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Journal of Clinical Psychopharmacology最新文献

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Aripiprazole-Vortioxetine Combination in Attention-Deficit/Hyperactivity Disorder With Comorbid Obsessive-Compulsive and Depressive Features: A Case Report. 阿立哌唑-沃替西汀联合治疗伴有强迫症和抑郁特征的注意缺陷/多动障碍1例
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-10-09 DOI: 10.1097/JCP.0000000000002268
Dila Çelik, Merve Akkuş
{"title":"Aripiprazole-Vortioxetine Combination in Attention-Deficit/Hyperactivity Disorder With Comorbid Obsessive-Compulsive and Depressive Features: A Case Report.","authors":"Dila Çelik, Merve Akkuş","doi":"10.1097/JCP.0000000000002268","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002268","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatic Nihilistic Delusions After Olanzapine Discontinuation in Psychotic Depression: A Case Report. 精神病性抑郁症停用奥氮平后躯体虚无妄想1例。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-10-02 DOI: 10.1097/JCP.0000000000002263
Rodan Alqudah, Mohammed Saadeh, Daniel Khalil
{"title":"Somatic Nihilistic Delusions After Olanzapine Discontinuation in Psychotic Depression: A Case Report.","authors":"Rodan Alqudah, Mohammed Saadeh, Daniel Khalil","doi":"10.1097/JCP.0000000000002263","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002263","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapidly Enlarging Multiloculated Ovarian Cyst With Dramatic Interval Regression Following Endoxifen Discontinuation in an Adolescent Psychiatric Patient: A Probable Adverse Drug Reaction. 一名青少年精神病患者停服内啡肽后迅速增大的多房性卵巢囊肿伴间期急剧消退：一种可能的药物不良反应。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-23 DOI: 10.1097/JCP.0000000000002266
Shobit Garg, Abhijeet Anand, Vineeta Gupta
{"title":"Rapidly Enlarging Multiloculated Ovarian Cyst With Dramatic Interval Regression Following Endoxifen Discontinuation in an Adolescent Psychiatric Patient: A Probable Adverse Drug Reaction.","authors":"Shobit Garg, Abhijeet Anand, Vineeta Gupta","doi":"10.1097/JCP.0000000000002266","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002266","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sertraline-Associated Anisocoria in a Young Adult: A Case Report. 青年人舍曲林相关异角性斜视1例报告。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-18 DOI: 10.1097/JCP.0000000000002260
Olga Martínez-Piera
{"title":"Sertraline-Associated Anisocoria in a Young Adult: A Case Report.","authors":"Olga Martínez-Piera","doi":"10.1097/JCP.0000000000002260","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002260","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Efficacy of Rapid-Titration Naltrexone/Bupropion for Alcohol Use Disorder With Multimorbidity: A Case Report. 快速滴定纳曲酮/安非他酮治疗多病性酒精使用障碍的安全性和有效性：1例报告
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-18 DOI: 10.1097/JCP.0000000000002261
Chen-Wei Liang, Yao-Tung Lee, Jiunn-Kae Wang
{"title":"Safety and Efficacy of Rapid-Titration Naltrexone/Bupropion for Alcohol Use Disorder With Multimorbidity: A Case Report.","authors":"Chen-Wei Liang, Yao-Tung Lee, Jiunn-Kae Wang","doi":"10.1097/JCP.0000000000002261","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002261","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Escitalopram Discontinuation-Related "Brain Zaps" in a Patient With Generalized Epilepsy. 广泛性癫痫患者艾司西酞普兰停药相关“脑电刺激”
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-18 DOI: 10.1097/JCP.0000000000002258
Halil İbrahim Eren, Uğur Takım
{"title":"Escitalopram Discontinuation-Related \"Brain Zaps\" in a Patient With Generalized Epilepsy.","authors":"Halil İbrahim Eren, Uğur Takım","doi":"10.1097/JCP.0000000000002258","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002258","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Dose Ayahuasca for Depressive and Anxiety Symptoms Associated With Cancer Diagnosis: A Single-Blind Feasibility Proof-of-Concept Trial. 单剂量死藤水治疗与癌症诊断相关的抑郁和焦虑症状：一项单盲可行性概念验证试验
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-18 DOI: 10.1097/JCP.0000000000002264
Renan Massanobu Maekawa, Lorena T L Guerra, Bianca Villanova, Caio Cesar de Paula, Anna Beatriz Vicentini Zacharias, Lucas Silva Rodrigues, José Augusto Silva Reis, Giordano Novak Rossi, José Carlos Bouso, Jaime Eduardo Cecilio Hallak, Rafael Guimarães Dos Santos
