Journal of Complementary and Integrative Medicine最新文献_第5页

In silico evaluation of bioactive compounds as potential inhibitors targeting HIF-1α/VEGFA/BACE1 pathway against Alzheimer's disease. 生物活性化合物作为HIF-1α/VEGFA/BACE1通路抗阿尔茨海默病潜在抑制剂的计算机评价

Journal of Complementary and Integrative Medicine Pub Date : 2026-02-25 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0278

Sakshi Rai, Suman Kumar Ray, Sukhes Mukherjee

{"title":"In silico evaluation of bioactive compounds as potential inhibitors targeting HIF-1α/VEGFA/BACE1 pathway against Alzheimer's disease.","authors":"Sakshi Rai, Suman Kumar Ray, Sukhes Mukherjee","doi":"10.1515/jcim-2025-0278","DOIUrl":"10.1515/jcim-2025-0278","url":null,"abstract":"Objectives: Neurodegenerative disorders such as Alzheimer's disease (AD) are characterized by progressive neuronal degeneration, predominantly caused by the accumulation of amyloid-beta (Aβ) and neuroinflammatory processes. Hypoxia, characterized by diminished oxygen levels, intensifies these mechanisms by stimulating hypoxiainducible factor 1-alpha (HIF-1α), potentially enhancing BACE1 enzyme activity and resulting in increased Aβ synthesis and render neurons especially susceptible to hypoxia, exacerbating disease progression. Existing therapies are constrained by inadequate medication distribution across the blood-brain barrier and associated adverse effects. This study aims to identify potential therapeutic agents targeting HIF-1α, VEGFA, BACE1 key molecules involved in AD by exploring neuroprotective effects of bioactive compounds like benzyl isothiocyanate (BITC), Aurantiamide Acetate (AA), and galantamine, with the goal of developing more effective, targeted treatments.Methods: We used in silico screening, such as molecular docking and ADMET analysis, to assess the binding affinity, pharmacokinetics, and toxicity of potential inhibitors, followed by in vitro testing.Results: Results identified several compounds with strong binding affinities and favorable ADMET profiles as potential inhibitors of HIF-1α, VEGFA, BACE1 and experimental data support that hypoxia, via HIF-1α, upregulates BACE1, increasing Aβ production and contributing to AD. Targeting these pathways may offer a multi-faceted approach to therapy, reducing neuroinflammation and amyloid pathology.Conclusions: In silico screening of potential molecules across different pathogenic pathways in Alzheimer's disease shows promise in developing successful therapeutic methods and continued validation may result in more tailored and safer medicines that address underlying neurodegenerative pathways.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"71-85"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of aromatherapy in children: a systematic review and a call for research in autism. 芳香疗法对儿童的影响：一项系统综述和对自闭症研究的呼吁。

Journal of Complementary and Integrative Medicine Pub Date : 2026-02-19 DOI: 10.1515/jcim-2025-0241

Leonardo Ribeiro Miedes, Edinaldo Siqueira Souza, Thais Miriã da Silva Santos, Matheus Silva Fornel, Kátia Bilhar Scapini, Iris Callado Sanches, Camilla de Paula Pereira Uzam, Juliana Monique Lino Aparecido, Nathalia Bernardes

{"title":"The effects of aromatherapy in children: a systematic review and a call for research in autism.","authors":"Leonardo Ribeiro Miedes, Edinaldo Siqueira Souza, Thais Miriã da Silva Santos, Matheus Silva Fornel, Kátia Bilhar Scapini, Iris Callado Sanches, Camilla de Paula Pereira Uzam, Juliana Monique Lino Aparecido, Nathalia Bernardes","doi":"10.1515/jcim-2025-0241","DOIUrl":"https://doi.org/10.1515/jcim-2025-0241","url":null,"abstract":"Introduction: Aromatherapy, the therapeutic use of essential oils, is a growing complementary practice in pediatric care. This systematic review analyzed the scientific evidence on its application and effects in children, with a secondary aim of exploring its use for children with autism spectrum disorder (ASD).Content: Following the PRISMA guidelines, the screening was carried out in Rayyan by two researchers, with studies from the PubMed, Cochrane Library, BVS Library and Web of Science databases, including only clinical trials. The risk of bias assessment used the Cochrane RoB 2 tool.Summary: Out of 1,089 identified studies, seven randomized controlled trials were included. The literature was predominantly focused on neurotypical children, revealing that acute inhalation of essential oils (mainly lavender and orange) was used for managing anxiety in specific settings, particularly dentistry. Findings showed a trend towards reduced anxiety and pain scores, alongside decreased heart rate. However, significant methodological heterogeneity and small sample sizes were noted. The secondary aim highlighted a pronounced evidence gap: only one small-scale study included children with ASD, which reported no significant benefits of aromatherapy.Outlook: Preliminary evidence suggests potential benefits of aromatherapy for anxiety in neurotypical children within controlled contexts. However, the evidence base is limited and insufficient for robust clinical guidance. A critical scarcity of research exists on aromatherapy for children with ASD, underscoring the need for more rigorous and adequately powered future studies.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Black maitake induces apoptosis and enhances the efficacy of standard chemotherapy in 2D and 3D U-87 MG glioblastoma cell models. 黑灰树花诱导2D和3D U-87 MG胶质瘤细胞模型细胞凋亡，提高标准化疗的疗效。

