Journal of Clinical Neurology最新文献_第10页

Psychotic Symptoms in Patients With Major Neurological Diseases. 重大神经系统疾病患者的精神症状。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2023.0501

Jong S Kim, Seung-Bong Hong, Keun-Woo Park, Allen T C Lee

引用次数: 0

Multinodular and Vacuolating Neuronal Tumor Initially Misdiagnosed as Acute Cerebral Infarction Presenting With Thunderclap Headache. 最初被误诊为急性脑梗死的多结节空泡型神经元肿瘤，表现为雷鸣般的头痛。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-05 DOI: 10.3988/jcn.2023.0337

Taehoon Do, Jae Sang Lee, Seung-Jae Lee, Jungbin Lee

引用次数: 0

Clinical Features of Autoimmune Nodopathy With Anti-Neurofascin-155 Antibodies in South Koreans. 韩国人自身免疫性结节病伴有抗神经筋膜素-155抗体的临床特征

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-01 DOI: 10.3988/jcn.2023.0055

Hyun Ji Lyou, Yeon Hak Chung, Min Ju Kim, MinGi Kim, Mi Young Jeon, Seung Woo Kim, Ha Young Shin, Byoung Joon Kim

{"title":"Clinical Features of Autoimmune Nodopathy With Anti-Neurofascin-155 Antibodies in South Koreans.","authors":"Hyun Ji Lyou, Yeon Hak Chung, Min Ju Kim, MinGi Kim, Mi Young Jeon, Seung Woo Kim, Ha Young Shin, Byoung Joon Kim","doi":"10.3988/jcn.2023.0055","DOIUrl":"10.3988/jcn.2023.0055","url":null,"abstract":"Background and purpose: Anti-neurofascin-155 (NF155) antibody is one of the autoantibodies associated with autoimmune nodopathy. We aimed to determine the clinical features of South Korean patients with anti-NF155-antibody-positive autoimmune nodopathy.Methods: The sera of 68 patients who fulfilled the diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP) were tested for anti-NF155 antibodies using a cell-based assay (CBA) and enzyme-linked immunosorbent assay (ELISA). The anti-NF155-positive sera were also assayed for NF155 immunoglobulin G (IgG) subclasses, and for anti-NF186 and NF140 antibodies. The clinical features of the patients were reviewed retrospectively.Results: Among the 68 patients, 6 (8.8%) were positive for anti-NF155 antibodies in both the CBA and ELISA. One of those six patients was also positive for anti-NF186 and anti-NF140 antibodies. IgG4 was the predominant subclass in four patients. The mean age at onset was 32.2 years. All six positive patients presented with progressive sensory ataxia. Five patients treated using corticosteroids presented a partial or no response. All six patients were treated using intravenous immunoglobulin (IVIg). Among them, five exhibited a partial or poor response and the other exhibited a good response. All three patients treated using rituximab showed a good response.Conclusions: The clinical characteristics of the patients were consistent with those in previous studies. Anti-NF155 antibody assay is necessary for diagnosing autoimmune nodopathy and its appropriate treatment, especially in young patients with CIDP who present with sensory ataxia and poor therapeutic responses to corticosteroids and IVIg.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":" ","pages":"186-193"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Movement Disorders: The Role of Eye Movements in Distinguishing Multisystem Atrophy From Parkinson's Disease. 解码运动障碍：眼球运动在区分多系统萎缩症和帕金森病中的作用。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2024.0017

Jeong-Yoon Choi

引用次数: 0

Steroid-Responsive Dengue Encephalitis Without Typical Dengue Symptoms. 无典型登革热症状的类固醇反应性登革热脑炎

IF 2.9 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2023.0254

Yeon-Jung Mun, Dong-Hyeon Shin, Jae Wook Cho, Hyun-Woo Kim

引用次数: 0

Healthcare Utilization and Supportive Care Timing in South Korean People Living With Amyotrophic Lateral Sclerosis: A Single-Center Retrospective Study. 韩国肌萎缩侧索硬化症患者的医疗保健利用率和支持性护理时机：单中心回顾性研究

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-05 DOI: 10.3988/jcn.2023.0211

Min Seol Jang, Shin Hye Yoo, Min Sun Kim, Belong Cho, Kyae Hyung Kim, Jeongmi Shin, Inyoung Hwang, Seok-Jin Choi, Jung-Joon Sung, Sun Young Lee

{"title":"Healthcare Utilization and Supportive Care Timing in South Korean People Living With Amyotrophic Lateral Sclerosis: A Single-Center Retrospective Study.","authors":"Min Seol Jang, Shin Hye Yoo, Min Sun Kim, Belong Cho, Kyae Hyung Kim, Jeongmi Shin, Inyoung Hwang, Seok-Jin Choi, Jung-Joon Sung, Sun Young Lee","doi":"10.3988/jcn.2023.0211","DOIUrl":"10.3988/jcn.2023.0211","url":null,"abstract":"Background and purpose: Despite the growing demands and challenges faced by patients with amyotrophic lateral sclerosis (ALS) in accessing healthcare services, our understanding of this access remains poor. This study aimed to investigate the healthcare utilization patterns and timing of nutritional and respiration support in patients with ALS in South Korea.Methods: A retrospective cohort study was conducted on patients diagnosed with ALS at a single tertiary hospital between 2016 and 2019 and followed up for 2 years. We evaluated patient characteristics, healthcare utilization (hospital admissions, outpatient visits, and emergency department [ED] visits), and the timing of nutritional and respiration support (noninvasive positive pressure ventilation [NIPPV], tracheostomy, gastrostomy, and nasogastric tube) at 6-month intervals from the first outpatient visit.Results: Among the 143 included patients, 73.4% were admitted at least once, 18.9% experienced unplanned admissions, and 30.1% visited the ED at least once during the study period. The most-common reason for ED visits was neurological symptoms during the first 6 months (59.1%), followed by respiratory symptoms. One fifth of patients who visited the ED underwent tracheostomy (20.9%) or NIPPV (20.9%). Two years after the first visit, 32.2% used a ventilator, and 13.3%, 26.6%, and 6.3% had undergone tracheostomy, gastrostomy, and nasogastric tube insertion, respectively.Conclusions: During the 2 years following their first outpatient visit, 20% of patients with ALS experienced unplanned admissions and 30% visited the ED. An active and prompt supportive-care program should be implemented to ensure timely functional support in order to reduce these risks of unplanned admissions.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":" ","pages":"166-174"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study. 下身骨折与痴呆症风险：一项基于全国人口的研究。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-01 DOI: 10.3988/jcn.2022.0257

