Journal of Clinical Neurology最新文献_第9页

Preclinical Catecholaminergic Biomarkers of Central Lewy Body Diseases. 中枢路易体疾病的临床前儿茶酚胺能生物标志物。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0629

David S Goldstein

{"title":"Preclinical Catecholaminergic Biomarkers of Central Lewy Body Diseases.","authors":"David S Goldstein","doi":"10.3988/jcn.2025.0629","DOIUrl":"10.3988/jcn.2025.0629","url":null,"abstract":"In the central Lewy body diseases (LBDs) Parkinson's disease and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests, substantial central neurodegeneration has already occurred. Biomarkers of preclinical disease are needed to test strategies that might delay the onset of symptomatic central LBDs and extend healthspan. The prospective, longitudinal PDRisk study asked whether cardiac sympathetic neuroimaging, cerebrospinal fluid catecholamine metabolites, cardiovascular physiological biomarkers, and alpha-synuclein seeding activity predict central LBDs in at-risk individuals. This review highlights and builds on several findings from this unique study. Some concepts induced from the present and previous data are: 1) Central LBDs can begin outside the brain (\"body-first\"), with early involvement of cardiac sympathetic nerves as evidenced by ¹⁸F-dopamine positron emission tomography (PET) and normal initial putamen dopaminergic innervation by ¹⁸F-DOPA PET. 2) DLB can follow a similar body-first progression pattern. 3) Body-first LBDs entail tri-phasic temporal sequences, corresponding conceptually to homeostasis, dyshomeostasis, and symptomatic disease, noted in the heart years before the striatum. 4) LBDs feature a vesicular storage defect in extant catecholaminergic terminals, exemplifying the \"sick-but-not-dead\" phenomenon. 5) There are multiple other functional abnormalities in residual catecholaminergic terminals in LBDs. 6) Based on computational modeling, disease-modifying treatments begun in the dyshomeostatic phase might delay the onset of symptomatic LBDs, compressing morbidity.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 1","pages":"6-16"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on: "Potentially Inappropriate Medication Use in Patients With Parkinson's Disease: Analysis of Korean National Health Insurance Claims Data". 评论：“帕金森病患者可能不适当的药物使用：韩国国民健康保险索赔数据分析”。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0494

Nayoung Ryoo

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Re: Comments on "The 30-Day Risk of Sudden Death in Patients With Epilepsy: A 10-Year Population-Based Cohort Study". 对“癫痫患者30天猝死风险：一项10年人群队列研究”的评论。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0506

Cheng-Yi Fan, Chih-Wei Sung, Eric Chou, Yun-Ting Chih, Edward Pei-Chuan Huang

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Chronic Migraine Is Associated With Region-Specific High-Grade Enlarged Perivascular Spaces: Retrospective Matched Case-Control Study. 慢性偏头痛与区域特异性高级别血管周围空间增大有关：回顾性匹配病例对照研究

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0271

Jae Wook Cho, Gha-Hyun Lee, Jiyoung Kim

{"title":"Chronic Migraine Is Associated With Region-Specific High-Grade Enlarged Perivascular Spaces: Retrospective Matched Case-Control Study.","authors":"Jae Wook Cho, Gha-Hyun Lee, Jiyoung Kim","doi":"10.3988/jcn.2025.0271","DOIUrl":"10.3988/jcn.2025.0271","url":null,"abstract":"Background and purpose: Enlarged perivascular spaces (EPVS) observed on magnetic resonance imaging (MRI) reflect impaired glymphatic system (GS) function; however, their association with chronic migraine remains unclear. This study aimed to investigate whether chronic migraine is associated with a high burden of region-specific high-grade EPVS.Methods: This retrospective case-control study included 44 patients with chronic migraine, 44 age- and sex-matched patients with episodic migraine, and 39 matched healthy controls. Brain MRI scans were assessed for EPVS in the centrum semiovale (CS), basal ganglia, and midbrain (MB) using a validated visual rating scale. High-grade EPVS was defined according to region-specific criteria. Logistic regression analyses were performed to evaluate the association between chronic migraine and high-grade EPVS, adjusting for age, sex, hypertension, alcohol consumption, and insomnia.Results: The prevalence of high-grade EPVS in the CS and MB differed significantly among the chronic migraine, episodic migraine, and control groups. Post-hoc analysis revealed a significantly higher prevalence in the chronic migraine group compared to controls in both regions, and compared to the episodic migraine group in the CS. Chronic migraine was independently associated with high-grade EPVS in the CS (adjusted odds ratio [OR]=9.345, p<0.001) and MB (adjusted OR=4.026, p=0.007).Conclusions: Chronic migraine is associated with an increased prevalence of high-grade EPVS in specific brain regions, suggesting an underlying GS dysfunction. Thus, EPVS is a potential imaging biomarker of chronic migraine.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 1","pages":"113-121"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145943805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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First Korean Case of C9orf72-Related Amyotrophic Lateral Sclerosis With Progressive Supranuclear Palsy-Like Features. 韩国首例c9orf72相关肌萎缩性侧索硬化症伴进行性核上性麻痹样特征。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0483

