Journal of Clinical Cardiology最新文献_第2页

Association between Leukocyte Telomere Length and Atrial Fibrillation: A Mendelian Randomization Study 白细胞端粒长度与心房颤动的关系:孟德尔随机研究

Journal of Clinical Cardiology Pub Date : 2023-06-28 DOI: 10.33696/cardiology.4.039

Jingmeng Liu, Jun Chen

{"title":"Association between Leukocyte Telomere Length and Atrial Fibrillation: A Mendelian Randomization Study","authors":"Jingmeng Liu, Jun Chen","doi":"10.33696/cardiology.4.039","DOIUrl":"https://doi.org/10.33696/cardiology.4.039","url":null,"abstract":"Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. The prevalence of AF increases significantly associated with increasing age, ranging from less than 0.5% of the population younger than 40 to 5% of those aged 65 and older and more than 10% of those surviving to the eighth decade of life. Therefore, AF is thought to be closely related to biological ageing. Telomeres (TL), repetitive DNA elements located at the ends of chromosomes, have been implicated as potential mediators of biological aging. TL is generally measured in leucocytes due to the easy accessibility of these cells in peripheral blood. Whether a causal effect of leucocytes TL (LTL) on AF is not clear. We used two-sample MR analysis model to evaluate the causal effect of LTL on AF. The summary statistics data for AF and LTL were derived from the recently published largest GWAS. Twenty SNPs at 17 genomic loci were discovered as genetic instruments for LTL. The MR analysis in the fixed-effect inverse-variance weighted models and MR Egger (bootstrap) method showed that LTL was associated with an increased risk of AF (odds ratio [OR], 1.145; 95% CI, 1.065-1.230, P<0.001; OR, 1.158; 95% CI, 1.007-1.331, P=0.021) based on 20 SNPs as the instrument variables. However, the opposite results were observed in other MR methods, which revealed LTL has no strong causal effect on AF at current evidence.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88403390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Fatal Interplay between Stress Induced Cardiomyopathy, Arrhythmia and Cardiogenic Shock 应激性心肌病、心律失常和心源性休克的致命相互作用

Journal of Clinical Cardiology Pub Date : 2023-06-28 DOI: 10.33696/cardiology.4.037

Mariam Khabsa, Bilal Al Kalaji, Sumaya Rasheed, Farah Zahra, Alok Patel

引用次数: 0

Effects of Anastomotic Angles and Distances of the Bypass Graft to the Stenosis on Blood Flow Hydrodynamics in a Bypass Grafting Coronary Artery 冠状动脉狭窄处吻合角度和吻合距离对冠状动脉搭桥术血流动力学的影响

Journal of Clinical Cardiology Pub Date : 2023-06-02 DOI: 10.33696/cardiology.2.036

A. Golshirazi, Vahid Javanbakht

{"title":"Effects of Anastomotic Angles and Distances of the Bypass Graft to the Stenosis on Blood Flow Hydrodynamics in a Bypass Grafting Coronary Artery","authors":"A. Golshirazi, Vahid Javanbakht","doi":"10.33696/cardiology.2.036","DOIUrl":"https://doi.org/10.33696/cardiology.2.036","url":null,"abstract":"It is believed that the proper distance between the grafting location and the stenosis location and the appropriate angle of graft or transplantation in the blocked artery of the heart are two important factors in the removal or decrease of reappearance and re-development of intimal hyperplasia (IH), blood clotting, and re-blockage of the surgical artery. In the present study, a 3-D geometry of the host coronary artery as non-elastic with 75% symmetric axial cross-sectional area reduction is considered. The main assumptions were incompressible, laminar, steady-state, Newtonian, and non-Newtonian (with Herschel Bulkley model) blood flow. The 3-D Navier-Stokes equations coupled with the non-Newtonian constitutive model were solved numerically using a finite volume method with the procedure of the SIMPLE program. Shear stress distribution was obtained on the areas of potential re-obstruction and the occurrence of IH such as the Toe, Heel, arterial bed, suture location, and graft artery walls. Based on the results, the distribution of wall shear stress near the Heel, Toe location, and the intersection of the host and graft arteries suddenly increased dramatically. Wall shear stress (WSS) distribution was obtained in the areas of hyperplasticity re-incidence for some important anastomosis angles of grafted arteries, i.e. α=35°,45°,65°,75°. In addition, the increase in the angle of the graft artery caused a sharp increase in the shear stress on the area after the graft and the arterial bed in front of the branching region, and the shear stress decreases in the pre-graft region. Therefore, the excessive angle of the graft artery can cause damage to the arterial endothelial cells in the surrounding suture region.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90352630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should we Target Myostatin, PCSK9 or Their Combination in Ischemia/Reperfusion Injury? 肌生成抑制素、PCSK9或两者联合治疗缺血/再灌注损伤?

