Journal of Clinical Neurology最新文献

Geometry and Wall Shear Stress of the Contralesional Middle Cerebral Artery Are Associated With the Burden of Cerebral Small Vessel Disease in Acute Ischemic Stroke. 急性缺血性脑卒中对侧大脑中动脉的几何形状和壁面剪应力与脑血管疾病负担相关

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0065

Ho Geol Woo, Hyug-Gi Kim, Kyung Mi Lee, Sang Hee Ha, HangJin Jo, Sung Hyuk Heo, Dae-Il Chang, Bum Joon Kim

{"title":"Geometry and Wall Shear Stress of the Contralesional Middle Cerebral Artery Are Associated With the Burden of Cerebral Small Vessel Disease in Acute Ischemic Stroke.","authors":"Ho Geol Woo, Hyug-Gi Kim, Kyung Mi Lee, Sang Hee Ha, HangJin Jo, Sung Hyuk Heo, Dae-Il Chang, Bum Joon Kim","doi":"10.3988/jcn.2025.0065","DOIUrl":"10.3988/jcn.2025.0065","url":null,"abstract":"Background and purpose: Cerebral small vessel disease (cSVD) is associated with the vascular geometry of the intracranial arteries. This study aimed to determine the associations of the burden of pre-existing cSVD with the geometry and hemodynamic parameters of the middle cerebral artery (MCA) in patients with acute ischemic stroke.Methods: This study enrolled consecutive patients with acute ischemic stroke in the MCA territory who underwent high-resolution vessel wall magnetic resonance imaging and four-dimensional flow magnetic resonance imaging in accordance with the protocol of Kyung Hee University Hospital. Patients were categorized into two groups based on the burden of pre-existing cSVD in the hemisphere contralateral to the stroke lesion: those with a modified burden score of 0-4 (low cSVD burden) and those with a modified burden score of 5-7 (high cSVD burden). The vascular geometry (straight, U-shaped, or inverted-U- and S-shaped) and wall shear stress (WSS) measured at five different points in the contralesional MCA were compared between the two burden groups.Results: This study included 145 patients with cSVD: 109 with a low burden and 36 with a high burden. A low cSVD burden was correlated with a U- or inverted-U-shaped MCA (p< 0.001). A high cSVD burden was associated with an S-shaped MCA (reference U- or inverted U-shaped MCA: odds ratio [OR]=8.653, 95% confidence interval [CI]=2.789-26.843, p<0.001), and with an increased maximum WSS at the second quintile point (OR=1.109, 95% CI=1.005-1.225, p=0.040) and elevated variability (standard deviation: OR=1.759, 95% CI=1.277-2.423, p=0.001).Conclusions: A tortuous MCA along with an increased WSS magnitude and variability were independently associated with a high cSVD burden.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"21 4","pages":"294-304"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent Jaw Drop Following Botulinum Injection as the Initial Clinical Manifestation of Spinal and Bulbar Muscular Atrophy. 注射肉毒杆菌后持续下颌下垂是脊髓和球性肌萎缩的最初临床表现。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0078

Woohee Ju, Young Gi Min, Suk-Won Ahn, Jung-Joon Sung

引用次数: 0

Racial Differences in Parkinson's Disease Mortality Trends: United States National Mortality Records. 帕金森病死亡率趋势的种族差异：美国国家死亡率记录。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0155

Roham Hadidchi, Hasan Jamil, Stuart Gilmour

引用次数: 0

Leukoencephalopathy With Cerebral Calcifications and Cysts With Novel SNORD118 Mutations Presenting With Bilateral Giant Cysts. 伴有脑钙化和囊肿的脑白质病伴新的SNORD118突变，表现为双侧巨大囊肿。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2024.0206

Ziyu Wang, Yingchao Liu, Zhigang Yao, Xiaohui Liu

引用次数: 0

Basilar Artery Angulation: A Novel Imaging Marker of Transtentorial Herniation. 基底动脉成角：一种新的幕前疝成像标记。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0158

Yong-Hwan Cho, Jin-Heon Jeong

引用次数: 0

Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. 普瑞巴林治疗韩国成人不宁腿综合征的疗效和安全性：一项随机、双盲、安慰剂对照试验

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0092

Jun-Sang Sunwoo, Yong Won Cho, Won Chul Shin, Jung-Ick Byun, Jung-Won Shin, Ki-Young Jung

