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Premnine HCl Estimation in Selected Formulations of âÂÂDashmulâ and inChloroform Extract of Premna integrifolia L. by a Selective, Validated andDeveloped HPTLC Fingerprint Method 建立高效液相色谱指纹图谱法测定黄花草ÃⅱÂÂDashmulÃⅱÂÂ和三氯甲烷提取物中盐酸含量
Journal of Chromatography & Separation Techniques Pub Date : 2017-02-20 DOI: 10.4172/2157-7064.1000352
Attarde Dl, Pal Sc, Bhambar Rs
{"title":"Premnine HCl Estimation in Selected Formulations of âÂÂDashmulâ and inChloroform Extract of Premna integrifolia L. by a Selective, Validated andDeveloped HPTLC Fingerprint Method","authors":"Attarde Dl, Pal Sc, Bhambar Rs","doi":"10.4172/2157-7064.1000352","DOIUrl":"https://doi.org/10.4172/2157-7064.1000352","url":null,"abstract":"HPTLC technique developed as validated method for estimation of Premnine HCl in P. integrifolia chloroform extract (PI-AK) and in selected marketed formulations ‘Dashmul arishta’,‘Dashmul kadha’ in 3 × 3 batches as per ICH guidelines. Premnine HCl (Pr-s) was isolated as per literature from P. integrifolia and focused first time as standard bioactive marker for quantification. Developed mobile phase Toluene: Acetone: Diethylamine (7:2:1) for Pr-S gave Rf 0.59 at λ max 283 nm in densitometric scan, focused for specificity, fingerprint and estimation study in PI-AK and selected formulation successively. Linearity assessed in range of 8 to 16 μg /band with regression coefficient of 0.9983, LOD 0.742 μg/Band, LOQ 2.225, also robust for Pr-S. Accuracy for % recovery performed on extract as well on formulation, further subjected for precision study with application one way ANOVA for finding F value, found within limit therefore no significance of variance. A rapid and selective HPTLC method shows good linearity, recovery and high precision, useful method for analysis of Pr-S and as quality control parameter for raw material as well formulation as per foremost need of WHO, FDA and Pharmacopoeia.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"86 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85619415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of the Volatile Components of Cannabis Preparations bySolid-Phase Microextraction Coupled to Headspace-Gas Chromatographywith Mass Detector (SPME-HSGC/MS) 固相微萃取-质谱联用顶空-气相色谱(SPME-HSGC/MS)表征大麻制剂中挥发性成分
Journal of Chromatography & Separation Techniques Pub Date : 2017-02-08 DOI: 10.4172/2157-7064.1000350
S. Arnoldi, Gabriella Roda, E. Casagni, L. Dell'acqua, M. D. Cas, F. Faré, C. Rusconi, G. L. Visconti, V. Gambaro
{"title":"Characterization of the Volatile Components of Cannabis Preparations bySolid-Phase Microextraction Coupled to Headspace-Gas Chromatographywith Mass Detector (SPME-HSGC/MS)","authors":"S. Arnoldi, Gabriella Roda, E. Casagni, L. Dell'acqua, M. D. Cas, F. Faré, C. Rusconi, G. L. Visconti, V. Gambaro","doi":"10.4172/2157-7064.1000350","DOIUrl":"https://doi.org/10.4172/2157-7064.1000350","url":null,"abstract":"Solid phase microextraction coupled to headspace sampling and GC/MS technique was applied to the characterization of the volatile components of several Cannabis preparations (hashish). Different parameters of the analytical method (fiber, coating thickness, sampling and exposition temperatures, sample preparation) were evaluated to optimize the characterization of the volatile components. a-Pinene, s-myrcene, limonene, 4-carene, trans-3(10) caren-2-ol, 4,7,7-trimethylbicyclo [4.1.0] heptan-3-ol, caryophyllene, s-humulene, azulene, gurjunene, ledene and caryophyllene oxide were identified among the volatile components of all hashish preparations. Moreover, a suitable internal standard (nonane) was chosen, the reproducibility and linearity of the method were evaluated in order to carry out the quantitative determination of caryphyllene, the most abundant volatile terpene. Its quantity ranged from 800 to 3000 µg/g.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"54 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85089132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Forced Degradation Study an Essential Approach to Develop StabilityIndicating Method 强制降解研究是发展稳定性指示方法的重要途径
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-27 DOI: 10.4172/2157-7064.1000349
M. Sharma, Manoharan Murugesan
