CNS Neuroscience & Therapeutics最新文献

{"title":"Effects of Obstructive Sleep Apnea on Cognition: An Analysis of Electroencephalography Microstates and Alpha Peak Frequency","authors":"Yan Wang,&nbsp;Ling Luo,&nbsp;Peilin Huang,&nbsp;Shaofan Jiang,&nbsp;Xiaodong Pan","doi":"10.1111/cns.70553","DOIUrl":"https://doi.org/10.1111/cns.70553","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Respiration-related sleep disorders such as obstructive sleep apnea (OSA) are risk factors for mild cognitive impairment and age-related neurocognitive deficits. Nearly 60% of patients with OSA suffer from a variety of impaired cognitive functions, including attention, working memory, and episodic memory, and are susceptible to mood disorders such as depression and anxiety. However, it remains largely unexplored regarding the features of the electroencephalography (EEG) microstates of these patients and the potential association between the EEG microstates and the cognitive impairments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>In this study, we performed polysomnography (PSG) on 70 patients who were recruited from the Department of Neurology and subsequently categorized into the OSA group (44 patients) and the non-OSA group (26 patients). We collected and analyzed their demographic information, blood and body fluid specimens, EEG alpha peak frequency, and EEG microstates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Compared with the non-OSA group, the OSA group reported more cases of comorbid anxiety symptoms (58.5% vs. 29%), and scored significantly lower in the word classification test. Of note, compared with the non-OSA counterparts, the OSA patients displayed markedly more microstate A, a significantly higher rate of B to A microstate conversion, and drastically lower Delta and Theta power at the F7-AV position.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings confirm that OSA may affect sleep quality and cognitive function by influencing EEG activity and microstates, which highlights a potential EEG network mechanism for OSA-induced cognitive impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Central Neural Pathways Connecting the Brain and Peripheral Acupoints Using Neural Tracers","authors":"Junquan Liang,&nbsp;Weikang Sun,&nbsp;Yifu Zhou,&nbsp;Pan Zhang,&nbsp;Yuang Chen,&nbsp;Xuejie Li,&nbsp;Haoxuan He,&nbsp;Xiangkai Liu,&nbsp;Shibiao Zhou,&nbsp;Jingran Shen,&nbsp;Hongli Jiang,&nbsp;Yanzhang Chen,&nbsp;Rundong Tang,&nbsp;Luda Yan","doi":"10.1111/cns.70554","DOIUrl":"https://doi.org/10.1111/cns.70554","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Acupuncture is widely used for therapeutic purposes, but the neural mechanisms underlying its effects are not fully understood. This study aims to investigate the neural projections from acupoints and subcutaneous (sham acupoints) sites to the central nervous system, using retrograde tracing technology, to clarify the specificity of acupuncture's neural pathways.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adult C57BL/6J mice were injected with the retrograde tracer PRV-CAG-3 × mScarlet at seven acupoints (LI4, GV20, LI11, BL23, LR3, ST25, ST36) and their corresponding subcutaneous sites (sham acupoints). After 120 h, the brains were processed to assess viral expression and neural projections using histological analysis and imaging techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results revealed differences in neural projections between the acupoint groups and their corresponding subcutaneous sites. Acupoints exhibited common neural projections to regions such as the primary motor cortex (M1), secondary motor cortex (M2), gigantocellular reticular nucleus (Gi), and ventrolateral periaqueductal gray (VLPAG), while subcutaneous sites showed more diffuse and less specific projections.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compared to subcutaneous injection sites (sham acupoints), acupoints exhibit common neural projections in the brain. In contrast to the more diffuse neural projection patterns observed in subcutaneous sites (sham acupoints), acupoints display more numerous and specific neural projections in the brain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Quinazoline Derivative, QNZ, Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Th1 and Th17 Cells","authors":"Fan Yang,&nbsp;Yuan Yang,&nbsp;Gan Zhang,&nbsp;Juan Li,&nbsp;Shan Chen,&nbsp;Yan Zhou,&nbsp;Yuhang Kong,&nbsp;Xingyan Luo,&nbsp;Yang Liu,&nbsp;Ying Xu,&nbsp;Yantang Wang","doi":"10.1111/cns.70555","DOIUrl":"https://doi.org/10.1111/cns.70555","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Multiple Sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the central nervous system (CNS). Substantial evidence implicates a central role for CD4+ T cells in MS pathogenesis, particularly IFN-γ+ Th1 cells and IL-17+ Th17 cells. NF-κB plays an essential role in regulating the differentiation of Th1 and Th17 cells, which typically mediate inflammatory responses as self-triggers. QNZ is a highly selective inhibitor of NF-κB transcriptional activation. In this study, we assessed the impact of QNZ on CD4+ T-cell polarization in MS. Utilizing the experimental autoimmune encephalomyelitis (EAE) model, we investigated these aspects of MS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>EAE was induced in C57BL/6 female mice by active immunization with myelin oligodendrocyte glycoprotein (MOG)_35–55 peptide. QNZ was injected intraperitoneally (<i>i.p</i>.) once every 2 days after the first immunization. Disease severity was clinically assessed and histopathologically assessed in the CNS. Phenotyping of CD4+ T cells was performed by flow cytometry in the spleen and cervical lymph nodes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Prophylactic administration of QNZ to EAE mice suppressed the differentiation of Th1 and Th17 cells and demyelination within the spinal cord. Notably, QNZ also reduced the proportion of IFN-γ+IL-17+ Th17.1 cells, potentially playing a critical role in MS pathogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Quinazoline derivative QNZ could suppress neuroinflammation, alleviate the progression of EAE and be associated with reduced Th1 and Th17 immunity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Protein Tyrosine Phosphatase 1B Contributes to Neuropathic Pain by Aggravating NF-κB and Glial Cells Activation-Mediated Neuroinflammation via Promoting Endoplasmic Reticulum Stress”","authors":"","doi":"10.1111/cns.70557","DOIUrl":"https://doi.org/10.1111/cns.70557","url":null,"abstract":"<p>Jiao, B., Zhang, W., Zhang, C., et al. “Protein Tyrosine Phosphatase 1B Contributes to Neuropathic Pain by Aggravating NF-κB and Glial Cells Activation-Mediated Neuroinflammation via Promoting Endoplasmic Reticulum Stress,” <i>CNS Neuroscience &amp; Therapeutics</i> 30, no. 2 (2024): e14609. https://doi.org/10.1111/cns.14609.</p><p>In the original version of this article, there was an error in Figure 2A. Specifically, the representative electron microscopy image for the Sham group was incorrect. The correct image is provided below. The correction does not change the results or conclusions of this paper.</p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Subtyping of Autoimmune Encephalitis Using an Attention-Based Multi-Instance Learning Model: A Multi-Center 18F-FDG PET Study","authors":"Yueqian Sun,&nbsp;Ruizhe Sun,&nbsp;Jiahua Lv,&nbsp;Qingxia Kong,&nbsp;Cixiang Dai,&nbsp;Bin Wang,&nbsp;Xiong Han,&nbsp;Min Chen,&nbsp;Ruihan Liu,&nbsp;Yan Jiang,&nbsp;Leilei Yuan,&nbsp;Lin Ai,&nbsp;Xiaodong Yang,&nbsp;Yiqiang Chen,&nbsp;Qun Wang","doi":"10.1111/cns.70513","DOIUrl":"https://doi.org/10.1111/cns.70513","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim was to develop an attention-based model using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET imaging to differentiate autoimmune encephalitis (AE) patients from controls and to discriminate among different AE subtypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multi-center retrospective study enrolled 390 participants: 222 definite AE patients (comprising four subtypes: LGI1-AE, NMDAR-AE, GABAB-AE, GAD65-AE), 122 age- and sex-matched healthy controls, and 33 age- and sex-matched antibody-negative AE patients along with 13 age- and sex-matched viral encephalitis patients, both serving as disease controls. An attention-based multi-instance learning (MIL) model was trained using data from one hospital and underwent external validation with data from other institutions. Additionally, a multi-modal MIL (m-MIL) model integrating imaging features, age, and sex parameters was evaluated alongside logistic regression (LR) and random forest (RF) models for comparative analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The attention-based m-MIL model outperformed classical algorithms (LR, RF) and single-modal MIL in AE vs. all controls binary classification, achieving the highest accuracy (84.00% internal, 67.38% external) and sensitivity (90.91% internal, 71.19% external). For multiclass AE subtype classification, the MIL-based model achieved 95.05% (internal) and 77.97% (external) accuracy. Heatmap analysis revealed that NMDAR-AE involved broader brain regions, including