Journal of Complementary and Integrative Medicine最新文献

{"title":"Prevalence and profile of New Zealand osteopaths treating people experiencing headaches and migraines.","authors":"Ana Paula Antunes Ferreira, Brett Vaughan, Jerry Draper-Rodi, Lee Muddle, Loïc Treffel, Cindy McIntyre, Michael Fleischmann, Francesco Cerritelli, Kesava Kovanur Sampath, Amie Steel","doi":"10.1515/jcim-2024-0283","DOIUrl":"https://doi.org/10.1515/jcim-2024-0283","url":null,"abstract":"<p><strong>Objectives: </strong>To describe the prevalence and profile of NZ osteopaths treating people experiencing headaches and migraines. This study is the first to describe this practice.</p><p><strong>Background: </strong>Manual and manipulative therapy interventions are commonly sought by individuals experiencing headaches or migraines. Evidence supports the use of manual therapy as part of the management of headache and migraine disorders. Osteopaths are health professionals who provide care for individuals experiencing headaches and migraines. However, there is a lack of data concerning the profile of osteopaths treating these conditions, in addition to their diagnostic and management strategies.</p><p><strong>Methods: </strong>The Osteopathy Research Connect-New Zealand (ORC-NZ), a practice-based research network for the New Zealand osteopathy profession, was established, and recruitment occurred between August to December 2018.</p><p><strong>Results: </strong>Two hundred and seventy-seven respondents provided responses to the headache and migraine items on the ORC-NZ practice questionnaire. Of these respondents, 235 (84.8 %) indicated treating headaches often, and 107 (38.6 %) indicated treating migraines often. Osteopaths who reported often treating patients with migraines and headaches were more likely to report clinically supervising associates and be co-located with a general practitioner. In terms of management, they tend to use HVLA, are likely to treat TMJ in the case of migraines, and the thoracic spine for patients with headaches. Further, NZ osteopaths frequently refer patients with migraines and/or headaches to other practitioners.</p><p><strong>Conclusions: </strong>NZ osteopaths treat patients with migraines and/or headaches and frequently refer them to other practitioners. NZ osteopaths are aware of the inter-professional approach required for this patient population.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cytidine-5'-diphosphocholine alone, caffeine or their combination on oxidative stress and inflammatory response in an experimentally-induced Parkinson's disease.","authors":"Soha Mohamed Hamdy, Nada Ahmed Elsayed, Eman R Youness, Heba Mohamed Rabie Elesh, Omar M E Abdel-Salam","doi":"10.1515/jcim-2024-0447","DOIUrl":"https://doi.org/10.1515/jcim-2024-0447","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of orally administered cytidine-5'-diphosphocholine (citicholine) (50,100,200 mg/kg), α-tocopherol (Vit E; 25 mg/kg), caffeine (10 mg/kg), L-dopa (25 mg/kg) or the combination of Vit E, caffeine with citicholine (100 mg/kg) on nigrostriatal neuronal damage induced in the mice brain by subcutaneous (s.c.) rotenone.</p><p><strong>Methods: </strong>Swiss male mice received rotenone (1.5 mg/kg, s.c, three times per week) alone or with other drugs for 2 weeks. Mice were evaluated for brain malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO), paraoxonase-1 (PON-1), acetylcholinesterase (ACHE), interlukin-1beta (IL-1β), nuclear factor kappa B (NF-κB) and monocyte chemoattractant protein (MCP-1). Histopathologic examination was also done.</p><p><strong>Results: </strong>Cticholine co-treatment at 50, 100 or 200 mg/kg significantly decreased brain MDA and increased PON-1 activity in a dose-dependent manner. When given at 200 mg/kg, it also significantly decreased NO production, while at 100 and 200 mg/kg significantly increased GSH brain. MCP-1 significantly decreased upon treatment with 100 or 200 mg/kg of citicholine. IL-1 β and NF-κB significantly decreased and AChE significantly increased by 200 mg/kg citicholine. Oxidative stress and inflammatory biomarkers also showed favorable changes after Vit E, caffeine or L-dopa. However, the combination of Vit E and/or caffeine with 100 mg/kg citicholine was not superior to that of only citicholine at 100 or 200 mg/kg.