Efficacy and Potential Mechanism of Chinese Herbal Formula Chaihu Shugan Powder on Animal Models of Depression: A Systematic Review and Meta-Analysis

IF 4.8 1区医学 Q1 NEUROSCIENCES

CNS Neuroscience & Therapeutics Pub Date : 2025-04-09 DOI:10.1111/cns.70375

Lulu Wu, Yi Deng, Liyuan Yu, Weihang Peng, Ya Li, Yuchao Feng, Li Chen, Peiying Huang, Bojun Chen

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引用次数: 0

Abstract

Background

Chaihu Shugan powder (CSP) is used in the clinical treatment of depression. However, its clinical mechanisms remain elusive. While acknowledging the extensive animal research, there is a need for systematic meta-analysis for comprehensive understanding. This study aims to evaluate the efficacy of CSP and its mechanisms in animal models of depression.

Methods

Animal studies on the antidepressant effects of CSP were reviewed in databases including PubMed, Web of Science, Cochrane Library, Embase database, CNKI, VIP, WangFang database, and CBM published before March 12, 2024. The R Studio software was used for statistical analyses.

Results

The present systematic review included 23 studies. The results revealed that CSP has a significant effect on behavior forced swimming test (FST) (SMD = −1.44, 95% CI: −1.87, −1.00); sucrose preference test (SPT) (SMD = 3.63, 95% CI: 1.87, 5.39), rearing numbers of open field test (OFT) (SMD = 1.46, 95% CI: 0.95, 1.96); crossing numbers of OFT (SMD = 2.15, 95% CI: 1.30, 3.01); and body weight (SMD = 2.16, 95% CI: 1.13, 3.18).

Conclusion

In summary, this study revealed that CSP could treat depression symptoms in animals, which is associated with its anti-inflammatory effects, regulation of the HPA axis, neurotrophic factors, and glucose metabolism.

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柴胡疏肝散对抑郁症动物模型的疗效及潜在机制：系统综述和meta分析

柴胡疏肝散是临床治疗抑郁症的常用方药。然而，其临床机制尚不明确。在承认广泛的动物研究的同时，需要进行系统的荟萃分析以全面了解。本研究旨在探讨CSP在抑郁症动物模型中的作用及其机制。方法检索PubMed、Web of Science、Cochrane Library、Embase数据库、中国知网（CNKI）、维普（VIP）、王方数据库、CBM等数据库在2024年3月12日前发表的有关CSP抗抑郁作用的动物实验。使用R Studio软件进行统计分析。结果本系统综述纳入23项研究。结果显示，CSP对行为强迫游泳测试（FST）有显著影响（SMD = - 1.44, 95% CI: - 1.87, - 1.00）；蔗糖偏好试验（SPT）（SMD = 3.63, 95% CI: 1.87, 5.39）、放养大田试验（OFT）（SMD = 1.46, 95% CI: 0.95, 1.96）；OFT交叉数（SMD = 2.15, 95% CI: 1.30, 3.01）；和体重（SMD = 2.16, 95% CI: 1.13, 3.18）。综上所述，本研究揭示了CSP对动物抑郁症状的治疗作用，其作用机制与其抗炎作用、调节HPA轴、神经营养因子及糖代谢有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.