Journal of Clinical Psychopharmacology最新文献

{"title":"Progress on Pharmacogenetic Tests for Antidepressant Drug Selection Requires Properly Designed Studies.","authors":"Bruce M Cohen, Leslie Citrome, Joseph F Goldberg, Matthew L Baum, Charles B Nemeroff","doi":"10.1097/JCP.0000000000002199","DOIUrl":"10.1097/JCP.0000000000002199","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"507-510"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serotonin Syndrome Associated With Polypharmacy in an Elderly Patient With Dementia and Parkinson Disease.","authors":"Ahmet Torun, Nesibe Boyraz, Furkan Toksoy, Burç Çağrı Poyraz","doi":"10.1097/JCP.0000000000002170","DOIUrl":"10.1097/JCP.0000000000002170","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"46 4","pages":"490-492"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal of Clinical Psychopharmacology Updates.","authors":"Anthony J Rothschild","doi":"10.1097/JCP.0000000000002201","DOIUrl":"10.1097/JCP.0000000000002201","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"373"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cardiac Safety of High-Dose Propranolol Used to Treat Severe Behaviors With Autism Spectrum Disorders.","authors":"Kristen A Moody, Eric D Fethke, Phillip Wilken, Eric B London","doi":"10.1097/JCP.0000000000002155","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002155","url":null,"abstract":"<p><strong>Background: </strong>Aggression and self-abusive behaviors are serious problems in the developmentally disabled. Several medications have shown efficacy, but many individuals remain inadequately treated or intolerant of the side effects of various medications. High-dose propranolol has been shown to be effective for some individuals with various diagnoses. Clinicians' use of high-dose propranolol has been limited by a lack of evidence of cardiac safety. We are presenting a retrospective review of the cardiologic workup of 52 cases of the use of high-dose propranolol for individuals with autism spectrum and related disorders.</p><p><strong>Procedures: </strong>We report the results of electrocardiogram, Holter monitor, blood pressure, heart rate, and echocardiography in this cohort who were on doses of propranolol up to 1200 mg per day with a mean dose of 496.6 mg per day. The ages ranged from 12 to 49 years with a mean of 21.6 years.</p><p><strong>Results: </strong>Clinically, there were no serious adverse events over the 8 years of accumulated data on this cohort. Three of the 52 cases were discontinued from propranolol due to side effects of bradycardia and or hypotension. There were no adverse effects noted on the Holter monitor or the echocardiography. There was a correlation between heart rate and blood pressure, but for the vast majority, these were not clinically significant.</p><p><strong>Conclusions: </strong>In our population, high-dose propranolol appeared to be safe from a cardiologic perspective. Our population skewed toward young individuals without preexisting heart pathology. We recommend its use with appropriate caution for any given individual.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"46 4","pages":"399-403"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Progress on Pharmacogenetic Tests for Antidepressant Drug Selection Requires Properly Designed Studies\".","authors":"Renee E Albers, Alexander Gutin, Boadie W Dunlop","doi":"10.1097/JCP.0000000000002189","DOIUrl":"10.1097/JCP.0000000000002189","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"510-514"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148149758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malignant Catatonia and Neuroleptic Malignant Syndrome Overlap in the Emergency Department: Diagnostic Challenges and Psychopharmacology Considerations.","authors":"Samyukta Girish Menon, Yulia Furlong","doi":"10.1097/JCP.0000000000002172","DOIUrl":"10.1097/JCP.0000000000002172","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"496-498"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need to Revise the Paliperidone Palmitate Loading Dose Strategy: Toward Personalized Medicine to Enhance Patient Safety.","authors":"Sheldon H Preskorn, Vy Le","doi":"10.1097/JCP.0000000000002186","DOIUrl":"10.1097/JCP.0000000000002186","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"369-371"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot, Dose-Finding, Pharmacodynamic and Pharmacokinetic Study of Orally Administered Botanical Kratom.","authors":"Chad J Reissig, Ling Chen, Srikanth C Nallani, E Gregory Hawkins, Steven Galati, Katherine Bonson, Siva Rama Raju Kanumuri, Christopher R McCurdy, Abhisheak Sharma, Beatrice Setnik, Denise Milovan, Debra Kelsh, Dominic Chiapperino","doi":"10.1097/JCP.0000000000002158","DOIUrl":"10.1097/JCP.0000000000002158","url":null,"abstract":"<p><strong>Background: </strong>Kratom ( Mitragyna speciosa ) is a plant indigenous to Southeast Asia. This pilot study evaluated the pharmacodynamic (PD) effects, safety, and pharmacokinetics (PK) of kratom and several of its alkaloids.