Journal of Clinical Psychopharmacology最新文献_第3页

Article Selected to Receive the Mitchell B. Balter Award. 文章被选为米切尔B.巴尔特奖。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1097/JCP.0000000000001992

Anthony J Rothschild, Richard I Shader, Richard Balon, Susan L McElroy

引用次数: 0

Bicytopenia in the Context of Olanzapine Treatment: A Case Report. 奥氮平治疗中的双氧体减少症：1例报告。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1097/JCP.0000000000001977

Blanca Serra-Sarró, Darío Ramis, Helena Álvarez, Ailin Herrero, Cecilia Mantellini, Miguel Vicente, Rosa Catalán, Miquel Bioque, Vicent Llorca-Bofí

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N -Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome : A Case Series. n -乙酰半胱氨酸对威廉斯综合征3例成人非自杀自伤行为的影响

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1097/JCP.0000000000001976

Hagar Kandel, Ava R Cruz, Robyn P Thom, Christopher J McDougle

{"title":"N -Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome : A Case Series.","authors":"Hagar Kandel, Ava R Cruz, Robyn P Thom, Christopher J McDougle","doi":"10.1097/JCP.0000000000001976","DOIUrl":"10.1097/JCP.0000000000001976","url":null,"abstract":"Background: Williams syndrome (WS) is a genetic disorder that results from a microdeletion of 25 to 27 genes on chromosome 7q11.23. Individuals with WS often exhibit comorbid neuropsychiatric symptoms, especially anxiety. To our knowledge, nonsuicidal self-injurious behavior (NSSIB) has not been reported in WS. N -acetylcysteine (NAC) is a safe and readily available drug that may modulate glutamate activity in the brain. NAC is effective for treating various neuropsychiatric symptoms and disorders. There are limited reports in the literature where NAC has been used to treat NSSIB effectively, but none in WS.Methods: This report describes using NAC to treat NSSIB in 3 adults with WS.Findings: Nonsuicidal self-injurious behavior was successfully treated in 3 adults with WS using NAC in doses ranging from 2400 to 3600 mg a day, resulting in significant improvement in their daily functioning. Additionally, NAC was well tolerated.Conclusions: NAC was effective for treating NSSIB in 3 adults with WS. By addressing these challenging behaviors, NAC offers a promising pharmacological intervention that can significantly improve the quality of life for patients with WS who engage in NSSIB. Further research and clinical trials are necessary.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"277-281"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Neutropenia Associated With Duloxetine: A Case Study of an 80-Year-Old Man With Depression Related to Long COVID. 度洛西汀相关中性粒细胞减少的风险：一名80岁男性长期COVID相关抑郁症病例研究

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1097/JCP.0000000000001978

Masahiro Ono, Sachiko Eguchi, Tetsuya Hagiwara, Daimei Sasayama, Shinsuke Washizuka

引用次数: 0

Persistent Psychosis Associated With Intravenous Ketamine in a Patient Using Cannabis: A Case Report and Literature Review. 持续精神病与静脉注射氯胺酮大麻患者：一个病例报告和文献综述。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1097/JCP.0000000000001995

Rachel M Pacilio, Jamarie A Geller

引用次数: 0

Citalopram-Associated Hyponatremia Presenting as Distal Extremity Numbness: A Case Report. 西酞普兰相关低钠血症表现为远端肢体麻木：1例报告。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1097/JCP.0000000000001994

Chenyue Xu, Lingzhuo Kong, Shaohua Hu, Jianbo Lai

引用次数: 0

Antimicrobial Exposure and Risk for Incident Major Depressive Disorder. 抗微生物药物暴露与发生重度抑郁症的风险。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1097/JCP.0000000000002004

Hope Thelander, Brett Heintz, Lucas Watson, Bruce Alexander, Brian C Lund

{"title":"Antimicrobial Exposure and Risk for Incident Major Depressive Disorder.","authors":"Hope Thelander, Brett Heintz, Lucas Watson, Bruce Alexander, Brian C Lund","doi":"10.1097/JCP.0000000000002004","DOIUrl":"10.1097/JCP.0000000000002004","url":null,"abstract":"Background: Antibacterials are among the most frequently prescribed medications. Antibacterial drugs have the unintended consequence of destroying healthy gut flora, which can lead to known adverse events such as Clostridium difficile infection. Given emerging research concerning the role of these microorganisms in the gut-brain axis and some limited epidemiological studies, the objective of this study was to determine if antimicrobial exposure is associated with increased risk for depression.Methods: National Veterans Health Administration administrative data were used to identify 878,405 veteran patients prescribed an incident antimicrobial during calendar year 2018. Sequence symmetry analysis was used to compare the incidence of a depressive disorder in the 6 months before and after antibacterial exposure, with additional analyses conducted with other antimicrobial classes as negative controls including antifungals, antivirals, and nonsystemic antibacterials.Results: Antibacterial initiation was associated with a small but significant increase in the risk of incident depression (symmetry ratio [SR] = 1.04, 95% confidence interval [CI]: 1.03, 1.05), which was limited to the first 8 weeks following exposure. The strength of association varied with categories of antibacterial spectrum, from SR = 0.98 (95% CI: 0.95, 1.01) with the narrowest spectrum regimens, to SR = 1.12 (95% CI: 1.09, 1.15) with the broadest regimens. No significant association with incident depression was observed for antifungals, antivirals, and nonsystemic antibacterials.Conclusions: Antibacterial exposure was associated with increased risk for a depressive disorder. These findings are consistent with emerging literature and support the need for further research investigating a causal relationship between antibacterial exposure and risk for adverse mental health outcomes.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"219-224"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1097/JCP.0000000000001997

