Journal of Clinical Psychopharmacology最新文献_第4页

Severe Mirtazapine Overdose in a 4-Year-Old Girl. 4岁女童重度米氮平过量。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-08-10 DOI: 10.1097/JCP.0000000000002208

Matthew J Kilroe, Reagan L Dehnbostel, Tyler R Webb, Alyssa K Soules, Mark L Riddle

引用次数: 0

Unmasking Serotonin Syndrome in an Adolescent With Behavioral Management, Polypharmacy, and Long-term Cyproheptadine Use. 在行为管理、多种药物和长期使用赛庚啶的青少年中揭示血清素综合征。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-07-20 DOI: 10.1097/JCP.0000000000002225

Itamar Shapira, Rimsha Arif, Melissa Reyes, Tania Michaels

引用次数: 0

Use of a Combination of Clozapine With a Long-Acting Injectable Antipsychotic: A Retrospective Study. 氯氮平与长效注射抗精神病药物联合使用的回顾性研究。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-04-03 DOI: 10.1097/JCP.0000000000002177

Sandeep Grover, Jyotika Kanwar, Subho Chakrabarti

{"title":"Use of a Combination of Clozapine With a Long-Acting Injectable Antipsychotic: A Retrospective Study.","authors":"Sandeep Grover, Jyotika Kanwar, Subho Chakrabarti","doi":"10.1097/JCP.0000000000002177","DOIUrl":"10.1097/JCP.0000000000002177","url":null,"abstract":"Background: About one-third of patients fail to respond to clozapine and require augmentation. Among the various augmentation strategies, the use of long-acting injectable (LAI) antipsychotics has been evaluated in a few studies, but the data remain inconclusive. Furthermore, there is a lack of data on the use of a combination of clozapine and LAI from developed countries. This retrospective study aimed to evaluate the impact of clozapine and LAI combination on symptom profile, rehospitalization rate, and functioning in the Indian setting.Methods: For this study, treatment records of patients on clozapine were reviewed for the use of a combination of clozapine and an LAI antipsychotic. Patients who had received a combination of clozapine and LAI were included in this study. The information available in the treatment records was used to rate the patients on the clinical global improvement (CGI) scale retrospectively to evaluate the beneficial effect of the combination.Results: Out of the 1102 patients who received clozapine while in contact with our services, 13 patients had received a combination of clozapine and an LAI. In 8 patients, LAI was started after an adequate clozapine trial, and in 5 patients, clozapine was added to the ongoing LAI antipsychotic medication. At 3 months, 12 patients were rated as \"much improved,\" and 1 patient was rated as \"very much improved\" on the CGI. At the last follow-up assessment, at 6 months to 6 years, the improvement was rated as \"very much improved\" for 9 patients, and \"much improved\" for 3 patients. While on the combination, only 2 patients required further inpatient care. The combination also led to a reduction in the number of relapses and an improvement in functioning.Conclusions: The present study suggests that combining LAI with clozapine leads to improvement in psychopathology and functioning.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"603-607"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sugarless Candy in Treatment-Resistant Clozapine-Induced Sialorrhea. 无糖糖果治疗耐药氯氮平诱导的唾液漏。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-06-01 DOI: 10.1097/JCP.0000000000002204

Felipe S Camelo, Mark P Sullivan

引用次数: 0

Reading the Signal: What Psychedelic Trials in Depression Still Can't Tell Us. 解读信号：抑郁症的迷幻试验仍然不能告诉我们什么。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-07-27 DOI: 10.1097/JCP.0000000000002239

Samela Mariano Brown, Vania Modesto Lowe, Margaret Chaplin

引用次数: 0

Toward Precision Psychiatry: Using Clinical and Pharmacokinetic Data to Increase Antidepressant Dose or Change Treatment in Late-Life Depression. 走向精确精神病学：使用临床和药代动力学数据来增加抗抑郁药物剂量或改变晚年抑郁症的治疗。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-04-28 DOI: 10.1097/JCP.0000000000002182

Helena K Kim, Xiaoyu Men, Samar S M Elsheikh, Daniel J Müller, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Laura B Ramsey, Charles F Reynolds, Zachary L Taylor, Benoit H Mulsant

{"title":"Toward Precision Psychiatry: Using Clinical and Pharmacokinetic Data to Increase Antidepressant Dose or Change Treatment in Late-Life Depression.","authors":"Helena K Kim, Xiaoyu Men, Samar S M Elsheikh, Daniel J Müller, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Laura B Ramsey, Charles F Reynolds, Zachary L Taylor, Benoit H Mulsant","doi":"10.1097/JCP.0000000000002182","DOIUrl":"10.1097/JCP.0000000000002182","url":null,"abstract":"Purpose: Decision trees can use clinical predictors to determine whether to continue the same antidepressant or switch to a different treatment in older patients with major depressive disorder (MDD). We examined whether pharmacogenetic and pharmacokinetic variables could improve their performance.Procedures: We analyzed 191 participants from the Incomplete Response in Late-Life Depression: Getting to Remission (IRL-Grey) trial who had not responded fully after 4 weeks of venlafaxine XR (150 mg/d) and for whom venlafaxine up to 300 mg/d was continued for 8 additional weeks. CYP2D6 genotypes were determined; venlafaxine, o-desmethylvenlafaxine (ODV), and active moiety (AM) exposures at week 4 were calculated using population pharmacokinetic modeling. Decision tree analysis was performed using 5 early clinical predictors of eventual nonresponse identified in previous research and 4 pharmacogenetic and pharmacokinetic potential predictors. One decision tree was designed to optimize specificity (k=0.3), and another to optimize sensitivity (k=0.7).Results: Longer episode duration and lack of partial response at week 4 were retained as clinical predictors, and lower AM and ODV exposures were identified as additional predictors. Negative predictive values (NPVs) of the high-specificity and high-sensitivity trees (77.7% and 73.0%, respectively) were similar to NPVs in trees based solely on clinical predictors.Implications: Our methods can guide future studies combining clinical and biomarker data to address applied pharmacological questions relevant to day-to-day practice.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"556-563"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memantine Augmentation for Obsessive-Compulsive Symptoms in Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. 双相情感障碍患者强迫症症状的美金刚增强：一项随机、双盲、安慰剂对照试验

