Journal of Clinical Psychopharmacology最新文献

{"title":"Lumateperone for Mixed Features in MDD and Bipolar Depression: Advancing Treatment or Raising New Questions.","authors":"Soumya Surekha, Ashish Kumar Lamiyan, Pankaj Khatri, Amol N Patil","doi":"10.1097/JCP.0000000000002018","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002018","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide-Mediated Lithium Toxicity.","authors":"Stevyndennis Onggo, Rita Chang, Jenna Marlett, Aaliyah Zimmerman, Haylee Bettencourt, Tilden Hughes, Mina Hah","doi":"10.1097/JCP.0000000000002017","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002017","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter From Surekha et al: \"Lumateperone for Mixed Features in MDD and Bipolar Depression: Advancing Treatment or Raising New Questions\".","authors":"Suresh Durgam, Susan G Kozauer, Willie R Earley, Changzheng Chen, Jason Huo, Hassan Lakkis, Stephen Stahl, Roger S McIntyre","doi":"10.1097/JCP.0000000000002019","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002019","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms.","authors":"Alessandro Di Lisi, Asia Dalla Valle, Marco Menchetti, Concetta Crisafulli, Chiara Fabbri","doi":"10.1097/JCP.0000000000002014","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002014","url":null,"abstract":"<p><strong>Background: </strong>The conception of psychiatric disorders as systemic diseases implies an important role of nutrition in mental health. Essential trace elements are present in very small amounts in the body, yet they are essential for many physiological functions.</p><p><strong>Methods: </strong>Little is known about the potential role of chromium and selenium supplementation in mental disorders and other populations. To contribute to filling this gap, this review is focused on the possible benefits of chromium and selenium, alone or in combination with pharmacological treatments, in the treatment of mental disorders or psychiatric symptoms.</p><p><strong>Results: </strong>Chromium and selenium show promising effects on psychiatric symptoms across mental disorders. Selenium may have benefits on anxious-depressive symptoms in healthy populations and groups at risk of nutritional deficits and psychiatric symptoms, for example, women in the post-partum. In addition, chromium was linked to improved insulin sensitivity and glucose metabolism, which can benefit not only metabolic health but also mood regulation, with specific benefits on atypical symptoms of depression, such as appetite/weight gain. Selenium plays a role in reducing oxidative stress and inflammation, which may suggest positive effects on psychopathology and other conditions linked to these mechanisms.</p><p><strong>Conclusions: </strong>Both trace elements may affect positively mental health and cardio-metabolic-inflammatory conditions, which have a strong link with psychiatric disorders and their prognosis. Despite the evidence is not conclusive, chromium and selenium supplementation are interesting options to investigate in future research on the personalization of treatment in mental disorders.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Risperidone Long-Acting Injection in the Treatment of Anorexia Nervosa: A Case Report.","authors":"Ash Moradi, Emma Gill","doi":"10.1097/JCP.0000000000001984","DOIUrl":"10.1097/JCP.0000000000001984","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review to Determine if Family History of Response to Medication Predicts Outcome in Mood Disorders.","authors":"Jeffrey J Rakofsky, Michael J Lucido, Boadie W Dunlop","doi":"10.1097/JCP.0000000000002011","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002011","url":null,"abstract":"<p><strong>Purpose/background: </strong>Examining a patient's family history of medication response is a commonly used method to inform treatment selection. Though widely recommended, there are no published reviews that assess the validity of this approach when treating patients with affective disorders.</p><p><strong>Methods/procedures: </strong>All published studies in the form of case-control or randomized controlled trials that enrolled probands with either bipolar I or II depression or major depression and were written in English were included. Studies must have also included biological relatives and must have included at least 2 families. The authors compared the methodology of each trial to a hierarchy of study designs best suited to demonstrate the predictive ability of a family history of response to a medication.</p><p><strong>Findings/results: </strong>All studies involved only a small number of participants and none of the publications included in this review used a study design that reached the highest level of study quality needed to prove the link between 2 family members' likelihood of response to a medicine. Two studies had some elements of a level I study while the remaining studies were classified at level II or III of the study hierarchy.</p><p><strong>Implications/conclusions: </strong>Although small studies suggest that a family history of drug response can predict outcome in mood disorder patients, the designs of these studies do not confirm this in a definitive manner.