Jung-Kyeom Kim, Sang-Won Park, Suk-Hee Lee, Payam Hosseinzadeh Kasani, Gi Hwan Byeon, Yeshin Kim, Jae-Won Jang, Seo-Young Lee

{"title":"Lower-Body Fractures and the Risk of Dementia: A Nationwide Population-Based Study.","authors":"Jung-Kyeom Kim, Sang-Won Park, Suk-Hee Lee, Payam Hosseinzadeh Kasani, Gi Hwan Byeon, Yeshin Kim, Jae-Won Jang, Seo-Young Lee","doi":"10.3988/jcn.2022.0257","DOIUrl":"10.3988/jcn.2022.0257","url":null,"abstract":"Background and purpose: The association between physical activity and dementia has been shown in various observational studies. We aimed to determine the risk of dementia in the elderly with lower-body fractures.Methods: We reconstructed a population-based matched cohort from the National Health Insurance Service-Senior Cohort data set that covers 511,953 recipients of medical insurance in South Korea.Results: Overall 53,776 subjects with lower-body fractures were identified during 2006-2012, and triplicate control groups were matched randomly by sex, age, and years from the index date for each subject with a fracture. There were 3,573 subjects (6.6%) with and 7,987 subjects (4.9%) without lower-body fractures who developed dementia from 2008 up to 2015. Lower-body fractures were independently associated with a subsequent dementia diagnosis with a higher adjusted hazard ratio (aHR) (1.55, 95% confidence interval [CI]=1.49-1.62) compared with upper-body fractures (aHR=1.19, 95% CI=1.14-1.23).Conclusions: These results support the protective role of physical activity against dementia and highlight the importance of promoting fracture prevention in the elderly.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":" ","pages":"208-213"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infliximab for Intractable Paradoxical Reaction in Culture-Negative Tuberculosis Meningitis. 英夫利西单抗治疗培养阴性结核性脑膜炎的难治性矛盾反应。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-05 DOI: 10.3988/jcn.2023.0290

Dong Hyun Kim, Tae Kyun Yoon, Jae-Phil Choi, Seung Hyun Lee

引用次数: 0

Smooth Pursuit and Reflexive Saccade in Discriminating Multiple-System Atrophy With Predominant Parkinsonism From Parkinson's Disease. 平滑追逐和反射性回旋在鉴别多系统萎缩伴帕金森症和帕金森病中的作用

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-01 DOI: 10.3988/jcn.2022.0413

Yaqin Yu, Jinyu Wang, Lihong Si, Huanxin Sun, Xiaolei Liu, Xinyi Li, Weihong Yan

{"title":"Smooth Pursuit and Reflexive Saccade in Discriminating Multiple-System Atrophy With Predominant Parkinsonism From Parkinson's Disease.","authors":"Yaqin Yu, Jinyu Wang, Lihong Si, Huanxin Sun, Xiaolei Liu, Xinyi Li, Weihong Yan","doi":"10.3988/jcn.2022.0413","DOIUrl":"10.3988/jcn.2022.0413","url":null,"abstract":"Background and purpose: Performing the differential diagnosis of Parkinson's disease (PD) and multiple-system atrophy of parkinsonian type (MSA-P) is challenging. The oculomotor performances of patients with PD and MSA-P were investigated to explore their potential role as a biomarker for this differentiation.Methods: Reflexive saccades and smooth pursuit were examined in 56 patients with PD and 34 with MSA-P in the off-medication state.Results: Patients with PD and MSA-P had similar oculomotor abnormalities of prolonged and hypometric reflexive saccades. The incidence rates of decreased reflexive saccadic velocity and saccadic smooth pursuit were significantly higher in MSA-P than in PD (p<0.05 for both). Multiple logistic regression analysis indicated that slowed reflexive saccades (odds ratio [OR]=8.14, 95% confidence interval [CI]=1.45-45.5) and saccadic smooth pursuit (OR=5.27, 95% CI=1.24-22.43) were significantly related to MSA-P.Conclusions: The distinctive oculomotor abnormalities of saccadic smooth pursuit and slowed reflexive saccades in MSA-P may serve as useful biomarkers for discriminating MSA-P from PD.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":" ","pages":"194-200"},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pembrolizumab-Associated Unilateral Optic Neuritis. Pembrolizumab 相关单侧视神经炎：两例病例报告和文献综述

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-01-05 DOI: 10.3988/jcn.2023.0201

Jihae Park, Jeong-Min Hwang, Hee Kyung Yang

引用次数: 0