Journal of Complementary and Integrative Medicine最新文献

{"title":"Induction of mitochondrial-dependent apoptosis, activation of mitochondrial ATPase and cytochrome c release by the methanol extract of <i>Funtumia elastica</i> stem bark.","authors":"Fatima B Musa, Tolulope A Oyedeji, Adeola O Olowofolahan, Hammed O Faleke, Olufunso O Olorunsogo","doi":"10.1515/jcim-2024-0326","DOIUrl":"10.1515/jcim-2024-0326","url":null,"abstract":"<p><strong>Objectives: </strong>Natural compounds that can induce the opening of the mitochondrial membrane permeability transition (MMPT) pore may be useful therapeutic agents in treating diseases associated with mitochondrial dysfunction e.g. cancer, diabetes, and neurodegenerative diseases. This pore represents a promising target for therapeutic intervention. Therefore, this study investigated the potential of the methanol extract of <i>Funtumia elastica</i> stem bark on the MMPT pore, mitochondrial ATPase (mATPase), cytochrome c release (cyt c), and mitochondrial lipid peroxidation (mLPO) in rat liver.</p><p><strong>Methods: </strong>Male Wistar rats (100-120 g) were used in this study. Differential centrifugation was used to isolate mitochondria from rat liver. MMPT pore opening, mATPase activity, cyt c, and mLPO were assayed.</p><p><strong>Results: </strong>The results indicate that the methanol extract of <i>F. elastica</i> induced MMPT pore opening in the absence of calcium ions. Also, in the presence of calcium ions, the extract significantly (p<0.05) reversed the opening of the MMPT pore by 21.0, 30.0, 34.0, and 38.0 % at 12, 36, 60, and 84 μg/mL, respectively. The extract activated mitochondrial ATPase activity significantly (p<0.05) compared to the control. The extract elevated cytochrome c release with increasing extract concentration relative to the control. The extract also inhibited iron-induced mitochondrial lipid peroxidation by 29.0, 38.7, 59.9, 83.0, and 87.0 % at 150, 300, 600, 1,200, and 2,400 μg/mL, respectively.</p><p><strong>Conclusions: </strong>Our results showed that the methanol extract of <i>F. elastica</i> contains potent phytochemicals that can trigger MMPT pore opening, activate mATPase, cyt c, and inhibit mLPO. This extract may find use in diseases associated with apoptosis dysfunction.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"471-478"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apitherapy for drug-induced kidney disease: a narrative review on its mechanisms.","authors":"Andrés Jagua-Gualdrón, Nicolai Andrés García-Reyes, Holman Leonardo Africano-Lopez","doi":"10.1515/jcim-2025-0082","DOIUrl":"https://doi.org/10.1515/jcim-2025-0082","url":null,"abstract":"<p><strong>Objectives: </strong>The use of medications for the treatment of various diseases often results in kidney damage. Apitherapy is a natural therapeutic tool with potential utility for this purpose. This narrative review analyzes and summarizes the scientific evidence on the use of apitherapy in drug-induced kidney disease.</p><p><strong>Content: </strong>This review summarizes and analyzes recent advances in drug-induced kidney disease and explores, based on the available scientific evidence, how apitherapy can modify these mechanisms and be utilized for prevention and treatment.</p><p><strong>Summary: </strong>Apitherapy (the complementary and integrative use of beehive products) is a potentially useful therapeutic system for the treatment of various diseases. This review examines the preclinical and clinical evidence available regarding its potential use in drug-induced kidney disease.</p><p><strong>Outlook: </strong>Apitherapy has effects on various pathophysiological mechanisms of drug-induced kidney disease, including oxidative stress, inflammation, decreased renal blood flow, glomerular damage, increased membrane permeability, activity of the renin-angiotensin-aldosterone axis, mitochondrial dysfunction, and apoptosis. Further studies in humans are needed to evaluate its efficacy in the clinical setting, but the available evidence is promising.