</p><p><strong>Conclusions: </strong>Citicholine is neuroprotective in acute rotenone nigrostriatal degeneration via antioxidant and anti-inflammatory properties. It is suggested that citicholine may have a role in treatment of Parkinson's disease by decreasing neuro-inflammation and oxidative stress, preventing the development of neuronal damage.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic acid mitigates alpha-naphthyl isothiocyanate-induced cholestasis in rats via FXR activation and inflammatory pathway modulation.","authors":"Hamza Ahmed Taher, Munaf Hashim Zalzala","doi":"10.1515/jcim-2024-0425","DOIUrl":"10.1515/jcim-2024-0425","url":null,"abstract":"<p><strong>Objectives: </strong>The liver is vital for metabolism, detoxification, storage, and secretion. Cholestasis, in which bile flow is hindered, can cause serious harm to the liver. This study examines the potential of ellagic acid to prevent cholestasis in male rats that has been caused by alpha-naphthyl isothiocyanate (ANIT).</p><p><strong>Method: </strong>Male rats were divided into four groups for an 8-day study. The control group received 5 % dimethyl sulfoxide (DMSO) orally for eight days and maize oil (1 mL/kg, orally) 48 h before sacrifice. The ANIT Group received 5 % DMSO orally for 8 days, the ANIT (100 mg/kg, orally) administered on the 6th day, 48 h before sacrifice. The low-Dose Ellagic Acid + ANIT Group was given ellagic acid (5 mg/kg, orally) for eight days, with ANIT (100 mg/kg, orally) on the 6th day, 48 h prior to sacrifice. The high-Dose Ellagic Acid + ANIT Group received ellagic acid (10 mg/kg, orally) for eight days, the ANIT (100 mg/kg, orally) on the 6th day, 48 h before sacrifice. Different biochemical and histopathological analyses were conducted to assess the protective effects of ellagic acid on ANIT-induced liver injury.</p><p><strong>Results: </strong>ANIT significantly elevated serum of liver enzymes. It caused severe bile duct inflammation and reduced bile salt export pump (BSEP) and Na+-taurocholate cotransporting polypeptide (NTCP) expression, indicating liver injury. Ellagic acid treatment mitigated these changes, improving biochemical parameters and reducing liver damage. ANIT-induced cholestasis results in bile acid accumulation due to decreased BSEP and NTCP expression linked to impaired farnesoid X receptor (FXR) signaling. Ellagic acid restored BSEP and NTCP levels via FXR activation, reducing bile acids and inflammatory markers IL-1β and TNF-α. Ellagic acid also enhanced SIRT1 activity, further improving FXR function and bile acid homeostasis.</p><p><strong>Conclusions: </strong>Ellagic acid exhibits protective effects against cholestasis by enhancing the FXR signaling and <i>ntcp</i> and <i>bsep</i> expression with mitigating liver damage and inflammation.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"296-303"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic activity of aqueous and methanol fruit pulp extracts of <i>Hyphaene thebaica</i> (Arecaceae) (Linn) mart in mice.","authors":"Francis Désiré Bomba Tatsinkou, Georlin E Fotabong, Bibiane A Wandji, Marius Mbiantcha, Erastus N Nembo, Armel Jackson Seukep, Elisabeth M Zeuko'o, Telesphore B Nguelefack, Emmanuel A Asongalem","doi":"10.1515/jcim-2024-0159","DOIUrl":"10.1515/jcim-2024-0159","url":null,"abstract":"<p><strong>Objectives: </strong>Pain affects about one in every five persons and is considered a major global health burden. <i>Hyphaene thebaica</i> (Arecaceae), is a medicinal plant used in Cameroon, fruit pulp are macerated and orally administered in traditional medicine to treat various ailments, including hypertension, pain, and inflammation. This study aimed to evaluate the pain-killing effect of fruit pulp extracts of <i>H. thebaica</i> in mice.</p><p><strong>Methods: </strong>Aqueous (AEHT) and methanol (MEHT) extracts were prepared from fruit pulp of <i>H. thebaica</i>, followed by a qualitative phytochemical analysis. The extracts were given orally at doses of 100, 200, and 400 mg/kg in acute pain models such as acetic acid, formalin, hotplate, and capsaicin. Control groups included distilled water (negative), and diclofenac, morphine, ruthenium red, diazepam (positive). Naloxone pretreatment was used to assess opioid pathway involvement. Locomotor and sedative effects were evaluated using rota-rod and open-field tests. Acute toxicity was assessed at 2,000 mg/kg.