Journal of Dental Research最新文献

{"title":"Filifactor alocis Pathogenicity Requires TLR2 and the Oral Microbiome.","authors":"A Vashishta,L Li,S Srivastava,T Sharma,S Jin,M Barati,D A Scott,R J Lamont,P I Diaz,S M Uriarte","doi":"10.1177/00220345251331959","DOIUrl":"https://doi.org/10.1177/00220345251331959","url":null,"abstract":"Enrichment of the oral microorganism Filifactor alocis is strongly associated with the progression of periodontitis. However, F. alocis is part of a complex dysbiotic microbial community, and the organism's direct pathogenic potential remains uncharacterized. Using the oral gavage model of experimental periodontitis, we revealed that F. alocis promotes alveolar bone loss, as well as significant overexpression of proinflammatory markers associated with osteoclastogenesis and inflammation in oral tissues. Interestingly, despite colonizing in low abundance, F. alocis infection promoted the perturbation of the homeostatic oral microbial community toward a dysbiotic state. Systemically, high levels of proinflammatory cytokines, chemokines, and antibody titers against F. alocis were detected in the sera of infected animals. Germ-free mice or TLR2-deficient mice did not develop alveolar bone loss when infected with F. alocis, demonstrating that the commensal microbial community and the presence of TLR2 are required for F. alocis to display its pathogenic potential. These findings identify F. alocis as an oral pathogen that can disrupt the homeostatic relationship between the host and the oral microbiome, causing inflammation and alveolar bone resorption. Our findings provide novel insights into the pathogenic potential of F. alocis in periodontitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"54 1","pages":"220345251331959"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Reduced Public Coverage Did Not Decrease Dental Visits\": Fact or Fiction?","authors":"Z Sarroukh,P Jeurissen,S Listl","doi":"10.1177/00220345251332194","DOIUrl":"https://doi.org/10.1177/00220345251332194","url":null,"abstract":"Challenges of access have sparked political debates about dental coverage in the Netherlands. So far, policy makers have been opposing an expansion of public coverage for the adult population, arguing that previous reductions of public coverage would not have led to reduced dental attendance within the Dutch population. To this end, this study aims to evaluate the effects of public coverage reductions since 1995 on dental care utilization. We used a population-wide data set from Statistics Netherlands containing dental care utilization rates across insurance- and age-based subpopulations between 1981 and 2019. Drawing from an interrupted time series design with segmented regressions, we evaluated how scaling down public coverage for curative dentistry in 1995 and preventive dentistry in 2004 affected dental attendance. Population groups that were not subject to the reforms served as control groups (i.e., nonadult population and privately insured persons). Following the 1995 reform and in comparison with privately insured persons (control group), the dental attendance of publicly insured persons (intervention group) decreased by an immediate 3.5 percentage points (95% CI, -5.8 to -1.1) and by a subsequent 0.6 percentage points (95% CI, -0.9 to -0.3) per year. When compared with that of the nonadult population (control group), dental attendance by 20- to 45-y-olds (intervention group) immediately dropped by 4.6 percentage points (95% CI, -7.0 to -2.1) and subsequently by 1.2 percentage points (95% CI, -1.5 to -0.8) per year. Contrary to Dutch policy makers' arguments, our findings suggest that reduced public coverage led to fewer people visiting the dentist in the Netherlands. These findings highlight the central role of policy evaluation for evidence-informed oral health policy making.