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Sonoreperfusion Therapy for Microvascular Obstruction: A Review 超声再灌注治疗微血管阻塞的研究进展
Journal of Clinical Cardiology Pub Date : 2021-12-21 DOI: 10.33696/cardiology.2.023
Filip Istvanic, Gary Z. Yu, Xucai Chen, John Pacella
{"title":"Sonoreperfusion Therapy for Microvascular Obstruction: A Review","authors":"Filip Istvanic, Gary Z. Yu, Xucai Chen, John Pacella","doi":"10.33696/cardiology.2.023","DOIUrl":"https://doi.org/10.33696/cardiology.2.023","url":null,"abstract":"Coronary artery disease and acute myocardial infarction are a leading cause of morbidity and mortality. Contemporary therapy is percutaneous coronary intervention (PCI), performed by balloon angioplasty and stent placement. PCI is nearly ubiquitously accompanied by some degree of microvascular obstruction (MVO), and in many cases characterized by poor microvascular perfusion of myocardium distal to the site of primary occlusion. This phenomenon, also termed “no reflow”, was first documented in 1974 [1]. MVO is a powerful independent predictor of mortality, independent of age, infarct size, or ejection fraction [2]. Ultrasound targeted microbubble cavitation, termed “sonoreperfusion therapy”, is a promising treatment option to relieve MVO and reestablish microvascular perfusion. The purpose of this review is to discuss the pathophysiology of MVO and the clinical translation of sonoreperfusion therapy.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80935304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement 经导管主动脉瓣置换术中脑栓塞保护的作用
Journal of Clinical Cardiology Pub Date : 2021-12-21 DOI: 10.33696/cardiology.2.024
J. Halim, Jming Cheng, P. Heijer, BE Schölzel, J. Vos, M. Meuwissen, B. Branden, M. Van, Gameren, N. Royen, Ajj Ijsselmuiden
{"title":"The Role of Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement","authors":"J. Halim, Jming Cheng, P. Heijer, BE Schölzel, J. Vos, M. Meuwissen, B. Branden, M. Van, Gameren, N. Royen, Ajj Ijsselmuiden","doi":"10.33696/cardiology.2.024","DOIUrl":"https://doi.org/10.33696/cardiology.2.024","url":null,"abstract":"Stroke is one of the most feared complications of transcatheter aortic valve replacement (TAVR) and is associated with an increased risk of morbidity and mortality [1-4]. Its consequences can be disastrous with permanent significant disability in 40% of the survivors, social isolation and financial problems in up to 80% of the patients and a 6-fold increase in mortality rate during the first month following TAVR [5-8]. It is caused by periprocedural embolization occurring during balloon dilatation, manipulation of the delivery system in the aortic arch, valve positioning and valve deployment [9]. Histopathologic findings have revealed that emboli can consist of native valve tissue, arterial wall tissue, calcification, thrombus and foreign material [10].","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"436 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75695363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary Revascularization in the Era of Transcatheter Aortic Valve Replacement: Treat the Patient, Manage the Disease 经导管主动脉瓣置换术时代的冠状动脉血运重建术:治疗患者，控制疾病
Journal of Clinical Cardiology Pub Date : 2021-12-21 DOI: 10.33696/cardiology.2.025
P. Tummala, C. Grines
{"title":"Coronary Revascularization in the Era of Transcatheter Aortic Valve Replacement: Treat the Patient, Manage the Disease","authors":"P. Tummala, C. Grines","doi":"10.33696/cardiology.2.025","DOIUrl":"https://doi.org/10.33696/cardiology.2.025","url":null,"abstract":"Coronary artery disease continues to be the greatest cause of global mortality. The prevalence of coronary artery disease in patients with severe aortic stenosis varies widely, from 80% in extreme high-risk trials to only 15% in more recent low risk trials [1-3]. Given the higher risk of mortality in patients with coronary artery disease, guidelines suggest that revascularization with coronary artery bypass grafting (CABG) be considered in patients undergoing surgical aortic valve replacement [4]. Therefore, early trials of transcatheter aortic valve replacement (TAVR) required coronary angiography prior to consideration of TAVR. Percutaneous coronary intervention (PCI) of proximal and mid lesions in major coronary arteries was recommended during the first decade of TAVR. Yet there have been conflicting data with regard to outcomes of patients undergoing PCI prior to TAVR.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80082379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simple Tool to Predict Transradial Access Fai lure for Coronary Angiography 一种预测冠状动脉造影经桡动脉通路失败的简单工具
Journal of Clinical Cardiology Pub Date : 2021-12-21 DOI: 10.33696/cardiology.2.026
B. Fogelson, Hassan Tahir, J. Livesay, Raj Baljepally, Usman Sarwar