Journal of Complementary and Integrative Medicine Pub Date : 2026-02-17 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0239

Sona Regonda, Victoria Iannetta, Hannah Drew, Siyaram Pandey

{"title":"Black maitake induces apoptosis and enhances the efficacy of standard chemotherapy in 2D and 3D U-87 MG glioblastoma cell models.","authors":"Sona Regonda, Victoria Iannetta, Hannah Drew, Siyaram Pandey","doi":"10.1515/jcim-2025-0239","DOIUrl":"10.1515/jcim-2025-0239","url":null,"abstract":"Objectives: Glioblastoma is an aggressive primary brain tumor marked by rapid growth, invasiveness, poor prognosis, and an over 90 % tumor recurrence rate. Current radiation and chemotherapy treatments are limited by non-selectivity and toxicity, creating a need for safer complementary treatments. Historically, natural health products (NHPs) have been used medicinally across cultures for their anti-inflammatory and antioxidant effects. More recently, they have gained recognition for their selective, non-toxic properties in cancer treatment, suggesting their potential as adjuncts to conventional therapies. Black maitake (Grifola frondosa) extract, a well-tolerated NHP with known immunomodulatory properties, has demonstrated anticancer effects in breast cancer models. This study investigates the ability of Black Maitake Odaira Extract - Prothera (BMOE; a trade name of the extract manufactured by Shogun Maitake Canada, London, ON) to induce cell death in the U-87 MG glioblastoma cell line using 2D and 3D models, alone and in combination with the standard chemotherapy: temozolomide (TMZ).Methods: Apoptosis was assessed via Hoechst 33,342, annexin V, and propidium iodide staining, along with morphological analyses. Mitochondrial depolarization was measured using TMRM, cell migration was assessed via wound-healing assays, and structural integrity was evaluated using 3D spheroids.Results: BMOE, alone and with TMZ, induced dose-dependent apoptosis, mitochondrial depolarization, and impaired glioblastoma cell migration. BMOE also disrupted 3D spheroid structures and promoted nuclear condensation, consistent with apoptotic processes. Most notably, BMOE significantly enhanced the anti-cancer effects of TMZ.Conclusions: These findings support the potential of BMOE as a complementary therapy that enhances the efficacy of current glioblastoma treatments.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":"23 1","pages":"62-70"},"PeriodicalIF":0.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the immunomodulatory activities of Scoparia dulcis extract against lipopolysaccharide-induced allergic inflammation in mice through suppression of innate pro-inflammatory cytokines, COX-2 and iNOS signalling pathways. 探讨茯苓提取物通过抑制先天促炎细胞因子、COX-2和iNOS信号通路对脂多糖诱导的小鼠变应性炎症的免疫调节作用。

Journal of Complementary and Integrative Medicine Pub Date : 2026-02-13 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0387

Jones Ofori-Amoah, Cynthia Amaning Danquah, Kwesi Boadu Mensah, Meshack Antwi-Adjei, Reuben Ayivor-Djanie, Abigail Hohoayi, Aaron Opoku Antwi, Sylvester Yao Lokpo