{"title":"Forced Degradation Study an Essential Approach to Develop StabilityIndicating Method","authors":"M. Sharma, Manoharan Murugesan","doi":"10.4172/2157-7064.1000349","DOIUrl":"https://doi.org/10.4172/2157-7064.1000349","url":null,"abstract":"Forced degradation studies (stress testing) are very important tool in pharmaceutical research and development to predict long-term stability. Stress studies should be performed in method development to understand drug behavior but also can be performed with method validation for regulatory filling predict stability and measure impurities. For stable formulation development, understanding of chemical behavior, degradation pathways and degradation products of drug substance and drug product is very important. There is not much regulatory guidance available, which can provide step-by-step details on stress testing. Therefore, in present review paper we described the extensive overview of forced degradation studies (stress studies) by specifying strategy to perform stress studies and development of stability indicating method.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"10 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82893180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Advanced Reprocessing – The Potential for Continuous Chromatographic Separations 高级后处理-连续色谱分离的潜力
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-20 DOI: 10.4172/2157-7064.1000348
H. Eccles, John David Emmott, G. Bond
{"title":"Advanced Reprocessing – The Potential for Continuous Chromatographic Separations","authors":"H. Eccles, John David Emmott, G. Bond","doi":"10.4172/2157-7064.1000348","DOIUrl":"https://doi.org/10.4172/2157-7064.1000348","url":null,"abstract":"This concept paper, discusses the challenges and opportunities for an extractive chromatographic process for the separation of fission products and minor actinides from uranium and plutonium isotopes in irradiated nuclear fuel. The paper highlights the constraints of the PUREX process, a process that is universally accepted for reprocessing of spent nuclear fuel now and for GEN IV reactor systems. It also identifies the challenges that a new separation process would have to overcome to dislodge its acceptance by both the operators and regulators. Although the concept of using a chromatography technique for this separation is challenging, recent developments of continuous chromatography such as simulated moving bed (SMB) and/or continuous annular chromatography (CAC) provides a degree of encouragement. Equally the development of new stationary phases in particular inorganic exchangers, many of which have not been examined for this application enhances confidence that an alternative to the PUREX \u0000process is possible.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82346429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Determining Odor-Active Compounds in a Commercial Sample ofCinnamomum cassia Essential Oil Using GC-MS and GC-O 气相色谱-质谱联用-气相色谱-气相色谱-气相色谱-气相色谱-气相色谱-气相色谱-气相色谱-气相色谱-气相色谱-气相色谱法测定肉桂精油商业样品中的气味活性成分
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-14 DOI: 10.4172/2157-7064.1000347
V. Bongiovanni, M. Colombo, A. Cavallero, D. Talarico
{"title":"Determining Odor-Active Compounds in a Commercial Sample ofCinnamomum cassia Essential Oil Using GC-MS and GC-O","authors":"V. Bongiovanni, M. Colombo, A. Cavallero, D. Talarico","doi":"10.4172/2157-7064.1000347","DOIUrl":"https://doi.org/10.4172/2157-7064.1000347","url":null,"abstract":"The volatiles of a commercial sample of Cinnamomum cassia (Nees and T. Nees) J. Presl. essential oil were analyzed by gas chromatography-mass spectrometry (GC-MS). The identification of the components was confirmed by Kovats retention index and their quantities were established using internal standard. These analyses had led to the identification of 72 chemicals and quantification of 41 of them. The majority of volatiles identified belongs to oxygenated compounds (e.g., aldehydes) while non oxygenated terpenes represent about 18% of the oil. The odor quality of cassia essential oil was assessed by Gas Chromatography-Olfactometry (GC-O). Among the 26 components identified with GC-O, AEDA (Aroma Extract Dilution Analysis) has allowed to establish a number of components with high dilution factor (strongly odorous) such as cinnamaldehyde, 3-phenylpropanal, guaiacol and 2-phenylethanol.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"85 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87675965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Investigation of Cells Migration Effects in Microfluidic Chips 微流控芯片中细胞迁移效应的研究
