Journal of Complementary and Integrative Medicine最新文献

{"title":"Peruvoside, a cardiac glycoside, induces cell cycle arrest in non-small cell lung cancer (A549 cell line) and modulates PI3K/AKT/mTOR.","authors":"Zahraa Shehab Ahmed, Meroj Ahmed Jasem, Bahir Abdul-Razzaq Mshimesh, Safaa A Al-Qaysi","doi":"10.1515/jcim-2026-0096","DOIUrl":"10.1515/jcim-2026-0096","url":null,"abstract":"<p><strong>Objectives: </strong>Lung cancer constitutes a global health crisis that leads to mortality. The cellular signaling and cell cycle are disrupted in lung cancer. From time immemorial, plants have been a major source of medications. Notably, cardiac glycosides (CGs) potently bind to Na⁺/K⁺-ATPase in cardiac tissue. CGs show promising potential as anticancer activity. Peruvoside belongs to the cardiac glycosides, Peruvoside derived from <i>Thevetia peruviana</i>. Noteworthy, Peruvoside has shown promising interest due to its powerful effect toward several cancer types. The presented study evaluates Peruvoside's effects on the proliferation as well as cell cycle progression of lung cancer A549 cells to validate its anticancer potential.</p><p><strong>Methods: </strong>A549 cells were cultured and allocated into two groups: treated with Peruvoside and an untreated control group. Viability of A549 cells was assessed by WST-8 assay; cell cycle analysis was performed by flow cytometry; CDK6 and cyclin D1 protein expression was determined by Western blot; and real-time PCR analysis was performed to identify the expression of <i>CHK1, CHK2, PI3K, AKT,</i> and <i>mTOR</i> genes.</p><p><strong>Results: </strong>Peruvoside at a concentration of 68.77 nM was associated with a notable anti-proliferative effect and the induction of an apoptotic cascade. Peruvoside induces cell cycle arrest at the G2/M phase, validated by Western blot and real-time PCR analysis, confirming that inhibition of proteins and genes related to cell cycle progression and expansion of the lung cancer, indicating that Peruvoside has antiproliferative and pro-apoptotic effects.</p><p><strong>Conclusions: </strong>Within this research, the data showed the arrest of the cell cycle and the inhibition of the proliferation regulatory gene by Peruvoside were associated with suppression of lung cancer survival, proliferation, metastatic dissemination, and promotion of cell death.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"458-465"},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the anticancer activity of black maitake odaira extract-prothera (<i>Grifola frondosa</i>) and its interactions with common chemotherapeutics in <i>in-vitro</i> and <i>in-vivo</i> models of human colorectal cancers.","authors":"Hannah Drew, Vanessa Chimienti, Sona Regonda, Mohammad El Hindawi, Divyanshi Mitra, Eesha Atikukke, Angelina Hermes, Siyaram Pandey","doi":"10.1515/jcim-2025-0300","DOIUrl":"10.1515/jcim-2025-0300","url":null,"abstract":"<p><strong>Objectives: </strong>Black maitake odaira extract-prothera (<i>Grifola frondosa</i>; BME), a β-glucan-rich natural product, has demonstrated anticancer activities including immunomodulation, inhibition of metastasis, enhanced chemotherapy sensitivity, and induction of apoptosis. This study investigated the effects of BME on human colorectal cancer cell lines HCT-116 and HT-29, evaluated its interaction with FOLFOX chemotherapy, and assessed selectivity using the healthy human colon epithelial cell line NCM-460.</p><p><strong>Methods: </strong>Anticancer activity was evaluated in two- and three-dimensional colorectal cancer cell models by measuring apoptosis and mechanism of action using fluorogenic markers, cell viability via formazan reduction, and migration through wound-healing assays. Selectivity was assessed in healthy NCM-460 colon epithelial cells. <i>In vivo</i> antitumour efficacy was examined using xenografted immunocompromised mouse models.</p><p><strong>Results: </strong>BME induced time- and dose-dependent apoptosis, reduced viability and migration, increased reactive oxygen species, and mediated mitochondrial dysfunction. Positive interactions were observed with FOLFOX chemotherapy. <i>In vivo</i>, BME enhanced antitumour activity, while no apoptotic effects were detected in normal NCM-460 colon epithelial cells, indicating selectivity.</p><p><strong>Conclusions: </strong>These findings suggest BME may have potential as an adjunct to colorectal cancer therapy and justify further clinical evaluation.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"466-484"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the neuroprotective secrets of <i>Tinospora sinensis</i>: navigating the rotenone induced storm of behavioral and biochemical challenges in Parkinson's disease rat models.","authors":"Prabha Bhong, Suvarna Ingale, Pallavi Jadhav","doi":"10.1515/jcim-2026-0074","DOIUrl":"10.1515/jcim-2026-0074","url":null,"abstract":"<p><strong>Objectives: </strong>Parkinson's disease (PD) is a chronic neurodegenerative disorder that leads to motor and non-motor challenges, significantly impacting the quality of life. Research highlights body's antioxidant systems role in mitigating PD. This study investigated neuroprotective capabilities of <i>Tinospora sinensis</i> stem extract (TSSE) in a rat model of PD induced by rotenone.