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Correction to “Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning” 更正“急性一氧化碳中毒患者海马亚区异常”
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-04 DOI: 10.1111/cns.70556
{"title":"Correction to “Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning”","authors":"","doi":"10.1111/cns.70556","DOIUrl":"https://doi.org/10.1111/cns.70556","url":null,"abstract":"<p>M. Tang, T. Li, Y. Deng, et al., “Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning,” CNS Neuroscience and Therapeutics 31, no. 6 (2025): e70482, https://doi.org/10.1111/cns.70482.</p><p>In the originally published version of this article, the authors' affiliation was incomplete. The correct and complete affiliation should be stated as follows: Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Maoyuan South Street 1, Nanchong 637000, Sichuan, PR China.</p><p>We apologize for this error.</p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disruptions in Cognitive-Affective Circuitry in Major Depression Disorder: Insights From REST-Meta-MDD and Its Implication for Predicting TMS Treatment Efficacy 重度抑郁症的认知-情感回路中断:REST-Meta-MDD的见解及其对预测经颅磁刺激治疗疗效的意义
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-04 DOI: 10.1111/cns.70533
Na Zhao, Liang Li, Matthew Lock, Yi-Fan Ai, Jian Liu, Chun-Ying Zhu, Yu-Feng Zang, Hua-Ning Wang, Bao-Juan Li
{"title":"Disruptions in Cognitive-Affective Circuitry in Major Depression Disorder: Insights From REST-Meta-MDD and Its Implication for Predicting TMS Treatment Efficacy","authors":"Na Zhao,&nbsp;Liang Li,&nbsp;Matthew Lock,&nbsp;Yi-Fan Ai,&nbsp;Jian Liu,&nbsp;Chun-Ying Zhu,&nbsp;Yu-Feng Zang,&nbsp;Hua-Ning Wang,&nbsp;Bao-Juan Li","doi":"10.1111/cns.70533","DOIUrl":"https://doi.org/10.1111/cns.70533","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Major depressive disorder (MDD) is a common psychiatric disorder whose causes and manifestations are diverse and numerous. To facilitate targeted therapeutic interventions, we characterized the abnormalities in effective connectivity within the cognitive–affective (CCN—AN) circuits to identify predictive biomarkers of TMS efficacy based on a large multicenter dataset and an independent dataset from patients receiving TMS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Both functional and effective connectivity (FC, EC) were analyzed. As there was only one significant connection observed in FC, classification based on the differences in EC was performed using REST-meta-MDD. Furthermore, correlations between these abnormal connectivity and depression severity, as well as depression and suicidality alleviation, were calculated to determine their predictive implications for TMS efficacy using an independent dataset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall increased connectivity from the AN to the CCN and decreased connectivity from the CCN to the AN in MDD were observed using EC. These disruptions drove the classification accuracy up to 79.1%. Furthermore, the connection from the right inferior parietal lobule (IPL. R) to the right amygdala (AMYG.R) was negatively correlated with depression scores. Notably, the IPL connectivity to the anterior cingulate cortex (ACC) and the AMYG.R were closely correlated with depression and suicidal ideation alleviation following TMS treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that MDD is characterized by disruptions in both top-down and bottom-up emotion regulation systems. Notably, the key abnormal connectivities, particularly those from the IPL to ACC and AMYG, could predict the efficacy of TMS treatment. This insight refines MDD diagnosis and paves the way for more precise targeted interventions in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double-Blind, Sham-Controlled Trial 前额叶交流电刺激对妇科腹腔镜术后睡眠障碍的预防作用:一项随机、双盲、假对照试验
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-04 DOI: 10.1111/cns.70529
Ni Du, Jin-Jin Yang, Xin-Yu Li, Zhi-Hao Li, Kenji Hashimoto, Lei Lei, Jian-Jun Yang