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"21 1","pages":"220345251332194"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo Channels in Dentistry: Decoding the Functional Effects of Forces.","authors":"J Lai,Q Wu,B Gao,W Cai,Y Wang","doi":"10.1177/00220345251329376","DOIUrl":"https://doi.org/10.1177/00220345251329376","url":null,"abstract":"The oral system is a highly complex mechanosensory structure that continuously adapts to changes in mechanical stimuli, exerting mechanical forces on cells and tissues. Understanding how these forces are converted into biochemical signals and how they mediate gene expression and cellular activities has been a significant focus in dentistry. Piezo channels, including Piezo1 and Piezo2, are mechanically activated cation channels characterized by an extracellular \"cap\" domain and 3 peripheral mechanosensitive blades. Recent research has demonstrated that mechanical forces applied to tissues can induce deformation of cell membranes, leading to conformational changes in Piezo channels that facilitate cation influx, thereby regulating cellular activities. The influx of Ca2+, the most discussed outcome of Piezo channel activation, initiates diverse signaling pathways that regulate dentin hypersensitivity, alveolar bone remodeling, and temporomandibular joint (TMJ) osteoarthritis. The chemical inhibition of Piezo channels has been shown to alleviate dentinal hypersensitivity, reduce the rate of orthodontic tooth movement, and slow the progression of TMJ osteoarthritis in rat models. Mice deficient in piezo channels exhibit impaired reactive dentin formation, reduced alveolar bone volume, and developmental deformities of the jawbone. Considering their roles in decoding the functional effects of mechanical forces, this review summarizes the involvement of Piezo channels in dentistry, organized by anatomical sites, to provide comprehensive knowledge of Piezo channels and their mediated signal crosstalk, which offers promising therapeutic prospects for the treatment of various force-related oral diseases.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"68 1","pages":"220345251329376"},"PeriodicalIF":7.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Poverty Reduction on Oral Health Outcomes among US Adults.","authors":"U Cooray,A Singh,J Aida,G Tsakos,M A Peres","doi":"10.1177/00220345251323183","DOIUrl":"https://doi.org/10.1177/00220345251323183","url":null,"abstract":"Poor oral health is a public health issue in the United States, disproportionately affecting people in poverty. This cross-sectional study investigates the impact of reducing absolute and relative poverty on the prevalence of periodontitis, caries, and dental pain among US adults. Data from 13,139 adults aged 30 to 70 y who completed dental examinations in the 2011-2018 National Health and Nutrition Examination Surveys were used. Periodontitis and dental caries outcomes were assessed with the 2011-2014 surveys (n = 6,563). Assessment of absolute and relative poverty was based on the poverty income ratio established by the US Census Bureau. Hypothetical counterfactual scenarios were emulated to assess the impact of poverty reductions (10%, 25%, and 50%) on periodontitis, dental caries, and dental pain. A targeted minimum loss-based estimator was used to estimate the outcomes under each scenario adjusted for age, sex, race, comorbidity, and marital status. Reductions in absolute and relative poverty were associated with a lower prevalence of oral disease. A 50% reduction in absolute poverty would avert 1.1 million cases of periodontitis, 0.4 million individuals with dental caries, and 0.6 million dental pain cases. A similar reduction in relative poverty would avert 5.4 million cases of periodontitis, 3.8 million individuals with caries, and 2 million cases of dental pain. The greatest impact was seen with a 50% relative poverty reduction: 12% reduction in periodontitis (prevalence ratio [PR], 0.88; 95% CI, 0.85 to 0.92), 13% reduction in caries (PR, 0.87; 95% CI, 0.81 to 0.92), and 18% reduction in frequent dental pain (PR, 0.82; 95% CI, 0.73 to 0.91). These findings highlight the potential of poverty reduction, especially relative poverty, to significantly lower the US oral disease burden and emphasize policy importance for reducing income inequality to achieve equitable oral health.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"31 1","pages":"220345251323183"},"PeriodicalIF":7.