{"title":"Exploring the immunomodulatory activities of Scoparia dulcis extract against lipopolysaccharide-induced allergic inflammation in mice through suppression of innate pro-inflammatory cytokines, COX-2 and iNOS signalling pathways.","authors":"Jones Ofori-Amoah, Cynthia Amaning Danquah, Kwesi Boadu Mensah, Meshack Antwi-Adjei, Reuben Ayivor-Djanie, Abigail Hohoayi, Aaron Opoku Antwi, Sylvester Yao Lokpo","doi":"10.1515/jcim-2025-0387","DOIUrl":"10.1515/jcim-2025-0387","url":null,"abstract":"Objectives: This study sought to evaluate the biological effects of the hydroethanolic extract of Scoparia dulcis (SDE) on some innate immune responses that are implicated in inflammatory respiratory diseases, using the lipopolysaccharide-induced mice model.Methods: Lipopolysaccharide (LPS, 0.5 mg/kg) was dissolved in 2 mL phosphate buffered saline and injected (IP) into mice 1 h after drug administration to induce inflammation and systemic immune responses. Mice were pre-treated with either 10 mg/kg prednisolone or SDE (50, 100, 250 mg/kg, p.o.). The expressions of TNF-α, IL-1β, IL-6, stem cell factor (SCF), nitric oxide (NO), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 enzymes (COX-2) were evaluated by a real-time PCR technique. Furthermore, histopathological examinations were performed on the lung tissues.Results: Pre-treatment with SDE significantly suppressed (p<0.001) the expressions of TNF-α, SCF, IL-1β, IL-6, and COX-2, as well as iNOS enzymes in the mRNAs of LPS-induced mice, and it also reduced NO levels and endotoxin-induced lung damage.Conclusions: SDE exhibited strong immunomodulatory activities and thus, would have potential benefits in immune-inflammatory disease management.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"128-138"},"PeriodicalIF":0.0,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the therapeutic effects of medicinal leech treatment on lower extremity ischemia-reperfusion injury. 药用水蛭治疗下肢缺血再灌注损伤的疗效观察。

Journal of Complementary and Integrative Medicine Pub Date : 2026-01-30 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0427

Kübranur Ünal, Başak Samur, Annahda Sharif, Leyla İbrahimkhanli, Nihat Yumuşak

{"title":"Investigation of the therapeutic effects of medicinal leech treatment on lower extremity ischemia-reperfusion injury.","authors":"Kübranur Ünal, Başak Samur, Annahda Sharif, Leyla İbrahimkhanli, Nihat Yumuşak","doi":"10.1515/jcim-2025-0427","DOIUrl":"10.1515/jcim-2025-0427","url":null,"abstract":"Objectives: This study aims to investigate the therapeutic effects of medical leech treatment (MLT) on ischemia/reperfusion (I/R) injuries in the lower extremities of rats.Methods: A total of 18 Wistar Albino rats were used and randomly assigned to three groups: Sham (n=6), I/R (n=6), and MLT (n=6). The I/R group rats underwent I/R induction in the femoral artery using an atraumatic vascular clamp. The same was done for the MLT group, after which MLT was carried out on the gastrocnemius muscle region of each rat. Histopathological analysis of the tissue and biochemical analysis was performed on the serum and tissue samples of the rats of each group.Results: According to the histopathological analysis, the scores of edema, degeneration, necrosis and inflammation of the MLT group were significantly lower than the I/R group (p<0.001). In the tissue and serum biochemical analysis, no statistically significant differences were detected among groups for interleukin-6 (IL-6), superoxide dismutase (SOD), calcitonin gene-related peptide (CGRP), nitric oxide (NO), tumor necrosis factor-α (TNF-α), hypoxia-inducible factor-1α (HIF-1α), ischemia-modified albumin (IMA), glutathione peroxidase (GPx), catalase (CAT) and endothelin-1 (EDN-1) levels.Conclusions: Although biochemical analysis results showed no significant differences among the groups, the histopathological analysis suggests notable clinical therapeutic effects of MLT in I/R models. Further research is warranted to substantiate these findings.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":"23 1","pages":"86-93"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the protective effect of the Echinacea Purpurea against apoptosis and inflammation induced by overdose of iron dextran on the hematopoietic system. 紫锥菊对右旋糖酐铁过量诱导的造血系统凋亡和炎症保护作用的评价。

Journal of Complementary and Integrative Medicine Pub Date : 2026-01-26 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0221