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the anticancer potential of Jerantinine A from <i>Tabernaemontana coronaria</i> against prostate, breast, and ovarian cancers: a computational approach.","authors":"Poornima Kannappan, Meenakshi Kaniyur Chandrasekaran, Manikandan Vani Raju, Shankari Gopalakrishnan, Prabhu Dhamodharan, Rathi Muthaiyan Ahalliya, Chella Perumal Palanisamy, Balaji Raju, Gopalakrishnan Velliyur Kanniappan","doi":"10.1515/jcim-2024-0443","DOIUrl":"10.1515/jcim-2024-0443","url":null,"abstract":"<p><strong>Objectives: </strong>Cancer remains a significant global health challenge, with prostate, breast, and ovarian cancers ranking among the leading causes of morbidity and mortality. Natural products, particularly those derived from medicinal plants, have gained attention for their potential in alternative cancer therapies. The main objective of the study was an isolation and characterization of Jerantinine A, a bioactive alkaloid from <i>Tabernaemontana coronaria</i>, and its interactions with key protein targets involved in cancer progression.</p><p><strong>Methods: </strong>Jerantinine A was isolated through column chromatography and characterized using spectroscopic techniques, including UV-visible spectroscopy, FTIR, and NMR. Molecular docking studies were performed to assess its binding affinities with six critical protein targets: PTEN and androgen receptor for prostate cancer, CXCR4 and HER2 for ovarian cancer, and CDK1 and NEK2 for breast cancer.</p><p><strong>Results: </strong>Molecular docking analyses revealed that Jerantinine A exhibits strong binding affinities with all six protein targets, suggesting its potential to inhibit cancer cell proliferation by interfering with key signaling pathways.</p><p><strong>Conclusions: </strong>These findings underscore the therapeutic potential of <i>T. coronaria</i>, particularly through Jerantinine A, as a promising candidate for cancer treatment. By targeting pivotal proteins associated with prostate, breast, and ovarian cancers, Jerantinine A offers a foundation for further research and development as a novel anti-cancer agent.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"363-372"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study examining older adult usage of complementary and alternative medications and natural health products for cognitive and mental health improvement.","authors":"Dalya Abdulla, Lia Tsotsos","doi":"10.1515/jcim-2024-2001","DOIUrl":"10.1515/jcim-2024-2001","url":null,"abstract":"<p><strong>Objectives: </strong>The use of complementary and alternative medications (CAM) and natural health products (NHPs) to enhance mood and reduce cognitive decline is well known yet research guiding Older Adult patients and their health care teams on such usage is limited. The purpose of this study was to understand CAM and NHP usage patterns for cognitive health among healthy Older Adults to enable the construct of better guidelines for health care practitioners regarding such usage.</p><p><strong>Methods: </strong>A qualitative study was designed to determine usage patterns of CAM and NHPs among Older Adults. Participants were recruited from the Center for Elder Research at Sheridan College and open-ended questions were utilized during one-on-one interviews with interested participants to determine usage patterns in relation to cognitive health.</p><p><strong>Results: </strong>A total of 10 participants completed the interviews with an age range of 63-86 years. Results were analyzed using the triangulation method based on a Grounded Theory approach to identify 6 main emerging themes: fear of cognitive health decline, strategies to mitigate perceived/self-diagnosed cognitive health decline, dietary influences on cognitive health, healthcare ownership and self-care, CAM and NHPs loyalty, and supporting Older Adult CAM and NHPs use. Percentages of each response within each main theme was also determined.</p><p><strong>Conclusions: </strong>Older Adults appeared to be cognizant of their cognitive health and tended to rely on CAM and NHPs to improve self-perceived decline in cognitive health. Older Adults expressed a desire for their health care practitioners to become more accommodating of such usage and for the government to support them financially for expenditures on CAM and NHPs. Older Adults indicated a preference of visiting health care practitioners who supported the use of these products.