{"title":"Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Jun-Sang Sunwoo, Yong Won Cho, Won Chul Shin, Jung-Ick Byun, Jung-Won Shin, Ki-Young Jung","doi":"10.3988/jcn.2025.0092","DOIUrl":"10.3988/jcn.2025.0092","url":null,"abstract":"Background and purpose: To evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS).Methods: In this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS with an International Restless Legs Scale (IRLS) score ≥15 were randomized 1:1 to receive either pregabalin (n=39) or placebo (n=39) for 12 weeks. The primary efficacy outcome was the change in the IRLS score, and the secondary outcomes included the Clinical Global Impression-Improvement scale and changes in scores on other RLS symptom questionnaires. Safety was assessed by monitoring treatment-emergent adverse events (TEAE). This study was registered at ClinicalTrials.gov (NCT04161027).Results: At baseline, the mean IRLS scores were 23.2±5.8 in the pregabalin and 24.5±5.2 in the placebo group (p=0.297). After 12 weeks, the baseline-adjusted change in the IRLS score was -6.8 (95% confidence interval [CI] -9.3 to -4.3) in the pregabalin group and -5.4 (95% CI -7.9 to -2.8) in the placebo group, with no significant difference between the groups (p=0.420). The secondary efficacy outcomes did not differ between the two groups. The incidence of TEAE was similar between the two groups (48.7% vs. 51.3%, p=0.821), with dizziness being the most common TEAE.Conclusions: This study failed to demonstrate the therapeutic effect of pregabalin compared with placebo for RLS in Korean adults. Possible reasons for the negative results include low dose, insufficient sample size, and substantial placebo response. Further investigations are warranted to optimize pregabalin therapy in Korean adults with RLS.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"21 4","pages":"325-331"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Amyloid Positron-Emission Tomography to Diagnose Alzheimer's Disease in Clinical Practice in South Korea: Expert Recommendations. 使用淀粉样正电子发射断层扫描诊断阿尔茨海默病在韩国的临床实践：专家建议。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0037

Kee Hyung Park, Seong Hye Choi, YongSoo Shim, Young Chul Youn, Dong Won Yang, SangYun Kim

{"title":"Use of Amyloid Positron-Emission Tomography to Diagnose Alzheimer's Disease in Clinical Practice in South Korea: Expert Recommendations.","authors":"Kee Hyung Park, Seong Hye Choi, YongSoo Shim, Young Chul Youn, Dong Won Yang, SangYun Kim","doi":"10.3988/jcn.2025.0037","DOIUrl":"10.3988/jcn.2025.0037","url":null,"abstract":"Amyloid positron-emission tomography (PET) is the optimal method for detecting amyloid plaque deposition in patients experiencing cognitive decline, which is essential for diagnosing Alzheimer's disease. However, its clinical application globally has been restricted by the high cost, short radiotracer half-life, and significant accessibility challenges. In particular, the lack of treatment options following diagnosis has been considered the largest obstacle to using amyloid PET as a diagnostic tool. Consequently, the current appropriate-use recommendations for amyloid PET tend to support restricting its use. However, the relatively low cost and superior accessibility of amyloid PET in South Korea have resulted in it being used much more frequently in clinical settings than in other countries. The recent introduction of disease-modifying drugs has increased the importance and frequency of amyloid PET usage. Considering these circumstances, this article presents expert opinions on the appropriate use of amyloid PET in South Korea based on existing recommendations and survey results from dementia experts in South Korea.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"21 4","pages":"251-264"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Clinical Applications of Structural MRI in Neurological Disorders. 结构MRI在神经系统疾病中的临床应用现状。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0185

Woo-Suk Tae, Byung-Joo Ham, Sung-Bom Pyun, Byung-Jo Kim

{"title":"Current Clinical Applications of Structural MRI in Neurological Disorders.","authors":"Woo-Suk Tae, Byung-Joo Ham, Sung-Bom Pyun, Byung-Jo Kim","doi":"10.3988/jcn.2025.0185","DOIUrl":"10.3988/jcn.2025.0185","url":null,"abstract":"Structural magnetic resonance imaging (sMRI) plays a pivotal role in the evaluation of neurological disorders by providing high-resolution anatomical information. Recent advances in quantitative postprocessing techniques have expanded the utility of sMRI beyond visual assessments by enabling the detection of subtle morphological changes associated with various neurological and psychiatric conditions. This review summarizes current clinical applications of sMRI-based analysis, including brain volumetry, shape analysis, voxel-based morphometry (VBM), surface-based morphometry, source-based morphometry, and voxel-based lesion-symptom mapping (VLSM). Volumetric and shape-based analyses allow for assessments of region-specific atrophy and subregional morphological alterations, while VBM and surface-based morphometry provide complementary insights into tissue volumes and the architecture of the cortical surface. Source-based morphometry reveals network-level patterns of structural covariance, and VLSM directly correlates lesion locations with functional outcomes, particularly in stroke. It has been demonstrated that these methodologies are clinically relevant in conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and major depressive disorder. By quantifying structural brain alterations that are not readily detectable using conventional imaging methods, these tools improve diagnostic accuracy, support prognostication, and facilitate monitoring of treatment effects. This review highlights the growing integration of sMRI postprocessing techniques into clinical neurology.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"21 4","pages":"277-293"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Experience of Lasmiditan for the Acute Treatment of Migraine. 拉斯米坦急性治疗偏头痛的临床经验。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0021