Doaa Kahim Abdul Ridha, Ali Faris Hassan

{"title":"Evaluation of the protective effect of the Echinacea Purpurea against apoptosis and inflammation induced by overdose of iron dextran on the hematopoietic system.","authors":"Doaa Kahim Abdul Ridha, Ali Faris Hassan","doi":"10.1515/jcim-2025-0221","DOIUrl":"10.1515/jcim-2025-0221","url":null,"abstract":"Objectives: Investigate the cytoprotective, anti-apoptotic, and anti-inflammatory effects of two different doses of Echinacea purpurea extract against iron overload-induced bone marrow suppression and spleen cell damage.Methods: 50 male rats divided into five groups: (I) received a 0.2 mL intraperitoneal saline injection, 1 mL oral gavage daily. (II) intraperitoneally injected (200 mg/kg iron); daily oral gavage 1 mL saline solution. (III) intraperitoneally injected (200 mg/kg iron), E. purpurea (100 mg/kg/day) orally administered. (IV) intraperitoneally injected (200 mg/kg iron), E. purpurea (200 mg/kg/day) orally administered. (V) intraperitoneally injected (200 mg/kg iron), orally administered vitamin E (200 mg/kg/day). Injections administered every 3 days; treatment for 4 weeks.Results: Echinacea Purpurea significantly reduces monocyte cell count, Akt1, Foxo-1, and NFκB; significantly elevates lymphocyte cell count; and highly significantly elevates Sirt-3 gene expression. It substantially reduces the levels of IL-6, MCP-1, and FasL.Conclusions: Echinacea Purpurea exhibits anti-inflammatory and immunomodulatory effects, and it reduces bone marrow suppression and spleen cell injury caused by iron overload.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"163-172"},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From ancient remedy to modern COVID-19 adjunct: a narrative review of mechanistic, in vitro, and clinical evidence on propolis. 从古代药物到现代COVID-19辅助药物：蜂胶的机制、体外和临床证据的叙述性回顾。

Journal of Complementary and Integrative Medicine Pub Date : 2026-01-19 eCollection Date: 2026-06-01 DOI: 10.1515/jcim-2025-0275

Giorgos Tzigkounakis, Jonathan Brown

{"title":"From ancient remedy to modern COVID-19 adjunct: a narrative review of mechanistic, in vitro, and clinical evidence on propolis.","authors":"Giorgos Tzigkounakis, Jonathan Brown","doi":"10.1515/jcim-2025-0275","DOIUrl":"10.1515/jcim-2025-0275","url":null,"abstract":"Introduction: Despite the global rollout of COVID-19 vaccines, limited access, vaccine hesitancy, and the emergence of viral variants continue to underscore the need for complementary antiviral strategies. Propolis, a resinous bee product widely used in traditional medicine, has attracted scientific interest due to its reported antiviral, anti-inflammatory, immunomodulatory, and antioxidant properties.Content: This narrative review examines the therapeutic potential of propolis as a candidate adjunctive treatment for COVID-19, focusing on mechanistic, in vitro, and clinical evidence. A comprehensive review was conducted using PubMed, Scopus, and Europe PMC (January 2020 to May 2025), covering molecular docking reports, in vitro assays, and human clinical studies evaluating propolis or its key constituents against SARS-CoV-2. In silico reports describe interactions of more than forty propolis constituents with key host and viral targets, providing mechanistic context. In vitro evidence demonstrates inhibition at entry and replication targets alongside attenuation of inflammatory signaling. Limited clinical data, spanning seven studies and two case reports, suggest milder symptoms and shorter hospital stays, with no serious adverse events observed.Summary and outlook: Preclinical and early clinical evidence suggest propolis may be a useful adjunct in COVID-19 therapy. Large, placebo-controlled trials with well characterized and standardized extracts are needed to confirm efficacy and safety.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"240-252"},"PeriodicalIF":0.0,"publicationDate":"2026-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Health Products Research Society of Canada Natural Health Products, Probiotics & Neurodegeneration Online Symposium 2025. 加拿大天然健康产品研究协会天然健康产品，益生菌和神经退行性疾病在线研讨会2025。

Journal of Complementary and Integrative Medicine Pub Date : 2026-01-19 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0460

引用次数: 0

Methoxy flavonoids inhibits proliferation and induces apoptosis of A549 lung cancer cells. 甲氧基黄酮类化合物抑制A549肺癌细胞增殖，诱导细胞凋亡。

Journal of Complementary and Integrative Medicine Pub Date : 2026-01-01 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0184