</p><p><strong>Methods: </strong>PD was induced in rats by subcutaneous rotenone injections (2 mg/kg/day) for 35 days. TSSE was administered orally at 100, 200, and 400 mg/kg doses, with levodopa-carbidopa as the standard reference. Motor impairments were assessed through catalepsy, locomotor activity, and rotarod tests. Biochemical evaluations included oxidative stress markers, antioxidant enzymes (glutathione, superoxide dismutase, and catalase), and dopamine levels, and monoamino oxidase-B (MAO-B). Histopathological examination of brain assessed neuronal integrity.</p><p><strong>Results: </strong>Rotenone administration led to significant motor impairments, increased oxidative stress, reduced dopamine levels, and neuronal damage. Treatment with TSSE resulted in notable, dose-dependent enhancements in motor abilities and restored antioxidant enzyme activities, while also reducing lipid peroxidation, as indicated by decreased malondialdehyde levels. Additionally, TSSE decreased MAO-B level and increased brain dopamine level and maintained neuronal structure. The TSSE 400 mg/kg exhibited neuroprotective effects comparable to those of standard.</p><p><strong>Conclusions: </strong>TSSE shows significant neuroprotective effects, likely by enhancing endogenous antioxidant defenses and restoring dopaminergic neurotransmission. These findings suggest, TSSE could serve as a complementary therapeutic approach that targets oxidative and neurodegenerative mechanisms in PD.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"439-447"},"PeriodicalIF":0.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of monk fruit sweetener on liver architecture, oxidative stress, and enzyme markers in adult Wistar rats.","authors":"Ibrahim Yusuf, Sirajo M Umar, Rabiu I Fage","doi":"10.1515/jcim-2026-0007","DOIUrl":"https://doi.org/10.1515/jcim-2026-0007","url":null,"abstract":"<p><strong>Background: </strong>Non-nutritive sweeteners (NNS) such as monk fruit sweetener (MFS) are increasingly adopted as sugar alternatives due to their high sweetening potency and low caloric content. Despite their widespread use, the metabolic and hepatic safety profiles of these agents remain underexplored. This study investigates the effect of MFS on the liver histology and key biochemical markers; alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) in adult male adult Wistar rats.</p><p><strong>Methods: </strong>Twenty adult male Wistar rats were assigned into four groups (n=5/group). Group A served as the control, while Groups B, C, and D received 100, 150, and 200 mg/kg body weight of MFS orally for four weeks. Liver histology was studied using H&E and Masson trichrome stained sections of the liver. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) were assessed. Data obtained was analyzed using one way ANOVA.</p><p><strong>Results: </strong>MFS administration resulted in significant elevations in ALT (p=0.001) and MDA (p=0.002), consistent with hepatocellular injury and increased oxidative stress. Although AST levels were elevated, the change did not reach statistical significance. Histological evaluation demonstrated dose-dependent hepatic alterations, including hepatocellular vacuolation, necrosis, sinusoidal and central vein congestion, and increased collagen deposition.</p><p><strong>Conclusions: </strong>Exposure to MFS was associated with biochemical and structural hepatic alterations in a dose-dependent manner, raising concerns regarding its hepatic safety under conditions of sustained use. Further mechanistic and long-term studies are warranted to clarify the translational relevance of these findings in humans.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modulatory role of thymoquinone in boldenone undecylenate induced testicular tissue damage: oxidative stress, inflammatory markers and androgen receptor dysregulation expression in adult male rats.","authors":"Noha A Mowaad, Marwa El-Sayed El-Shamarka, Eman Refaat Youness, Eman Gomaa, Noha S E Bayomi","doi":"10.1515/jcim-2025-0378","DOIUrl":"https://doi.org/10.1515/jcim-2025-0378","url":null,"abstract":"<p><strong>Objectives: </strong>Boldenone undecylenate (Bold), a synthetic anabolic steroid, poses health risks including testicular damage. Thymoquinone (TQ), from <i>Nigella sativa</i>, has antioxidant and anti-inflammatory properties. To evaluate TQ's protective effects against Bold-induced testicular impairment.</p><p><strong>Methods: </strong>Thirty-two male Wistar rats were divided into four groups (control, TQ 25 mg/kg orally, Bold 5 mg/kg intramuscularly, and Bold + TQ) for 8 weeks. Serum FSH, LH, and free testosterone, and testicular IL-1β, MCP-1, TNF-α, MDA, and NO were measured. Testes were examined histologically and for AR expression.