{"title":"Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double-Blind, Sham-Controlled Trial","authors":"Ni Du,&nbsp;Jin-Jin Yang,&nbsp;Xin-Yu Li,&nbsp;Zhi-Hao Li,&nbsp;Kenji Hashimoto,&nbsp;Lei Lei,&nbsp;Jian-Jun Yang","doi":"10.1111/cns.70529","DOIUrl":"https://doi.org/10.1111/cns.70529","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Postoperative sleep disturbance (PSD) is a common complication following surgical procedures. We aimed to evaluate the effect of prefrontal transcranial alternating current stimulation (tACS) in preventing PSD among patients undergoing gynecological laparoscopic surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 176 eligible patients, aged 18–65 years, with ASA Class I to III, and scheduled for gynecological laparoscopic surgery, were randomly allocated to receive either a single 20-min session of prefrontal tACS (2 mA, 7 Hz) or sham stimulation immediately after extubation. The primary outcome was the occurrence of PSD on postoperative day (POD) 1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The intention-to-treat analysis showed a statistically significant reduction in PSD incidence on POD 1 in the active tACS group (23.9%) compared to the sham group (43.2%), with an odds ratio of 0.41 (95% CI, 0.22–0.79; <i>p</i> = 0.007). Additionally, patients in the active tACS group reported significantly lower anxiety scores on POD 1 (<i>p</i> &lt; 0.001), while depression scores were comparable between the groups. The active tACS group also reported significantly lower pain scores, both on PODs 1 (movement: <i>p</i> = 0.002; rest: <i>p</i> &lt; 0.001) and 3 (movement: <i>p</i> = 0.028; rest: <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A single session of prefrontal tACS significantly reduces the incidence of PSD on POD 1 and may offer additional benefits in reducing early postoperative anxiety and pain, with a favorable safety and tolerability profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>China Clinical Trial Registration Center: ChiCTR2300078658</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteocalcin Ameliorates CUMS-Induced Depressive-Like Behaviors by Reducing Mitochondrial Damage in Hippocampal Neurons 骨钙素通过减少海马神经元线粒体损伤改善cums诱导的抑郁样行为
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-01 DOI: 10.1111/cns.70530
Hui Chen, Jindong Mao, Min Wang, Qian Zhang, Rui Zheng, Zhaoxia Zhang, Qianqian Lv, Qingquan Liu, Yumei Wu, Xue Ma
{"title":"Osteocalcin Ameliorates CUMS-Induced Depressive-Like Behaviors by Reducing Mitochondrial Damage in Hippocampal Neurons","authors":"Hui Chen,&nbsp;Jindong Mao,&nbsp;Min Wang,&nbsp;Qian Zhang,&nbsp;Rui Zheng,&nbsp;Zhaoxia Zhang,&nbsp;Qianqian Lv,&nbsp;Qingquan Liu,&nbsp;Yumei Wu,&nbsp;Xue Ma","doi":"10.1111/cns.70530","DOIUrl":"https://doi.org/10.1111/cns.70530","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Depression is a common psychological disorder characterized by limited treatments. Osteocalcin (OCN), a bioactive protein that originates from bone tissue, has been implicated in emotional regulation and the reduction of oxidative stress in peripheral tissues. However, the precise mechanisms by which OCN functions within the central nervous system are still not fully understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to clarify the function of OCN in depression-like behavior, identify its functional brain region, and explore its impact on neuronal mitochondrial function and the exact molecular mechanisms involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this study, the antidepressant effects and mitochondrial protective properties of OCN were examined in adult male C57BL/6 mice subjected to chronic unpredictable mild stress (CUMS); then, the potential molecular pathway was explored both in vivo and in vitro conditions. The CUMS model was employed to induce depression in mice. Initially, depressive-like behaviors in CUMS mice were evaluated following a 3-week intraperitoneal injection of OCN. Subsequently, the expression levels and distribution of GPR158 and GPR37 were examined. Next, the specific effects of OCN on mitochondrial function were determined. Finally, the molecular pathways through which OCN demonstrates its antidepressant properties and offers mitochondrial protection were explored in both in vivo and in vitro conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>OCN