Journal of Clinical Psychopharmacology最新文献

{"title":"Psychosis as an Adverse Effect of Antibiotics in Children and Adolescents.","authors":"Brian J Miller, Dale Peeples","doi":"10.1097/JCP.0000000000002252","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002252","url":null,"abstract":"<p><strong>Background: </strong>Adverse neuropsychiatric effects of antibiotics-ranging from insomnia to psychosis and delirium-have been documented in adults; however, there is less extensive research in children and adolescents. The tetracycline antibiotic minocycline has been investigated as an adjunctive treatment in autism and in adults with psychotic disorders. The present study investigated the prevalence of spontaneously reported adverse drug reactions (ADRs) of psychotic symptoms in children and adolescents for antibiotics and the odds of psychosis ADRs compared to minocycline for individual antibiotics and antibiotic classes.</p><p><strong>Methods: </strong>We searched the US FDA Adverse Event Reporting System (FAERS) from inception through August 2025 for which an antibiotic was the suspected agent of an adverse drug reaction (ADR).</p><p><strong>Results: </strong>We investigated 24 different antibiotics, comprising 30,884 ADRs, including 417 psychosis ADRs (1.4% of all ADRs). For psychosis ADRs, the mean age was 10.5, 55% were male, and 38% were hospitalized. Compared to minocycline, exposure to any antibiotic was associated with a significant, more than 3-fold increased reported odds of a psychosis ADR (rOR=3.26, 99% CI=1.27-9.10). Ten individual antibiotics were associated with significantly increased reported odds of a psychosis ADR compared to minocycline (rORs=3.72 to 8.74), including sulfonamides, penicillins, fluoroquinolones, macrolides, and cephalosporins.</p><p><strong>Conclusions: </strong>Findings suggest that psychosis is a potential adverse effect of antibiotic treatment in children and adolescents, though risks vary by specific agents. Future studies in this area are needed to identify specific underlying biological mechanisms that contribute to these associations. Findings may also inform clinical decisions regarding the selection of antibiotic therapy in vulnerable patient populations.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of Different Doses of Ayahuasca on Intelligence and Verbal Memory in Healthy Volunteers: A Preliminary, Exploratory, Double-Blind, Randomized, Placebo-controlled Study.","authors":"Caio César de Paula, Anna B Vicentini, Lorena T L Guerra, Renan M Maekawa, José A Silva Reis, Bianca Villanova, Caroline C Gomes, Taini Bellucci, Giordano N Rossi, José C Bouso, Jaime E C Hallak, Rafael G Dos Santos","doi":"10.1097/JCP.0000000000002267","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002267","url":null,"abstract":"<p><strong>Background: </strong>Observational studies with ritual ayahuasca users suggest that experienced users tend to have better cognitive performance, while novice users may experience transient impairments, particularly in working memory. However, no randomized clinical trials have systematically evaluated the cognitive effects of ayahuasca in healthy volunteers.</p><p><strong>Procedures: </strong>This double-blind, randomized, placebo-controlled trial evaluated the effects of a single dose of ayahuasca on intelligence and verbal memory in 28 healthy volunteers. Participants were randomized to receive placebo (1.0 mL/kg) or ayahuasca at doses of 0.5, 1.0, or 1.5 mL/kg (n=7 per group). The Wechsler Abbreviated Scale of Intelligence and the Rey Auditory Verbal Learning Test were administered at baseline, 4 hours, and 21 days postadministration.</p><p><strong>Results: </strong>For intelligence, significant time effects were observed across multiple domains (P<0.05), but no group × time interactions were detected. For verbal memory, significant time effects were observed for total learning, immediate recall, delayed recall, recognition, and total learning (P<0.05). A significant group × time interaction was observed only for delayed recall (P=0.006), with post hoc analysis revealing that the placebo performed better than the 0.5 mL/kg ayahuasca group at 4 hours (P=0.006). No other interactions reached significance, and no effects persisted at 21 days.</p><p><strong>Conclusions: </strong>In this preliminary exploratory trial, we found no evidence that a single administration of ayahuasca produced significant or persistent changes in standardized measures of intelligence or verbal memory in healthy volunteers. These findings provide preliminary information regarding short-term tolerability and cognitive performance following controlled administration and may inform future adequately powered trials.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Pulmonary Embolism During Clozapine and Olanzapine Treatment: An Underrecognized Clinical Risk Highlighted by Pharmacovigilance Data\".","authors":"Carlos De Las Cuevas, Emilio J Sanz, Jose de Leon","doi":"10.1097/JCP.0000000000002285","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002285","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tirzepatide-Associated Lithium Toxicity: A Case Report.","authors":"Jay Davis, Sorabh Singhal, Austin Butterfield","doi":"10.1097/JCP.0000000000002271","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002271","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probable Olanzapine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome.","authors":"Dattawadkar P Pramod, Ranjitha Ramachandraiah, Veena Ramesh, Vijay Kumar","doi":"10.1097/JCP.0000000000002270","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002270","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Question: Can Body Dysmorphic Disorder and Obsessive-Compulsive Disorder Be Misdiagnosed as Psychotic Depression, and Are There Treatment Implications?","authors":"Katharine A Phillips","doi":"10.1097/JCP.0000000000002277","DOIUrl":"10.1097/JCP.0000000000002277","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Embolism During Clozapine and Olanzapine Treatment: An Underrecognized Clinical Risk Highlighted by Pharmacovigilance Data.","authors":"Takahiko Nagamine","doi":"10.1097/JCP.0000000000002284","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002284","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kratom Is an Opioid.","authors":"Andrew Kolodny, Christopher P Holstege","doi":"10.1097/JCP.0000000000002272","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002272","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"If You Use Intramuscular Clozapine, It Is Your Responsibility to Use It Safely.","authors":"Jose de Leon, Stefano Ferrea","doi":"10.1097/JCP.0000000000002276","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002276","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aripiprazole-Vortioxetine Combination in Attention-Deficit/Hyperactivity Disorder With Comorbid Obsessive-Compulsive and Depressive Features: A Case Report.","authors":"Dila Çelik, Merve Akkuş","doi":"10.1097/JCP.0000000000002268","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002268","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}