Journal of Drug Targeting最新文献_第7页

Correction. 修正。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1080/1061186X.2025.2513758

引用次数: 0

Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models. 纳米氧化硅增强自愈水凝胶用于兔耳垂软骨修复和再生的研究。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-03-07 DOI: 10.1080/1061186X.2025.2473675

Seyedeh-Sara Hashemi, Reza Alizadeh, Alireza Rafati, Aliakbar Mohammadi, Mojtaba Mortazavi, Mohammad Hashem Hashempur

{"title":"Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models.","authors":"Seyedeh-Sara Hashemi, Reza Alizadeh, Alireza Rafati, Aliakbar Mohammadi, Mojtaba Mortazavi, Mohammad Hashem Hashempur","doi":"10.1080/1061186X.2025.2473675","DOIUrl":"10.1080/1061186X.2025.2473675","url":null,"abstract":"This study developed an alginate, gelatine and chondroitin sulphate hydrogel incorporating silicon oxide nanoparticles to assess hydrogel morphology, cell proliferation and viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, an observer group with hydrogels lacking nanoparticles and a treatment group with nanoparticle-enhanced hydrogels for post-injury repair. At 15, 30 and 60 days post-surgery, the rabbits were humanely euthanized and excised tissue samples were fixed in 10% formalin for histopathological analysis, then processed and embedded in paraffin for microscopic evaluation. Statistical analysis was performed using SPSS software with ANOVA and Tukey's post hoc test. Results indicated that the hydrogels supported cell viability and encouraged differentiation into chondrocyte-like phenotypes. Scanning electron microscopy confirmed the hydrogels' porosity and showed significant differences in cell survival rates compared to the control group, underscoring the potential of hydrogels in cartilage tissue engineering and regenerative repair strategies.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1190-1202"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies. 恶性叶状瘤患者源性类器官模型的药物敏感性测试和靶向治疗策略的确定。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-03-13 DOI: 10.1080/1061186X.2025.2473010

Jie Chen, Liangquan Liu, Yunxu Yang, Jing Luo, Shengchun Liu

{"title":"Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies.","authors":"Jie Chen, Liangquan Liu, Yunxu Yang, Jing Luo, Shengchun Liu","doi":"10.1080/1061186X.2025.2473010","DOIUrl":"10.1080/1061186X.2025.2473010","url":null,"abstract":"Background: Malignant phyllodes tumours (MPT) of the breast are rare fibroepithelial neoplasms. It exhibits rapid growth, large size, and a high local recurrence rate.Methods: In this study, we established novel patient-derived organoid (PDO) models from two primary MPT samples and conducted comprehensive genetic profiling and drug screening.Results: The PDO models faithfully recapped the histopathological and molecular features of the primary tumours, including stromal overgrowth, leaf-like projections, and the expression of key diagnostic markers. Drug testing revealed significant heterogeneity in response profiles to chemotherapeutic reagents between the two MPT-derived organoids, implying the importance of personalised drug testing. Next-generation sequencing analysis identified recurrent mutations in TP53, RB1, EGFR, ATM, and RECQL4, which correlated with the drug sensitivity profiles observed in the organoid models. Targeted therapeutic drugs, such as Abemaciclib (targeting the RB1 pathway) with an IC50 value of 1.744 µM, and Alflutinib Mesylate (targeting the EGFR pathway) with an IC50 value of 0.9150 µM, exhibited significant cytotoxic effects in the MPT2 organoid models.Conclusions: This study highlights the novel application of PDOs for studying the molecular landscape of MPTs and identifying effective therapeutic targets, offering a promising platform for guiding personalised treatment strategies for this rare and challenging cancer.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1179-1189"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches. 白藜芦醇治疗溃疡性结肠炎：治疗机制、动物模型证据和新方法。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-03-10 DOI: 10.1080/1061186X.2025.2469750

Yukta Garg, Nandini Sharma, Shivang Saxena, Nihar Ranjan Sahoo, Sushil Kumar, Sankushdeep Singh, Amandeep Singh

{"title":"Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches.","authors":"Yukta Garg, Nandini Sharma, Shivang Saxena, Nihar Ranjan Sahoo, Sushil Kumar, Sankushdeep Singh, Amandeep Singh","doi":"10.1080/1061186X.2025.2469750","DOIUrl":"10.1080/1061186X.2025.2469750","url":null,"abstract":"Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it easily relapses, thus, providing a considerable threat to human health. A number of inflammatory mediators, oxidative stress and role of gut microbes have been studied thoroughly to understand the exact pathophysiology behind the disease occurrence. Several conventional therapies are available for the treatment of ulcerative colitis but each one of them have one or the other side effect. Therefore, to overcome this limitation, we are moving ahead towards herbal drug therapies. The current review presents the emerging role of Resveratrol, a natural occurring polyphenol derived from plant species. It is associated with potential antioxidative and anti-inflammatory properties. Protective effects of Resveratrol in different ulcerative colitis induced animal models are discussed in this review. Various strategies to improve bioavailability of drug include encapsulation of drug in several nanocarriers. Although many animal models have proved the effectiveness of Resveratrol in the treatment of ulcerative colitis, further research on human subjects is still required to understand the exact mechanism and safety to establish its uses clinically.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1043-1066"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-based immunotherapy in oesophageal cancer. 食管癌的细胞免疫治疗。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-03-17 DOI: 10.1080/1061186X.2025.2477077