</p><p><strong>Results: </strong>Phytochemical tests revealed saponins, flavonoids, tannins, and phenols. Both extracts greatly decreased the writhing induced by acetic acid. MEHT inhibited both phases of formalin-induced pain (p<0.01). Both extracts significantly inhibited hotplate-induced nociception (p<0.001), partially reversed by naloxone, except for MEHT. In the capsaicin test, extracts produced a remarkable reduction of paw licking time (p<0.01). No motor coordination alteration or acute toxicity effects were observed.</p><p><strong>Conclusions: </strong>The findings demonstrated the analgesic activity of AEHT and MEHT, mediated by the stimulation of opioids and blockage of vanilloid receptors pathways.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"258-269"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of medical leech on experimentally induced incisional wound healing in rats.","authors":"Alican Bilden, Özlem Kara, Merve Kahraman, Nebahat Çağlayan, Muttalip Çiçek","doi":"10.1515/jcim-2024-0351","DOIUrl":"10.1515/jcim-2024-0351","url":null,"abstract":"<p><strong>Objectives: </strong>This study was conducted in response to the increasing interest in understanding the effects of both modern and traditional complementary medicine on incisional wound healing. Herein, it was aimed to investigate the wound healing effects of medicinal leech therapy and leech saliva in an experimentally created incisional skin wound model.</p><p><strong>Methods: </strong>Fifteen rats underwent full-thickness incisions on their dorsal regions and were randomly assigned to five equal groups, as the Leech Saliva (LS) group, where wounds were treated topically with leech saliva once daily; Leech Therapy-1 (LT-1) group, where leech therapy was administered once at the beginning of the experiment; Leech Therapy-2 (LT-2) group, where leech therapy was applied twice, on days 0 and 3; Positive Control (PC) group, where wounds were treated daily with Phyto cream containing <i>Triticum vulgare</i>; and Negative Control (NC) group, where no treatment was given.</p><p><strong>Results: </strong>Wound healing was assessed daily, and the experiment continued until complete healing was observed. At the conclusion, the wound size, appearance, and histological features were analyzed to compare healing progress across the groups.</p><p><strong>Conclusions: </strong>Medicinal leech therapy was observed to have a positive wound healing effect in the rat model.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"288-295"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of amifostine on apoptotic inflammatory makers in cisplatin induced brain damage in rats.","authors":"Mahmoud M Masoud, Nabila A El-Laithy, Eman R Youness, Nadia M Ahmed, Elsayed M E Mahdy, Wafaa Gh Shousha","doi":"10.1515/jcim-2024-0250","DOIUrl":"10.1515/jcim-2024-0250","url":null,"abstract":"<p><strong>Objectives: </strong>To lessen the negative effects of the medication, we assessed the neuroprotective impact of amifostine nanoparticles against the neurotoxicity generated by cisplatin.</p><p><strong>Methods: </strong>60 adult male albino Wistar rats were arranged into six groups. Group 1; received saline intraperitonealy (IP) and served as negative control. Group 2; received IP injection of silica nano-emulsion, Group 3 received cispatin for three consecutive days at the end of the study, Group 4 received amifostine intrapretonealy (IP) before cisplatin injection, Group 5 received silica nano-emulsion alone for one month, group 6 received silica nano-emulsion in combination with cisplatin for three consecutive days at the end of the study. Monocyte chemoattractant protein-1 (MCP-1) and glial fibrillary acidic protein (GFAP) were estimated by ELISA, butrylcholinesterase (BChE) by spectrophotometric method while caspase-3 as a marker of apoptosis by PCR.</p><p><strong>Results: </strong>The mean levels of brain GFAP, MCP-1, and caspase-3 in the cisplatin group were considerably higher than those in the control group. However, there was a drop in the average level of brain BChE activity. Additionally, the injection of (SiNPs@AMF + cisplatin) increased BChE activities while reducing GFAP, MCP-1, and caspase-3 levels, thereby reversing the negative effects of cisplatin on the brain tissue. On the other hand, the group treated with SiNPs@AMF + cisplatin showed improvement in overall brain structure and minimal pyknotic nuclei and apoptotic neurons were found.