Journal of Clinical Psychopharmacology最新文献

{"title":"Question: Which Antidepressants Would Be Safest to Use in an Elderly Patient, Currently Taking Bupropion, Experiencing Decreasing Renal Function?","authors":"Carl Salzman","doi":"10.1097/JCP.0000000000001991","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001991","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bicytopenia in the Context of Olanzapine Treatment: A Case Report.","authors":"Blanca Serra-Sarró, Darío Ramis, Helena Álvarez, Ailin Herrero, Cecilia Mantellini, Miguel Vicente, Rosa Catalán, Miquel Bioque, Vicent Llorca-Bofí","doi":"10.1097/JCP.0000000000001977","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001977","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Neutropenia Associated With Duloxetine: A Case Study of an 80-Year-Old Man With Depression Related to Long COVID.","authors":"Masahiro Ono, Sachiko Eguchi, Tetsuya Hagiwara, Daimei Sasayama, Shinsuke Washizuka","doi":"10.1097/JCP.0000000000001978","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001978","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors and Correlates of Psychiatric Polypharmacy Among Child and Adolescent Psychiatric Inpatients: A Retrospective Study.","authors":"Sean Lynch, Timothy Becker, Parul Shanker, Dalton Martin, Paige Staudenmaier, Alicia Leong, Timothy Rice","doi":"10.1097/JCP.0000000000001981","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001981","url":null,"abstract":"<p><strong>Purpose/background: </strong>Rates of prescriptions of psychotropic medications to youth have increased, a significant proportion of which are recipients of psychiatric polypharmacy. Polypharmacy can increase the risk of multiple negative outcomes. Prior studies attempting to identify predictors/correlates of polypharmacy have been heterogeneous. This study aimed to examine factors associated with polypharmacy among psychiatrically hospitalized youth, and measure changes in polypharmacy over time throughout the COVID-19 pandemic.</p><p><strong>Methods/procedures: </strong>The medical records of 1101 patients were reviewed. Sociodemographic and clinical information was collected and analyzed using SPSS.</p><p><strong>Findings/results: </strong>About one-third of patients received psychotropic polypharmacy; this group contained a higher percentage of males, White patients, and fewer Asian/South Asian patients. They had on average more hospitalizations, a longer hospitalization period, and were more likely to be diagnosed with an impulsive/behavioral disorder, developmental disorder, or bipolar spectrum disorder. They were twice as likely to receive medication for agitation while hospitalized. A regression model identified positive predictors of polypharmacy as having a history of violence and a higher number of psychiatric hospitalizations. Negative predictors included non-White race. The rate of polypharmacy was relatively stable throughout the study time period, and no impact of the COVID-19 pandemic was found.</p><p><strong>Implications/conclusions: </strong>Pediatric psychiatric polypharmacy is relatively common and may be associated with poorer outcomes. Certain sociodemographic and clinical characteristics may aid clinicians in predicting which youth may be at risk for polypharmacy. Longitudinal studies are indicated to examine outcomes of polypharmacy so that providers can effectively implement judicious prescribing practices in the community.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapse in Anorexia Nervosa Associated With Tirzepatide: A Case Report.","authors":"Anna I Guerdjikova, Heather Dlugosz, Robert Wolterman, Susan L McElroy","doi":"10.1097/JCP.0000000000001975","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001975","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Paliperidone Long-Acting Injections in Huntington's Disease.","authors":"Kamalakar Surineni, Vy Le, Kevin McKaughan, Namie Fotion","doi":"10.1097/JCP.0000000000001989","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001989","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orofacial Dyskinesia in a Patient With Sotos Syndrome Treated With Methylphenidate.","authors":"Züleyha Ulusoy, Esra Hoşoğlu, Bahadır Turan","doi":"10.1097/JCP.0000000000001988","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001988","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Pyramidal Sign as an Unexpected Presentation in Antipsychotic-Induced Acute Dystonia: Case Reports and Literature Review.","authors":"Yi-Hui Liu, Ming Chen, Ye-Kai Huang, Wei-Lin Wang, Jia-Rong Liang, Fu-Jun Jia, Cai-Lan Hou","doi":"10.1097/JCP.0000000000001985","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001985","url":null,"abstract":"<p><strong>Background: </strong>Acute drug-induced dystonia (DID) is an extrapyramidal side effect triggered by certain medications, primarily antipsychotics. It presents as acute involuntary muscle contractions, causing twisting, repetitive movements, or abnormal postures. Pyramidal signs, typically from upper motor neuron damage, are characterized by positive pathological reflexes, increased muscle tone, and hyperactive tendon reflexes.</p><p><strong>Procedures: </strong>This study describes 2 cases of acute DID following antipsychotic treatment, both presenting with positive pyramidal sign. A literature review was conducted to find reports of abnormal pyramidal signs in acute DID cases, focusing on medical tests for differential diagnosis and neurological assessments related to DID.</p><p><strong>Results: </strong>After reviewing the detailed medication history and conducting comprehensive tests, it was concluded that risperidone and haloperidol caused DID. Adjusting the medication and providing symptomatic treatment led to significant improvement.</p><p><strong>Conclusions: </strong>These cases highlight the importance of being alert to the possibility of acute DID when using antipsychotics and pyramidal signs appear, providing insights for future research into the mechanisms of these unusual symptoms.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of Catatonia With Cariprazine-A Case Report.","authors":"Alexandra Rockett, Andrew Stoner, Catherine Ironbar, Joseph Chien","doi":"10.1097/JCP.0000000000001993","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001993","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Once Daily Dosing on Protein Binding of Clozapine and Norclozapine.","authors":"Marieke M Beex-Oosterhuis, S F Cedric Lau, Charlotte van Kesteren, Steven Verloop, Koen P Grootens, Gunnar Faber, Arthur R Van Gool, E R Rob Heerdink, Rob J van Marum, Daan J Touw","doi":"10.1097/JCP.0000000000001979","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001979","url":null,"abstract":"<p><strong>Purpose/background: </strong>Clozapine and norclozapine are highly protein bound. Currently, clozapine is increasingly prescribed once daily (QD). Higher (once daily) doses may theoretically lead to saturation of protein binding of (nor)clozapine, resulting in increased unbound fractions. This study investigated whether protein binding of clozapine and norclozapine becomes saturated at higher concentrations. Secondly, the correlation between unbound (nor)clozapine fractions and alpha-1 acid glycoprotein (AGP) concentrations was studied.</p><p><strong>Methods/procedures: </strong>From 44 patients taking clozapine QD or twice daily a total of 319 blood samples were collected at different time points within a dose interval. AGP concentrations were measured in samples drawn just before clozapine intake. A validated liquid chromatography-tandem mass spectrometry method was used for quantification of the (nor)clozapine concentrations. Ultrafiltration was used to separate the bound and unbound molecules. The relation between total concentrations and fractions, and between unbound fractions and AGP concentrations were investigated using linear mixed model analysis.</p><p><strong>Findings/results: </strong>There was no significant correlation between total clozapine (P = 0.270) and norclozapine (P = 0.678) concentrations and its unbound fractions with total clozapine concentrations up to 1500 μg/L. A statistically significant (negative) correlation between AGP concentrations and clozapine (P = 0.000) and norclozapine (P = 0.028) unbound fractions was found.</p><p><strong>Implications/conclusions: </strong>In general, total concentrations remain suitable for therapeutic drug monitoring if clozapine is used once daily. Future research is needed to define if higher total concentrations are warranted in case of lower unbound fractions due to increased AGP concentrations.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}