significantly alleviated depressive-like symptoms in CUMS mice, which was evidenced by improvements in weight variations, increased consumption of sucrose, and a greater total distance traveled in the open field test (OFT). Additionally, it shortened the immobility time observed in both the forced swim test and the tail suspension test. OCN influenced hippocampal neuronal activity by modifying the expression levels of PR158 and GPR37, demonstrated by its ability to counteract the downregulation of both receptors in experiments conducted in vivo and in vitro. Furthermore, OCN mitigated mitochondrial damage in neurons induced by depression through the PKA/AMPK/PGC1α signaling pathway, resulting in elevated ATP levels and reduced ROS levels. Notably, inhibiting PKA and AMPK abolished OCN's effects on PGC-1α, ATP production, and ROS reduction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ABIDA: An Automated Brain Imaging Data Processing and Analysis Platform ABIDA:自动脑成像数据处理和分析平台
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-01 DOI: 10.1111/cns.70552
Han Yang, Min-Jie Zhang, Pu-Xin Sun, Xi-Jian Dai
{"title":"ABIDA: An Automated Brain Imaging Data Processing and Analysis Platform","authors":"Han Yang,&nbsp;Min-Jie Zhang,&nbsp;Pu-Xin Sun,&nbsp;Xi-Jian Dai","doi":"10.1111/cns.70552","DOIUrl":"https://doi.org/10.1111/cns.70552","url":null,"abstract":"<p>Addressing RS-fMRI toolkit limitations—notably operational complexity and expertise barriers—this study introduces ABIDA toolbox. Integrating cross-toolkit functions with intelligent algorithms and quantitative metrics enhances workflow through intuitive design and automation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-Year Outcomes After Intravenous Recombinant Tissue Plasminogen Activator for Ischemic Stroke: A Real-World Study. 静脉注射重组组织型纤溶酶原激活剂治疗缺血性卒中的一年疗效:一项现实世界研究。
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-01 DOI: 10.1111/cns.70543
Rui Xue, Xiaoxian Gong, Yuhui Huang, Wansi Zhong, Haidi Jin, Zhicai Chen, Yi Chen, Shenqiang Yan, Haitao Hu, Changzheng Yuan, Min Lou
{"title":"One-Year Outcomes After Intravenous Recombinant Tissue Plasminogen Activator for Ischemic Stroke: A Real-World Study.","authors":"Rui Xue, Xiaoxian Gong, Yuhui Huang, Wansi Zhong, Haidi Jin, Zhicai Chen, Yi Chen, Shenqiang Yan, Haitao Hu, Changzheng Yuan, Min Lou","doi":"10.1111/cns.70543","DOIUrl":"10.1111/cns.70543","url":null,"abstract":"<p><strong>Background: </strong>The longer-term benefits of intravenous recombinant tissue plasminogen activator (IV rt-PA) in Chinese acute ischemic stroke (AIS) patients remain lacking. We aimed to evaluate the 1-year clinical outcomes after IV rt-PA for Chinese AIS patients in a real-world setting.</p><p><strong>Methods: </strong>Based on a prospective multicenter stroke registry in China, we analyzed the data of patients with AIS (aged ≥ 18 years) who arrived at hospital within 4.5 h of symptom onset. Participants were from 80 stroke centers in China between January 2017 and March 2020. IV rt-PA-treated patients were propensity score-matched (1:1) by baseline characteristics with non-reperfusion patients. Primary outcome was 1-year all-cause mortality. Secondary outcomes included 1-year functional outcomes.</p><p><strong>Results: </strong>Participants were mostly male (59.9%), with a mean age of 70.2 years. One-year all-cause mortality was similar between the two groups (11.1% vs. 12.2%; HR, 0.90 [95% CI: 0.78-1.05], p = 0.183). At 1 year, the IV rt-PA group had a higher proportion of functional independence (modified Rankin Scale [mRS] 0-2: 70.9% vs. 66.4%; OR, 1.25 [95% CI, 1.12-1.39]) and favorable outcome (mRS 0-1: 59.5% vs. 54.6%; OR, 1.23 [95% CI, 1.11-1.36]) compared to the non-reperfusion group (both p < 0.001). A lower proportion of severe disability/death was also observed in the IV rt-PA group versus the non-reperfusion group (mRS 5-6: 15.9% vs. 20.3%; OR, 0.73 [95% CI, 0.64-0.83]) (all p < 0.001).</p><p><strong>Conclusions: </strong>IV rt-PA treatment in Chinese AIS patients eligible for thrombolysis was associated with improved 1-year functional outcomes despite having similar mortality to those who did not receive any reperfusion treatments.</p><p><strong>Trial registration: </strong>This study is registered on https://clinicaltrials.gov; Unique identifier: NCT0539533.</p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":"e70543"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The HBP Pathway Inhibitor FR054 Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O-GlcNAcylation. HBP通路抑制剂FR054通过促进铁凋亡和抑制o - glcn酰化增强替莫唑胺在胶质母细胞瘤细胞中的敏感性。
