's capacity to copolymerize with adhesives while forming strong chemical interactions with collagen creates a durable, chemically integrated polymer-collagen complex that resists enzymatic degradation and inhibits cariogenic bacterial activity. Incorporating MAPA into adhesives stabilizes bonding interfaces and provides antibiofilm benefits, offering a promising approach to extending the longevity of composite restorations.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"3 1","pages":"220345251332271"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Gut Microbiome in Temporomandibular Joint Disorder Pathogenesis.","authors":"Y Jiang,J Zhou,L Huang,Y Bai,Z Zhang","doi":"10.1177/00220345251332885","DOIUrl":"https://doi.org/10.1177/00220345251332885","url":null,"abstract":"Due to the unclear etiology and pathogenesis of temporomandibular joint disorders (TMDs), current treatments often fail to provide long-term relief or halt disease progression. Therefore, this study aims to explore the underlying etiologic mechanisms by focusing on the causal relationship between the gut microbiome (GM) and TMD through a multi-omics approach. This includes mendelian randomization (MR) analysis of GM, metabolomics, and TMD data, as well as transcriptomic analysis. In accordance with MR guidelines, we utilized summary-level genome-wide association study data to perform bidirectional MR, identifying 28 gut microbial taxa with causal effects on TMD. The following species had the strongest associations with TMD incidence: RUG147 sp900315495 (odds ratio [OR], 2.016; 95% CI, 1.219 to 3.333; P = 0.006), CAG-194 sp002441865 (OR, 0.713; 95% CI, 0.555 to 0.916; P = 0.008), CAG-145 sp000435615 (OR, 1.166; 95% CI, 1.040 to 1.308; P = 0.009), and CAG-81 sp000435795 (OR, 1.150; 95% CI, 1.036 to 1.276; P = 0.009). To explore the mediating role of metabolites, a 2-step mediation MR approach was employed, revealing that lipid-related metabolites serve as key mediators in the GM-TMD interaction. Specifically, total cholesterol in high-density lipoprotein 3 was identified as a mediator of CAG-145 sp000435615 on TMD (-4.13%). Further analysis based on transcriptomic data identified differentially expressed and shared genes between GM and TMD, with the AGE-RAGE (advanced glycation end products-receptor for advanced glycation end products) and processes related to cell adhesion and inflammation emerging as significant pathways. These findings highlight the role of GM dysbiosis in TMD pathogenesis, potentially through disruptions in lipid metabolism and inflammatory processes, suggesting new therapeutic strategies targeting GM and its associated pathways.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"26 1","pages":"220345251332885"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filifactor alocis Pathogenicity Requires TLR2 and the Oral Microbiome.","authors":"A Vashishta,L Li,S Srivastava,T Sharma,S Jin,M Barati,D A Scott,R J Lamont,P I Diaz,S M Uriarte","doi":"10.1177/00220345251331959","DOIUrl":"https://doi.org/10.1177/00220345251331959","url":null,"abstract":"Enrichment of the oral microorganism Filifactor alocis is strongly associated with the progression of periodontitis. However, F. alocis is part of a complex dysbiotic microbial community, and the organism's direct pathogenic potential remains uncharacterized. Using the oral gavage model of experimental periodontitis, we revealed that F. alocis promotes alveolar bone loss, as well as significant overexpression of proinflammatory markers associated with osteoclastogenesis and inflammation in oral tissues. Interestingly, despite colonizing in low abundance, F. alocis infection promoted the perturbation of the homeostatic oral microbial community toward a dysbiotic state. Systemically, high levels of proinflammatory cytokines, chemokines, and antibody titers against F. alocis were detected in the sera of infected animals. Germ-free mice or TLR2-deficient mice did not develop alveolar bone loss when infected with F. alocis, demonstrating that the commensal microbial community and the presence of TLR2 are required for F. alocis to display its pathogenic potential. These findings identify F. alocis as an oral pathogen that can disrupt the homeostatic relationship between the host and the oral microbiome, causing inflammation and alveolar bone resorption. Our findings provide novel insights into the pathogenic potential of F. alocis in periodontitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"54 1","pages":"220345251331959"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Reduced Public Coverage Did Not Decrease Dental Visits\": Fact or Fiction?","authors":"Z Sarroukh,P Jeurissen,S Listl","doi":"10.1177/00220345251332194","DOIUrl":"https://doi.org/10.1177/00220345251332194","url":null,"abstract":"Challenges of access have sparked political debates about dental coverage in the Netherlands. So far, policy makers have been opposing an expansion of public coverage for the adult population, arguing that previous reductions of public coverage would not have led to reduced dental attendance within the Dutch population. To this end, this study aims to evaluate the effects of public coverage reductions since 1995 on dental care utilization. We used a population-wide data set from Statistics Netherlands containing dental care utilization rates