</p><p><strong>Methods: </strong>Recreational polydrug users (8 participants/cohort; 6 active: 2 placebo, N=40) completed the study. Participants had experience with opioids but were otherwise healthy. This study utilized a double-blind, between-subjects design where participants randomly received a single dose of placebo or kratom. The kratom used in the study had alkaloid levels representative of botanical kratom products (i.e., leaf) previously characterized in the literature and contained trace levels of 7-hydroxymitragynine (7-OH). The starting dose was 1 g and doses of 3, 8, 10, and 12 g were administered after safety reviews after each dose. After dosing, pupillometry and assessments of subjective effects were performed, and blood samples were collected. Safety assessments included adverse events (AE) monitoring, laboratory tests, vital signs, ECG assessments, physical examination findings, and assessment of suicidality.</p><p><strong>Results: </strong>No deaths or serious adverse events (SAEs) occurred. Somnolence, vomiting, and nausea were the most common AEs reported. Kratom alkaloid concentrations showed generally orderly, dose-related effects. At doses ≥3 g, kratom produced pupillary constriction. Few dose-related effects were observed, although the 12 g dose of kratom produced increases on several subjective measures including ratings of \"drug liking.\"</p><p><strong>Conclusions: </strong>This study investigated the safety of single-sourced botanical kratom; the results may not be representative of other kratom-containing products. Kratom produced some opioid-like effects including pupillary constriction, and the 12 g dose produced effects commonly associated with drugs of abuse such as visual analog scale (VAS) ratings of drug liking, good effects, and high.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"386-398"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Treatment and Cognition in Bipolar I Disorder: Evidence From a Prospective Study in India.","authors":"Bhavya Bhavya, Ajay Kumar Shukla, Abhijit Rozatkar, Shubham Atal","doi":"10.1097/JCP.0000000000002162","DOIUrl":"10.1097/JCP.0000000000002162","url":null,"abstract":"<p><strong>Background: </strong>Bipolar I disorder is frequently accompanied by persistent cognitive dysfunction, but the extent to which routine pharmacological treatment influences subjective and objective cognition remains unclear. We sought to examine short-term changes in cognitive functioning among euthymic bipolar I disorder patients receiving routine pharmacotherapy.</p><p><strong>Methods: </strong>In this prospective observational study, adults with bipolar I disorder in euthymia (Young Mania Rating Scale ≤10; Hamilton Depression Rating Scale ≤7) underwent cognitive assessment using the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and the Montreal Cognitive Assessment (MoCA) at baseline and again after 3 to 4 months. Medication regimens, dose stability, adherence, and clinical variables were recorded. Paired tests evaluated within-subject cognitive change; categorical shifts were examined using the McNemar test. Limitations related to study design were explicitly evaluated.</p><p><strong>Results: </strong>Fifty-one participants were enrolled (median age 39 years), and 50 completed follow-up. COBRA scores improved from 7.48±7.13 to 4.04±5.94 (mean change -3.44; P <0.001), and MoCA scores increased from 23.90±4.89 to 25.84±4.40 (mean change +1.94; P <0.001). The proportion with normal cognition increased from 42% to 78% on MoCA, while COBRA-defined impairment decreased from 20% to 6%. Improvements were observed across medication classes, and no regimen demonstrated consistent superiority.</p><p><strong>Conclusions: </strong>Routine pharmacological treatment was associated with short-term cognitive improvement, but the findings are preliminary and not causal.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"420-426"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salute to Our Reviewers.","authors":"","doi":"10.1097/JCP.0000000000002200","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002200","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"46 4","pages":"518-519"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}