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-01 DOI: 10.1111/cns.70546
Rongxu Ye, Wanghao Zhang, Huayang Zhang, Shanqiang Qu, Junyi Xu, Rongyang Xu, Ye Zhu, Guanglong Huang, Xi-An Zhang, Guo-Zhong Yi
{"title":"The HBP Pathway Inhibitor FR054 Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O-GlcNAcylation.","authors":"Rongxu Ye, Wanghao Zhang, Huayang Zhang, Shanqiang Qu, Junyi Xu, Rongyang Xu, Ye Zhu, Guanglong Huang, Xi-An Zhang, Guo-Zhong Yi","doi":"10.1111/cns.70546","DOIUrl":"10.1111/cns.70546","url":null,"abstract":"<p><strong>Background: </strong>The clinical efficacy of temozolomide (TMZ) in glioblastoma (GBM) patients is often limited by the development of resistance. To date, no clinically validated therapeutic strategies exist to restore sensitivity to TMZ treatment. In this study, we investigated the potential of FR054, a hexosamine biosynthesis pathway (HBP) inhibitor, to sensitize GBM cells to TMZ and elucidated its underlying molecular mechanism.</p><p><strong>Methods: </strong>TMZ-resistant U87-MG and A172 cell lines were generated through stepwise exposure to increasing concentrations of TMZ. Proteomics and bioinformatics analyses revealed HBP activation in these resistant cells. The effects of FR054 alone or in combination with TMZ were assessed using cell line models, GBM organoid models, and intracranial xenograft models. Transcriptomic analysis and validation experiments were further conducted to explore the molecular mechanisms involved.</p><p><strong>Results: </strong>Long-term exposure to TMZ induced resistance in U87-MG and A172 GBM cells, which was associated with the activation of the HBP pathway. PGM3, a key enzyme in the HBP, was found to correlate with poor prognosis in GBM patients. The combination of FR054, a specific PGM3 inhibitor, with TMZ exhibited synergistic inhibitory effects in vitro and superior inhibitory efficacy in GBM organoid models. In vivo, this combination significantly suppressed tumor progression and prolonged survival in orthotopic xenograft mice with minimal side effects. Mechanistically, FR054 enhanced TMZ sensitivity by inhibiting protein O-GlcNAcylation and promoting ferroptosis via the upregulation of HMOX1 and downregulation of GPX4.</p><p><strong>Conclusion: </strong>Our findings demonstrate that targeting the HBP pathway with FR054 can overcome TMZ resistance in GBM by reducing O-GlcNAc modification and inducing ferroptosis. This novel approach enhances the efficacy of TMZ, offering a promising therapeutic strategy for GBM patients with limited treatment options.</p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":"e70546"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kapβ2 Reverses Sevoflurane-Induced Hydrogel Phase Transition of hnRNPA2/B1-SG in Hypoxic Primary Rat Hippocampal Neurons. Kapβ2逆转七氟醚诱导的缺氧大鼠海马神经元hnRNPA2/B1-SG水凝胶相变
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-08-01 DOI: 10.1111/cns.70532
Miao Zhang, Xinyi Wang, Feiyu Jia, Chenyi Yang, Zixuan Wang, Huihui Liao, Lin Zhang, Xi Xin, Haiyun Wang
{"title":"Kapβ2 Reverses Sevoflurane-Induced Hydrogel Phase Transition of hnRNPA2/B1-SG in Hypoxic Primary Rat Hippocampal Neurons.","authors":"Miao Zhang, Xinyi Wang, Feiyu Jia, Chenyi Yang, Zixuan Wang, Huihui Liao, Lin Zhang, Xi Xin, Haiyun Wang","doi":"10.1111/cns.70532","DOIUrl":"10.1111/cns.70532","url":null,"abstract":"<p><strong>Aims: </strong>Sevoflurane can aggravate the progression of neurodegeneration, although the underlying mechanisms remain incompletely understood. Our previous study identified a link between heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) and sevoflurane-induced neurocognitive impairments. The abnormal hydrogel phase transition of stress granules (SGs) assembled via liquid-liquid phase separation (LLPS) by hnRNPA2/B1 is a crucial element in neurodegeneration. Karyopherin-β2 (Kapβ2) is known to specifically recognize hnRNPA2/B1 and reverses the hydrogel transition of SGs. This study aimed to elucidate the mechanistic role of hnRNPA2/B1-SG phase transition in sevoflurane-induced hippocampal neuronal dysfunction under hypoxic conditions, and to determine whether Kapβ2 can mitigate these effects.