{"title":"A Simple Tool to Predict Transradial Access Fai lure for Coronary Angiography","authors":"B. Fogelson, Hassan Tahir, J. Livesay, Raj Baljepally, Usman Sarwar","doi":"10.33696/cardiology.2.026","DOIUrl":"https://doi.org/10.33696/cardiology.2.026","url":null,"abstract":"Based on multiple large clinical trials, the transradial access (TRA) approach has been widely accepted as the preferred method of vascular access for coronary angiography and percutaneous coronary intervention [1-3]. However, it is not without its limitations and complications. The major concern with the radial approach is access failure, requiring crossover to the traditional transfemoral access (TRA) approach. The rate of TRA failure requiring TFA crossover has been documented in the literature to occur in up to 11% of cases [4-7]. Unfortunately, the need for TFA crossover due to TRA failure can negatively affect patient care. For example, patients experience the discomfort associated with two needle punctures and are exposed to the potential complications of both radial and femoral artery access, which includes infection, bleeding, thrombosis, and arterial aneurysm. Additionally, TRA failure requiring TFA crossover can delay emergent coronary interventions in patients presenting with STsegment elevation myocardial infarctions, where every minute is valuable time to the myocardium [8].","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90550360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left Atrial Dysfunction in Patients with Coronary Slow Flow 冠状动脉慢血流患者的左心房功能障碍
Journal of Clinical Cardiology Pub Date : 2021-12-21 DOI: 10.33696/cardiology.2.021
Li Liu, Jing Dong, Zhiyuan Shui
{"title":"Left Atrial Dysfunction in Patients with Coronary Slow Flow","authors":"Li Liu, Jing Dong, Zhiyuan Shui","doi":"10.33696/cardiology.2.021","DOIUrl":"https://doi.org/10.33696/cardiology.2.021","url":null,"abstract":"Coronary slow flow phenomenon (CSFP) is not an infrequent angiographic finding in patients scheduled for coronary angiography. The incidence varies from 1% to 5.5% [1-3], although some cardiologists believe it is often underrecognized, its incidence could be as high as 34% [4]. The CSFP was firstly described by Tambe in 1972 in 6 subjects presenting with chest pain syndromes [5], and now it attracted intensive attention among interventional cardiologists since its original description. The current adapted diagnostic criteria was proposed by John Beltrame in 2012 [6] where CSFP is defined as delayed distal vessel opacification of contrast in the absence of significant epicardial coronary stenosis (coronary artery stenosis ≤40%), with the Thrombolysis in Myocardial Infarction (TIMI) blood flow grade of 2 or corrected TIMI frame count (cTFC) of greater than 27 frames in one or more epicardial vessel. Currently, it’s believed that CSFP is not just a simple angiographic curiosity, it has significant implications in clinical setting. Its pathophysiological mechanism remains unclear, although several possible mechanisms were proposed. In this article, we will summarize the clinical implications, possible mechanisms, and the alteration of cardiac function, especially the changes of left atrial functions in patients with CSFP according to our research and existing literature. Our purpose is to provide further insight into its clinical significance and pathophysiological mechanisms.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75725554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asystole during Tilt Testing-Induced Syncope: A Long-Term Follow-Up 倾斜试验诱发晕厥时心脏骤停:长期随访
Journal of Clinical Cardiology Pub Date : 2021-10-19 DOI: 10.33696/cardiology.2.018
E. Velázquez-Rodríguez, M. Fernández-Muñoz, Marcelo Jiménez-Cruz
{"title":"Asystole during Tilt Testing-Induced Syncope: A Long-Term Follow-Up","authors":"E. Velázquez-Rodríguez, M. Fernández-Muñoz, Marcelo Jiménez-Cruz","doi":"10.33696/cardiology.2.018","DOIUrl":"https://doi.org/10.33696/cardiology.2.018","url":null,"abstract":"Enrique Velázquez-Rodríguez1,2,4*, María de Jesús Fernández-Muñoz3,4, Marcelo Jiménez-Cruz1,4 1Unidad Médica de Alta Especialidad Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Servicio de Electrofisiología, Instituto Mexicano del Seguro Social, Universidad Nacional Autónoma de México, Ciudad de México, México 2Hospital Central Norte de Concentración Nacional, Pemex Servicio de Cardiología y Unidad de Cuidados Intensivos Cardiológicos, Universidad Nacional Autónoma de México, Ciudad de México, México 3Unidad Médica de Alta Especialidad, Hospital de Especialidades Dr. Bernardo Sepúlveda Centro Médico Nacional Siglo XXI, Servicio de Cardiología, Instituto Mexicano del Seguro Social, Universidad Nacional Autónoma de México, Ciudad de México, México 4Centro Médico Dalinde 2000, Hospital Ángeles Clínica Londres, Centro Hospitalario Sanatorio Durango, Ciudad de México, México","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88416751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparing for a More Public Health-Aware Practice of Medicine in Response to COVID-19 为应对COVID-19提高公共卫生意识的医学实践做准备
Journal of Clinical Cardiology Pub Date : 2021-10-19 DOI: 10.33696/cardiology.2.016
K. Brisolara, Dean G. Smith