Masoud Lahouty, Amirhossein Soleymanzadeh, Sama Kazemi, Haniyeh Saadati-Maleki, Sanaz Masoudi, Arash Ghasemi, Tohid Kazemi, Sahar Mehranfar, Manouchehr Fadaee

引用次数: 0

Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis. 开发具有抗炎特性的生物启发吞噬稳定纳米幽灵，用于控制溃疡性结肠炎的炎症。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-03-10 DOI: 10.1080/1061186X.2025.2474644

Ahmed Mohsin Huran Al-Jawadri, Zahra Karami, Ismaeil Haririan, Mohammad Akrami, Mahdi Gholami

{"title":"Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis.","authors":"Ahmed Mohsin Huran Al-Jawadri, Zahra Karami, Ismaeil Haririan, Mohammad Akrami, Mahdi Gholami","doi":"10.1080/1061186X.2025.2474644","DOIUrl":"10.1080/1061186X.2025.2474644","url":null,"abstract":"Background: New bio-mimetic approaches are needed to develop effective delivery systems for inflammation regulation in chronic diseases like ulcerative colitis, avoiding fast clearance by immune system. The cell membrane-coated nanoparticle with a therapeutic payload has been considered as a promising delivery system to address the requirement.Methods: Here, Glibenclamide (GLY)-loaded PLGA nanoparticles (NPs) were constructed by a single emulsion procedure and camouflaged by a layer of monocyte membrane using the extrusion technique to fabricate bio-mimetic nanoghosts (NGs), followed by physiochemical and biological characterisations.Results: Upon coating the NPs by the membrane, the hydrodynamic size and zeta potential of NGs was changed. The formation of the shell compartment with diameter of about 15.5 nm around NP core was confirmed by TEM. The expression levels of NLRP3, IL-1β, IL-18, caspase-1, TNF-α and IL-6 were decreased upon the NGs treatment. The lower cellular internalisation of the NGs exhibited potential for improved circulation stability against macrophage phagocytosis. Treatment of acetic acid-induced UC with NGs exhibited healing of the mucosal lining in the colon tissue.Conclusion: The monocyte membrane-coated NPs with a sulfonylurea derivatives payload can be considered as an excellent biologically inspired candidate for management of inflammatory diseases like UC via inflammation regulation.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1215-1226"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins. 从粘附到侵袭：结核分枝杆菌脂蛋白的多方面作用。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-03-03 DOI: 10.1080/1061186X.2025.2472208

Min Li, Qiao Zhang, Yun Wang, Jianping Xie, Tian Liang, Zhou Liu, Xiaohong Xiang, Qiang Zhou, Zhen Gong

引用次数: 0

Preparation, in vitro and in vivo evaluation of phloretin-loaded TPGS/Pluronic F68 modified mixed micelles with enhanced bioavailability and anti-ageing activity. 具有增强生物利用度和抗衰老活性的TPGS/Pluronic F68修饰混合胶束的制备、体外和体内评价

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 Epub Date: 2025-02-24 DOI: 10.1080/1061186X.2025.2469753

Jiaying Li, Tingyuan Li, Mingjie Gong, Xiaowen Wang, Qinyang Hua, Xia Jiang, Qilong Wang, Elmurat Toreniyazov, Jiangnan Yu, Xia Cao, Michael Adu-Frimpong, Ximing Xu