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SDoH Impact on Periodontal Disease Using Machine Learning and Dental Records","authors":"J. Patel, M. Badi, R. Katiyar, C. Ogwo, R.C. Wiener, T. Tiwari, U. Sambamoorthi, T. Folks","doi":"10.1177/00220345251328968","DOIUrl":"https://doi.org/10.1177/00220345251328968","url":null,"abstract":"The impact of social determinants of health (SDoH) on periodontal disease (PD) is critical to study, as a deeper understanding of SDoH offers significant potential to inform policy and help clinicians provide holistic patient care. The use of machine learning (ML) to analyze the association of SDoH with PD provides significant advantages over traditional statistical methods. While statistical approaches are effective for identifying trends, they often struggle with the complexity and unstructured nature of data from dental electronic health records (DEHRs). The objective of this study was to determine the association between PD and SDoH using big data through linked DEHR and census data using ML. We used the records of 89,937 unique patients (754,414 longitudinal records) from the Temple University School of Dentistry who received at least 1 treatment between 2007 and 2023. Patient PD outcomes were categorized based on progression, improvement, or no change, using longitudinal data spanning up to 16 y. We applied ML models, including logistic regression, Gaussian naive Bayes, random forest, and XGBoost, to identify SDoH predictors and their associations with PD. XGBoost demonstrated the best performance with 94% accuracy and high precision, recall, and F1 scores. SHapley Additive exPlanations (SHAP) values were used to provide explainable ML analysis. The leading predictors for PD progression were higher social vulnerability index, poverty, population density, fewer dental offices, more fast-food restaurants, longer travel times, higher stress levels, tobacco use, and multiple comorbidities. Our findings underscore the critical role of SDoH in PD progression and oral health inequity, advocating for the integration of these factors in PD risk assessment and management. This study also demonstrates the potential of big data analytics and ML in providing valuable insights for clinicians and researchers to study oral health disparities and promote equitable health outcomes.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"113 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical Evaluation of an Interactive Image Search System of Oral Pathology","authors":"R.R. Herdiantoputri, D. Komura, M. Ochi, Y. Fukawa, K. Oba, M. Tsuchiya, Y. Kikuchi, Y. Matsuyama, T. Ushiku, T. Ikeda, S. Ishikawa","doi":"10.1177/00220345251329042","DOIUrl":"https://doi.org/10.1177/00220345251329042","url":null,"abstract":"The limited number of specialists and diseases’ long-tail distribution create challenges in diagnosing oral tumors. Health care facilities with sole practicing pathologists face difficulties when encountering the rare cases. Such specialists may lack prior exposure to uncommon presentations, needing external reference materials to formulate accurate diagnoses. An image search or content-based image retrieval (CBIR) system may help diagnose rare tumors by providing histologically similar reference images, thus reducing the pathologists’ workload. However, the effectiveness of CBIR systems in aiding pathologists’ diagnoses through interactive use has not been evaluated. We conducted a remote evaluation in a near-clinical environment using Luigi-Oral, an interactive patch-based CBIR system that uses deep learning to diagnose oral tumors. The database comprised 54,676 image patches at multiple magnifications from 603 cases across 85 oral tumor categories. We recruited 15 general pathologists and 13 oral pathologists with varied experience to evaluate 10 retrospective test cases from 2 institutions using this dedicated system. At top-1 and top-3 differential diagnoses, the overall diagnostic accuracy among the 2 groups was significantly higher with Luigi-Oral than without (12.05% and 21.61% increase, <jats:italic>P</jats:italic> = 0.002 and <jats:italic>P</jats:italic> &lt; 0.001, respectively). Improvements were more evident for tumor cases in which the category was underrepresented in the database, benefiting novice and experienced pathologists. Misdiagnoses using Luigi-Oral could be due to inappropriate query input, poor retrieval performance in cases with a rare morphologic type, the difficulty of diagnosis without elaborate clinical information, or the system’s inability to retrieve accurate categories with convincing images. This study proves the clinical usability of an interactive CBIR system and highlights areas for improvement to ensure adequate assistance for pathologists, which potentially reduces pathologists’ workload and provides accessible specialist-level histopathology diagnosis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"18 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral Pathway between Social Support and Network, and