</p><p><strong>Conclusions: </strong>These outcomes demonstrated amifostine's ability to lessen the histological changes brought on by cisplatin. To sum up, SiNPs@AMF may be a suitable and secure supplemental treatment agent to lessen cisplatin's toxicity in the brain and enhance the treatment's effects throughout chemotherapy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"279-287"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific investigation on antibacterial, antioxidant, cytotoxic effects and TLC bioautography of <i>Terminalia schimperiania</i> stem bark extracts.","authors":"Marius Sipping, T Sathish Kumar, Nestor Kamdem","doi":"10.1515/jcim-2024-0251","DOIUrl":"10.1515/jcim-2024-0251","url":null,"abstract":"<p><strong>Objectives: </strong><i>Terminalia schimperiana</i> Hochst, belonging to the <i>Combretaceae</i> family, is known for its ethnomedicinal values, particularly in treating various diseases in Africa. This study aimed to investigate the antibacterial, antioxidant, and cytotoxic properties of <i>T. schimperiana</i> stem bark extracts, with a specific focus on assessing their bioactive potential and identifying active compounds via TLC bioautography.</p><p><strong>Methods: </strong>The <i>in vitro</i> antimicrobial activity was assessed using the agar well diffusion method against selected clinical strains. Antioxidant activity was evaluated using several methods including free radical scavenging, ferrous ion chelation assays and total phenolic content analysis. The cytotoxicity of the extracts was assessed using MTT assay towards Raw 264.7 and Vero cell lines.</p><p><strong>Results: </strong>All extracts demonstrated significant antibacterial activity against the bacteria tested, with inhibition zones (IZ) ranging from 6.50 ± 0.71 to 15.50 ± 0.71 mm and minimum inhibitory concentrations (MIC) ranging from 1.95 to 1,250 μg/mL. The hydroethanolic extract exhibited strongest antioxidant activities with EC₅₀ values of 188.50; 245.30, and 281.50 μg/mL for DPPH; ABTS, ferrous ion chelation assays respectively, and a high content of phenolic compounds (101.67 ± 2.97 µgEFA/mg DW). Importantly, no cytotoxic effects were observed on Raw 264.7 and Vero cell lines. HPTLC analysis identified alkaloids and phenolic compounds in both aqueous and hydroethanolic extracts.</p><p><strong>Conclusions: </strong>These findings indicate <i>T. schimperiana</i> provides a wealth of bio-compounds that can be utilised in the pharmaceutical industry as antibacterial and antioxidant agents to combat antibiotic resistance.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"114-123"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial.","authors":"Roholla Hemmati, Dorsa Bahrami Zanjanbar, Mohammad Iman Shishesaz, Abbas Soleimani, Tahereh Yari","doi":"10.1515/jcim-2024-0427","DOIUrl":"10.1515/jcim-2024-0427","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cardiovascular diseases (CVDs), including acute coronary syndrome (ACS), represent a major global health challenge. Arrhythmias such as ventricular tachycardia (VT), ventricular fibrillation (VF), atrial fibrillation (AF), premature ventricular contractions (PVCs), and premature atrial contractions (PACs) frequently complicate ACS, needing effective management strategies. Omega-3 fatty acids have shown potency in preventing sudden cardiac death by modulating arrhythmias, but their acute effects in ACS patients remain controversial. This study aimed to evaluate the impact of Omega-3 supplementation on reducing common arrhythmias among ACS patients.</p><p><strong>Methods: </strong>A randomized clinical trial involving 74 ACS patients was conducted. Participants were randomly assigned to receive either 1 gr of Omega-3 daily or placebo (olive oil capsules) for five days. Arrhythmia frequencies (AF, PVCs, PACs, VT, VF) were monitored using daily ECGs, and statistical analyses were performed using SPSS software (version 24).