Journal of clinical & cellular immunology最新文献_第7页

Immuno-modulatory and Therapeutic Effect of Curcumin in an Allergensensitized Murine Model of Chronic Asthma 姜黄素对慢性哮喘致敏小鼠模型的免疫调节和治疗作用

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000551

Pramathadhip Paul, Sourav Majhi, S. Mitra, E. Banerjee

{"title":"Immuno-modulatory and Therapeutic Effect of Curcumin in an Allergensensitized Murine Model of Chronic Asthma","authors":"Pramathadhip Paul, Sourav Majhi, S. Mitra, E. Banerjee","doi":"10.4172/2155-9899.1000551","DOIUrl":"https://doi.org/10.4172/2155-9899.1000551","url":null,"abstract":"Background: Asthma is a chronic allergic disease of the lung and airways, characterized by persistent inflammation and airway hyper-responsiveness. More than 200 million people are affected with severe asthma worldwide. T cells, especially Th2 cells, secreting IL-4, IL-5 and IL-13, are pivotal in orchestrating the disease process. We herein investigated the inhibition mechanism of curcumin, a polyphenol present in turmeric, and its ability to alleviate allergic asthma in C57BL/6J mice.Methods: Mice were sensitized and challenged with Ovalbumin for 54 days. We investigated cellular infiltration in blood and BALF, assessed levels of serum IgE, assessed structural changes by histological analysis, and determined the levels of expression of relevant genes and proteins.Results: Our data revealed that curcumin has some anti-inflammatory effect and is successful in ameliorating the disease. We found that curcumin most likely acts by inhibiting the activation of NFκB and its subsequent downstream processes. Our data provided evidence in support of therapeutic application of curcumin in allergic inflammation and airway remodeling.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"150 2 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91128298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Lactic Acid Bacteria as Vectors: A Novel Approach for Mucosal Vaccine Delivery 乳酸菌作为载体:一种新的粘膜疫苗递送方法

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000548

B. Israr, Jae-Han Kim, S. Anam, F. R. Anjum

{"title":"Lactic Acid Bacteria as Vectors: A Novel Approach for Mucosal Vaccine Delivery","authors":"B. Israr, Jae-Han Kim, S. Anam, F. R. Anjum","doi":"10.4172/2155-9899.1000548","DOIUrl":"https://doi.org/10.4172/2155-9899.1000548","url":null,"abstract":"Lactic Acid Bacteria (LAB) has been used in food industry due to its classification as food grade microorganism. It has been used for food production as well as preservation on large scale. It is also considered as promising bacterial strain due to its probiotic activity that confirms human health. Moreover, it also shows resistance regarding its survival in Gastrointestinal Tract (GIT). Therefore, use of LAB as delivery platform for drugs as well as production of recombinant protein is a challenging approach for researchers now a day. As, it not only reduces the production cost of drug, but also act as live vector to synthesize and deliver target or therapeutic protein of interest. Moreover, it is possible to produce different proteins from same bacteria simultaneously. Thus altogether, this approach has not only provided an alternative option for intravenous administration of recombinant protein but also gives an alternative insight for delivery system of mucosal vaccine. This review aims to provide an overview in order to use specific species of LAB such as lactococci lactis and Lactobacillus as vector for transfer of vaccine for mucosal as well as in recombinant form. Moreover, use of intron for desired genetic variation into target sites is explained to give directional insight for future studies.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"70 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75055143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Lupus Profundus as an Initial Manifestation of a Late Indolent SLE 深狼疮是迟发性红斑狼疮的初始表现

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000572

H. M. Attia

引用次数: 0

Modulation of the CD141/DC-SIGN/CD1c Monocyte by the Airway Epithelium: a Dysregulated Mechanism in Chronic Inflammatory Lung Disorders? 气道上皮对CD141/DC-SIGN/CD1c单核细胞的调节:慢性炎性肺疾病的失调机制?

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000542

C. Obregón

引用次数: 0

Facilitating Cells: A Journey from Bench to Bedside 促进细胞:从实验室到床边的旅程

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000545

A. Merchak, A. Chhabra, S. Ildstad

{"title":"Facilitating Cells: A Journey from Bench to Bedside","authors":"A. Merchak, A. Chhabra, S. Ildstad","doi":"10.4172/2155-9899.1000545","DOIUrl":"https://doi.org/10.4172/2155-9899.1000545","url":null,"abstract":"The development of safe conditioning protocols has reduced the morbidity and mortality of hematopoietic stem cell transplantation (HSCT), allowing broader application for treatment of a variety of non-malignant conditions including autoimmune diseases, hemoglobinopathies, metabolic disorders etc., as well as inducing tolerance to solid organ transplants. One of the most successful clinical trials using a facilitating cell enhanced HSCT paired with a kidney transplant has effectively induced tolerance in the absence of immunosuppressive drugs, maintaining the function of the transplanted kidney, and reconstituting the immunocompetence of the recipient. This novel protocol eliminates the need for immunosuppressive drugs, the key source of kidney and liver toxicity, increased malignancy, and shortened life span. CD8+ TCR facilitating cells (FC) are a population of tolerogenic cell which promote hematopoietic stem cell engraftment across human leukocyte antigen (HLA) barriers. In this review, we discuss the bench to bedside journey of FC, from discovery in mouse models, characterization of the subpopulations of FC, the mechanisms by which FC induce tolerance and clinical application. As a novel personalized medicine, FC may change the approach to overcoming HLA barriers for both HSCT and solid organ transplant recipients.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"33 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74659539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prednisone May Improve the Outcomes of Women with Recurrent Pregnancy Loss and Increased Levels of Peripheral Nk Cells: A Real World Clinical Report 强的松可能改善复发性流产妇女的结局和外周血Nk细胞水平升高:一份真实世界的临床报告