Dhirendra Singh, Amit Kumar, Inderjeet Verma, Govind Yadav, Sanket Shukla

{"title":"Methoxy flavonoids inhibits proliferation and induces apoptosis of A549 lung cancer cells.","authors":"Dhirendra Singh, Amit Kumar, Inderjeet Verma, Govind Yadav, Sanket Shukla","doi":"10.1515/jcim-2025-0184","DOIUrl":"10.1515/jcim-2025-0184","url":null,"abstract":"Objectives: Lung cancer is one of the most common malignancies and the leading cause of cancer-related mortality worldwide, posing a major public health challenge. Flavonoids, a large and diverse group of plant metabolites, exhibit various anticancer properties, making them promising candidates for therapeutic applications. This study evaluated the anticancer efficacy of methoxy flavonoids and elucidated their underlying mechanisms of action in A549 lung cancer cells.Methods: A549 cells were treated with various flavonoids (AKC1-AKC5), and their effects were analyzed using an MTT assay, DAPI staining, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) production, colony formation, and wound scratch tests. Molecular docking was also performed to confirm the binding of AKC1 and AKC3 to EGFR, BCL-2, and CDK-2 proteins.Results: AKC1 and AKC3 prevented the growth of A549 lung cancer cells with IC50 of 64.57 and 19.80 μM among 5 methoxy flavonoids. AKC1 and AKC3 triggered notable alterations in the shape and reduced the colony-forming potential of A549 cells. The DAPI staining experiment demonstrated that AKC1 and AKC3 impede the growth of cancer cells through activation of apoptotic cell death. Moreover, the anticancer properties of AKC1 and AKC3 were attributed to significant inhibition of MMP and a notable ROS enhancement in a dose-related pattern. The wound scratch assay demonstrated that AKC1 and AKC3 suppressed A549 lung cancer cell migration, suggesting their anti-metastatic properties. Molecular docking studies confirmed that AKC-1 and AKC-3 bind strongly to EGFR, BCL-2, and CDK2, suggesting a multi-target mechanism that underlies their anti-proliferative and pro-apoptotic effects in A549 cells.Conclusions: AKC1 and AKC3 exhibited significant anticancer activity against A549 cells and may serve as promising therapeutic drugs for lung cancer treatment.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":"23 1","pages":"94-106"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of ethanolic extract Panax ginseng roots on hypothyroidism-induced memory impairment, inflammation, and hippocampal tissue oxidative damage in rats. 人参根乙醇提取物对甲状腺功能减退大鼠记忆障碍、炎症及海马组织氧化损伤的影响。

Journal of Complementary and Integrative Medicine Pub Date : 2025-12-30 eCollection Date: 2026-04-01 DOI: 10.1515/jcim-2025-0213

Hedyeh Askarpour, Mahdiyeh Hedayati-Moghadam, Faezeh Mirzaee, Sobhan Eslami, Yousef Baghcheghi

{"title":"The effect of ethanolic extract Panax ginseng roots on hypothyroidism-induced memory impairment, inflammation, and hippocampal tissue oxidative damage in rats.","authors":"Hedyeh Askarpour, Mahdiyeh Hedayati-Moghadam, Faezeh Mirzaee, Sobhan Eslami, Yousef Baghcheghi","doi":"10.1515/jcim-2025-0213","DOIUrl":"10.1515/jcim-2025-0213","url":null,"abstract":"Objectives: Panax ginseng is rich in ginsenosides, which possess antioxidant, anti-inflammatory, and neuroprotective effects. This study aimed to evaluate the effects of ethanolic extract P. ginseng roots (GSNG) on memory deficits, inflammation, and oxidative damage in the hippocampal tissue of male rats subjected to hypothyroidism.Methods: Male Wistar rats were divided into four groups: Control, PTU, PTU-GSNG 50 (50 mg/kg), and GSNG100 (100 mg/kg). Over 42 days, PTU was provided in drinking water at a concentration of 0.05 %. GSNG was administered via gavage during the PTU treatment and throughout the behavioral testing phase. In fifth week the behavioral tests including water maze and shuttle box were conducted. After 42 days, hippocampal tissues were harvested post-euthanasia for analysis of oxidative stress markers and interleukin-6.Results: Administration of GSNG significantly ameliorated memory impairment and reduced oxidative damage and inflammation in the hippocampus of hypothyroid rats. Behavioral assessments using the water maze and shuttle box indicated marked improvements in memory impairment induced by hypothyroidism (p<0.01 and p<0.001). Biochemical analyses revealed significant modulation of oxidative stress markers, including MDA, total thiol groups, SOD activity, catalase levels, and interleukin-6, with both doses of Ginseng demonstrating beneficial effects. Notably, the higher dose (100 mg/kg) exhibited superior efficacy compared to the lower dose (50 mg/kg) across all measured parameters.Conclusions: The findings suggest that P. ginseng effectively mitigates hypothyroidism-induced memory impairment by attenuating oxidative stress and neuroinflammation, highlighting its potential as a therapeutic agent for cognitive deficits associated with thyroid dysfunction.","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"139-149"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0