the medial temporal lobe (MTL) and basal ganglia (BG), whereas LGI1-AE and GABAB-AE showed focal attention on the MTL and BG. In contrast, GAD65-AE demonstrated concentrated attention exclusively in the MTL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The m-MIL model effectively discriminates AE patients from controls and enables subtyping of different AE subtypes, offering a valuable diagnostic tool for the clinical assessment and classification of AE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning”","authors":"","doi":"10.1111/cns.70556","DOIUrl":"https://doi.org/10.1111/cns.70556","url":null,"abstract":"<p>M. Tang, T. Li, Y. Deng, et al., “Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning,” CNS Neuroscience and Therapeutics 31, no. 6 (2025): e70482, https://doi.org/10.1111/cns.70482.</p><p>In the originally published version of this article, the authors' affiliation was incomplete. The correct and complete affiliation should be stated as follows: Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Maoyuan South Street 1, Nanchong 637000, Sichuan, PR China.</p><p>We apologize for this error.</p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruptions in Cognitive-Affective Circuitry in Major Depression Disorder: Insights From REST-Meta-MDD and Its Implication for Predicting TMS Treatment Efficacy","authors":"Na Zhao,&nbsp;Liang Li,&nbsp;Matthew Lock,&nbsp;Yi-Fan Ai,&nbsp;Jian Liu,&nbsp;Chun-Ying Zhu,&nbsp;Yu-Feng Zang,&nbsp;Hua-Ning Wang,&nbsp;Bao-Juan Li","doi":"10.1111/cns.70533","DOIUrl":"https://doi.org/10.1111/cns.70533","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Major depressive disorder (MDD) is a common psychiatric disorder whose causes and manifestations are diverse and numerous. To facilitate targeted therapeutic interventions, we characterized the abnormalities in effective connectivity within the cognitive–affective (CCN—AN) circuits to identify predictive biomarkers of TMS efficacy based on a large multicenter dataset and an independent dataset from patients receiving TMS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Both functional and effective connectivity (FC, EC) were analyzed. As there was only one significant connection observed in FC, classification based on the differences in EC was performed using REST-meta-MDD. Furthermore, correlations between these abnormal connectivity and depression severity, as well as depression and suicidality alleviation, were calculated to determine their predictive implications for TMS efficacy using an independent dataset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall increased connectivity from the AN to the CCN and decreased connectivity from the CCN to the AN in MDD were observed using EC. These disruptions drove the classification accuracy up to 79.1%. Furthermore, the connection from the right inferior parietal lobule (IPL. R) to the right amygdala (AMYG.R) was negatively correlated with depression scores. Notably, the IPL connectivity to the anterior cingulate cortex (ACC) and the AMYG.R were closely correlated with depression and suicidal ideation alleviation following TMS treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that MDD is characterized by disruptions in both top-down and bottom-up emotion regulation systems. Notably, the key abnormal connectivities, particularly those from the IPL to ACC and AMYG, could predict the efficacy of TMS treatment. This insight refines MDD diagnosis and paves the way for more precise targeted interventions in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic Effect of Prefrontal Alternating Current Stimulation on Postoperative Sleep Disturbance in Patients Undergoing Gynecological Laparoscope: A Randomized, Double-Blind, Sham-Controlled Trial","authors":"Ni Du,&nbsp;Jin-Jin Yang,&nbsp;Xin-Yu Li,&nbsp;Zhi-Hao Li,&nbsp;Kenji Hashimoto,&nbsp;Lei Lei,&nbsp;Jian-Jun Yang","doi":"10.1111/cns.70529","DOIUrl":"https://doi.org/10.1111/cns.70529","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Postoperative sleep disturbance (PSD) is a common complication following surgical procedures. We aimed to evaluate the effect of prefrontal transcranial alternating current stimulation (tACS) in preventing PSD among patients undergoing gynecological laparoscopic surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 176 eligible patients, aged 18–65 years, with ASA Class I to III, and scheduled for gynecological laparoscopic surgery, were randomly allocated to receive either a single 20-min session of prefrontal tACS (2 mA, 7 Hz) or sham stimulation immediately after extubation. The primary outcome was the occurrence of PSD on postoperative day (POD) 1.