{"title":"Single-Dose Ayahuasca for Depressive and Anxiety Symptoms Associated With Cancer Diagnosis: A Single-Blind Feasibility Proof-of-Concept Trial.","authors":"Renan Massanobu Maekawa, Lorena T L Guerra, Bianca Villanova, Caio Cesar de Paula, Anna Beatriz Vicentini Zacharias, Lucas Silva Rodrigues, José Augusto Silva Reis, Giordano Novak Rossi, José Carlos Bouso, Jaime Eduardo Cecilio Hallak, Rafael Guimarães Dos Santos","doi":"10.1097/JCP.0000000000002264","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002264","url":null,"abstract":"<p><strong>Background: </strong>Depressive and anxiety symptoms are highly prevalent among patients with cancer and are associated with substantial reductions in quality of life. However, effective therapeutic options remain limited. Ayahuasca, a serotonergic psychedelic traditionally used in Amazonian ritual contexts, has shown rapid antidepressant and anxiolytic effects following a single administration in previous studies.</p><p><strong>Methods: </strong>This single-blind study included 6 female participants. Depressive and anxiety symptoms were evaluated at baseline and at 1, 2, 3 weeks and 3 months following the dosing session using the Beck Depression Inventory-II, the Patient Health Questionnaire-9 and the Beck Anxiety Inventory scales.</p><p><strong>Findings: </strong>Results indicated significant reductions in depressive and anxiety symptoms lasting up to 3 weeks following administration, with no serious adverse effects reported. Greater improvements in depressive symptoms were associated with more intense affective and subjective psychedelic experiences during the session.</p><p><strong>Conclusions: </strong>These preliminary findings suggest that ayahuasca may produce sustained improvements in mood and anxiety symptoms in patients with cancer. However, the small sample size and lack of a control group limit generalization, underscoring the need for larger, placebo-controlled studies.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "Clozapine-Induced Nephritis During Titrations May Be More Frequent Than What Was Described But Is Essentially Preventable". 回复“滴定期间氯氮平引起的肾炎可能比所描述的更频繁，但基本上是可以预防的”。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-18 DOI: 10.1097/JCP.0000000000002255
James Ragg, Stanley Innes, Fearghal Bannon, Judy Hope
{"title":"Reply to \"Clozapine-Induced Nephritis During Titrations May Be More Frequent Than What Was Described But Is Essentially Preventable\".","authors":"James Ragg, Stanley Innes, Fearghal Bannon, Judy Hope","doi":"10.1097/JCP.0000000000002255","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002255","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Tolerability of Zonisamide for Alcohol Use Disorder: A Systematic Review and Meta-Analysis. 唑尼沙胺治疗酒精使用障碍的疗效和耐受性：一项系统综述和荟萃分析
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-18 DOI: 10.1097/JCP.0000000000002259
Vivien Obitulata, Kush Sehgal, Juan Diego Freire Florez, Michelle Mussi, Neil Nero, Kedon Newton, Minahil Iqbal, Mateus Rodrigues Alessi, Akhil Anand
{"title":"Efficacy and Tolerability of Zonisamide for Alcohol Use Disorder: A Systematic Review and Meta-Analysis.","authors":"Vivien Obitulata, Kush Sehgal, Juan Diego Freire Florez, Michelle Mussi, Neil Nero, Kedon Newton, Minahil Iqbal, Mateus Rodrigues Alessi, Akhil Anand","doi":"10.1097/JCP.0000000000002259","DOIUrl":"https://doi.org/10.1097/JCP.0000000000002259","url":null,"abstract":"<p><strong>Purpose: </strong>Zonisamide, an anticonvulsant with GABAergic and glutamatergic effects, has been investigated as a treatment for alcohol use disorder (AUD), but its efficacy and tolerability remain uncertain. This systematic review and meta-analysis synthesizes evidence from randomized controlled trials evaluating zonisamide for AUD.</p><p><strong>Procedures: </strong>We searched MEDLINE, Embase, PsycINFO, Scopus, and CENTRAL from inception through June 23, 2025, with an updated search on March 31, 2026, for randomized controlled trials comparing zonisamide to placebo in adults with AUD. The primary outcome was a reduction in alcohol use. Data were pooled using random-effects meta-analyses. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool.</p><p><strong>Findings: </strong>Five randomized controlled trials (N=344) met inclusion criteria. Zonisamide significantly reduced drinks per day (MD=-0.79; 95% CI=-0.95 to -0.63; P<0.001) and drinking days (MD=-7.93; 95% CI=-11.03 to -4.83; P<0.001). No significant effect was observed for heavy drinking days (MD=-0.95; 95% CI=-2.12 to 0.22; P=0.11), with high heterogeneity (I²=91%). Zonisamide was associated with a significantly lower rate of nervousness, anxiety, or irritability (RR=0.53; 95% CI=0.34-0.84; P=0.007); other adverse events did not differ from placebo.</p><p><strong>Implications: </strong>Zonisamide reduced drinks per day and drinking days but not heavy drinking days, suggesting a selective benefit on overall consumption. A protective effect on nervousness, anxiety, and irritability was also observed, consistent with zonisamide's GABAergic mechanism. Further well-powered trials are needed to inform clinical recommendations.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Schizophrenia With Clozapine in the Context of Comorbid Waldenström's Macroglobulinemia. 氯氮平治疗伴有Waldenström巨球蛋白血症的精神分裂症
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2026-09-09 DOI: 10.1097/JCP.0000000000002256
Ceren İçöz Özbayır, Ali Saffet Gönül
{"title":"Management of Schizophrenia With Clozapine in the Context of Comorbid Waldenström's Macroglobulinemia.","authors":"Ceren İçöz Özbayır, Ali Saffet Gönül","doi":"10.1097/JCP.0000000000002256","DOIUrl":"10.1097/JCP.0000000000002256","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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