Journal of Complementary and Integrative Medicine最新文献

{"title":"Exploring the anticancer potential of Jerantinine A from <i>Tabernaemontana coronaria</i> against prostate, breast, and ovarian cancers: a computational approach.","authors":"Poornima Kannappan, Meenakshi Kaniyur Chandrasekaran, Manikandan Vani Raju, Shankari Gopalakrishnan, Prabhu Dhamodharan, Rathi Muthaiyan Ahalliya, Chella Perumal Palanisamy, Balaji Raju, Gopalakrishnan Velliyur Kanniappan","doi":"10.1515/jcim-2024-0443","DOIUrl":"10.1515/jcim-2024-0443","url":null,"abstract":"<p><strong>Objectives: </strong>Cancer remains a significant global health challenge, with prostate, breast, and ovarian cancers ranking among the leading causes of morbidity and mortality. Natural products, particularly those derived from medicinal plants, have gained attention for their potential in alternative cancer therapies. The main objective of the study was an isolation and characterization of Jerantinine A, a bioactive alkaloid from <i>Tabernaemontana coronaria</i>, and its interactions with key protein targets involved in cancer progression.</p><p><strong>Methods: </strong>Jerantinine A was isolated through column chromatography and characterized using spectroscopic techniques, including UV-visible spectroscopy, FTIR, and NMR. Molecular docking studies were performed to assess its binding affinities with six critical protein targets: PTEN and androgen receptor for prostate cancer, CXCR4 and HER2 for ovarian cancer, and CDK1 and NEK2 for breast cancer.</p><p><strong>Results: </strong>Molecular docking analyses revealed that Jerantinine A exhibits strong binding affinities with all six protein targets, suggesting its potential to inhibit cancer cell proliferation by interfering with key signaling pathways.</p><p><strong>Conclusions: </strong>These findings underscore the therapeutic potential of <i>T. coronaria</i>, particularly through Jerantinine A, as a promising candidate for cancer treatment. By targeting pivotal proteins associated with prostate, breast, and ovarian cancers, Jerantinine A offers a foundation for further research and development as a novel anti-cancer agent.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"363-372"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study examining older adult usage of complementary and alternative medications and natural health products for cognitive and mental health improvement.","authors":"Dalya Abdulla, Lia Tsotsos","doi":"10.1515/jcim-2024-2001","DOIUrl":"https://doi.org/10.1515/jcim-2024-2001","url":null,"abstract":"<p><strong>Objectives: </strong>The use of complementary and alternative medications (CAM) and natural health products (NHPs) to enhance mood and reduce cognitive decline is well known yet research guiding Older Adult patients and their health care teams on such usage is limited. The purpose of this study was to understand CAM and NHP usage patterns for cognitive health among healthy Older Adults to enable the construct of better guidelines for health care practitioners regarding such usage.</p><p><strong>Methods: </strong>A qualitative study was designed to determine usage patterns of CAM and NHPs among Older Adults. Participants were recruited from the Center for Elder Research at Sheridan College and open-ended questions were utilized during one-on-one interviews with interested participants to determine usage patterns in relation to cognitive health.</p><p><strong>Results: </strong>A total of 10 participants completed the interviews with an age range of 63-86 years. Results were analyzed using the triangulation method based on a Grounded Theory approach to identify 6 main emerging themes: fear of cognitive health decline, strategies to mitigate perceived/self-diagnosed cognitive health decline, dietary influences on cognitive health, healthcare ownership and self-care, CAM and NHPs loyalty, and supporting Older Adult CAM and NHPs use. Percentages of each response within each main theme was also determined.</p><p><strong>Conclusions: </strong>Older Adults appeared to be cognizant of their cognitive health and tended to rely on CAM and NHPs to improve self-perceived decline in cognitive health. Older Adults expressed a desire for their health care practitioners to become more accommodating of such usage and for the government to support them financially for expenditures on CAM and NHPs. Older Adults indicated a preference of visiting health care practitioners who supported the use of these products.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer effects of <i>Plantago major</i> extract on colorectal and gastric cancer cell lines: an <i>in vitro</i> study and molecular docking analysis.","authors":"Rabia Yilmaz Ozturk, Hilal Calik, Ayhan Demir, Rabia Cakir","doi":"10.1515/jcim-2024-0340","DOIUrl":"10.1515/jcim-2024-0340","url":null,"abstract":"<p><strong>Objectives: </strong>Colorectal cancer and gastric cancer are one of the most prevalent types of cancer and are leading causes of cancer-related mortality worldwide. The chemotherapy is insufficient due to the poor targeting and affinity of drugs, low therapeutic effectiveness, and significant side effects. Consequently, developing effective therapeutic formulations is crucial for treating colorectal and gastric cancers. <i>Plantago major</i> (<i>P. major</i>) is a medicinal plant that has been investigated for medical research for cancer therapy owing to its rich phytochemical composition.