</p><p><strong>Results: </strong>Bold decreased FSH, LH, and testosterone, increased oxidative stress and inflammatory markers, caused histological damage, and reduced AR expression. TQ co-treatment significantly mitigated these effects.</p><p><strong>Conclusions: </strong>TQ protects against Bold-induced testicular injury by reducing oxidative stress and inflammation, suggesting its potential as a preventive supplement.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the anticancer potential of black maitake extract in A375 human malignant melanoma cells.","authors":"Joshua Mathews, Sona Regonda, Anent Grewal, Hannah Drew, Siyaram Pandey","doi":"10.1515/jcim-2025-0267","DOIUrl":"10.1515/jcim-2025-0267","url":null,"abstract":"<p><strong>Objectives: </strong>Melanoma is one of the deadliest skin cancers, characterized by high metastatic potential and poor prognosis in advanced stages. While chemotherapeutic agent temozolomide (TMZ) is the standard treatment, its clinical utility is hindered by toxicity and limited specificity. This study evaluates Black Maitake Odaira Extract Prothera (BME) from the <i>Grifola frondosa</i> mushroom as a complementary treatment for melanoma, examining its apoptotic, anti-migratory, and anti-proliferative effects in 2D and 3D models. We aim to investigate the therapeutic potential of BME alone and in combination with standard chemotherapy in A375 melanoma cells.</p><p><strong>Methods: </strong>A375 melanoma cells were treated with BME alone and in combination with TMZ. Cell viability was quantified via Trypan Blue exclusion assays. Apoptosis was assessed using Hoechst 33342, Annexin V, and propidium iodide staining, while mitochondrial depolarization was evaluated using TMRM staining. Cancer cell migration was analyzed through wound healing assays, and 3D spheroid cultures were used to evaluate how BME disrupts complex tumour-like structures.</p><p><strong>Results: </strong>BME induced dose-dependent apoptosis in 2D cell models. BME enhanced the efficacy of TMZ in inducing apoptosis when treated in combination. Wound healing assays revealed a marked reduction in cell migration, particularly in combination treatments with TMZ. In 3D cell cultures, BME with TMZ exhibited increased mitochondrial depolarization.</p><p><strong>Conclusions: </strong>BME demonstrates pro-apoptotic and anti-migratory activity in melanoma cells, while improving the efficacy of standard chemotherapy. These findings support its potential as an effective adjuvant natural health product for melanoma treatment.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"485-494"},"PeriodicalIF":0.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of taurine on the cardiotoxicity induced by bisphenol-A in male albino rats.","authors":"Yasser A Khadrawy, Eman N Hosny, Noha M Khoder, Neveen A Noor, Mohamed M Nazmy, Amel I Othman, Heba S Aboul Ezz, Nasr M Radwan","doi":"10.1515/jcim-2025-0446","DOIUrl":"10.1515/jcim-2025-0446","url":null,"abstract":"<p><strong>Objectives: </strong>Due to the widespread and extensive use of the endocrine disruptor bisphenol A (BPA) in our daily life, several studies were performed to attenuate its adverse effects. Thus, taurine was used in the current study to evaluate its protective action against BPA cardiotoxic effects.</p><p><strong>Methods: </strong>Rats were divided into control rats, BPA-intoxicated rats, and BPA-intoxicated rats treated with taurine. After six weeks of daily oral BPA treatment (25 mg/kg), the cardio-protective effect of taurine (100 mg/kg) was determined by the measurement of the serum activities of lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) and the levels of Wnt, β-catenin, lipid peroxidation (MDA), nitric oxide (NO), reduced glutathione (GSH) and Na⁺, K⁺, ATPase activity in the myocardium. Additionally, the effects of taurine on the cardiac histopathological alterations caused by BPA were evaluated.</p><p><strong>Results: </strong>BPA-treated animals exhibited significantly elevated levels of MDA (4.7 ± 0.4 vs. 3.2 ± 0.2), Wnt (4.3 ± 0.3 vs. 2.9 ± 0.1), β-catenin (781.4 ± 37.9 vs. 599.1 ± 43.2), and increased serum activities of LDH (957.9 ± 78.6 vs. 662.3 ± 30.2) and CK-MB (347.3 ± 32.1 vs. 74.9 ± 15.2). In addition, BPA significantly decreased myocardial levels of GSH (4.6 ± 0.2 vs. 5.7 ± 0.2) and NO (0.2 ± 0.01 vs. 0.2 ± 0.01) levels, and Na⁺, K⁺-ATPase (1.2 ± 0.1 vs. 1.5 ± 0.1) activity. Histopathological examination showed myocardial striations, pyknosis, congestion and dilation of blood vessels. Taurine protection alleviates BPA-induced changes in MDA, NO, GSH, Na⁺, K⁺, ATPase, LDH, CK-MB, and Wnt restoring them to control-like values. However, β-catenin level was increased in taurine-rats. Taurine also improved the histopathological changes caused by BPA. Accordingly, taurine could potentially impose cardio-protection against BPA cardiotoxicity in male rats.