</p><p><strong>Methods: </strong>Using a hypoxic primary rat hippocampal neuron model and Kapβ2 overexpression, we investigated the effects of sevoflurane on hnRNPA2/B1 expression and subcellular distribution, phase separation dynamics, and the liquid-to-solid transition of hnRNPA2/B1-associated SGs. We also assessed neuronal function and cognitive protein expression. Experimental approaches included Western blotting, RT-qPCR, immunofluorescence staining, and fluorescence recovery after photobleaching (FRAP).</p><p><strong>Results: </strong>In hypoxic hippocampal neurons, sevoflurane altered the nuclear-to-cytoplasmic distribution of hnRNPA2/B1, promoted abnormal LLPS, and facilitated the formation of irreversible solid-phase hnRNPA2/B1-containing SGs. These changes were associated with neuronal dysfunction and reduced expression of cognition-related proteins. Kapβ2 overexpression disrupted these aggregates, restored the dynamic reversibility of hnRNPA2/B1 LLPS, reversed the sevoflurane-induced hydrogel phase transition of hnRNPA2/B1-SGs, and enhanced the expression of cognition-related proteins.</p><p><strong>Conclusion: </strong>The hydrogel phase transition of hnRNPA2/B1-SG is a key pathological mechanism of sevoflurane-induced hippocampal neuronal injury. Kapβ2 may serve as a potential therapeutic target to counteract sevoflurane-related neurotoxicity.</p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":"e70532"},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Different Components and Levels of Physical Exercise, Depressive Symptoms, Inhibitory Control, and Possible Cognitive Neural Mechanisms in College Students 大学生体育锻炼不同成分与水平、抑郁症状、抑制控制及可能的认知神经机制的关系
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-07-31 DOI: 10.1111/cns.70520
Shufan Li, Shuqi Jia, Somang Yun, Zhaohui Guo, Xing Wang, QingWen Zhang
{"title":"The Relationship Between Different Components and Levels of Physical Exercise, Depressive Symptoms, Inhibitory Control, and Possible Cognitive Neural Mechanisms in College Students","authors":"Shufan Li,&nbsp;Shuqi Jia,&nbsp;Somang Yun,&nbsp;Zhaohui Guo,&nbsp;Xing Wang,&nbsp;QingWen Zhang","doi":"10.1111/cns.70520","DOIUrl":"https://doi.org/10.1111/cns.70520","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Based on event-related potential (ERP) evidence, this study aims to identify specific indicators of inhibitory control in college students with depressive symptoms, explore the relationship between different components and levels of physical exercise and the specific indicators of depressive symptoms and inhibitory control, and clarify potential targets for exercise interventions and possible mechanisms for alleviating depressive symptoms in college students.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An observational research design was adopted, utilizing convenience sampling to randomly recruit 225 college students. Participants were asked to complete a demographic questionnaire, the Beck Depression Inventory, and the Physical Activity Scale. Behavioral performance during inhibitory control tasks, as well as synchronous ERP brain signals, was collected.