Journal of Complementary and Integrative Medicine最新文献

{"title":"Effects of the intravenous application of sodium ascorbate in patients with the diagnosis of sepsis in the intensive care unit - observational, analytical, retrospective, comparative study.","authors":"Adlay Martinez Ramos, Hugo Mario Galindo Salom, Helber Armando Prieto Lozano, Paulo Andres Lopez Posada, Juan Manuel Martinez, Marixa Guerrero, Carlos Alberto Carrillo Bravo","doi":"10.1515/jcim-2025-0066","DOIUrl":"https://doi.org/10.1515/jcim-2025-0066","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate whether high-dose intravenous sodium ascorbate improves inflammatory markers in patients with sepsis.</p><p><strong>Methods: </strong>A retrospective, observational, analytical, and comparative study was conducted on patients diagnosed with sepsis and admitted to the ICU at Clínica Estrios (Cartagena, Colombia) between July 1 and 30, 2024. Patients receiving standard treatment were compared with those who also received high-dose intravenous sodium ascorbate (>462 mg/kg/day), supplied by Biological Therapies, Australia. The main outcome was the duration of altered SIRS and SOFA scores.</p><p><strong>Results: </strong>Patients treated with sodium ascorbate showed a statistically significant reduction in the duration of altered SIRS and SOFA scores (<i>X</i> ²=9.00, p=0.003) compared to those who received standard therapy.</p><p><strong>Conclusions: </strong>High-dose sodium ascorbate may serve as an effective adjuvant therapy in sepsis.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative evaluation of locally delivered licorice gel and tetracycline gel as an adjunct to non-surgical therapy in the treatment of controlled type -2 diabetic patients with periodontitis stage II and grade B - A split mouth randomized clinical trial.","authors":"Mopati N R Gokul, Konathala S V Ramesh, Penmetsa S Gautami, Naga V S Sruthima, Mohankumar Pasupuleti, Venkatalakshmi Mathala","doi":"10.1515/jcim-2024-0434","DOIUrl":"https://doi.org/10.1515/jcim-2024-0434","url":null,"abstract":"<p><strong>Objectives: </strong>Periodontitis is an inflammatory disease affecting tooth-supporting structures due to dysbiosis in plaque bio-film. While NSPT remains the gold standard treatment, it limits in its capacity to fully eradicate pathogens, necessitating adjunct antimicrobial therapy. Local drug delivery(LDD) offers targeted treatment with fewer side effects compared to systemic antimicrobial therapy. Recent studies highlight herbal extracts, such as licorice (<i>Glycyrrhiza glabra</i>), which exhibit antimicrobial and anti-inflammatory properties, making them promising candidates for LDD. Therefore, the goal was to evaluate the effectiveness of licorice gel and tetracycline gel as a non-surgical treatment auxiliary for individuals with stage II periodontitis and grade B type-2 diabetes.</p><p><strong>Methods: </strong>In this randomized, double-blind clinical trial, 20 patients with Type-II diabetes were included. Following NSPT, licorice and tetracycline gel were applied locally as adjuncts to both the test and control groups. Clinical parameters such as Probing pocket depth (PPD), Clinical attachment level (CAL), Bleeding on probing (BOP) were evaluated at base line and 1 month and Landry's healing index at 7th day.</p><p><strong>Results: </strong>In intergroup analysis, licorice gel has shown statistically significant reduction in PPD and CAL with better healing when compared to tetracycline gel.However, there was no statistically significant difference between the groups in terms of bleeding on probing.</p><p><strong>Conclusions: </strong>Both licorice and tetracycline gel are equally effective in treating pockets but licorice gel as an LDD agent has shown better and encouragingoutcomes in terms of healing, PPD and CAL.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of olive oil consumption on surgical outcomes in patients undergoing open heart surgery: a randomized clinical trial.","authors":"Reza Bahrami, Abbas Ebadi, Yaser Saeid, Seyed Saeed Farzam, Elahe Gomrokchian, Malihe Sadat Moayed","doi":"10.1515/jcim-2024-0256","DOIUrl":"10.1515/jcim-2024-0256","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of post-surgery outcomes, such as pain and constipation, in patients undergoing coronary artery bypass surgery can impact the healing process and the quality of life of patients. This study aimed to investigate the effect of olive oil consumption on pain and constipation in adult coronary bypass surgery patients.