Lulu Wu, Yi Deng, Liyuan Yu, Weihang Peng, Ya Li, Yuchao Feng, Li Chen, Peiying Huang, Bojun Chen
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The R Studio software was used for statistical analyses.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The present systematic review included 23 studies. The results revealed that CSP has a significant effect on behavior forced swimming test (FST) (SMD = −1.44, 95% CI: −1.87, −1.00); sucrose preference test (SPT) (SMD = 3.63, 95% CI: 1.87, 5.39), rearing numbers of open field test (OFT) (SMD = 1.46, 95% CI: 0.95, 1.96); crossing numbers of OFT (SMD = 2.15, 95% CI: 1.30, 3.01); and body weight (SMD = 2.16, 95% CI: 1.13, 3.18).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>In summary, this study revealed that CSP could treat depression symptoms in animals, which is associated with its anti-inflammatory effects, regulation of the HPA axis, neurotrophic factors, and glucose metabolism.</p>\n </section>\n </div>","PeriodicalId":154,"journal":{"name":"CNS Neuroscience & Therapeutics","volume":"31 4","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70375","citationCount":"0","resultStr":"{\"title\":\"Efficacy and Potential Mechanism of Chinese Herbal Formula Chaihu Shugan Powder on Animal Models of Depression: A Systematic Review and Meta-Analysis\",\"authors\":\"Lulu Wu, Yi Deng, Liyuan Yu, Weihang Peng, Ya Li, Yuchao Feng, Li Chen, Peiying Huang, Bojun Chen\",\"doi\":\"10.1111/cns.70375\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Chaihu Shugan powder (CSP) is used in the clinical treatment of depression. However, its clinical mechanisms remain elusive. While acknowledging the extensive animal research, there is a need for systematic meta-analysis for comprehensive understanding. This study aims to evaluate the efficacy of CSP and its mechanisms in animal models of depression.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Animal studies on the antidepressant effects of CSP were reviewed in databases including PubMed, Web of Science, Cochrane Library, Embase database, CNKI, VIP, WangFang database, and CBM published before March 12, 2024. The R Studio software was used for statistical analyses.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The present systematic review included 23 studies. The results revealed that CSP has a significant effect on behavior forced swimming test (FST) (SMD = −1.44, 95% CI: −1.87, −1.00); sucrose preference test (SPT) (SMD = 3.63, 95% CI: 1.87, 5.39), rearing numbers of open field test (OFT) (SMD = 1.46, 95% CI: 0.95, 1.96); crossing numbers of OFT (SMD = 2.15, 95% CI: 1.30, 3.01); and body weight (SMD = 2.16, 95% CI: 1.13, 3.18).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>In summary, this study revealed that CSP could treat depression symptoms in animals, which is associated with its anti-inflammatory effects, regulation of the HPA axis, neurotrophic factors, and glucose metabolism.</p>\\n </section>\\n </div>\",\"PeriodicalId\":154,\"journal\":{\"name\":\"CNS Neuroscience & Therapeutics\",\"volume\":\"31 4\",\"pages\":\"\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cns.70375\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CNS Neuroscience & Therapeutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cns.70375\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CNS Neuroscience & Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cns.70375","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Efficacy and Potential Mechanism of Chinese Herbal Formula Chaihu Shugan Powder on Animal Models of Depression: A Systematic Review and Meta-Analysis
Background
Chaihu Shugan powder (CSP) is used in the clinical treatment of depression. However, its clinical mechanisms remain elusive. While acknowledging the extensive animal research, there is a need for systematic meta-analysis for comprehensive understanding. This study aims to evaluate the efficacy of CSP and its mechanisms in animal models of depression.
Methods
Animal studies on the antidepressant effects of CSP were reviewed in databases including PubMed, Web of Science, Cochrane Library, Embase database, CNKI, VIP, WangFang database, and CBM published before March 12, 2024. The R Studio software was used for statistical analyses.
Results
The present systematic review included 23 studies. The results revealed that CSP has a significant effect on behavior forced swimming test (FST) (SMD = −1.44, 95% CI: −1.87, −1.00); sucrose preference test (SPT) (SMD = 3.63, 95% CI: 1.87, 5.39), rearing numbers of open field test (OFT) (SMD = 1.46, 95% CI: 0.95, 1.96); crossing numbers of OFT (SMD = 2.15, 95% CI: 1.30, 3.01); and body weight (SMD = 2.16, 95% CI: 1.13, 3.18).
Conclusion
In summary, this study revealed that CSP could treat depression symptoms in animals, which is associated with its anti-inflammatory effects, regulation of the HPA axis, neurotrophic factors, and glucose metabolism.
期刊介绍：
CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.
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