Journal of clinical & cellular immunology最新文献_第8页

A Missing Link between Neuron Specific Enolase Release and Poor Prognosis in Aging Patients with B-cell Lymphoma. 神经元特异性烯醇化酶释放与老年 B 细胞淋巴瘤患者预后不良之间的缺失联系

Journal of clinical & cellular immunology Pub Date : 2018-01-01 Epub Date: 2018-05-15 DOI: 10.4172/2155-9899.1000e121

Rachel Polcyn, Jason God, Mollie Capone, Denise Matzelle, Naren L Banik, Azizul Haque

引用次数: 0

Sudden Lower Limb Arthralgia/Trauma Triggering Fibromyalgia 突发下肢关节痛/创伤引发纤维肌痛

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000557

S. Ismail

引用次数: 0

Total Glucosides of Paeony in Combination with Mizolastine Decreased Serum Concentrations of Il-17 And Il-25 in Patients with Chronic Autoimmune Urticaria: A 12-Week Study 白芍总苷联合咪唑斯汀降低慢性自身免疫性荨麻疹患者血清Il-17和Il-25浓度:一项为期12周的研究

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000570

Shuzhen Qi, S. Hu, Min Zhou, Yingxia Gao, Y. Wu, Zufeng Sun, Qingjie Hu

引用次数: 0

The Salutogenic Effects of Cow’s Milk and Dairy Products in Celiac Disease 乳糜泻中牛奶及乳制品的有益健康作用

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000549

Lerner Aaron, Matthias Torsten

引用次数: 1

Immunomodulatory and Anticancer Activities of Enterocin Oe-342 Produced by Enterococcus Feacalis Isolated from Stool 粪肠球菌产肠蛋白e-342的免疫调节和抗癌活性

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000558

Omnia Momtaz Al-Fakharany, A. Aziz, T. El-Banna, F. Sonbol

{"title":"Immunomodulatory and Anticancer Activities of Enterocin Oe-342 Produced by Enterococcus Feacalis Isolated from Stool","authors":"Omnia Momtaz Al-Fakharany, A. Aziz, T. El-Banna, F. Sonbol","doi":"10.4172/2155-9899.1000558","DOIUrl":"https://doi.org/10.4172/2155-9899.1000558","url":null,"abstract":"Objectives: This study evaluated the anticancer activity of Entr. faecalis enterocin OE-342 by testing its direct antitumor effects on colorectal cancer cell line, as well as, its immunomodulatory effects. Methods: The anticancer potentiality of this enterocin against human colorectal adenocarcinoma (HCT-116) cells was evaluated using cytotoxicity, cell cycle analysis, apoptosis and monitoring morphological changes of the treated cells. Also the immunomodulatory effects of the tested enterocin were quantified on LPS-induced PBMCs cell model with monitoring TNF-α and IFNγ levels using flowcytometry. Results: The obtained data showed that enterocin OE342 inhibited HCT-116 cellular viability in a concentration dependant manner with somewhat high IC50 value recording 49.920 mg/ml. Upon HCT-116 treatment with this enterocin the appearance of undergoing apoptotic cells characterized by cellular rounding up, shrinkage and membrane blebbing was observed. Cytotoxicity of enterocin OE-342 was accompanied by cell cycle arrest in the G2/M phase (24.66%) accompanied with an increase in the ratio of the apoptotic cells in the preG1cell cycle phase. Also, this enterocin affected the generation of TNF-α and IFNγ from LPS-induced PBMCs cell resulting in inhibition of the first by 27.3% and induction of the second by 69.5% which suggest the immunomodulatory effects of the tested enterocin. Conclusion: Taken together, our results suggest the anticancer potentialities of enterocin OE-342 against human colon cancer cells represented through its effects on both apoptotic and inflammatory pathways.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90057920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Parkinson's disease is Subtly Distinguishable from Vascular Parkinsonism as shown by their Variable Ranges of Sensitivity to Dopaminergic Therapy 帕金森氏病与血管性帕金森氏病的微妙区别在于它们对多巴胺能治疗的不同敏感范围

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000556

F. Zarola

引用次数: 1

Immunomodulatory Effects of Phyllanthus muellerianus: A Mechanistic Approach 千叶草免疫调节作用的机理研究

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000565

Martha N. Ofokansi, C. Nworu, T. Akunne, M. Agbo, P. Akah

引用次数: 4

The anti-neo-epitopes tissue and microbial transglutaminases are new reliable serological markers in celiac disease diagnosis 抗新表位组织和微生物转谷氨酰胺酶是诊断乳糜泻新的可靠的血清学标志物

Journal of clinical & cellular immunology Pub Date : 2017-12-01 DOI: 10.4172/2155-9899-C1-041