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The intention-to-treat analysis showed a statistically significant reduction in PSD incidence on POD 1 in the active tACS group (23.9%) compared to the sham group (43.2%), with an odds ratio of 0.41 (95% CI, 0.22–0.79; <i>p</i> = 0.007). Additionally, patients in the active tACS group reported significantly lower anxiety scores on POD 1 (<i>p</i> &lt; 0.001), while depression scores were comparable between the groups. The active tACS group also reported significantly lower pain scores, both on PODs 1 (movement: <i>p</i> = 0.002; rest: <i>p</i> &lt; 0.001) and 3 (movement: <i>p</i> = 0.028; rest: <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A single session of prefrontal tACS significantly reduces the incidence of PSD on POD 1 and may offer additional benefits in reducing early postoperative anxiety and pain, with a favorable safety and tolerability profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>China Clinical Trial Registration Center: ChiCTR2300078658</p>\u0000 </section>\u0000 </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteocalcin Ameliorates CUMS-Induced Depressive-Like Behaviors by Reducing Mitochondrial Damage in Hippocampal Neurons","authors":"Hui Chen,&nbsp;Jindong Mao,&nbsp;Min Wang,&nbsp;Qian Zhang,&nbsp;Rui Zheng,&nbsp;Zhaoxia Zhang,&nbsp;Qianqian Lv,&nbsp;Qingquan Liu,&nbsp;Yumei Wu,&nbsp;Xue Ma","doi":"10.1111/cns.70530","DOIUrl":"https://doi.org/10.1111/cns.70530","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Depression is a common psychological disorder characterized by limited treatments. Osteocalcin (OCN), a bioactive protein that originates from bone tissue, has been implicated in emotional regulation and the reduction of oxidative stress in peripheral tissues. However, the precise mechanisms by which OCN functions within the central nervous system are still not fully understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>This study aimed to clarify the function of OCN in depression-like behavior, identify its functional brain region, and explore its impact on neuronal mitochondrial function and the exact molecular mechanisms involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this study, the antidepressant effects and mitochondrial protective properties of OCN were examined in adult male C57BL/6 mice subjected to chronic unpredictable mild stress (CUMS); then, the potential molecular pathway was explored both in vivo and in vitro conditions. The CUMS model was employed to induce depression in mice. Initially, depressive-like behaviors in CUMS mice were evaluated following a 3-week intraperitoneal injection of OCN. Subsequently, the expression levels and distribution of GPR158 and GPR37 were examined. Next, the specific effects of OCN on mitochondrial function were determined. Finally, the molecular pathways through which OCN demonstrates its antidepressant properties and offers mitochondrial protection were explored in both in vivo and in vitro conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>OCN significantly alleviated depressive-like symptoms in CUMS mice, which was evidenced by improvements in weight variations, increased consumption of sucrose, and a greater total distance traveled in the open field test (OFT). Additionally, it shortened the immobility time observed in both the forced swim test and the tail suspension test. OCN influenced hippocampal neuronal activity by modifying the expression levels of PR158 and GPR37, demonstrated by its ability to counteract the downregulation of both receptors in experiments conducted in vivo and in vitro. Furthermore, OCN mitigated mitochondrial damage in neurons induced by depression through the PKA/AMPK/PGC1α signaling pathway, resulting in elevated ATP levels and reduced ROS levels. Notably, inhibiting PKA and AMPK abolished OCN's effects on PGC-1α, ATP production, and ROS reduction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABIDA: An Automated Brain Imaging Data Processing and Analysis Platform","authors":"Han Yang,&nbsp;Min-Jie Zhang,&nbsp;Pu-Xin Sun,&nbsp;Xi-Jian Dai","doi":"10.1111/cns.70552","DOIUrl":"https://doi.org/10.1111/cns.70552","url":null,"abstract":"<p>Addressing RS-fMRI toolkit limitations—notably operational complexity and expertise barriers—this study introduces ABIDA toolbox. Integrating cross-toolkit functions with intelligent algorithms and quantitative metrics enhances workflow through intuitive design and automation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 8","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}