Hoe Jong Jeong, Mi Ji Lee

{"title":"Real-World Experience of Lasmiditan for the Acute Treatment of Migraine.","authors":"Hoe Jong Jeong, Mi Ji Lee","doi":"10.3988/jcn.2025.0021","DOIUrl":"10.3988/jcn.2025.0021","url":null,"abstract":"Background and purpose: We aimed to determine efficacy, safety, and predictors of response and side effects of lasmiditan in Korean patients with migraine.Methods: We prospectively recruited patients who took lasmiditan at the Seoul National University Hospital between April 2023 and March 2024. We collected data on treatment, adverse events, and dosage adjustment profiles. Tolerability was defined as dosage maintenance or dosage increase. Logistic regression analyses were performed to identify predictors of a response to lasmiditan and adverse events.Results: This study included 154 patients. At visit 1, 110 (71.4%) and 44 (28.6%) patients were prescribed 50 and 100 mg of lasmiditan daily, respectively, with a treatment response observed at visit 2 in 49 (44.5%) and 20 (45.5%) patients, respectively. Adverse events were reported in 75 (48.7%) patients. Multivariate logistic analyses showed that female sex (odds ratio [OR]= 4.51, 95% confidence interval [CI]=1.43-14.19, p=0.01) and higher daily dose (100 mg vs. 50 mg: OR=2.35, 95% CI=1.14-4.83, p=0.02) were independently associated with adverse events. Dosage increase, dosage reduction, and treatment discontinuation occurred in 56 (36.4%), 17 (11.0%), and 40 (26.0%) patients, respectively. Lasmiditan was well tolerated by 97 (63.0%) patients.Conclusions: This was the first real-world study of lasmiditan in Korean patients with migraine. Although administered at a low dosage, lasmiditan was effective in approximately half of the patients. Dizziness was the most common adverse event, and it occurred at a higher rate than in clinical trials.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"21 4","pages":"332-339"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Brain Injury and Dementia: Mechanisms, Risk Stratification, and Clinical Management. 创伤性脑损伤和痴呆：机制、风险分层和临床管理。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2025-07-01 DOI: 10.3988/jcn.2025.0079

Ali Al-Rubaie

{"title":"Traumatic Brain Injury and Dementia: Mechanisms, Risk Stratification, and Clinical Management.","authors":"Ali Al-Rubaie","doi":"10.3988/jcn.2025.0079","DOIUrl":"10.3988/jcn.2025.0079","url":null,"abstract":"Traumatic brain injury (TBI) is one of the main mechanisms underlying health issues associated with functional and structural brain changes. While direct effects such as cognitive and physical impairments are well documented, recent research has linked TBI to neurodegenerative changes similar to dementia. TBI-related neurodegeneration includes progressive brain-tissue degeneration that leads to behavioral changes, cognitive decline, and dementia-like symptoms. The exact underlying mechanisms are complex, and include neuroinflammation, oxidative stress, excitotoxicity, and disruption to protein homeostasis. Neuroinflammation is controlled by the activation of astrocytes and microglia and causes neuronal damage and the prolonged release of proinflammatory cytokines. Oxidative stress damages cell and impairs mitochondrial function, while the accumulation of misfolded proteins such as tau and β-amyloid mimics the pathology of Alzheimer's disease. Excitotoxicity involves excessive neurotransmitter release that may lead to further injuries. Epidemiological studies show that the risk of dementia is increased after moderate-to-severe TBI and influenced by age and genetic factors. Current management strategies focus on symptom relief, and there is ongoing research aimed at improving the understanding of the underlying mechanisms and the development of effective treatments.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"21 4","pages":"265-276"},"PeriodicalIF":3.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0