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000571

P. Micco, I. Strina, R. Nisini, Marco Antonio Rigatti, C. Lodigiani

引用次数: 0

In Vitro Analysis of Visceral Leishmaniasis and Pulmonary Tuberculosis Patient’s Cytokines Responses to Related and Unrelated Antigen Stimulation 内脏利什曼病和肺结核患者细胞因子对相关和不相关抗原刺激的体外分析

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000560

H. F. G. Mahgoob, M. Mukhtar

引用次数: 0

Venoms versus Vasculature and Hemostasis: In Search for Non-Hemorrhagic Anti- Hemostatic Venom Components 毒液与血管和止血:寻找非出血性抗止血毒液成分

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000563

J. Eble, M. Estevão-Costa, S. Niland, E. Sanchez

{"title":"Venoms versus Vasculature and Hemostasis: In Search for Non-Hemorrhagic Anti- Hemostatic Venom Components","authors":"J. Eble, M. Estevão-Costa, S. Niland, E. Sanchez","doi":"10.4172/2155-9899.1000563","DOIUrl":"https://doi.org/10.4172/2155-9899.1000563","url":null,"abstract":"Snake venoms target multiple essential organ systems, among them the hemostatic system and the vasculature. Both snake venom serine proteinases (SVSPs) and snake venom metalloproteinases (SVMPs) exist which cleave coagulation factors, platelet receptors and/or extracellular matrix (ECM) components. To treat vascular occlusion and ischemic diseases, cleavage of coagulation factors and platelet receptors is a treatment goal, whereas degradation of the vessel wall ECM results in unwanted and life-threatening hemorrhages. Identification of anticoagulant and antithrombotic snake venom proteinases, which are non-hemorrhagic, provides potential new pharmacological tools. While larger forms of SVMPs belonging to the P-III and P-IIsubclasses are hemorrhagic in general, some P-I-SVMPs and SVSPs offer the potential to cleave fibrinogen thereby forming easily dissolvable clots or degrading fibrin, without attacking the vascular ECM. However, it is unclear which features of the molecular structures determine whether a P-I-SVMP belongs to this medically relevant group of fibrin(ogen)olytic, nonhemorrhagic snake venom proteinases.","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89757596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Secoisolariciresinol Diglycoside in Carbon Tetrachloride Induced Hepatotoxicity in Rats 二异松脂醇二糖苷对四氯化碳致大鼠肝毒性的保护作用

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000567

S. Mareai, Khalid Mohammed Naji, K. Gawli, J. Rajesha

引用次数: 3

Identification of Thyroglobulin and its Isoforms as Target Antigens for IgG4 Thyroiditis 甲状腺球蛋白及其同型异构体作为IgG4甲状腺炎靶抗原的鉴定

Journal of clinical & cellular immunology Pub Date : 2018-01-01 DOI: 10.4172/2155-9899.1000568

Keiko Inomata, Hironori Kurisaki, H. Yamashita, Shinya Sato, S. Tachibana, K. Kakudo, Yaqiong Li, Hidenobu Koga, S. Nagafuchi

{"title":"Identification of Thyroglobulin and its Isoforms as Target Antigens for IgG4 Thyroiditis","authors":"Keiko Inomata, Hironori Kurisaki, H. Yamashita, Shinya Sato, S. Tachibana, K. Kakudo, Yaqiong Li, Hidenobu Koga, S. Nagafuchi","doi":"10.4172/2155-9899.1000568","DOIUrl":"https://doi.org/10.4172/2155-9899.1000568","url":null,"abstract":"Copyright: © 2018 Inomata K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Identification of Thyroglobulin and its Isoforms as Target Antigens for IgG4 Thyroiditis Keiko Inomata1#*, Hironori Kurisaki2#, Hiroyuki Yamashita1,3, Shinya Sato3, Seigo Tachibana4, Kennichi Kakudo5, Yaqiong Li6, Hidenobu Koga7 and Seiho Nagafuchi8* 1Department of Clinical and Laboratory Medicine, Yamashita Thyroid Hospital, Fukuoka, Japan 2Department of Medical Science and Technology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Surgery, Yamashita Thyroid Hospital, Fukuoka, Japan 4Department of Endocrinology, Yamashita Thyroid Hospital, Fukuoka, Japan 5Department of Pathology, Faculty of Medicine, Kindai University, Ikoma, Japan 6Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, PR China 7Clinical Research Support Office, ASO Iizuka Hospital, Iizuka, Japan 8Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan #These authors contributed equally","PeriodicalId":15473,"journal":{"name":"Journal of clinical & cellular immunology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74419043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5