{"title":"Preparation, in vitro and in vivo evaluation of phloretin-loaded TPGS/Pluronic F68 modified mixed micelles with enhanced bioavailability and anti-ageing activity.","authors":"Jiaying Li, Tingyuan Li, Mingjie Gong, Xiaowen Wang, Qinyang Hua, Xia Jiang, Qilong Wang, Elmurat Toreniyazov, Jiangnan Yu, Xia Cao, Michael Adu-Frimpong, Ximing Xu","doi":"10.1080/1061186X.2025.2469753","DOIUrl":"10.1080/1061186X.2025.2469753","url":null,"abstract":"Phloretin exhibits strong antioxidant and anti-ageing properties by inhibiting mitochondrial oxidation of glutamate, succinic acid, and ascorbic acid. However, its clinical application is limited by poor aqueous solubility and low oral bioavailability. To enhance its bioavailability and efficacy, we incorporated phloretin into nano-micelles (phloretin-MM) using the thin film dispersion method. Characterisation revealed that the optimal formulation had TPGS and Pluronic F68 in a 4:1 ratio as the excipients, which resulted in spherical micelles with an average particle size of 33.28 nm and an encapsulation efficiency of 71.2 ± 0.48%. The in vitro release profile showed that the phloretin-MM showed significantly higher cumulative release rates than free phloretin across various pH conditions, while the pharmaceutical analysis in rats indicated that phloretin-MM significantly improved the oral bioavailability of phloretin (about 5 folds) in circulation. Additionally, through the analysis of the staining of zebrafish under light microscopy and the average gray value, it can be concluded that phloretin has anti-ageing drug effect, and phloretin-MM is better than free phloretin. These findings suggest that TPGS/Pluronic F68-modified phloretin-MM could serve as an excellent nano-drug carrier system, potentially enhancing the solubility, bioavailability, and anti-ageing effects of phloretin for broader clinical applications.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1167-1178"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging trends in viral infection inhibition using a chitosan-based drug delivery system. 利用壳聚糖为基础的药物传递系统抑制病毒感染的新趋势。

IF 3.9 4区医学

Journal of Drug Targeting Pub Date : 2025-08-01 DOI: 10.1080/1061186X.2025.2540858

Somayeh Kakehbaraei, Morteza Arab-Zozani, Seyran Kakebaraei

{"title":"Emerging trends in viral infection inhibition using a chitosan-based drug delivery system.","authors":"Somayeh Kakehbaraei, Morteza Arab-Zozani, Seyran Kakebaraei","doi":"10.1080/1061186X.2025.2540858","DOIUrl":"https://doi.org/10.1080/1061186X.2025.2540858","url":null,"abstract":"Viral diseases damage the host's cells and weaken the host's immunity, leading to multiple relapses or lasting a long time. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a prevalent infection that can cause immunostimulation, serious medical complications or even promote the risk of side effects and fatality, especially among older adults. Due to the replication process of the viral genome, it is significant to design and develop new pharmaceuticals to alleviate the illness and global death rates attributed to infection. Chitosan, a versatile biopolymer derived from natural sources, possesses cationic properties and has been employed to produce nanoparticles (NPs). These NPs exhibit biocompatibility, biodegradability, antimicrobial and anticancer properties, non-toxicity, ready availability, and the ability to function as drug delivery systems (DDSs). The physicochemical attributes of chitosan and its NPs in the transfer of bioactive agents are detected in nanotechnology, which can enhance anti-viral efficacy. This review highlights progressions in nanoscience for chitosan-based drug delivery in treating viral diseases. New research is expected to suggest new strategies in the field of DDS for the therapeutics of infectious diseases.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small extracellular vesicles-based drug delivery systems for therapies of gastrointestinal tumours. 基于细胞外小泡的胃肠道肿瘤药物递送系统的研究。

IF 4.3 4区医学

Journal of Drug Targeting Pub Date : 2025-07-28 DOI: 10.1080/1061186X.2025.2535375

Lan Luo, Dongli Wang, Wenrong Xu, Jiajia Jiang

{"title":"Small extracellular vesicles-based drug delivery systems for therapies of gastrointestinal tumours.","authors":"Lan Luo, Dongli Wang, Wenrong Xu, Jiajia Jiang","doi":"10.1080/1061186X.2025.2535375","DOIUrl":"10.1080/1061186X.2025.2535375","url":null,"abstract":"Gastrointestinal tumours pose a significant threat to human health. Small extracellular vesicles (sEVs) have emerged as a promising approach for drug delivery in the treatment of gastrointestinal tumours. sEVs exhibit intrinsic advantages over synthetic nanoparticles, including native targeting ligands, the ability to cross biological barriers via membrane fusion, and reduced immune clearance mediated by surface CD47, thereby overcoming limitations of conventional nanocarriers such as rapid opsonisation and hepatic sequestration. These minute vesicles are surrounded by a stable phospholipid bilayer and can be engineered with specific targeting ligands or loaded with diverse therapeutic cargoes, thereby overcoming the limitations of conventional drug delivery systems (DDSs) and improving tumour-specific accumulation while minimising off-target effects. In this review, we explore the recent advancements in sEV-based DDSs, with a focus on design approaches for engineered sEVs, immunotherapy-related engineered sEVs technologies and the utilisation of engineered sEVs in gastrointestinal tumours. Additionally, we discuss the current challenges and future prospects of sEV-based DDSs in clinical practice, underscore the innovative role of engineered sEVs in cancer therapy, and provide promising avenues for enhancing the treatment of gastrointestinal tumours and improving patient outcomes.","PeriodicalId":15573,"journal":{"name":"Journal of Drug Targeting","volume":" ","pages":"1-17"},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0