</p><p><strong>Methods: </strong>A randomized controlled trial in Qazvin, Iran (2022-2023) assigned 110 patients scheduled for coronary artery bypass surgery to two groups using four-block randomization. In the intervention group, patients received 30 cc of extra virgin olive oil daily with food from the day before the operation to 30 days after. The control group received usual care. Pain and constipation levels were measured before and after surgery and up to 30 days post-surgery using the visual pain scale (VAS) and Bristol stool form scale (BSFS).</p><p><strong>Results: </strong>With similar background variables between the two groups, the results indicated that the average pain and constipation scores in the intervention group decreased more than in the control group (p-value < 0.05).</p><p><strong>Conclusions: </strong>Based on the study's findings and the positive impact of olive oil consumption on reducing pain and constipation, incorporating olive oil into the diet of heart surgery patients is recommended.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical innovations in oral cancer therapy: targeting oncogenic pathways with natural compounds.","authors":"Punniyakoti V Thanikachalam, Mahalakshmi Devaraji, Nandhini Jayaprakash, Harshitha Sivakumar, Divya Balamurugan, Harish Kanna Shanmugan","doi":"10.1515/jcim-2025-0118","DOIUrl":"https://doi.org/10.1515/jcim-2025-0118","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) remains a significant global health concern due to its high mortality rate, late-stage diagnosis, and limited treatment options. Conventional therapies such as surgery, radiotherapy, and chemotherapy often face limitations including drug resistance, recurrence, and systemic toxicity, prompting the need for alternative strategies. This narrative review synthesizes recent preclinical evidence on the use of natural phytochemicals including alkaloids, flavonoids, tannins, saponins, and terpenoids for OSCC treatment. These compounds demonstrate anticancer effects through apoptosis induction, oxidative stress modulation, immunoregulation, and metastasis inhibition. <i>In vitro</i> and <i>in vivo</i> studies highlight their cytotoxicity, tumor-suppressive properties, and pharmacokinetic profiles. Additionally, nanotechnology-based delivery systems have shown potential in overcoming bioavailability barriers and enhancing therapeutic efficacy. However, most findings are preclinical, and challenges such as poor pharmacokinetics, off-target effects, and limited clinical trial data must be addressed. This review emphasizes the translational promise of phytochemicals and calls for further clinical validation to integrate these agents into OSCC management.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effect of hydrolyzed collagen gel from mackerel scad (<i>Decapterus macarellus</i>) to attenuate chronic UVB-induced photodamage.","authors":"Elisa Herawati, Rizki S Titisari, Helen Kristin, Filosofia F T A Prasasti, Pipin Agnesia, Okid P Astirin, Shanti Listyawati, Evi Susanti, Nuniek Herdyastuti, Noer Laily, Fatim Illaningtyas","doi":"10.1515/jcim-2025-0093","DOIUrl":"https://doi.org/10.1515/jcim-2025-0093","url":null,"abstract":"<p><strong>Objectives: </strong>Hydrolyzed collagen (HC) extracted from fish skin is a safe and effective native collagen alternative that can potentially protect skin from experiencing photoaging. This study is among the first to explore HC from mackerel scad (<i>Decapterus macarellus</i>) application via <i>in vitro</i> and <i>in vivo</i> approaches.</p><p><strong>Methods: </strong>The protective effects of HC were investigated on Mouse Embryonic Fibroblasts (MEFs) induced by acute and chronic UVB, followed by testing of HC gel on UVB-induced photoaging models of mice. Cell viability test using the MTT method was performed on UVB-induced MEFs treated with HC concentrations of 10, 20, 50, and 100 g/mL. A gel form HC was applied topically in UVB-induced skin tissues of animal models and analyzed with ELISA to evaluate the inhibitory effect of MMP-1 and IL-6 expression.</p><p><strong>Results: </strong><i>In vitro</i> analysis showed that HC (10, 20, 50 μg/mL) could increase the viability of acute UVB-induced MEFs at a 60 mJ/cm² dose. In chronic UVB exposure, all HC concentrations could protect the viability of induced MEFs at 40 mJ/cm² dose. HC gel effectively inhibited the increased expression of MMP-1 and IL-6 in UVB-exposed skin, which may be related to its ability to suppress the activation of MAPK and NF-κB signaling pathways. Furthermore, HC gel intervened in the development of epidermal thickening and dermal layer damage in photoaged skin.