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"555-562"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer effects of <i>Plantago major</i> extract on colorectal and gastric cancer cell lines: an <i>in vitro</i> study and molecular docking analysis.","authors":"Rabia Yilmaz Ozturk, Hilal Calik, Ayhan Demir, Rabia Cakir","doi":"10.1515/jcim-2024-0340","DOIUrl":"10.1515/jcim-2024-0340","url":null,"abstract":"<p><strong>Objectives: </strong>Colorectal cancer and gastric cancer are one of the most prevalent types of cancer and are leading causes of cancer-related mortality worldwide. The chemotherapy is insufficient due to the poor targeting and affinity of drugs, low therapeutic effectiveness, and significant side effects. Consequently, developing effective therapeutic formulations is crucial for treating colorectal and gastric cancers. <i>Plantago major</i> (<i>P. major</i>) is a medicinal plant that has been investigated for medical research for cancer therapy owing to its rich phytochemical composition.</p><p><strong>Methods: </strong>This study aims to evaluate the antiproliferative activity of <i>P. major</i> leaf extract on NIH/3T3 fibroblast cells, AGS gastric, and Caco-2 colorectal cancer cell lines for 24 h using XTT cell viability assay. The apoptotic activity of <i>P. major</i> was examined by detecting caspase 3/7 level in cells. The ROS levels in cells were measured using the DCFH-DA dye. Additionally, it assesses the interaction and binding affinities of the active compounds of <i>P. major</i> with the overexpressed EPCAM through molecular docking.</p><p><strong>Results: </strong>The results demonstrate a dose-dependent anticancer effect of <i>P. major</i> on AGS and Caco-2 cell lines by reducing cell proliferation, increasing intracellular ROS accumulation and activating the caspase 3/7 apoptosis pathway. <i>P. major</i> exhibited no significant cytotoxic effects on non-cancerous NIH/3T3 fibroblast cells. Molecular docking analysis confirmed the high binding affinity of active compounds in <i>P. major</i>, such as apigenin, aucubin, baicalein, caffeic acid, and luteolin, towards the EpCAM protein overexpressed in gastric and colorectal cancer.</p><p><strong>Conclusions: </strong>In conclusion, the <i>P. major</i> can be a promising effective therapeutic strategy for gastrointestinal cancers.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"327-334"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer.","authors":"Kavita Goyal, M Arockia Babu, Muhammad Afzal, Arcot Rekha, Haider Ali, Saurabh Gupta, Ravindra Pal Singh, Anurag Mishra, Himmat Singh, Mohit Agrawal, Mohit Rana, Mohd Imran, Abida Khan","doi":"10.1515/jcim-2024-0444","DOIUrl":"10.1515/jcim-2024-0444","url":null,"abstract":"<p><p>Fisetin, a flavonol belonging to the flavonoid subclass, is a ubiquitous dietary flavonoid present in fruits and vegetables, including fruit peels, and has proven potential for anticancer activity, especially for lung cancer - a leading cause of cancer-related deaths globally. The current paper provides the most detailed and elaborate list of the various roles of fisetin in experimentally induced lung cancer cells, and these roles include the promotion of apoptosis, inhibition of cell proliferation, migration, and invasion, as well as the regulation of autophagy. Among the molecular targets, some identified pathways, such as PI3K/Akt, MAPK, and NF-κB, that fisetin affects are crucial for tumor formation, so it can be considered a potential chemopreventive agent. Moreover, fisetin improves the effectiveness of conventional treatments as a chemo- and radiosensitizer and minimizes side effects. However, the overall utility of fisetin for clinical use is now somewhat restricted by its poor solubility and short half-life. It is predicted that the future development of nanotechnologies for drug delivery, such as nanoparticle encapsulation, might help solve these difficulties. Further Preclinical and clinical investigations are required to uniformly determine the safety, efficacy, and standard dosage of fisetin for consumption in lung cancer