Journal of Clinical Cardiology Pub Date : 2022-09-22 DOI: 10.33696/cardiology.3.029

引用次数: 0

Late ECG Changes after Cisplatin-Based Chemotherapy in Testicular Cancer Survivors 睾丸癌幸存者顺铂化疗后晚期心电图变化

Journal of Clinical Cardiology Pub Date : 2022-09-22 DOI: 10.33696/cardiology.3.027

L. Bacharova, Andrea Thaler, L. Petrikova, B. Mladosievičová, D. Světlovská, Katarina, Kalavska, Z. Krivošíková, J. Mardiak, M. Mego, M. Chovanec

引用次数: 0

The Novel Antiplatelet Agent Revacept in Cardiovascular Medicine: The Promise of Efficacy Without Bleeding 新型抗血小板药物Revacept在心血管医学中的应用:无出血疗效的前景

Journal of Clinical Cardiology Pub Date : 2022-09-22 DOI: 10.33696/cardiology.3.028

引用次数: 1

Beta 3-Adrenergic Receptor (?3-AR) Activation at the End of Sustained Ischemia and/or Early Reperfusion may Prove to be a Valuable Cardioprotective Strategy 在持续缺血和/或早期再灌注结束时激活β 3-肾上腺素能受体(?3-AR)可能被证明是一种有价值的心脏保护策略

Journal of Clinical Cardiology Pub Date : 2022-09-14 DOI: 10.33696/cardiology.2.034

R. Salie, E. Marais, A. Lochner

引用次数: 1

Prognosis of Patients with Advanced Liver Disease and Positive Stress Echocardiograms: Impact of Coronary Artery Disease, Non-alcoholic Steatohepatitis, and Beta-blocker Therapy 晚期肝病和阳性应激超声心动图患者的预后:冠状动脉疾病、非酒精性脂肪性肝炎和受体阻滞剂治疗的影响

Journal of Clinical Cardiology Pub Date : 2022-08-30 DOI: 10.33696/cardiology.2.032

K. Nazif, R. Mastouri, Joseph Zenisek, Deborah Green-Hess, M. Ghabril, H. Feigenbaum, S. Sawada

{"title":"Prognosis of Patients with Advanced Liver Disease and Positive Stress Echocardiograms: Impact of Coronary Artery Disease, Non-alcoholic Steatohepatitis, and Beta-blocker Therapy","authors":"K. Nazif, R. Mastouri, Joseph Zenisek, Deborah Green-Hess, M. Ghabril, H. Feigenbaum, S. Sawada","doi":"10.33696/cardiology.2.032","DOIUrl":"https://doi.org/10.33696/cardiology.2.032","url":null,"abstract":"Background: In the general population, a positive dobutamine stress echocardiogram (DSE) in the absence of obstructive coronary artery disease (CAD) still identifies a high risk group. DSE is a widely employed screening method in candidates for liver transplantation. We investigated the prognostic impact of a positive DSE, CAD, and clinical factors in advanced liver disease.\u0000\u0000Methods: We obtained follow-up for cardiovascular events (angina requiring revascularization, heart failure, infarction, and cardiac death) in 61 liver transplant candidates who had positive DSE and coronary angiography. Event-free survival was compared between 22 patients with obstructive CAD (≥ 70% stenosis) and 39 patients with no obstructive CAD. Cox regression was used to identify factors associated with events.\u0000\u0000Results: Over a mean follow-up of 27 ± 28 months, 21% (8/39) of patients with positive DSE and no CAD had events compared with 45% (10/22) of patients with positive DSE and CAD (p = 0.04). Event free survival was better in those without CAD (p = 0.014) but one year cardiac mortality was similar in those with (9%) and without CAD (8%). Multivariable analysis showed that beta blocker use (HR: 4.1, 95% CI: 1.7 – 9.9, p-value = 0.010), CAD (HR: 4.4 95% CI: 1.8– 10.8, p-value = 0.008), and non-alcoholic steatohepatitis (NASH) (HR: 4.9, 95% CI: 2.0 – 11.7, p-value = 0.04) were independently associated with events.\u0000\u0000Conclusion: Advanced liver disease patients with positive DSE are at increased risk. CAD, beta blocker use and NASH are independently associated with cardiac events.","PeriodicalId":15510,"journal":{"name":"Journal of Clinical Cardiology","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74829685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated Plasma Volume Status (ePVS) for Diastolic Heart Failure in the Intensive Care Unit: A Retrospective Cohort Study 重症监护病房舒张性心力衰竭的估计血浆容量状态(ePVS):回顾性队列研究

Journal of Clinical Cardiology Pub Date : 2022-08-22 DOI: 10.33696/cardiology.2.033

Jun Chen, Qiang Liu

引用次数: 0

COVID-19 Delays Presentation and Management of Acute Coronary Syndrome COVID-19延迟急性冠状动脉综合征的表现和治疗

Journal of Clinical Cardiology Pub Date : 2022-01-01 DOI: 10.33696/cardiology.3.030

引用次数: 0