</p><p><strong>Methods: </strong>This study aims to evaluate the antiproliferative activity of <i>P. major</i> leaf extract on NIH/3T3 fibroblast cells, AGS gastric, and Caco-2 colorectal cancer cell lines for 24 h using XTT cell viability assay. The apoptotic activity of <i>P. major</i> was examined by detecting caspase 3/7 level in cells. The ROS levels in cells were measured using the DCFH-DA dye. Additionally, it assesses the interaction and binding affinities of the active compounds of <i>P. major</i> with the overexpressed EPCAM through molecular docking.</p><p><strong>Results: </strong>The results demonstrate a dose-dependent anticancer effect of <i>P. major</i> on AGS and Caco-2 cell lines by reducing cell proliferation, increasing intracellular ROS accumulation and activating the caspase 3/7 apoptosis pathway. <i>P. major</i> exhibited no significant cytotoxic effects on non-cancerous NIH/3T3 fibroblast cells. Molecular docking analysis confirmed the high binding affinity of active compounds in <i>P. major</i>, such as apigenin, aucubin, baicalein, caffeic acid, and luteolin, towards the EpCAM protein overexpressed in gastric and colorectal cancer.</p><p><strong>Conclusions: </strong>In conclusion, the <i>P. major</i> can be a promising effective therapeutic strategy for gastrointestinal cancers.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"327-334"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer.","authors":"Kavita Goyal, M Arockia Babu, Muhammad Afzal, Arcot Rekha, Haider Ali, Saurabh Gupta, Ravindra Pal Singh, Anurag Mishra, Himmat Singh, Mohit Agrawal, Mohit Rana, Mohd Imran, Abida Khan","doi":"10.1515/jcim-2024-0444","DOIUrl":"https://doi.org/10.1515/jcim-2024-0444","url":null,"abstract":"<p><p>Fisetin, a flavonol belonging to the flavonoid subclass, is a ubiquitous dietary flavonoid present in fruits and vegetables, including fruit peels, and has proven potential for anticancer activity, especially for lung cancer - a leading cause of cancer-related deaths globally. The current paper provides the most detailed and elaborate list of the various roles of fisetin in experimentally induced lung cancer cells, and these roles include the promotion of apoptosis, inhibition of cell proliferation, migration, and invasion, as well as the regulation of autophagy. Among the molecular targets, some identified pathways, such as PI3K/Akt, MAPK, and NF-κB, that fisetin affects are crucial for tumor formation, so it can be considered a potential chemopreventive agent. Moreover, fisetin improves the effectiveness of conventional treatments as a chemo- and radiosensitizer and minimizes side effects. However, the overall utility of fisetin for clinical use is now somewhat restricted by its poor solubility and short half-life. It is predicted that the future development of nanotechnologies for drug delivery, such as nanoparticle encapsulation, might help solve these difficulties. Further Preclinical and clinical investigations are required to uniformly determine the safety, efficacy, and standard dosage of fisetin for consumption in lung cancer therapy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of herbaceous Apiaceae family plants on primary dysmenorrhea: a systematic review protocol.","authors":"Athul T P, Vijaya Lekshmi R, Nithya V S, Anju Aravind T, Shibna M V, Meenakshi Pandey, Galib R, Tanuja M Nesari, Meena S Deogade","doi":"10.1515/jcim-2024-0469","DOIUrl":"10.1515/jcim-2024-0469","url":null,"abstract":"<p><strong>Objectives: </strong>Primary dysmenorrhea is a leading cause of job and school absenteeism among young females. Despite its high prevalence, contemporary medicine offers limited treatment options. Herbaceous members of the Apiaceae family, such as <i>Pimpinella anisum</i> L<i>., Anethum sowa</i> L<i>., Cuminum cyminum</i> L<i>., and Foeniculum vulgare</i> Mill., are commonly used in traditional medicine to treat primary dysmenorrhea. Currently, there is no comprehensive assessment of their therapeutic efficacy and safety. This study protocol assesses how effective and safe these herbs are in managing primary dysmenorrhea.</p><p><strong>Methods: </strong>The following databases will be searched without language restriction until May 2024: Cochrane CENTRAL, PubMed, AYUSH Research Portal, and DHARA, along with grey literature, and other sources. The risk of bias tool (RoB2) will evaluate the validity and applicability of study results. The review will address publication bias by taking appropriate measures. The review will adhere to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines for transparent and systematic reporting.</p><p><strong>Results: </strong>The review will incorporate randomized controlled trials (RCTs) comparing Apiaceae herbs to no treatment, placebo, medication, or standard care. It is anticipated that these herbs will significantly reduce menstrual pain severity, measured via the visual analogue scale (VAS), and exhibit fewer adverse events than nonsteroidal anti-inflammatory drugs (NSAIDs).