CECCY试验的启示:肌钙蛋白应该成为蒽环类药物心脏毒性预防的靶点吗?

E. Bocchi, D. Belfort, M. Avila
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摘要

在过去的几十年里,肿瘤学的进步,如更好的医疗保健系统,早期的癌症诊断和新的化疗方法,导致肿瘤患者的生存时间更长[1]。然而,这一人群容易发生心血管药物相关不良事件,如心肌病,导致心力衰竭,损害生存和生活质量[2,3]。在不同类别的化疗药物中,蒽环类药物(ANT)与心肌病的关系最为密切,9%的病例可能影响肿瘤存活[4]。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insights of CECCY Trial: Should Troponin be the Target for Anthracycline Cardiotoxicity Prevention?
Advances in oncology such as better access to health care system, earlier cancer diagnosis and new chemotherapies have led to longer survival of oncologic patients over the last decades [1]. However, this population is vulnerable to cardiovascular drug-related adverse events like cardiomyopathy, which leads to heart failure and impairs survival and quality of life [2,3]. Among different classes of chemotherapeutic agents, anthracyclines (ANT) stand out as the most related to cardiomyopathy, and may affect cancer survivals in 9% of all cases [4].
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