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Compared to healthy college students, the specific indicators of inhibitory control in college students with depressive symptoms included the Nogo accuracy and the N2 amplitude of Fz potentials under the Nogo condition for response inhibition, and the Stroop incongruent reaction time and the P3 amplitude of Fz potentials under the Stroop incongruent condition for interference inhibition (all &lt;i&gt;p&lt;/i&gt; &lt; 0.05). Physical exercise volume, intensity, duration, and frequency were significantly correlated with depressive symptom scores (all &lt;i&gt;p&lt;/i&gt; &lt; 0.05). Intensity, duration, and frequency were identified as key influencing factors. Moderate-intensity sustained exercise and high-intensity non-sustained exercise, as well as high-intensity sustained exercise, showed stronger effects. Longer durations (31–59 min and &gt; 60 min) and higher frequencies (1–2 times/week and 3–5 times/week) also showed stronger effects. Physical exercise volume and intensity were significantly correlated with the N2 amplitude of Fz potentials under the Nogo condition for response inhibition (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), with no significant differences observed for different exercise intensities (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). Physical exercise volume, intensity, and duration were significantly correlated with Stroop incongruent reaction time and the P3 amplitude of Fz potentials under the Stroop incongruent condition (all &lt;i&gt;p&lt;/i&gt; &lt; 0.05). Intensity and duration were key influencing factors. In terms of behavioral task performance, moderate-intensity sustained exercise and high-intensity non-sustained exercise, as well as high-intensity sustained exercise, exhibited stronger effects. Regarding cognitive neural processing, high-intensity non-sustai","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Plasticity Induced by Working Memory Training: Insights From Cortical Microstructure and Transcriptional Profiles 工作记忆训练诱导的神经可塑性:来自皮层微观结构和转录谱的见解
IF 5 1区 医学
CNS Neuroscience & Therapeutics Pub Date : 2025-07-30 DOI: 10.1111/cns.70479
Tian Zhang, Yuntao Gao, Yijun Li, Lin Wu, Xinxin Lin, Yilin Hou, Wei He, Yuanqiang Zhu, Jun Jiang, Yuanjun Xie, Peng Fang
{"title":"Neural Plasticity Induced by Working Memory Training: Insights From Cortical Microstructure and Transcriptional Profiles","authors":"Tian Zhang,&nbsp;Yuntao Gao,&nbsp;Yijun Li,&nbsp;Lin Wu,&nbsp;Xinxin Lin,&nbsp;Yilin Hou,&nbsp;Wei He,&nbsp;Yuanqiang Zhu,&nbsp;Jun Jiang,&nbsp;Yuanjun Xie,&nbsp;Peng Fang","doi":"10.1111/cns.70479","DOIUrl":"https://doi.org/10.1111/cns.70479","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>To investigate the effects of an 8-week standardized computerized working memory training (WMT) program on cortical microstructure, morphometric similarity network (MSN) changes, and associated genetic factors in healthy adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 76 participants were divided into WMT and control groups. Cortical morphological measurements, including cortical thickness (CT) and fractional dimensions (FD), were measured. MSN changes based on CT and FD measures were analyzed. Additionally, partial least squares (PLS) analysis was conducted to investigate the relationship between critical microstructural alterations and gene transcript expression levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The WMT group exhibited reduced response times for updating, switching functions, and phonological loop tasks. The cortical morphological measurements revealed increases in CT in several right frontal regions, as well as FD in the frontopolar and middle frontal areas after WMT compared to baseline. Furthermore, significant decreases in MSN based on CT measures were found in specific occipital and intraparietal sulci. Similarly, the MSN of FD showed notable decreases in eigenvector and degree centrality in the left frontomarginal cortex and right middle temporal gyrus. PLS analysis revealed strong links between microstructural changes and gene expression, with PLS+ genes enriched in synaptic transmission, neural regulation, and energy metabolism, while PLS− genes were associated with intracellular transport, protein modification, and stress responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings highlight the subtle influences of WMT on brain structure and underlying biological processes, providing insights into its role in neural plasticity and suggesting potential genetic contributions to these structural changes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70479","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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