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-08-13 DOI: 10.1097/JCP.0000000000002188

Hamzeh Rostami, Zahra Dorafshan, Neda Sadrizadeh Irani, Sedighe Mofradnejad, Shahin Norouzi

{"title":"Memantine Augmentation for Obsessive-Compulsive Symptoms in Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Hamzeh Rostami, Zahra Dorafshan, Neda Sadrizadeh Irani, Sedighe Mofradnejad, Shahin Norouzi","doi":"10.1097/JCP.0000000000002188","DOIUrl":"10.1097/JCP.0000000000002188","url":null,"abstract":"Background: Obsessive-compulsive symptoms are frequently observed in patients with bipolar disorder and present a significant therapeutic challenge. This study evaluated the efficacy and safety of memantine as an adjunctive therapy for obsessive-compulsive disorder in patients with bipolar disorder.Methods: In this randomized, double-blind, placebo-controlled trial, 46 patients with bipolar disorder and obsessive-compulsive disorder, stabilized on quetiapine and lithium, were randomly assigned to receive either memantine (n = 23) or placebo (n = 23) for 6 weeks.Results: The memantine group showed a significant reduction in Yale-Brown Obsessive-Compulsive Scale scores compared with the placebo group (Cohen d = 1.57 vs 0.42, P < 0.001). Nausea was the most common side effect, but overall adverse effects were minimal.Conclusion: Memantine appears to be a safe and effective adjunctive treatment for obsessive-compulsive disorder in patients with bipolar disorder, warranting further investigation.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"564-570"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intramuscular Clozapine: A Systematic Scoping Review of Clinical Feasibility, Safety, and Efficacy. 肌注氯氮平：临床可行性、安全性和有效性的系统综述。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-05-25 DOI: 10.1097/JCP.0000000000002198

Noori Dhaliwal, Sid Kaladharan, Jana Waldmann, Dan Siskind, Stephen Parker

{"title":"Intramuscular Clozapine: A Systematic Scoping Review of Clinical Feasibility, Safety, and Efficacy.","authors":"Noori Dhaliwal, Sid Kaladharan, Jana Waldmann, Dan Siskind, Stephen Parker","doi":"10.1097/JCP.0000000000002198","DOIUrl":"10.1097/JCP.0000000000002198","url":null,"abstract":"Background: The use of oral clozapine for treatment-resistant schizophrenia (TRS) is often limited by acute psychotic symptoms and medical instability. Intramuscular (IMI) clozapine has been infrequently used as a bridge to oral therapy. This literature review considers the available evidence regarding IMI clozapine's feasibility, effectiveness, and safety.Methods: A systematic scoping review with a protocol preregistered on the OSF Registry. Records extracted from Ovid MEDLINE, CINAHL, Embase, PsycInfo, Web of Science Core Collection, Scopus, CENTRAL, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and Google Scholar. Risk of bias and quality assessments were conducted.Results: Twenty records met the inclusion criteria, primarily consisting of case reports or series; no randomized trials were identified. Half of the included studies were rated as either \"fair\" or \"good\" quality (n=11/20). Most records addressed the initiation of clozapine in the context of oral (PO) refusal, with services describing IMI clozapine as feasible within strict governance guidelines and pharmacy support. IMI clozapine was reported to provide a bridge to PO administration, with transitions commonly occurring within days, and the use of coercive measures decreasing over time. Patient-reported data were limited; however, safety profiles mirrored those of oral clozapine; route-specific adverse effects were localized, and serious events were infrequently reported.Conclusions: The existing literature suggests that IMI clozapine may be used as a time-limited intervention to support continued PO administration. Further prospective studies with standardized procedures, patient-centered outcomes, and extended follow-up periods are necessary to inform clinical practice and policy development.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"625-635"},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the Cycle: Intravenous Dexmedetomidine for Refractory Agitation and Impending Rhabdomyolysis to Prevent Acute Kidney Injury. 打破循环：静脉注射右美托咪定治疗难治性躁动和即将发生的横纹肌溶解以预防急性肾损伤。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-06-08 DOI: 10.1097/JCP.0000000000002212

Xiaoyuan Han, Yixuan Song, Junxi Wen, Ningning Liu, Ming Cha

引用次数: 0

Intermediate Steps in the Practice of Psychopharmacology: The Role of Clinical Judgment. 精神药理学实践的中间步骤：临床判断的作用。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2026-09-01 Epub Date: 2026-06-04 DOI: 10.1097/JCP.0000000000002206

Giovanni A Fava, Steven L Dubovsky, Richard Balon

引用次数: 0