therapy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"379-389"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol.","authors":"Athul T P, Vijaya Lekshmi R, Nithya V S, Anju Aravind T, Shibna M V, Meenakshi Pandey, Galib R, Tanuja M Nesari, Meena S Deogade","doi":"10.1515/jcim-2024-0469","DOIUrl":"10.1515/jcim-2024-0469","url":null,"abstract":"<p><strong>Objectives: </strong>Primary dysmenorrhea is a leading cause of job and school absenteeism among young females. Despite its high prevalence, contemporary medicine offers limited treatment options. Herbaceous members of the Apiaceae family, such as <i>Pimpinella anisum</i> L<i>., Anethum sowa</i> L<i>., Cuminum cyminum</i> L<i>., and Foeniculum vulgare</i> Mill., are commonly used in traditional medicine to treat primary dysmenorrhea. Currently, there is no comprehensive assessment of their therapeutic efficacy and safety. This study protocol assesses how effective and safe these herbs are in managing primary dysmenorrhea.</p><p><strong>Methods: </strong>The following databases will be searched without language restriction until May 2024: Cochrane CENTRAL, PubMed, AYUSH Research Portal, and DHARA, along with grey literature, and other sources. The risk of bias tool (RoB2) will evaluate the validity and applicability of study results. The review will address publication bias by taking appropriate measures. The review will adhere to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines for transparent and systematic reporting.</p><p><strong>Results: </strong>The review will incorporate randomized controlled trials (RCTs) comparing Apiaceae herbs to no treatment, placebo, medication, or standard care. It is anticipated that these herbs will significantly reduce menstrual pain severity, measured via the visual analogue scale (VAS), and exhibit fewer adverse events than nonsteroidal anti-inflammatory drugs (NSAIDs).</p><p><strong>Conclusions: </strong>This review aims to compile evidence on the efficacy and safety of Apiaceae herbs for primary dysmenorrhea, highlighting the need for further studies.</p><p><strong>Prospero registration number: </strong>CRD42024538888.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"373-377"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial.","authors":"Batool Kamalimanesh, Maryam Moradi, Mehdi Fathi, Maliheh Afiat, Mahnaz Boroumand Rezazadeh, Mohammad Taghi Shakeri","doi":"10.1515/jcim-2024-0353","DOIUrl":"10.1515/jcim-2024-0353","url":null,"abstract":"<p><strong>Objectives: </strong>A clinical trial was conducted to address the trend of high cesarean section rates resulting from maternal fear of childbirth. This trial aimed to investigate the effectiveness of self-hypnosis in mitigating fear and pain during childbirth.</p><p><strong>Methods: </strong>This study was a parallel, not blinded, randomized controlled trial conducted in 2019 in Mashhad, Iran. Ninety-three nulliparous women were selected by convenience sampling and randomized by random allocation software (4 blocking groups) to either self-hypnosis or control groups. During the clinical trial, both groups received usual care for pregnancy and childbirth. However, the self-hypnosis group also participated in two hypnosis sessions and was given two audio files to practice self-hypnosis at home until delivery. The follow-up period ranged from the 37th week of pregnancy to the postpartum period. Fear of childbirth was assessed at 39 weeks and at cervical dilatation of 8-10 cm, while labor pain was measured at the same stage of labor as the primary outcomes between two groups. Data were analyzed using SPSS 16, applying the Independent sample t-test, Mann-Whitney U test, and Chi-square test. A p-value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Thirty women in the self-hypnosis group, aged 24.96±5.42, and 33 women in the control group, aged 23.63±4.68, completed the study. The average scores of fear of childbirth during pregnancy at 39 weeks (self-hypnosis: 46.46±14.53, control: 73.18±17.91), during the active phase of labor at cervical dilatation of 8-10 cm (self-hypnosis: 40.80±17.37, control: 75.12±19.40), and labor pain at cervical dilatation of 8-10 cm (self-hypnosis: 83.03±16.43, control: 95.36±10.36) were significantly lower in the self-hypnosis group compared to the control group (p<0.001 for all).