across insurance- and age-based subpopulations between 1981 and 2019. Drawing from an interrupted time series design with segmented regressions, we evaluated how scaling down public coverage for curative dentistry in 1995 and preventive dentistry in 2004 affected dental attendance. Population groups that were not subject to the reforms served as control groups (i.e., nonadult population and privately insured persons). Following the 1995 reform and in comparison with privately insured persons (control group), the dental attendance of publicly insured persons (intervention group) decreased by an immediate 3.5 percentage points (95% CI, -5.8 to -1.1) and by a subsequent 0.6 percentage points (95% CI, -0.9 to -0.3) per year. When compared with that of the nonadult population (control group), dental attendance by 20- to 45-y-olds (intervention group) immediately dropped by 4.6 percentage points (95% CI, -7.0 to -2.1) and subsequently by 1.2 percentage points (95% CI, -1.5 to -0.8) per year. Contrary to Dutch policy makers' arguments, our findings suggest that reduced public coverage led to fewer people visiting the dentist in the Netherlands. These findings highlight the central role of policy evaluation for evidence-informed oral health policy making.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"21 1","pages":"220345251332194"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo Channels in Dentistry: Decoding the Functional Effects of Forces.","authors":"J Lai,Q Wu,B Gao,W Cai,Y Wang","doi":"10.1177/00220345251329376","DOIUrl":"https://doi.org/10.1177/00220345251329376","url":null,"abstract":"The oral system is a highly complex mechanosensory structure that continuously adapts to changes in mechanical stimuli, exerting mechanical forces on cells and tissues. Understanding how these forces are converted into biochemical signals and how they mediate gene expression and cellular activities has been a significant focus in dentistry. Piezo channels, including Piezo1 and Piezo2, are mechanically activated cation channels characterized by an extracellular \"cap\" domain and 3 peripheral mechanosensitive blades. Recent research has demonstrated that mechanical forces applied to tissues can induce deformation of cell membranes, leading to conformational changes in Piezo channels that facilitate cation influx, thereby regulating cellular activities. The influx of Ca2+, the most discussed outcome of Piezo channel activation, initiates diverse signaling pathways that regulate dentin hypersensitivity, alveolar bone remodeling, and temporomandibular joint (TMJ) osteoarthritis. The chemical inhibition of Piezo channels has been shown to alleviate dentinal hypersensitivity, reduce the rate of orthodontic tooth movement, and slow the progression of TMJ osteoarthritis in rat models. Mice deficient in piezo channels exhibit impaired reactive dentin formation, reduced alveolar bone volume, and developmental deformities of the jawbone. Considering their roles in decoding the functional effects of mechanical forces, this review summarizes the involvement of Piezo channels in dentistry, organized by anatomical sites, to provide comprehensive knowledge of Piezo channels and their mediated signal crosstalk, which offers promising therapeutic prospects for the treatment of various force-related oral diseases.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"68 1","pages":"220345251329376"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Poverty Reduction on Oral Health Outcomes among US Adults.","authors":"U Cooray,A Singh,J Aida,G Tsakos,M A Peres","doi":"10.1177/00220345251323183","DOIUrl":"https://doi.org/10.1177/00220345251323183","url":null,"abstract":"Poor oral health is a public health issue in the United States, disproportionately affecting people in poverty. This cross-sectional study investigates the impact of reducing absolute and relative poverty on the prevalence of periodontitis, caries, and dental pain among US adults. Data from 13,139 adults aged 30 to 70 y who completed dental examinations in the 2011-2018 National Health and Nutrition Examination Surveys were used. Periodontitis and dental caries outcomes were assessed with the 2011-2014 surveys (n = 6,563). Assessment of absolute and relative poverty was based on the poverty income ratio established by the US Census Bureau. Hypothetical counterfactual scenarios were emulated to assess the impact of poverty reductions (10%, 25%, and 50%) on periodontitis, dental caries, and dental pain. A targeted minimum loss-based estimator was used to estimate the outcomes under each scenario adjusted for age, sex, race, comorbidity, and marital status. Reductions in absolute and relative poverty were associated with a lower prevalence of oral disease. A 50% reduction in absolute poverty would avert 1.1 million cases of periodontitis, 0.4 million individuals with dental caries, and 0.6 million dental pain cases. A similar reduction in relative poverty would avert 5.4 million cases of periodontitis, 3.8 million individuals with caries, and 2 million cases of dental pain. The greatest impact was seen with a 50% relative poverty reduction: 12% reduction in periodontitis (prevalence ratio [PR], 0.88; 95% CI, 0.85 to 0.92), 13% reduction in caries (PR, 0.87; 95% CI, 0.81 to 0.92), and 18% reduction in frequent dental pain (PR, 0.82; 95% CI, 0.73 to 0.91). These findings highlight the potential of poverty reduction, especially relative poverty, to significantly lower the US oral disease burden and emphasize policy importance for reducing income inequality to achieve equitable oral health.