</p><p><strong>Results: </strong>Over the five days, patients receiving Omega-3 showed significant reductions in the occurrence of AF (26.66-11.66 %, p=0.015), PACs (21.66-3.33 %, p=0.043), and PVCs (36.66-3.33 %, p=0.021) compared to the control group. The frequency of VT and VF cases was low, with only one VT case in the Omega-3 group, which resolved without intervention after the second day.</p><p><strong>Conclusions: </strong>This study highlights the potential of Omega-3 fatty acids as adjunct therapy for arrhythmia management post-ACS, particularly in reducing AF, PACs, and PVCs. However, the minimal effects on VF and VT and the lack of thorough statistical analysis for these arrhythmias warrant further investigation.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"173-180"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preclinical study on effect of betanin on sodium fluoride induced hepatorenal toxicity in Wistar rats.","authors":"Darrel Castelino, Amrita Parida, Bharti Chogtu Magazine, Aqsa Fathima, Mohandas Rao K G","doi":"10.1515/jcim-2024-0262","DOIUrl":"10.1515/jcim-2024-0262","url":null,"abstract":"<p><strong>Background: </strong>Excessive fluoride exposure leads to increased oxidative stress and lipid peroxidation, causing harmful effects on the metabolic organs in the human body. Betanin, a pigment obtained from beetroot, is seen to have powerful anti-inflammatory and antioxidant. The study was conducted to determine the role of betanin in fluoride induced hepato-renal toxicity in Wistar rats.</p><p><strong>Methods: </strong>Twenty four rats were divided into four groups. Group Ⅰ (control) rats received 1 mL distilled water; group Ⅱ rats were administered 10 mg/kg of sodium fluoride (NaF); group Ⅲ received 10 mg/kg NaF and 50 mg/kg (low dose) betanin; group Ⅳ received 10 mg/kg NaF and 200 mg/kg (high dose) betanin. Animals were dosed orally for 90 days. Various markers of liver and kidney function as well as oxidative stress were measured. Liver and kidney samples were examined for histopathology.</p><p><strong>Results: </strong>Animals in group Ⅱ had significantly increased levels of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine, and blood urea nitrogen compared to the NaF + betanin treated animals (group Ⅲ & Ⅳ). Malondialdehyde, nitric oxide levels were significantly lower in rats treated with NaF + betanin (low and high dose). Histologically, in group II rats, signs of interstitial nephritis were seen in the kidneys while liver sections showed clear indication of features of fatty liver and inflammatory cell infiltration. Treatment with betanin alleviated the severity of histopathological changes induced by NaF.</p><p><strong>Conclusions: </strong>Betanin significantly ameliorated NaF-induced oxidative stress and inflammation, therefore, has potential to be used as protective agent against fluoride induced hepato-renal toxicity.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"94-102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apitherapy for diabetes mellitus: mechanisms and clinical implications.","authors":"Andrés Jagua-Gualdrón, Nicolai Andrés García-Reyes, Roger Edwin Fernández-Bernal","doi":"10.1515/jcim-2024-0367","DOIUrl":"10.1515/jcim-2024-0367","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus is a complex disease in terms of its causes and pathophysiological processes, it produces a significant impact on health and leads to complications that are difficult to manage.</p><p><strong>Content: </strong>This review summarizes and analyzes recent advances in the understanding of the mechanisms of diabetes mellitus and how apitherapy affects them. Also present the available clinical evidence on its application.</p><p><strong>Summary: </strong>Apitherapy (complementary-integral use of beehive products) is a potentially useful therapeutic system with a significant level of evidence. This review shows and analyzes the preclinical and clinical evidence on the use of apitherapy in diabetes mellitus.</p><p><strong>Outlook: </strong>Apitherapy shows significant effects on epigenetics, chronic inflammation, oxidative stress, metabolic control, dysbiosis, premature cell death and tissue remodeling. Clinical evidence shows an impact on these mechanisms. Apitherapy is a very useful complementary medicine in the treatment of diabetes mellitus.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"228-236"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}