Journal of Complementary and Integrative Medicine最新文献

{"title":"<i>Albizia ferruginea</i> (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat.","authors":"Akingbolabo Daniel Ogunlakin, Meek Oyinlola Meruwoma, Princewill Obinna Ihiasota, Oluwafemi Adeleke Ojo, Adeyemi Abdullahi Adegoke, Idayat Adeola Akinwumi, Owoola Azeezat Ambali, Oyindamola Esther Awosola, Mubo Adeola Sonibare","doi":"10.1515/jcim-2024-0287","DOIUrl":"10.1515/jcim-2024-0287","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the potential ameliorative effects of <i>Albizia ferruginea</i> leaves on letrozole-induced polycystic ovarian syndrome (PCOS) in Wistar rats.</p><p><strong>Methods: </strong>PCOS was induced in 25 female Wistar rats by administering letrozole (1 mg/kg), followed by treatment with 100 and 250 mg/kg body weight <i>A. ferruginea</i> leaf methanolic extract, as well as 1 mg/kg body weight of clomiphene citrate as standard.</p><p><strong>Results: </strong>An acute toxicity study revealed a toxic dosage of 2,000 mg/kg for the plant extract. The <i>A. ferruginea</i> extract exhibited potent hydroxyl radical scavenging ability. Treatment with <i>A. ferruginea</i> leaf extract improved the irregular estrus cycle and hormonal imbalance. Additionally, the extract administration led to decreased testosterone and increased estradiol levels when compared to the untreated PCOS rat. Furthermore, methanol extract normalizes the levels of insulin receptor substrate (IRS), type 2 17-HSD (HsD17β2), P53, 11a-hydroxylase/17,20-desmolase (CYP11a), and fat mass and obesity-associated (FTO), genes in the cervix of PCOS rats.</p><p><strong>Conclusions: </strong>Overall, <i>A. ferruginea</i> demonstrated beneficial properties on polycystic ovary circumstances in rats, presenting its potential as a promising treatment for PCOS.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"124-133"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of thread embedding acupuncture on pain score, neck disability index, and pressure pain threshold for myofascial pain therapy in the upper trapezius muscle.","authors":"Emilia Puspitasari Winarno, Hasan Mihardja, Atikah Chalida Barasila, Stefanus Agung Budianto","doi":"10.1515/jcim-2024-0132","DOIUrl":"10.1515/jcim-2024-0132","url":null,"abstract":"<p><strong>Objectives: </strong>Myofascial pain characterized by myofascial trigger point (MTrP) is a common cause of musculoskeletal pain and the main cause of neck and shoulder pain in the working population. Thread embedding acupuncture (TEA) is a new modality that can provide long-term stimulation to prolong the same therapeutic effect as conventional acupuncture. This study aimed to determine the effect of TEA therapy on pain score, neck disability index (NDI), and pressure pain threshold (PPT) for myofascial pain in the upper trapezius muscle.</p><p><strong>Methods: </strong>The research design in this study was a double-blind, randomized clinical trial. This study with 44 research subjects was divided into TEA group (n=22) and sham TEA group (n=22). Both groups will receive TEA therapy once using CARA brand monofilament polydioxanone thread 29Gx50 mm or sham TEA (thread removed) at one trigger point in the upper trapezius muscle which will be followed-up on 3 days, 1 week, 4 weeks, and 8 weeks post-therapy.</p><p><strong>Results: </strong>Both groups experienced significantly reduced pain intensity and disability, also increased PPT at 3 days, 1 week, 4 weeks, and 8 weeks post-therapy (p<0.001). TEA therapy had better effectiveness in improving pain intensity at 4 weeks (p=0.007) and 8 weeks post-therapy (p=0.004), NDI scores at 8 weeks post-therapy (p=0.004), and PPT at 4 weeks (p=0.04) and 8 weeks post-therapy (p=0.002) compared to sham TEA.</p><p><strong>Conclusions: </strong>TEA reduced pain intensity and disability, and increased PPT for patients with myofascial pain in the upper trapezius muscle.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic activity of <i>Inonotus obliquus</i> water extract in alloxan-induced diabetic mice.","authors":"Nyamsurendejid Delgersaikhan, Erdenezaya Odkhuu, Purevsuren Khaltar, Enkhbaatar Samdan, Uranchimeg Dugarsuren, Shine-Od Dalkhsuren, Amgalanbaatar Dorjkhuu, Dolgorsuren Aldartsogt, Avirmed Amgalanbaatar","doi":"10.1515/jcim-2024-0316","DOIUrl":"10.1515/jcim-2024-0316","url":null,"abstract":"<p><strong>Objectives: </strong>The <i>Inonotus obliquus</i> is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural <i>Inonotus obliquus</i> on alloxan-induced diabetic mice.