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Clozapine in Pregnancy: A Retrospective Study From North India.","authors":"Sandeep Grover, Surabhi Gupta","doi":"10.1097/JCP.0000000000002013","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002013","url":null,"abstract":"<p><strong>Background: </strong>There is limited information on the use of clozapine during pregnancy. This retrospective study aimed to assess pregnancy-related outcomes in women exposed to clozapine. The additional aim was to assess the outcome of the infants at the last follow-up.</p><p><strong>Methods: </strong>Treatment records of all the female patients in the database were evaluated for conception, pregnancy, lactation-related information, and the long-term outcome of the infants.</p><p><strong>Results: </strong>We analyzed 14 pregnancies in 12 women. Most pregnancies (71.4%) were unplanned. A small number of mothers experienced hypertension (14.3%) and gestational diabetes mellitus (7.1%) during the pregnancy. Of 14 pregnancies, 5 (35.7%) ended in miscarriage, while 9 resulted in live births, including 6 normal vaginal deliveries and 3 cesarean sections. No congenital malformations were noted. Neonatal outcomes included 1 case of fetal macrosomia and another with meconium aspiration. Breastfeeding was done in 3 out of 9 infants with no hematological or other adverse outcomes for the infants. In terms of the long-term outcome of neonates, at the mean follow-up period of 8.88 (SD: 6.33; range: 1-18) months, the growth was normal for 8 infants. Information for one infant was not available.</p><p><strong>Conclusions: </strong>The use of clozapine in pregnancy is not associated with congenital malformations but was found to be associated with miscarriage in one-third of pregnancies. There is a need for long-term prospective studies to evaluate the impact of clozapine on pregnancy and neonatal outcomes.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I: A Review of the Pharmacokinetic Literature and Proposed Changes.","authors":"Jose de Leon, Ross J Baldessarini, Richard Balon, John Bilbily, Stanley N Caroff, Leslie Citrome, Christoph U Correll, Robert O Cotes, John M Davis, Lynn E DeLisi, Justin Faden, Oliver Freudenreich, David R Goldsmith, Ronald Gurrera, Richard C Josiassen, John M Kane, Deanna L Kelly, Matcheri S Keshavan, Robert S Laitman, Y W Francis Lam, Jonathan G Leung, Raymond C Love, Betsy McCollum, Ian R McGrane, Jonathan Meyer, Henry A Nasrallah, Frederick C Nucifora, Anthony J Rothschild, Jose M Rubio, Martha Sajatovic, Deepak K Sarpal, Georgios Schoretsanitis, Mujeeb Shad, Charles Shelton, Leo Sher, Balwinder Singh, Sandarsh Surya, Theodore R Zarzar, Emilio J Sanz, Carlos De Las Cuevas","doi":"10.1097/JCP.0000000000001987","DOIUrl":"10.1097/JCP.0000000000001987","url":null,"abstract":"<p><strong>Purpose/background: </strong>Clozapine was approved in the United States (US) using 1989 regulations and knowledge. After 30 years, many sections of the US package insert (PI) are outdated.</p><p><strong>Methods: </strong>We comprehensively reviewed the literature to propose PI updates. We present the information in 2 articles. In Part I, we focus on basic pharmacology based on 407 relevant articles. Part II focuses on clinical aspects and pharmacovigilance.</p><p><strong>Findings/results: </strong>Based on more recent expectations of Food and Drug Administration regulations, we reviewed clozapine basic pharmacology including the following: 1) clearance, 2) pharmacokinetics and pharmacodynamics, and 3) monitoring tools. We identified 9 major problems in the basic pharmacological sections of the PI including the following: 1) in vivo studies indicate that clozapine is dependent on CYP1A2 for its metabolism, 2) the minor role of CYP2D6 in clozapine metabolism requires removing the PI recommendation to lower clozapine doses in CYP2D6 poor metabolizers, 3) in nontoxic concentrations CYP3A4 has a minor role in clozapine metabolism and potent CYP3A4 inhibitors lack clinically relevant effects, 4) several drug-drug interactions need to be updated based on recent literature, 5) systemic inflammation may decrease clozapine metabolism and increase the risk of clozapine intoxication, 6) obesity may decrease clozapine metabolism, 7) patients of Asian and Indigenous American ancestry need lower clozapine doses, 8) personalized titration and c-reactive protein monitoring should be considered until prospective studies are available, and 9) the half-life section needs to be modified to acknowledge that single dosing at night is frequent in the US.</p><p><strong>Implications/conclusions: </strong>An improvement in the US clozapine PI may lead to improvement in PIs worldwide.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"179-196"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olanzapine-Associated Hyperbilirubinemia in an Adolescent With Autistic Spectrum Disorder Comorbid With Schizophrenia: A Case Report.","authors":"Chi-Wei Ye, Chia-Heng Lin, Shin-Jie Wang","doi":"10.1097/JCP.0000000000001974","DOIUrl":"10.1097/JCP.0000000000001974","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"298-300"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Paliperidone Long-Acting Injections in Huntington's Disease.","authors":"Kamalakar Surineni, Vy Le, Kevin McKaughan, Namie Fotion","doi":"10.1097/JCP.0000000000001989","DOIUrl":"10.1097/JCP.0000000000001989","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"293-295"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}