Effects of the intravenous application of sodium ascorbate in patients with the diagnosis of sepsis in the intensive care unit - observational, analytical, retrospective, comparative study.

Q2 Medicine

Journal of Complementary and Integrative Medicine Pub Date : 2025-07-17 DOI:10.1515/jcim-2025-0066

Adlay Martinez Ramos, Hugo Mario Galindo Salom, Helber Armando Prieto Lozano, Paulo Andres Lopez Posada, Juan Manuel Martinez, Marixa Guerrero, Carlos Alberto Carrillo Bravo

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引用次数: 0

Abstract

Objectives: To evaluate whether high-dose intravenous sodium ascorbate improves inflammatory markers in patients with sepsis.

Methods: A retrospective, observational, analytical, and comparative study was conducted on patients diagnosed with sepsis and admitted to the ICU at Clínica Estrios (Cartagena, Colombia) between July 1 and 30, 2024. Patients receiving standard treatment were compared with those who also received high-dose intravenous sodium ascorbate (>462 mg/kg/day), supplied by Biological Therapies, Australia. The main outcome was the duration of altered SIRS and SOFA scores.

Results: Patients treated with sodium ascorbate showed a statistically significant reduction in the duration of altered SIRS and SOFA scores (X ²=9.00, p=0.003) compared to those who received standard therapy.

Conclusions: High-dose sodium ascorbate may serve as an effective adjuvant therapy in sepsis.

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静脉应用抗坏血酸钠对重症监护室诊断为败血症的患者的影响——观察、分析、回顾性、比较研究。

目的：评价静脉注射大剂量抗坏血酸钠是否能改善脓毒症患者的炎症标志物。方法：对2024年7月1日至30日在Clínica Estrios (Cartagena, Colombia) ICU确诊为脓毒症的患者进行回顾性、观察性、分析性和对比性研究。接受标准治疗的患者与同时接受高剂量静脉注射抗坏血酸钠（>462 mg/kg/天）的患者进行比较，后者由澳大利亚生物疗法公司提供。主要结果是SIRS和SOFA评分改变的持续时间。结果：与接受标准治疗的患者相比，接受抗坏血酸钠治疗的患者SIRS和SOFA评分改变的持续时间有统计学意义的减少（x2 =9.00, p=0.003）。结论：大剂量抗坏血酸钠可作为脓毒症的有效辅助治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Complementary and Integrative Medicine Medicine-Complementary and Alternative Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Journal of Complementary and Integrative Medicine (JCIM) focuses on evidence concerning the efficacy and safety of complementary medical (CM) whole systems, practices, interventions and natural health products, including herbal and traditional medicines. The journal is edited by Ed Lui of the University of Western Ontario. Topics: -Quality, efficacy, and safety of natural health products, dietary supplements, traditional medicines and their synthetic duplicates -Efficacy and safety of complementary therapies -Evidence-based medicine and practice, including evidence of traditional use -Curriculum development, educational system and competency of complementary health programs -Methodologies on research and evaluation of traditional medicines and herbal products -Integrative medicine: basic and clinical research and practice -Innovation in CAM Curriculum -Educational Material Design