Edentulism","authors":"F. Alobaidi, E. Heidari, W. Sabbah","doi":"10.1177/00220345251329337","DOIUrl":"https://doi.org/10.1177/00220345251329337","url":null,"abstract":"The aims of this study were to evaluate how behaviors cluster together and to investigate the relationship among cluster of behaviors, social support and network, socioeconomic factors, and edentulism in older English adults. Data on social factors (Wave 3, 2006/07), behaviors (Wave 5, 2010/11), and edentulism (Wave 7, 2014/15) were extracted from the English Longitudinal Study of Ageing (ELSA). Baseline demographic factors (gender, ethnicity, and age) were included. Latent class analysis (LCA) was conducted on 4 behaviors (smoking, alcohol intake, fruit and vegetable consumption, physical activity). Confirmatory factor analysis (CFA) was used to create 2 latent variables, social support and network (positive support, negative support, network), and socioeconomic factors (education, wealth, self-rated social status). Two models of structural equation modeling (SEM) were constructed to assess the direct and indirect effect of latent variables on edentulism. A total of 3,087 participants were included. In the LCA, a 2-class model was chosen: class 1 (risky) and class 2 (healthy). The first SEM model showed that social support and network was not linked directly to edentulism, but higher levels of social support and network predicted being dentate indirectly through cluster of behaviors. The second model additionally accounting for socioeconomic position showed that social support and network was not associated with edentulism directly or indirectly, but higher socioeconomic position predicted directly and indirectly being dentate. In both models, cluster of behaviors was associated with edentulism. The result of this study clearly shows that cluster of behaviors mediate the relationship between each of social support and socioeconomic position and edentulism. Actions to improve socioeconomic conditions might have strong effects on changing behaviors and improved oral health.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"36 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioheterojunctions Prevent Tooth Caries via Cascade Antibacterial Strategy","authors":"J. Zhu, L. He, X. Xu, H. Wu, J. Li, B. Yan, Y. Deng, Y. Gao, K. Liang","doi":"10.1177/00220345251329334","DOIUrl":"https://doi.org/10.1177/00220345251329334","url":null,"abstract":"Tooth caries is a prevalent chronic oral disease with microorganisms as the initiating factor and carbohydrates as the key environmental factor. Clinical antimicrobial therapies rely mainly on broad-spectrum antibiotics, which usually increase the risk of bacterial resistance. Recently, phototherapy has shown powerful antibacterial effects, although it cannot effectively eliminate cariogenic microenvironments and the antibacterial effect is not sustained after the light is removed. Here, we developed novel bioheterojunctions (bio-HJs) comprising MXene/Ag <jats:sub>3</jats:sub> PO <jats:sub>4</jats:sub> (MX/AgP) and glucose oxidase (GOx), denoted MX/AgP-GOx, aiming at both the chemical and biological components of dental plaque biofilm. The bio-HJs decomposed the glucose rich in the cariogenic environment through GOx while providing abundant H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> for subsequent Fenton reaction. Under near-infrared (NIR) light, the bio-HJs produced hyperthermia and generated large amounts of reactive oxygen species based on the above H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> , exerting powerful phototherapy properties (log reduction: 1.45 log 10 CFU/mL). It is worth noting that MX/AgP-GOx still exerted antibacterial effects in the dark via Ag <jats:sup>+</jats:sup> bactericidal effects, Ag <jats:sup>0</jats:sup> NPs catalytic activity, and GOx-mediated glucose depletion (log reduction: 0.39 log 10 CFU/mL), ensuring a sustained anticaries effect after the removal of NIR light. In addition, the rat caries model revealed that MX/AgP-GOx significantly reduced enamel mineral loss and had good biocompatibility. This study constructed efficacy-cascade bio-HJs targeting the sugar-rich cariogenic microenvironment, which promotes subsequent photodynamic therapy and combines photothermal and metal ion synergistic antibacterial means to continuously and effectively eliminate biofilm and prevent the occurrence and development of tooth caries.