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"31 1","pages":"220345251323183"},"PeriodicalIF":7.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SDoH Impact on Periodontal Disease Using Machine Learning and Dental Records","authors":"J. Patel, M. Badi, R. Katiyar, C. Ogwo, R.C. Wiener, T. Tiwari, U. Sambamoorthi, T. Folks","doi":"10.1177/00220345251328968","DOIUrl":"https://doi.org/10.1177/00220345251328968","url":null,"abstract":"The impact of social determinants of health (SDoH) on periodontal disease (PD) is critical to study, as a deeper understanding of SDoH offers significant potential to inform policy and help clinicians provide holistic patient care. The use of machine learning (ML) to analyze the association of SDoH with PD provides significant advantages over traditional statistical methods. While statistical approaches are effective for identifying trends, they often struggle with the complexity and unstructured nature of data from dental electronic health records (DEHRs). The objective of this study was to determine the association between PD and SDoH using big data through linked DEHR and census data using ML. We used the records of 89,937 unique patients (754,414 longitudinal records) from the Temple University School of Dentistry who received at least 1 treatment between 2007 and 2023. Patient PD outcomes were categorized based on progression, improvement, or no change, using longitudinal data spanning up to 16 y. We applied ML models, including logistic regression, Gaussian naive Bayes, random forest, and XGBoost, to identify SDoH predictors and their associations with PD. XGBoost demonstrated the best performance with 94% accuracy and high precision, recall, and F1 scores. SHapley Additive exPlanations (SHAP) values were used to provide explainable ML analysis. The leading predictors for PD progression were higher social vulnerability index, poverty, population density, fewer dental offices, more fast-food restaurants, longer travel times, higher stress levels, tobacco use, and multiple comorbidities. Our findings underscore the critical role of SDoH in PD progression and oral health inequity, advocating for the integration of these factors in PD risk assessment and management. This study also demonstrates the potential of big data analytics and ML in providing valuable insights for clinicians and researchers to study oral health disparities and promote equitable health outcomes.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"113 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evaluation of an Interactive Image Search System of Oral Pathology","authors":"R.R. Herdiantoputri, D. Komura, M. Ochi, Y. Fukawa, K. Oba, M. Tsuchiya, Y. Kikuchi, Y. Matsuyama, T. Ushiku, T. Ikeda, S. Ishikawa","doi":"10.1177/00220345251329042","DOIUrl":"https://doi.org/10.1177/00220345251329042","url":null,"abstract":"The limited number of specialists and diseases’ long-tail distribution create challenges in diagnosing oral tumors. Health care facilities with sole practicing pathologists face difficulties when encountering the rare cases. Such specialists may lack prior exposure to uncommon presentations, needing external reference materials to formulate accurate diagnoses. An image search or content-based image retrieval (CBIR) system may help diagnose rare tumors by providing histologically similar reference images, thus reducing the pathologists’ workload. However, the effectiveness of CBIR systems in aiding pathologists’ diagnoses through interactive use has not been evaluated. We conducted a remote evaluation in a near-clinical environment using Luigi-Oral, an interactive patch-based CBIR system that uses deep learning to diagnose oral tumors. The database comprised 54,676 image patches at multiple magnifications from 603 cases across 85 oral tumor categories. We recruited 15 general pathologists and 13 oral pathologists with varied experience to evaluate 10 retrospective test cases from 2 institutions using this dedicated system. At top-1 and top-3 differential diagnoses, the overall diagnostic accuracy among the 2 groups was significantly higher with Luigi-Oral than without (12.05% and 21.61% increase, <jats:italic>P</jats:italic> = 0.002 and <jats:italic>P</jats:italic> &lt; 0.001, respectively). Improvements were more evident for tumor cases in which the category was underrepresented in the database, benefiting novice and experienced pathologists. Misdiagnoses using Luigi-Oral could be due to inappropriate query input, poor retrieval performance in cases with a rare morphologic type, the difficulty of diagnosis without elaborate clinical information, or the system’s inability to retrieve accurate categories with convincing images. This study proves the clinical usability of an interactive CBIR system and highlights areas for improvement to ensure adequate assistance for pathologists, which potentially reduces pathologists’ workload and provides accessible specialist-level histopathology diagnosis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"18 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}