</p><p><strong>Methods: </strong>Alloxan monohydrate (200 mg/kg) was intraperitoneally single injected into C57BL/6 mice to induce diabetes. Alloxan-induced diabetic mice were orally given the water extract of inonotus obliquus (WEIO) at doses of 500 mg/kg and subcutaneously administered with insulatard 0.6 IU for 4 weeks. Subsequently, the levels of factors related to blood glucose, insulin and lipids were assessed.</p><p><strong>Results: </strong>WEIO significantly restored body weight, reduced fasting blood glucose levels, improved glucose tolerance ability, and increased insulin levels compared to the control diabetic mice. WEIO also enhanced cholesterol transportation in the liver, correlated with increased HDL-C levels and decreased TC, TG and LDL-C levels. Histologic examinations revealed that WEIO alleviated alloxan-induced pancreatic tissue damage.</p><p><strong>Conclusions: </strong>Natural Mongolian I. Obliquus water extracts have an antihyperglycemic effect and enhance islet cell function in alloxan-induced diabetic mice. It is a good candidate for a hypoglycemic functional food or medicine.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"472-480"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts for INCAM Research Symposium 2024: Traditions, Transitions & Tipping Points: Exploring the Relevance & Impact of Integrative Health Research on Individuals, Communities, and the Planet.","authors":"","doi":"10.1515/jcim-2024-0360","DOIUrl":"https://doi.org/10.1515/jcim-2024-0360","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts for INCAM Research Symposium 2024: Traditions, Transitions & Tipping Points: Exploring the Relevance & Impact of Integrative Health Research on Individuals, Communities, and the Planet.","authors":"","doi":"10.1515/jcim-2024-0360","DOIUrl":"10.1515/jcim-2024-0360","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts for INCAM Research Symposium 2024: Traditions, Transitions & Tipping Points: Exploring the Relevance & Impact of Integrative Health Research on Individuals, Communities, and the Planet.","authors":"","doi":"10.1515/jcim-2024-0360","DOIUrl":"https://doi.org/10.1515/jcim-2024-0360","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":"21 4","pages":"eA1-eA13"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of complementary and alternative medicine (CAM) during pregnancy.","authors":"Viviana Stampini, Carmen Imma Aquino, Chiara Airoldi, Sara Parini, Daniela Surico, Valentino Remorgida","doi":"10.1515/jcim-2024-0207","DOIUrl":"10.1515/jcim-2024-0207","url":null,"abstract":"<p><strong>Objectives: </strong>Approximately one-third of the global population uses complementary medicine, as yoga and meditation, not endorsed by evidence-based conventional medicine and, with more difficulties in case of pregnancy.</p><p><strong>Methods: </strong>Our study investigates the prevalence of Complementary and Alternative Medicine (CAM) usage in Novara (Italy) and its province through a survey to pregnant women at 36 gestational weeks.</p><p><strong>Results: </strong>The sample consisted of 70 women, average age of 33 years, most Caucasian, highly educated, mostly employed, under private gynecological care, with a prevalence of CAM use of 24.3 % [95 % CI 14.83; 36.01]. Six women (35.3 %) did not inform their healthcare provider of using these medicines, 15 women (88.2 %) express willingness to use complementary medicine in their next pregnancy, while 2 (11.8 %) are uncertain. The study found a significant association between higher education and CAM usage among pregnant women. Other factors, including nationality, occupation, choice of private practice, parity, physical activity, diet, smoking, pregnancy complications, and vaccination status, did not show significant relationships with CAM usage.</p><p><strong>Conclusions: </strong>Our objective is to delineate the characteristics of CAM users, explore the methodologies and motivations of their usage, and ascertain any correlations with the rejection of conventional vaccination practices. The analyzed population consists of 70 women aged 32.9 years in mean, mostly Caucasian, with a high level of education. Most women are under private gynecological care (84.3 %), half of the participants are experiencing their first pregnancy. Physical activity levels vary, with 34.3 % reporting high activity levels. Regarding diet, 77.1 % consider their eating habits moderately healthy, with a notable portion of smokers women (24.3 %); 20.0 % have experienced pregnancy complications. 