Lerner Aaron

{"title":"The anti-neo-epitopes tissue and microbial transglutaminases are new reliable serological markers in celiac disease diagnosis","authors":"Lerner Aaron","doi":"10.4172/2155-9899-C1-041","DOIUrl":"https://doi.org/10.4172/2155-9899-C1-041","url":null,"abstract":"I humans, a complex interaction between the host immune system and commensal microbiota is required to maintain gut homeostasis. In this symbiotic relationship, the microbiota provides carbohydrate fermentation and digestion, vitamin synthesis and gut-associated lymphoid tissue development, as well as preventing colonization by pathobionts, whereas the host offers a niche and nutrients for the survival of the microbiota. However, when this mutualistic relationship is compromised and an altered interaction between immune cells and microorganisms occurs, the gut microbiota may contribute to the autoimmune diseases development. Researchers have made efforts to clarify the role of the microbiota in autoimmune disease and find new therapeutic approaches to treat immune-mediated diseases. However, the exact mechanisms involved in the breakdown of the gut epithelial barrier and bacterial translocation are currently unknown. In our autoimmune diabetes study, we observed prevalence of Bacteroides vulgatus, Bacteroides rodentium, Blautia coccoides, Prevotella copri, Akkermansia muciniphila and Bacteroides xylanisolvens. Positive correlation was found (P=0.02; r=0.67) between fasting glucose and glycated hemoglobin A1C percentages (P=0.03; r= 0.74) with Bacteroides xylanisolvens. Plasma levels of IL-6 were increased in patients (P<0.05) and negative correlations between TNF (P=0.04; r=-0.57) and IFN-γ (P=0.01; r=-0.65) with Bacteroides xylanisolvens readings were observed. In conclusion, we observed dysbiosis in T1D patients, with lower diversity of phyla and species compared with controls. Further studies with the gram-negative Bacteroides xylanisolvens are necessary to determine whether it may represent a target for probiotics.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72648486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus 幽门螺杆菌感染与系统性红斑狼疮的关系

Journal of clinical & cellular immunology Pub Date : 2017-11-16 DOI: 10.4172/2155-9899.1000528

Arefeh Ejtehadi, R. Roghanian, Z. Bonakdar

{"title":"Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus","authors":"Arefeh Ejtehadi, R. Roghanian, Z. Bonakdar","doi":"10.4172/2155-9899.1000528","DOIUrl":"https://doi.org/10.4172/2155-9899.1000528","url":null,"abstract":"Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune disease of unknown etiology. However, a complex combination of host and environmental factors are believed to play a pivotal role. In the pathogenesis of SLE, several infectious agents have been held responsible such as Cytomegalovirus, Parvovirus B19, Epstein Barr virus and Retrovirus. There is a variable relationship between SLE and Helicobacter, which is different from that of lupus and other infections. The aim of this study was to investigate the association between Helicobacter pylori (H.pylori) infection and SLE development. Method: In this study, 82 serum samples and 65 stool samples were collected from the SLE patients as well as the control group, respectively. An enzyme-linked immunosorbent assay (ELISA) was used to detect the presence of specific IgG/IgM antibodies against H.pylori in all serum samples. The presence of H.pylori antigen was examined in all stool samples by using stool antigen test. Suitable statistical analysis was applied. Results: Thirteen (15.9%) out of 82 SLE patients and 30 (36.6%) out of 82 control group were anti-H.pylori IgM seropositive. There was a significant difference between the level of IgM in SLE patients and control group (p 0.05). Conclusions: Based on data obtained in this study, it is concluded that there was a significant difference between the number of IgM seropositive in SLE patients and control group, which shows that SLE disease may have an inhibitory role in H.pylori infection occurance.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Measurement of Serum Levels of Interleukin 17 and 23 in the Immune System with Different Amounts of Spleens White Pulp Size after Inoculation of New Leishmania Vaccine in Susceptible Mice 新型利什曼原虫疫苗接种后不同脾脏白髓大小免疫系统白细胞介素17和23水平的测定

Journal of clinical & cellular immunology Pub Date : 2017-11-15 DOI: 10.4172/2155-9899.1000527

A. Latifynia, M. Gharagozlou, R. Samani, S. Charedar, Bagheri Hadi, H. Homa, Khansari Nematollah

{"title":"Measurement of Serum Levels of Interleukin 17 and 23 in the Immune System with Different Amounts of Spleens White Pulp Size after Inoculation of New Leishmania Vaccine in Susceptible Mice","authors":"A. Latifynia, M. Gharagozlou, R. Samani, S. Charedar, Bagheri Hadi, H. Homa, Khansari Nematollah","doi":"10.4172/2155-9899.1000527","DOIUrl":"https://doi.org/10.4172/2155-9899.1000527","url":null,"abstract":"Objective: Different species of Leishmania parasite can cause leishmaniasis and its prevalence is growing in Iran and same as in other parts of the world is twice every ten years. According to studies conducted an effective vaccine is better way to prevent this disease than anthers. Method: In our study, six groups were vaccinated and the seventh group was control group. The vaccine groups received two injection doses (100 and 200 micrograms/0.1 ml) of cocktail leishmania vaccine respectively both with two adjuvants ( Teucrium Polium or BCG). Results: Results showed that mice survived along study period in all vaccinated groups. The serum cytokine’s results showed that IL-23 was highest in group LT100 μg/0.1 ml and group LBT 200 μg/0.1 ml was lowest, and, highest IL-17 related to control and LBT 100 μg/0.1 ml and lowest to LBT 200 μg/0.1 ml. Spleen results show that highest mean of spleen weight related to LT100 μg/0.1 ml and lowest to LBT 100 and 200 μg/0.1 ml. The highest percentage of median spleen divided by the mean body weight related to same three groups: LB 100, LB200, LT200 μg/0.1 ml and lowest to LBT200 μg/0.1 ml. The largest number of spleen's lymphoid follicles: related to LB 200 μg/0.1 ml and lowest to LT100. Conclusion: Our findings about health, decline of mortality and undesirable immunological changes of this new leishmania vaccine show that no significant changes were observed in its IL-17, IL-23. Besides that, It was safe, harmless, without any complications and clinical pathological macroscopic and microscopic dangerous in animal models, and one of the most important points was survival of mice along study. The experience with the vaccine was repeated for the third time and the results were satisfactory and confirmed our previous experience on this new formulation of leishmania vaccine.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"33 5","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72553097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1