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-04 DOI: 10.4172/2157-7064.1000345
Y. Lin, Wenting Liu, Chunfei Hu
{"title":"Investigation of Cells Migration Effects in Microfluidic Chips","authors":"Y. Lin, Wenting Liu, Chunfei Hu","doi":"10.4172/2157-7064.1000345","DOIUrl":"https://doi.org/10.4172/2157-7064.1000345","url":null,"abstract":"Microfluidic chips offer the unique opportunity to establish novelty in vitro cells models where the in vivo cells microenvironment could be precisely reconstituted. Although they have significances in the fields of cell biology, the real applications are extremely limited by ambient materials for cells culture, i.e., cells morphology and migration are greatly influenced by substrate material. In this study, we investigated the cells migration effects in four kinds of microfluidic chips with the same geometry. They are PDMS mold structures bonded on culture dish, glass slide, and PDMS substrates, respectively, and another PMMA mold structure bonded on PMMA substrate. For convenient description, we denoted these four chips as PDMS-DISH, PDMS-GLASS, PDMS-PDMS, and PMMA-PMMA, respectively. We compared and summarized the relationship of cells migration effects on different substrate. The cells are initially introduced into the culture area. The experiment results indicate that cells spreading time, spreading area and cells migration on these chips has obvious diversities. To further investigate the cells migration in these chips, a new model is prepared using trypsin/EDTA solution and cell culture medium. It shows a good repeatability. Most of cells could be formed a good morphology and monolayer growth in these microfluidic chips. The cells migrated furthest is in the PDMS-DISH chip after monitored 24 hours. The migration rates are 20.30 μm/h, 18.63 μm/h, 15.00 μm/h, and 10.75 μm/h in PDMS-DISH, PDMS-GLASS, PDMS-PDMS, and PMMA-PMMA, respectively. This study turns open up opportunities for new biochips in prospective applications of wound healing and antiscarring expected in drug screening and the related fields.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"110 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87671286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A Rapid Liquid Chromatography Method for Determination of Gylphosatein Crude Palm Oil with Fluorescence Detection 荧光法快速液相色谱法测定粗棕榈油中甘油磷酸酯的含量
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-02 DOI: 10.4172/2157-7064.1000346
Fariq Fitri Msm, Halimah Muhamad, D. Omar, N. Asib
{"title":"A Rapid Liquid Chromatography Method for Determination of Gylphosatein Crude Palm Oil with Fluorescence Detection","authors":"Fariq Fitri Msm, Halimah Muhamad, D. Omar, N. Asib","doi":"10.4172/2157-7064.1000346","DOIUrl":"https://doi.org/10.4172/2157-7064.1000346","url":null,"abstract":"A rapid and simple method for the determination of glyphosate in crude palm oil (CPO) was developed and validated using high performance liquid chromatography with fluorescence detector. Glyphosate was derivatized with \u0000 9-fluorenylmethylchloroformate (FMOC-Cl) and then separated using a C18 reverse phase column with potassium \u0000 dihydrogen phosphate and acetonitrile as the mobile phase. A linear correlation was obtained for the concentration \u0000 of glyphosate from 0.05-1.5 μg mL-1 with a correlation coefficient of 0.9998. The average recovery obtained for \u0000 glyphosate ranged between 80% and 100% at five fortification levels with the relative standard deviation (RSD) of less than 3% of all cases. The limit of detection and limit of quantification for glyphosate were 0.05 and 0.1 μg/g, \u0000 respectively. The method will facilitate palm oil trade through quality assurance in terms of glyphosate residues in \u0000palm oil products and also to counter any issues related to food safety for palm based products.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"41 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77983375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
I-Number Assay and Erythropoietin Potency: Retrospective Capillary Zone Electrophoresis Data Analysis of the Biological Reference Preparations of Erythropoietin i -数测定和促红细胞生成素效价:促红细胞生成素生物参比制剂的回顾性毛细管区带电泳数据分析
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-01 DOI: 10.4172/2157-7064.S8-002