</p><p><strong>Conclusions: </strong>This review aims to compile evidence on the efficacy and safety of Apiaceae herbs for primary dysmenorrhea, highlighting the need for further studies.</p><p><strong>Prospero registration number: </strong>CRD42024538888.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"373-377"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of self-hypnosis on fear and pain of natural childbirth: a randomized controlled trial.","authors":"Batool Kamalimanesh, Maryam Moradi, Mehdi Fathi, Maliheh Afiat, Mahnaz Boroumand Rezazadeh, Mohammad Taghi Shakeri","doi":"10.1515/jcim-2024-0353","DOIUrl":"10.1515/jcim-2024-0353","url":null,"abstract":"<p><strong>Objectives: </strong>A clinical trial was conducted to address the trend of high cesarean section rates resulting from maternal fear of childbirth. This trial aimed to investigate the effectiveness of self-hypnosis in mitigating fear and pain during childbirth.</p><p><strong>Methods: </strong>This study was a parallel, not blinded, randomized controlled trial conducted in 2019 in Mashhad, Iran. Ninety-three nulliparous women were selected by convenience sampling and randomized by random allocation software (4 blocking groups) to either self-hypnosis or control groups. During the clinical trial, both groups received usual care for pregnancy and childbirth. However, the self-hypnosis group also participated in two hypnosis sessions and was given two audio files to practice self-hypnosis at home until delivery. The follow-up period ranged from the 37th week of pregnancy to the postpartum period. Fear of childbirth was assessed at 39 weeks and at cervical dilatation of 8-10 cm, while labor pain was measured at the same stage of labor as the primary outcomes between two groups. Data were analyzed using SPSS 16, applying the Independent sample t-test, Mann-Whitney U test, and Chi-square test. A p-value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Thirty women in the self-hypnosis group, aged 24.96±5.42, and 33 women in the control group, aged 23.63±4.68, completed the study. The average scores of fear of childbirth during pregnancy at 39 weeks (self-hypnosis: 46.46±14.53, control: 73.18±17.91), during the active phase of labor at cervical dilatation of 8-10 cm (self-hypnosis: 40.80±17.37, control: 75.12±19.40), and labor pain at cervical dilatation of 8-10 cm (self-hypnosis: 83.03±16.43, control: 95.36±10.36) were significantly lower in the self-hypnosis group compared to the control group (p<0.001 for all).</p><p><strong>Conclusions: </strong>Our findings suggest that self-hypnosis could be a more effective intervention than usual care alone for reducing fear and pain during natural childbirth in nulliparous women.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"353-362"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema.","authors":"Ming Li, Heng Deng, Shuqing Xu, Xiaoli Fang, Kun Tang, Li Chen, Ansheng Zha","doi":"10.1515/jcim-2024-0435","DOIUrl":"10.1515/jcim-2024-0435","url":null,"abstract":"<p><strong>Objectives: </strong>This investigation aimed to evaluate the efficacy, key active ingredients, and mechanisms of Zuoqing San (ZQS), a traditional Chinese medicine formula, in managing sigmoid ulcerative colitis (SUC).</p><p><strong>Methods: </strong>A cohort of 126 participants was recruited and treated with ZQS at a daily dosage of 100 mL for 12 weeks. The primary endpoint was the percentage of subjects achieving favorable treatment outcomes. Liquid chromatography-mass spectrometry was employed to identify the principal ingredients of ZQS. Network pharmacology was utilized to predict the central targets of its active ingredients. Protein-protein interaction networks, Gene Ontology enrichment analyses, and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted for identified core targets. Finally, molecular dynamics simulations of key active ingredients and core targets were performed.</p><p><strong>Results: </strong>Following 12 weeks of therapy, with a withdrawal rate of 7.93 %, favorable treatment outcomes were observed in 31.03 % of subjects at 4 weeks, 66.37 % at 8 weeks (Odds Ratio: 1.54, 95 % Confidence Interval: 0.41-1.83), and 68.10 % at 12 weeks (Odds Ratio: 1.86, 95 % CI: 0.32-1.27). ZQS comprises 31 principal chemical constituents. Key targets within the protein-protein interaction network included TNF, AKT1, IL6, IL1β, PTGS2, TP53, JUN, MMP9, CASP3, HIF1A, and BCL1. Pathway analysis indicated ZQS primarily impacts the TNF, NF-kB, and IL-17 signaling pathways. Molecular dynamics simulation results showed oxymatrine, cynarin had higher affinity with TNF and IL1β, respectively.</p><p><strong>Conclusions: </strong>This research elucidates the active components of ZQS and its potential multicomponent-multitarget-multipathway pharmacological mechanisms, demonstrating promising therapeutic potential for SUC management.