Seok-Jin Choi, Hyeyoung Park, Jung-Joon Sung

引用次数: 0

Therapeutic Management in an AGRN-Related Congenital Myasthenic Syndrome Patient. 1例与agrn相关的先天性肌无力综合征患者的治疗管理。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0434

Ahmet Yusuf Erturk, Ipek Kurt, Orkhan Mammadov, Ihsan Sukru Sengun

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Re: Comments on "Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial". 关于“普瑞巴林治疗韩国成人不宁腿综合征的有效性和安全性：一项随机、双盲、安慰剂对照试验”的评论。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0523

Ki-Young Jung, Jun-Sang Sunwoo

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Immunotherapy in Chronic Inflammatory Demyelinating Polyneuropathy and the Emerging Role of Efgartigimod. 慢性炎症性脱髓鞘性多神经病变的免疫治疗及Efgartigimod的新作用。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0669

Jin-Sung Park, Minsung Kang

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Comments on: "Efficacy and Safety of Pregabalin for Restless Legs Syndrome in Korean Adults: A Randomized, Double-Blind, Placebo-Controlled Trial". 评论：“普瑞巴林治疗韩国成人不宁腿综合征的有效性和安全性：一项随机、双盲、安慰剂对照试验”。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0507

Fatima Kalam, Aleena Kamal, Minhal Anwer

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From Ablation to Neuromodulation Platform: The Evolving Role of Magnetic Resonance-Guided Focused Ultrasound in Functional Neurosurgery. 从消融术到神经调节平台：磁共振引导聚焦超声在功能性神经外科中的作用。

IF 3.1 3区医学

Journal of Clinical Neurology Pub Date : 2026-01-01 DOI: 10.3988/jcn.2025.0563

Seongwoo Lee, Jin Woo Chang

{"title":"From Ablation to Neuromodulation Platform: The Evolving Role of Magnetic Resonance-Guided Focused Ultrasound in Functional Neurosurgery.","authors":"Seongwoo Lee, Jin Woo Chang","doi":"10.3988/jcn.2025.0563","DOIUrl":"10.3988/jcn.2025.0563","url":null,"abstract":"Magnetic resonance-guided focused ultrasound (MRgFUS) has rapidly evolved from an experimental concept into a versatile platform in functional neurosurgery. Initially pioneered as a noninvasive thermal ablation modality for essential tremor, MRgFUS has since gained regulatory approval and demonstrated durable long-term efficacy. Its clinical applications have expanded to include Parkinson's disease, chronic pain, psychiatric disorders, and investigational use in dystonia, epilepsy, and brain tumors. Beyond lesioning, low-intensity focused ultrasound enables reversible neuromodulation and transient blood-brain barrier opening, facilitating drug and gene delivery in conditions such as Alzheimer's disease and glioblastoma. Comparative analyses highlight MRgFUS as an incisionless alternative to traditional modalities like deep brain stimulation, radiofrequency ablation, and radiosurgery, offering unique advantages in precision, safety, and patient acceptability while retaining certain limitations, including irreversibility and eligibility constraints due to skull properties. Emerging innovations-such as dual-target strategies, staged bilateral procedures, adaptive focusing technologies, and integration with immuno- or gene therapies-are expanding its therapeutic potential. Collectively, these advances position MRgFUS as not only an ablative tool but also a transformative neuromodulation platform with broad implications for the treatment of movement disorders, neuropsychiatric disease, and neurodegeneration.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 1","pages":"17-41"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0