</p><p><strong>Conclusions: </strong>These findings indicated that HC from mackerel scad skin effectively provided a protective effect against the photoaging process.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of citronellol on Escherichia coli septicemia-derived liver lesions in Wistar rats.","authors":"Seyed Moein Ziaei Sistany, Fatemeh Zahra Gharib, Seyed Mohammad Hosseini","doi":"10.1515/jcim-2025-0131","DOIUrl":"https://doi.org/10.1515/jcim-2025-0131","url":null,"abstract":"<p><strong>Objectives: </strong>Indiscriminate and widespread use of antibiotics has caused resistance among infectious bacteria. Citronellol (Cit) is a monoterpene that is defined as an essential oil and is found in lemon, rosemary, oranges, and aromatic plants. This experimental study investigated the effects of Cit on the complications caused by <i>E-coli</i> septicemia in liver tissue in rats.</p><p><strong>Methods: </strong>210 male Wistar rats with an approximate weight of 220 ± 20 were randomly divided into 7 groups of 30 including 1. Control group, 2. Sham group, 3. Received Cit at a dose of 100 mg/kg by intraperitoneal injection, 4. Received Cit at a dose of 200 mg/kg, 5. the <i>E-coli</i> group was administrated enteropathogenic <i>E-coli</i> bacteria O111 with a dose of 1 × 10⁹ Colony-forming unit (CFU), 6. the first treatment group received E-coli and Cit at a dose of 100 mg/kg and 7. the second treatment group received E-coli and Cit at a dose of 200 mg/kg.</p><p><strong>Results: </strong>Our findings showed that <i>E-coli</i> can cause a significant increase in alanine transaminase (ALT) and alkaline phosphatase (ALP) indices, while in the treatment groups, these indices were significantly reduced. In addition, <i>E-coli</i> septicemia caused oxidative stress in the liver tissue by increasing malondialdehyde (MDA) levels and reducing Superoxide dismutase (SOD) enzymes, which both were significantly regulated in the treatment groups.</p><p><strong>Conclusions: </strong>Our results suggested the positive effects of Cit on the septicemia caused by <i>E-coli</i> in the liver tissue by upregulating the antioxidant balance and protective characteristics.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Icariin as a therapeutic agent in breast cancer: modulating apoptosis and suppressing proliferation.","authors":"Kavita Goyal, Muhammad Afzal, M Arockia Babu, R Roopashree, Pooja Bansal, Shivang Mishra, G V Siva Prasad, Md Sadique Hussain, Poonam Negi, Saurabh Gupta, Sachin Kumar Singh, Dinesh Kumar Chellappan, Gaurav Gupta","doi":"10.1515/jcim-2024-0405","DOIUrl":"https://doi.org/10.1515/jcim-2024-0405","url":null,"abstract":"<p><p>Breast cancer remains the leading cause of cancer-related death worldwide, underscoring the urgent need for novel therapeutic strategies. Icariin, a prenylated flavonol glycoside derived from <i>Epimedium</i> species, has emerged as a promising multi-targeted agent with potent anticancer activity. Preclinical studies demonstrate that icariin modulates key oncogenic pathways, including PI3K/Akt, MAPK, NF-κB/SIRT6, and AMPK/mTOR to inhibit tumor cell proliferation, induce apoptosis, and regulate autophagy. Moreover, icariin exhibits anti-metastatic effects by suppressing epithelial-to-mesenchymal transition, matrix metalloproteinase activity, and immunomodulatory actions that may enhance antitumor immunity. Despite these encouraging findings, a comprehensive understanding of its molecular mechanisms and translational potential remains limited. Here, we systematically review the latest <i>in vitro</i> and <i>in vivo</i> evidence on icariin's pharmacological effects in breast cancer models. We highlight advances in nanoformulation approaches to improve their bioavailability and identify critical knowledge gaps. This review aims to guide future research toward optimized delivery systems and well-designed clinical trials by integrating mechanistic insights with formulation science. Ultimately, elucidating the full therapeutic profile of icariin will inform its incorporation into complementary and integrative oncology regimens, potentially improving outcomes for patients with diverse breast cancer subtypes.