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"15 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of TRPM2 in Oxidative Stress–Mediated Bone Loss in Periodontitis","authors":"Y. Jiang, J. Chen, S. Guo, W. Cui, Y. Zhou, X. Chen, D. Wang, X. Wang, L. Li, Y. Xu","doi":"10.1177/00220345251329330","DOIUrl":"https://doi.org/10.1177/00220345251329330","url":null,"abstract":"Oxidative stress has emerged as a critical player in the development and progression of periodontitis. Transient receptor potential melastatin 2 (TRPM2) is a crucial oxidative stress sensor, while its role in periodontitis and its relationship with the oxidative stress microenvironment remains poorly understood. The objective of this research is to unravel the mechanism by which reactive oxygen species (ROS) activate the TRPM2 channel, driving osteoclast differentiation and eventually leading to bone degradation in periodontitis. By doing so, we aim to provide novel insights into the initiation, progress, and potential treatment methodologies for bone loss instigated by periodontitis. In this study, our results revealed significant upregulation of TRPM2 expression in inflamed periodontal tissues and a close alliance with osteoclast differentiation. First, significant upregulation of TRPM2 in periodontitis, with a clear association with osteoclast differentiation, was observed based on the GEO database. In addition, enhanced levels of TRPM2 and oxidative stress markers were evident in samples from both periodontitis patients and the mouse model of periodontitis. Importantly, the ablation of TRPM2 distinctly alleviated alveolar bone resorption in periodontitis-affected mice. In vitro assays concluded that ROS-induced TRPM2 activation fostered osteoclast differentiation and amplification of osteoclast-related genes. Moreover, RNA-seq results illuminated a close alliance of TRPM2 with osteoclast differentiation, oxidative phosphorylation, mitochondrial inner membrane, and mitochondrial protein complexes. Further validation indicated that damaged mitophagy could overproduce ROS to activate TRPM2 as a positive regulator of osteoclast differentiation via the Ca <jats:sup>2+</jats:sup> /NFATc1 signaling pathway. Finally, we conducted in vivo and in vitro interventions using a TRPM2 inhibitor and found that the inhibition of TRPM2 significantly alleviated bone loss induced by periodontitis. Consequently, our results suggest that TRPM2 plays a crucial role in triggering osteoclast differentiation in periodontitis’s oxidative stress microenvironment, signifying a potential therapeutic target for prevention and treatment of bone erosion induced by periodontitis.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"52 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimethyl Citraconate Alleviates Periodontitis via Activating the NRF2 Cascade","authors":"Y. Wang, Y. Li, Y. Cai, X. Yang, H. Li, Q. Wang, D. Huang, L. Liu, Z. Fan, Q. Yuan, Y. Wang","doi":"10.1177/00220345251319249","DOIUrl":"https://doi.org/10.1177/00220345251319249","url":null,"abstract":"Nuclear factor erythroid 2–related factor 2 (NRF2) is a pivotal transcription factor that regulates redox signaling, playing a protective role in inflammation. Citraconate is verified as the strongest NRF2 agonist among its isomers. Dimethyl citraconate (DMC), an esterified derivative of citraconate, holds the potential for activating NRF2 and relieving inflammation. Here, we show that DMC is a strong NRF2-activating compound, stabilizing the intracellular NRF2 level and its nuclear translocation. DMC increases the expression levels of NRF2 downstream genes, thereby restricting the accumulation of reactive oxygen species and performing anti-inflammatory functions. The local administration of DMC effectively alleviates periodontal destruction in a ligation-induced periodontitis mouse model, elevating the NRF2 levels and downstream antioxidant enzymes. Moreover, the protective effect of DMC against periodontitis is absent in <jats:italic> Nfe2l2 <jats:sup>-/-</jats:sup> </jats:italic> mice. Mechanically, DMC prolongs the half-life of NRF2 and facilitates its dissociation from KEAP1 (Kelch-like ECH-associated protein 1), which suggests that DMC interrupts the crosstalk between KEAP1 and NRF2. Collectively, our findings illustrate the role of DMC in activating NRF2 and ameliorating periodontal inflammation, suggesting its therapeutic potential for inflammation-related diseases.","PeriodicalId":15596,"journal":{"name":"Journal of Dental Research","volume":"31 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}