{"title":"Preparing for a More Public Health-Aware Practice of Medicine in Response to COVID-19","authors":"K. Brisolara, Dean G. Smith","doi":"10.33696/cardiology.2.016","DOIUrl":"https://doi.org/10.33696/cardiology.2.016","url":null,"abstract":"After one year in a pandemic, we mourn the loss of over half a million lives in the United States, and over four million worldwide, and remain concerned over the challenges facing the families of 35 million people in the United States, and 200 million worldwide, who have suffered from cases of COVID-19. The public and the practice of medicine has become aware of the field of public health and the important roles of all health professionals in addressing the pandemic [1,2]. Our way out of this pandemic will not be led by public health, medicine, or another field alone. It will take a concerted and coordinated effort, which may thereafter change the practice of medicine to include more components of public health. Involvement of physicians and other health professionals in public health, will involve recruiting, training, and sustaining a workforce that is knowledgeable and capable of addressing complex issues [3]. Recruiting implies bringing practitioners into public health who might have previously been unaware, or insufficiently aware, of the field of public health and the importance of its work. Training implies offering the combination of knowledge and skills that enable practitioners to make important contributions. Sustaining implies training and programs that meet the needs of the present while enabling the continuation of efforts over time.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80221067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease 溴结构域和超末端家族蛋白抑制剂:一种治疗心脏病的潜在新疗法
Journal of Clinical Cardiology Pub Date : 2021-10-19 DOI: 10.33696/cardiology.2.020
Jing Mu, M. Zou
{"title":"Bromodomain and Extra-Terminal Family Protein Inhibitors: A Potentially New Therapy for Heart Disease","authors":"Jing Mu, M. Zou","doi":"10.33696/cardiology.2.020","DOIUrl":"https://doi.org/10.33696/cardiology.2.020","url":null,"abstract":"Bromodomain-containing protein 4 (BRD4) is a member of the mammalian bromoand extra-terminal domain (BET) protein family, which also comprises BRD2, BRD3, and testis-specific BRDt. The BET family of proteins shares the structure of two evolutionarily conserved tandem N-terminal bromodomains, as well as an extra-terminal (ET) domain (Figure 1). They bind acetylated histone tails through bromodomains, which results in localization to the chromosome, where they recruit other regulatory complexes, such as transcription elongation factor b (P-TEFb) and mediators, to influence gene expression [1,2]. In 2010, two groups independently discovered JQ1 and I-BET as BET bromodomain inhibitors, a class of small molecules that forms monovalent interactions with individual BET bromodomains that compete for binding of bromodomains to their natural ligand, acetylated Abstract","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79645220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid Hormones in Dilated Cardiomyopathy: Is It a Promising Therapeutic Option? 甲状腺激素治疗扩张型心肌病:是一个有希望的治疗选择吗?
Journal of Clinical Cardiology Pub Date : 2021-10-19 DOI: 10.33696/cardiology.2.019
Hala Mahfouz Badranz
{"title":"Thyroid Hormones in Dilated Cardiomyopathy: Is It a Promising Therapeutic Option?","authors":"Hala Mahfouz Badranz","doi":"10.33696/cardiology.2.019","DOIUrl":"https://doi.org/10.33696/cardiology.2.019","url":null,"abstract":"Dilated cardiomyopathy (DCM) is chronic heart muscle disease characterized by progressive ventricular enlargement and contractile dysfunction involving either left or both ventricles [1,2]. It is considered one of the leading causes of heart failure with reduced ejection fraction (HFrEF) worldwide. The reported prevalence of DCM in Europe and North America is ~36 cases per 100,000 population, which is clearly lower in Eastern Asia (i.e., 14 cases per 100,000 in Japan), and might be higher in Africa and Latin [3].","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88912964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention? CECCY试验的启示:肌钙蛋白应该成为蒽环类药物心脏毒性预防的靶点吗?
Journal of Clinical Cardiology Pub Date : 2021-10-19 DOI: 10.33696/cardiology.2.017
E. Bocchi, D. Belfort, M. Avila
{"title":"Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?","authors":"E. Bocchi, D. Belfort, M. Avila","doi":"10.33696/cardiology.2.017","DOIUrl":"https://doi.org/10.33696/cardiology.2.017","url":null,"abstract":"Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades [1]. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life [2,3]. Among different classes of chemotherapeutic agents, anthracyclines (ANT) stand out as the most related to cardiomyopathy, and may affect cancer survivals in 9% of all cases [4].","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74234868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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