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing I LOVE U and field massages on weight and gastrointestinal function among NICU-admitted preterm infants: a clinical trial.","authors":"Golnoush Motamedi, Jamileh Farokhzadian, Monirsadat Nematollahi, Maryam Alikamali, Zahra Jamali, Sedigheh Khodabandeh Shahraki","doi":"10.1515/jcim-2024-0295","DOIUrl":"https://doi.org/10.1515/jcim-2024-0295","url":null,"abstract":"<p><strong>Objectives: </strong>Preterm infants often face multiple challenges due to immature organ systems. Given the clinical status of infants, massage can serve as a non-pharmaceutical intervention. This study evaluates the effects of I LOVE U and field massages on weight and gastrointestinal function in NICU-admitted preterm infants.</p><p><strong>Methods: </strong>A controlled trial was conducted with 84 preterm infants. The infants were randomized into two intervention groups (I LOVE U and field massages) and a control group. The control group received routine care, while the intervention groups received routine care plus either I LOVE U or field massages. Massages were administered for 15 min twice daily before feeding for 5 days. Gastrointestinal variables were measured, including residual gastric volume, abdominal circumference, defecation frequency, and weight before and after the intervention. Data were analyzed with SPSS version 22.</p><p><strong>Results: </strong>The study findings revealed no significant differences in weight or gastrointestinal function indices among the groups over the study period.</p><p><strong>Conclusions: </strong>The findings demonstrated that infants in the massage intervention group exhibited better weight status and lost less weight than the controls post-intervention. Moreover, the I LOVE U massage technique enhanced defecation in infants, suggesting better impacts on gastrointestinal factors. Further interventional studies, however, are recommended to explore the effects of this specific massage technique.</p><p><strong>Trial registration: </strong>This trial was registered with the Iranian Registry of Clinical Trials under Reg. NO. IRCT20221220056884N1.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of dietary inclusions of alligator pepper (<i>Aframomum melegueta</i>) and bastard melegueta (<i>Aframomum danielli</i>) seeds on scopolamine-induced amnesia in rats.","authors":"Odunayo M Agunloye, Esther A Olawuyi, Ganiyu Oboh","doi":"10.1515/jcim-2024-0450","DOIUrl":"https://doi.org/10.1515/jcim-2024-0450","url":null,"abstract":"<p><strong>Objectives: </strong>Neurodegeneration continues to drive conditions of progressive cognitive decline from amnesia to severe dementia in different age groups. Despite, the availability of standard drugs, the need for multi-targeted interventions with no side-effects remains to be explored. Hence, this study evaluates the neuroprotective effects of <i>Aframomum melegueta</i> and <i>Aframomum danielli</i> seeds dietary inclusion on neurocognitive decline in scopolamine-administered male rats.</p><p><strong>Methods: </strong>Seven groups of experimental rats were studied for 14 days: normal rats (group 1), untreated scopolamine-administered rats (group 2), scopolamine-administered rats treated with donepezil (group 3), scopolamine-administered rats treated with dietary inclusions of 4 and 8 % <i>A. melegueta</i> (groups 4 and 5 respectively), and 4 and 8 % <i>A. danielli</i> (groups 6 and 7 respectively). Rats were trained with Morris water maze, pre-treated with the diets, and administered (I. P) scopolamine (3 mg/kg body weight from days 12-14). Memory functionality was evaluated using the maze test and hippocampal and cortical brain regions were analyzed biochemically.</p><p><strong>Results: </strong>Scopolamine administration impaired working memory, evidenced by increased escape latency and activities of neurodegenerative biomarkers in untreated rats. <i>A. melegueta</i> and <i>A. danielli</i> dietary inclusions significantly reduced escape latency, improved working memory, and restored key biomarkers, including acetylcholinesterase, butyrylcholinesterase, monoamine oxidase, and reactive oxygen species. Treated rats also exhibited elevated total thiol levels, and improved anti-inflammatory markers (IL-10).</p><p><strong>Conclusions: </strong>Both <i>A. melegueta</i> and <i>A. danielli</i> seeds showed improved neuroprotective effect in the brain of scopolamine-induced amnesia rats highlighting significant intervention against cognition. However, <i>A. melegueta</i> showed greater neuroprotective efficacy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Health Products Research Society of CanadaNatural Health Products and Cancer Mini-Symposium 2025.","authors":"","doi":"10.1515/jcim-2025-0200","DOIUrl":"https://doi.org/10.1515/jcim-2025-0200","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}