17 participants utilized non-conventional or alternative medicine, with a prevalence of 24.3 [95 % CI 14.83; 36.01]. Six women (35.3 %) did not inform their healthcare provider about using CAM. Seven women (46.7 %) claim significant beneficial effects in most cases, while 8 (53.3 %) state this occasionally. Based on their experiences, 15 women (88.2 %) express willingness to use complementary alternative medicine in their subsequent pregnancy, while 2 (11.8 %) are uncertain. Only one person (11.1 %) used this type of therapy as a substitute for conventional treatment, but they informed their attending physician. The study seeks to enhance our understanding of CAM utilization in pregnancy, informing more comprehensive and evidence-based healthcare practices for expectant mothers.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"548-553"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory activity of <i>Ziziphus jujuba</i> hydroalcoholic extract in acetic acid-induced ulcerative colitis model.","authors":"Shabnam Bahrami, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Jaleh Mohajeri Borazjani, Mahdieh Farzanehpour","doi":"10.1515/jcim-2024-0178","DOIUrl":"10.1515/jcim-2024-0178","url":null,"abstract":"<p><strong>Objectives: </strong>Ulcerative colitis (UC) is a common gastrointestinal (GI) disorder characterized by chronic inflammation. Current treatments primarily focus on symptom management, but they have inherent limitations. Global attention is increasingly directed towards exploring herbal remedies as complementary approaches. This study aims to investigate the effects of the hydroalcoholic extract of jujuba on an experimental model of ulcerative colitis.</p><p><strong>Methods: </strong>In this study, 15 male BALB/c mice were divided into three experimental groups. The first group served as the untreated UC model, acting as the positive control (PC). The second group received treatment with the hydroalcoholic extract of <i>Ziziphus jujuba</i>, while the third group was treated with mesalamine. UC was induced by injecting 100 μL of 4 % acetic acid (AA) intra-rectally several times. Treatment commenced after the onset of symptoms such as diarrhea and bloody stools. The mice were eventually euthanized ethically, and their spleen and intestinal tissues were collected for analysis. Evaluations included the Disease Activity Index (DAI), myeloperoxidase activity (MPO), nitric oxide (NO) levels, cytokine levels (IL-1β, IL-6, TNF-α), and gene expression (iNOS, COX-2, and cytokines).</p><p><strong>Results: </strong>The hydroalcoholic extract of the jujuba plant significantly reduced MPO, NO, the DAI, and the production and expression of inflammatory cytokines, as well as the genes iNOS and COX-2, in the group receiving this extract compared to the positive control group (p<0.05).</p><p><strong>Conclusions: </strong>The study demonstrates that the hydroalcoholic extract of <i>Ziziphus jujuba</i> significantly reduces inflammation markers such as TNF-α, NO, MPO, IL-1β, and IL-6 in a mouse model of ulcerative colitis. Additionally, it downregulates the expression of pro-inflammatory genes, including iNOS and COX-2. These findings suggest that <i>Z. jujuba</i> extract has potential as an effective anti-inflammatory treatment for managing ulcerative colitis symptoms.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"481-489"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new chapter in traditional, complementary, and integrative medicine: Advancing the <i>Journal of Complementary and Integrative Medicine</i> through open science, meta-research, artificial intelligence, and early career researcher involvement.","authors":"Jeremy Y Ng","doi":"10.1515/jcim-2024-0364","DOIUrl":"10.1515/jcim-2024-0364","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"409-411"},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new chapter in traditional, complementary, and integrative medicine: Advancing the <i>Journal of Complementary and Integrative medicine</i> through open science, meta-research, artificial intelligence, and early career researcher involvement.","authors":"Jeremy Y Ng","doi":"10.1515/jcim-2024-0364","DOIUrl":"https://doi.org/10.1515/jcim-2024-0364","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}