Madhuri H Nanjundaswamy, Aana Shah, Shraddha Lotlikar, Rashmi Arasappa, Sundarnag Ganjekar, Harish Thippeswamy, Prabha S Chandra, Geetha Desai

{"title":"Lactation-Related Side Effects of Aripiprazole: A Study From Perinatal Psychiatry Services in India.","authors":"Madhuri H Nanjundaswamy, Aana Shah, Shraddha Lotlikar, Rashmi Arasappa, Sundarnag Ganjekar, Harish Thippeswamy, Prabha S Chandra, Geetha Desai","doi":"10.1097/JCP.0000000000001997","DOIUrl":"10.1097/JCP.0000000000001997","url":null,"abstract":"Background: Aripiprazole, a prolactin-sparing antipsychotic, is considered relatively safe during pregnancy and has a better metabolic profile compared to other antipsychotics. However, its impact on lactation has not been adequately studied. This study aimed to assess the relationship between aripiprazole use during pregnancy and the postpartum period with lactation outcomes.Methods: Clinical charts of women attending perinatal psychiatry services between January 2016 and December 2021 were reviewed for details of aripiprazole prescription, clinical information, and lactation outcomes. Lactation failure was defined as the total absence of milk flow or secretion of minimal amounts for at least 7 days.Results: Among the 398 women attending perinatal psychiatry services, 60 were prescribed aripiprazole during pregnancy, with lactation data available for 35 women who continued the drug during the postpartum period. The mean age of women in years was 29 (±4.4) years. The most common diagnosis for aripiprazole prescription was schizophrenia (60%). Approximately 54.2% of the women were primiparous. Of the 35 women with available lactation data, 26 (74%) experienced complete lactation failure, and 4 (11%) had insufficient milk production while on aripiprazole. The mean dose of aripiprazole was 16.4 mg/day, with a mean duration of use of 20 months.Conclusions: In this study, most women who continued aripiprazole through pregnancy and postpartum experienced either lactation failure or insufficient milk production. It is important to discuss lactation issues associated with the use of aripiprazole with women during pregnancy and the postpartum period.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"258-266"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relapse in Anorexia Nervosa Associated With Tirzepatide: A Case Report. 替西帕肽治疗神经性厌食症复发1例。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1097/JCP.0000000000001975

Anna I Guerdjikova, Heather Dlugosz, Robert Wolterman, Susan L McElroy

引用次数: 0

The Impact of Once Daily Dosing on Protein Binding of Clozapine and Norclozapine. 每日一次给药对氯氮平和去氯氮平蛋白结合的影响。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.1097/JCP.0000000000001979

Marieke M Beex-Oosterhuis, S F Cedric Lau, Charlotte van Kesteren, Steven Verloop, Koen P Grootens, Gunnar Faber, Arthur R Van Gool, E R Rob Heerdink, Rob J van Marum, Daan J Touw

{"title":"The Impact of Once Daily Dosing on Protein Binding of Clozapine and Norclozapine.","authors":"Marieke M Beex-Oosterhuis, S F Cedric Lau, Charlotte van Kesteren, Steven Verloop, Koen P Grootens, Gunnar Faber, Arthur R Van Gool, E R Rob Heerdink, Rob J van Marum, Daan J Touw","doi":"10.1097/JCP.0000000000001979","DOIUrl":"10.1097/JCP.0000000000001979","url":null,"abstract":"Purpose/background: Clozapine and norclozapine are highly protein bound. Currently, clozapine is increasingly prescribed once daily (QD). Higher (once daily) doses may theoretically lead to saturation of protein binding of (nor)clozapine, resulting in increased unbound fractions. This study investigated whether protein binding of clozapine and norclozapine becomes saturated at higher concentrations. Secondly, the correlation between unbound (nor)clozapine fractions and alpha-1 acid glycoprotein (AGP) concentrations was studied.Methods/procedures: From 44 patients taking clozapine QD or twice daily a total of 319 blood samples were collected at different time points within a dose interval. AGP concentrations were measured in samples drawn just before clozapine intake. A validated liquid chromatography-tandem mass spectrometry method was used for quantification of the (nor)clozapine concentrations. Ultrafiltration was used to separate the bound and unbound molecules. The relation between total concentrations and fractions, and between unbound fractions and AGP concentrations were investigated using linear mixed model analysis.Findings/results: There was no significant correlation between total clozapine ( P = 0.270) and norclozapine ( P = 0.678) concentrations and its unbound fractions with total clozapine concentrations up to 1500 μg/L. A statistically significant (negative) correlation between AGP concentrations and clozapine ( P = 0.000) and norclozapine ( P = 0.028) unbound fractions was found.Implications/conclusions: In general, total concentrations remain suitable for therapeutic drug monitoring if clozapine is used once daily. Future research is needed to define if higher total concentrations are warranted in case of lower unbound fractions due to increased AGP concentrations.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"231-235"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0