Protective effects of citronellol on Escherichia coli septicemia-derived liver lesions in Wistar rats.

Q2 Medicine

Journal of Complementary and Integrative Medicine Pub Date : 2025-07-08 DOI:10.1515/jcim-2025-0131

Seyed Moein Ziaei Sistany, Fatemeh Zahra Gharib, Seyed Mohammad Hosseini

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引用次数: 0

Abstract

Objectives: Indiscriminate and widespread use of antibiotics has caused resistance among infectious bacteria. Citronellol (Cit) is a monoterpene that is defined as an essential oil and is found in lemon, rosemary, oranges, and aromatic plants. This experimental study investigated the effects of Cit on the complications caused by E-coli septicemia in liver tissue in rats.

Methods: 210 male Wistar rats with an approximate weight of 220 ± 20 were randomly divided into 7 groups of 30 including 1. Control group, 2. Sham group, 3. Received Cit at a dose of 100 mg/kg by intraperitoneal injection, 4. Received Cit at a dose of 200 mg/kg, 5. the E-coli group was administrated enteropathogenic E-coli bacteria O111 with a dose of 1 × 10⁹ Colony-forming unit (CFU), 6. the first treatment group received E-coli and Cit at a dose of 100 mg/kg and 7. the second treatment group received E-coli and Cit at a dose of 200 mg/kg.

Results: Our findings showed that E-coli can cause a significant increase in alanine transaminase (ALT) and alkaline phosphatase (ALP) indices, while in the treatment groups, these indices were significantly reduced. In addition, E-coli septicemia caused oxidative stress in the liver tissue by increasing malondialdehyde (MDA) levels and reducing Superoxide dismutase (SOD) enzymes, which both were significantly regulated in the treatment groups.

Conclusions: Our results suggested the positive effects of Cit on the septicemia caused by E-coli in the liver tissue by upregulating the antioxidant balance and protective characteristics.

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香茅醇对Wistar大鼠大肠杆菌败血症肝损伤的保护作用。

目的：抗生素的滥用和广泛使用已引起感染性细菌的耐药性。香茅醇（citronelol, Cit）是一种单萜烯，被定义为一种精油，存在于柠檬、迷迭香、橙子和芳香植物中。本实验研究了Cit对大肠杆菌败血症大鼠肝组织并发症的影响。方法：210只体重约为220±20的雄性Wistar大鼠随机分为7组，每组30只，其中1只。对照组2人。假手术组，3例。3 .腹腔注射Cit，剂量为100 mg/kg；以200 mg/kg的剂量接受Cit， 5。大肠杆菌组给予肠致病性大肠杆菌O111，剂量为1 × 109菌落形成单位（CFU）；第一治疗组分别给予100 mg/kg和7。第二组给予大肠杆菌和Cit，剂量为200 mg/kg。结果：我们的研究结果显示，大肠杆菌可引起谷丙转氨酶（ALT）和碱性磷酸酶（ALP）指标显著升高，而在治疗组，这些指标均显著降低。此外，大肠杆菌败血症通过增加丙二醛（MDA）水平和降低超氧化物歧化酶（SOD）酶引起肝组织氧化应激，这两种酶在治疗组均得到显著调节。结论：Cit通过上调肝组织中大肠杆菌引起的败血症的抗氧化平衡和保护特性，对大肠杆菌引起的肝组织败血症具有积极作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Complementary and Integrative Medicine Medicine-Complementary and Alternative Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Journal of Complementary and Integrative Medicine (JCIM) focuses on evidence concerning the efficacy and safety of complementary medical (CM) whole systems, practices, interventions and natural health products, including herbal and traditional medicines. The journal is edited by Ed Lui of the University of Western Ontario. Topics: -Quality, efficacy, and safety of natural health products, dietary supplements, traditional medicines and their synthetic duplicates -Efficacy and safety of complementary therapies -Evidence-based medicine and practice, including evidence of traditional use -Curriculum development, educational system and competency of complementary health programs -Methodologies on research and evaluation of traditional medicines and herbal products -Integrative medicine: basic and clinical research and practice -Innovation in CAM Curriculum -Educational Material Design