</p><p><strong>Conclusions: </strong>Our findings suggest that self-hypnosis could be a more effective intervention than usual care alone for reducing fear and pain during natural childbirth in nulliparous women.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"353-362"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema.","authors":"Ming Li, Heng Deng, Shuqing Xu, Xiaoli Fang, Kun Tang, Li Chen, Ansheng Zha","doi":"10.1515/jcim-2024-0435","DOIUrl":"10.1515/jcim-2024-0435","url":null,"abstract":"<p><strong>Objectives: </strong>This investigation aimed to evaluate the efficacy, key active ingredients, and mechanisms of Zuoqing San (ZQS), a traditional Chinese medicine formula, in managing sigmoid ulcerative colitis (SUC).</p><p><strong>Methods: </strong>A cohort of 126 participants was recruited and treated with ZQS at a daily dosage of 100 mL for 12 weeks. The primary endpoint was the percentage of subjects achieving favorable treatment outcomes. Liquid chromatography-mass spectrometry was employed to identify the principal ingredients of ZQS. Network pharmacology was utilized to predict the central targets of its active ingredients. Protein-protein interaction networks, Gene Ontology enrichment analyses, and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted for identified core targets. Finally, molecular dynamics simulations of key active ingredients and core targets were performed.</p><p><strong>Results: </strong>Following 12 weeks of therapy, with a withdrawal rate of 7.93 %, favorable treatment outcomes were observed in 31.03 % of subjects at 4 weeks, 66.37 % at 8 weeks (Odds Ratio: 1.54, 95 % Confidence Interval: 0.41-1.83), and 68.10 % at 12 weeks (Odds Ratio: 1.86, 95 % CI: 0.32-1.27). ZQS comprises 31 principal chemical constituents. Key targets within the protein-protein interaction network included TNF, AKT1, IL6, IL1β, PTGS2, TP53, JUN, MMP9, CASP3, HIF1A, and BCL1. Pathway analysis indicated ZQS primarily impacts the TNF, NF-kB, and IL-17 signaling pathways. Molecular dynamics simulation results showed oxymatrine, cynarin had higher affinity with TNF and IL1β, respectively.</p><p><strong>Conclusions: </strong>This research elucidates the active components of ZQS and its potential multicomponent-multitarget-multipathway pharmacological mechanisms, demonstrating promising therapeutic potential for SUC management.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"343-352"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catechins in cancer therapy: integrating traditional and complementary approaches.","authors":"Renu Dwivedi, Rajni Bala, Sumitra Singh, Rakesh K Sindhu","doi":"10.1515/jcim-2024-0472","DOIUrl":"10.1515/jcim-2024-0472","url":null,"abstract":"<p><p>Catechin is a group of bioactive flavonoids found in various plant sources such as tea, cocoa, and fruits. Recent studies have suggested that catechins has significant potential in preventing and treating cancer. Catechin exhibits a variety of biological activities that may contribute to its anticancer effects, including antioxidant, anti-inflammatory, and pro-apoptotic properties. Studies have demonstrated that catechin can inhibit cancer cell proliferation, induce cell cycle arrest, and promote apoptosis across multiple cancer types, including skin, breast, lung, liver, prostate, and colon cancers. Furthermore, catechin has shown the ability to inhibit angiogenesis, a critical process for tumor growth and metastasis, by restricting new blood vessel formation. Catechin's impact on cancer extends beyond its direct effects on cancer cells. It modulates various signaling pathways involved in cancer progression, such as those associated with cell survival, inflammation, and metastasis. Despite these promising findings, additional research is needed to clarify the precise mechanisms of catechin's anticancer action, optimal dosing strategies, and long-term safety in cancer prevention and treatment. This review will explore the current research landscape on tea polyphenols, particularly catechin, and their potential role in cancer prevention and therapy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}