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"343-352"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catechins in cancer therapy: integrating traditional and complementary approaches.","authors":"Renu Dwivedi, Rajni Bala, Sumitra Singh, Rakesh K Sindhu","doi":"10.1515/jcim-2024-0472","DOIUrl":"10.1515/jcim-2024-0472","url":null,"abstract":"<p><p>Catechin is a group of bioactive flavonoids found in various plant sources such as tea, cocoa, and fruits. Recent studies have suggested that catechins has significant potential in preventing and treating cancer. Catechin exhibits a variety of biological activities that may contribute to its anticancer effects, including antioxidant, anti-inflammatory, and pro-apoptotic properties. Studies have demonstrated that catechin can inhibit cancer cell proliferation, induce cell cycle arrest, and promote apoptosis across multiple cancer types, including skin, breast, lung, liver, prostate, and colon cancers. Furthermore, catechin has shown the ability to inhibit angiogenesis, a critical process for tumor growth and metastasis, by restricting new blood vessel formation. Catechin's impact on cancer extends beyond its direct effects on cancer cells. It modulates various signaling pathways involved in cancer progression, such as those associated with cell survival, inflammation, and metastasis. Despite these promising findings, additional research is needed to clarify the precise mechanisms of catechin's anticancer action, optimal dosing strategies, and long-term safety in cancer prevention and treatment. This review will explore the current research landscape on tea polyphenols, particularly catechin, and their potential role in cancer prevention and therapy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective mechanisms of icariin in methotrexate-induced renal damage: role of Nrf2/HO-1 and apoptosis reduction.","authors":"Riya Mishra","doi":"10.1515/jcim-2024-0431","DOIUrl":"10.1515/jcim-2024-0431","url":null,"abstract":"<p><strong>Objectives: </strong>Thus, the study was designed to assess the ability of ICA to ameliorate MTX-induced renal toxicity in rats and determine the pathogenetic pathways of oxidative stress, inflammation, and apoptosis.</p><p><strong>Methods: </strong>Mtx renal toxicity was developed following an intraperitoneal administration of 20 mg/kg MTX. ICA was orally given at 100 mg/kg/day for two consecutive weeks. Experimental indicators included: biochemical renal function - BUN, SCr; and oxidative stress - SOD, GSH-Px, MDA. Other histological studies included immunohistochemical staining for Nrf2 and HO-1, QPCR of pro-inflammatory cytokines and biomarker of kidney injury, and TUNEL assay to assess the protective effects affiliated with ICA.</p><p><strong>Results: </strong>In an animal model treated with MTX, renal damage was reflected by increased oxidative stress, inflammatory-borne cytokines, and apoptotic indices. ICA treatment ameliorated these effects to a great extent by reversing changes in antioxidant enzyme activities, suppressing lipid peroxidation and regulating the Nrf2/HO-1 pathway. This was evidenced by the decrease in pro-inflammatory and kidney injury genes in the ICA-treated groups but by significant histological ameliorations of kidney structure. TUNEL assay proved the decreased apoptotic index in kidney tissue.</p><p><strong>Conclusions: </strong>These findings exhibited the therapeutic efficacy of ICA for attenuating renal injury from MTX and established that it mainly exerts its cytoprotective effects through the Nrf2/HO-1 pathway.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"335-342"},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression.","authors":"Aarti Sati, Pynshngainlang Kyllait, Prashant Gahtori, Hans Raj Bhat, Md Sadique Hussain, Gaurav Gupta, Archana Gahtori","doi":"10.1515/jcim-2024-0417","DOIUrl":"10.1515/jcim-2024-0417","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the antidepressant-like effects of Phenylthiazolyl-1,3,5-triazine derivatives through behavioral tests, molecular docking, and histopathological analysis in a rat brain model of depression.</p><p><strong>Methods: </strong>Phenylthiazolyl-1,3,5-triazine derivatives were synthesized and administered at a dose of 30 mg/kg in albino rats. Behavioral effects were assessed using the Forced Swim Test and Tail Suspension Test. Molecular docking with MD simulations via CDocker was employed to analyze ligand-receptor interactions. Histological analysis of brain tissues was conducted to assess structural and vascular changes.</p><p><strong>Results: </strong>Among the derivatives, PS1 and PS5 showed significant antidepressant-like activity compared to standard imipramine. Molecular docking revealed that hydrogen bonding, pi-pi interactions, and intermolecular neighbor effects stabilized the ligand-receptor complexes. Histopathological analysis of PS1-treated rats demonstrated preserved vascular integrity, reduced edema, and the absence of hydrophobic alterations.</p><p><strong>Conclusions: </strong>Phenylthiazolyl-1,3,5-triazines, particularly PS1, exhibit promising potential as antidepressant agents. Their behavioral efficacy and protective histological effects suggest therapeutic relevance. Further studies integrating biomarkers and gene expression analyses are needed to optimize these derivatives for clinical application.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"270-278"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}