H. P.
{"title":"I-Number Assay and Erythropoietin Potency: Retrospective Capillary Zone Electrophoresis Data Analysis of the Biological Reference Preparations of Erythropoietin","authors":"H. P.","doi":"10.4172/2157-7064.S8-002","DOIUrl":"https://doi.org/10.4172/2157-7064.S8-002","url":null,"abstract":"The capillary zone electrophoresis data of erythropoietin reference preparations batch 1 (BRP1), batch 2 (BRP2) and batch 3 (BRP3) of three collaborative studies published in 2004, 2007 and 2015 have retrospectively been analyzed by the author via the I-number assay, a physicochemical assay that allows potency calculation of erythropoietin samples in a precise and accurate manner. The results are summarized as follows: The I-number assay revealed an inter-laboratory precision of CV 3.0%. This retrospective analysis by the author of the CZE data of the (candidate) EPO BRPs has revealed that the bioactivity stated for EPO BRP1 (130.0 IU/μg) should have been stated about 5% higher (“BRP1+5%”=136.5 IU/μg) and the bioactivity stated for EPO BRP2 (130.0 IU/μg) should have been stated about 10% higher (“BRP2+10%”=143.0 IU/μg), and the two new potency values are proposed by the author herewith. The potency assigned for EPO BRP3 (141.1 IU/μg) was without any doubt and therefore confirmed.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"1 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78946637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Metabolomic Study on Fatty Acids in Placenta of Preeclamptic Pregnancies by Gas Chromatography-Mass Spectrometry 气相色谱-质谱联用研究子痫前期胎盘脂肪酸代谢组学
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-01 DOI: 10.4172/2157-7064.S8-003
M. Paik, J. Shim, Chan Seo, Hyeon‐Seong Lee, Haeng-Soo Kim, Gwang Lee, J. Yang
{"title":"Metabolomic Study on Fatty Acids in Placenta of Preeclamptic Pregnancies by Gas Chromatography-Mass Spectrometry","authors":"M. Paik, J. Shim, Chan Seo, Hyeon‐Seong Lee, Haeng-Soo Kim, Gwang Lee, J. Yang","doi":"10.4172/2157-7064.S8-003","DOIUrl":"https://doi.org/10.4172/2157-7064.S8-003","url":null,"abstract":"Preeclampsia is a serious pregnancy-associated complication and can critically affect the health of the mother and fetus. However, the pathogenesis of preeclampsia remains unclear. One of the characteristics of preeclampsia is abnormal lipid metabolism. Thus, profiling analysis of 23 fatty acids (FAs) as tert-butyldimethylsilyl derivative was performed in the placenta of preeclamptic term pregnancies and uncomplicated term pregnancies by gas chromatography-mass spectrometry. The compositions of saturated, monounsaturated and n-3 polyunsaturated FAs were significantly reduced, whereas those of oleic acid among monounsaturated FAs and arachidonic acid among n-6 polyunsaturated FAs were significantly increased in preeclampsia group compared to the normal group. The distorted star pattern of the preeclamptic pregnancy group was different from the tricosagonal shape of the normal group. Thus, the present FA profiling analysis combined with the star symbol plotting method will be useful for the biochemical monitoring of placental abnormalities and visual discrimination between preeclamptic and normal pregnancies.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"17 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72823121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Novel Fingerprinting Method for Glycosides in Nakshatra Plants by HPTLC 一种新的hplc指纹图谱测定草甘膦苷的方法
Journal of Chromatography & Separation Techniques Pub Date : 2017-01-01 DOI: 10.4172/2157-7064.1000382
Rameshwar Rk, Lokesh T, Rajasekhar Rb, Dileep Kk, Varadacharyulu C, G. S, Begum Ms
{"title":"A Novel Fingerprinting Method for Glycosides in Nakshatra Plants by HPTLC","authors":"Rameshwar Rk, Lokesh T, Rajasekhar Rb, Dileep Kk, Varadacharyulu C, G. S, Begum Ms","doi":"10.4172/2157-7064.1000382","DOIUrl":"https://doi.org/10.4172/2157-7064.1000382","url":null,"abstract":"Nakshatra plants are medicinally important and used from olden days onwards to treat various diseases. In the present study, a HPTLC method was developed for separation of glycosides in plants. The powdered drug of Nakshatra plant was extracted with ethanol and identification was done chemically by Molisch's, Fehling's, Bial's test and separation of glycosides was performed densitometrically at λ=254-700 nm using as a mobile phase, ethyl acetate: methanol: water (20:2.5:2.5). The results of qualitative analysis revealed the presence of carbohydrates, reducing sugars and pentose. HPTLC method achieved a good separation of glycosides at 254 nm, 304 nm, 354 nm, 404 nm with recorded peak areas and Rf values. The comparative common compound of sample glycosides was also done.","PeriodicalId":15534,"journal":{"name":"Journal of Chromatography & Separation Techniques","volume":"34 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80972075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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