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Compendium of Reporting Guidelines for Traditional, Complementary, and Integrative Medicine from the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) Network.","authors":"Jeremy Y Ng, Niveen Syed, David Moher","doi":"10.1515/jcim-2026-0073","DOIUrl":"10.1515/jcim-2026-0073","url":null,"abstract":"<p><p>High-quality and transparent reporting is fundamental to the credibility, reproducibility, and impact of health research. While widely endorsed reporting guidelines such as CONSORT and PRISMA have improved reporting across many fields, traditional, complementary, and integrative medicine (TCIM) research presents distinctive conceptual, methodological, and contextual challenges that are not always adequately addressed by general frameworks. In response, a growing number of TCIM-specific reporting guidelines have been developed over the past two decades. This manuscript provides a structured compendium of all 30 reporting guidelines listed on the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) Network under the clinical area labelled \"Complementary and Alternative Medicine\" as of March 2026. The compendium summarizes each reporting guideline's scope, study design focus, TCIM modality, relationship to established parent reporting guidelines where applicable, and methodological strengths and weaknesses. The identified reporting guidelines span a wide range of research domains, including randomized trials, protocols, systematic reviews, case reports, case series, clinical practice guidelines, and basic research, and encompass modalities such as acupuncture, herbal medicine, homeopathy, massage, moxibustion, cupping, biofield therapies, and reflexology. By consolidating these resources in a single, accessible overview, this compendium aims to support researchers, journal editors, and peer reviewers in identifying and applying appropriate TCIM-specific reporting guidance, thereby strengthening the transparency, consistency, and overall quality of TCIM research.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"206-227"},"PeriodicalIF":0.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profiling and cytotoxic potential of hydroalcoholic extract of <i>Begonia malabarica</i> in HepG2 cells: an <i>in vitro</i> phytopharmacological study.","authors":"Swaliha Chediyankandy, Akila Srinivasan, Barathane Datchanamurthy, Kannan Manivel","doi":"10.1515/jcim-2025-0365","DOIUrl":"https://doi.org/10.1515/jcim-2025-0365","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, the hydroalcoholic extract of entire <i>Begonia malabarica</i> plant was screened to identify its specific phytochemical groups and <i>in vitro</i> cytotoxic potential against HepG2 (Human Hepatocellular carcinoma) cell lines.</p><p><strong>Methods: </strong>Annexin V/PI Apoptotic assay and the MTT assay, were employed in this study. MTT assay was used to evaluate <i>in vitro</i> cytotoxic potential of <i>B. malabarica</i> extract against the HepG2 cell line. The Annexin V/PI Apoptotic assay was performed to estimate the proportion of cells undergoing apoptosis. The results were compared with doxorubicin as standard.</p><p><strong>Results: </strong>The MTT assay found that at highest concentration of 500 μg/mL, the hydroalcoholic extract of <i>B. malabarica</i> reduced cell viability to 24.17 %, while doxorubicin treated cell showed cell viability to 4.8 % at highest concentration of 100 μg/mL. Flow cytometry based Annexin V analysis revealed that <i>B. malabarica</i> extract induced pronounced apoptosis in HepG2 cells, marked by a dominant late apoptotic population (70.56 %) and dead cells (22.17 %), with minimal early apoptotic (0.04 %) and viable cells (7.23 %). The percentage of cells undergone late apoptosis was identical to standard drug doxorubicin (71.2 %). These results suggest a late apoptotic response, potentially involving mitochondrial disruption, oxidative stress, or caspase activation.</p><p><strong>Conclusions: </strong>These findings highlight the presence of bioactive compounds in <i>B. malabarica</i> that can modulate cell death pathways, supporting its potential as a potential anti-cancer agent. However, more research can help in better understanding of the role of this plant as a potential new source of cancer therapy and uncover previously unknown pharmacological activities and properties.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethics in the age of artificial intelligence: reflections from mapping the terrain and implications for traditional, complementary, and integrative medicine.","authors":"Jeremy Y Ng","doi":"10.1515/jcim-2026-0082","DOIUrl":"10.1515/jcim-2026-0082","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"201-205"},"PeriodicalIF":0.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}