Jiao-Jiao Fan, Yang Liu, Guanxiong Li, Rui-Chao Liu, Ziteng Xie
{"title":"An Analysis of Delta Apparent Diffusion Coefficient Values for Epithelial Ovarian Cancer Classification and Ki-67 Expression.","authors":"Jiao-Jiao Fan, Yang Liu, Guanxiong Li, Rui-Chao Liu, Ziteng Xie","doi":"10.1097/RCT.0000000000001737","DOIUrl":"10.1097/RCT.0000000000001737","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer is one of the most common malignant tumors of the female reproductive system, characterized by high malignancy and poor prognosis. Epithelial ovarian cancer (EOC) accounts for 90% to 95% of all cases. This study aims to investigate the diagnostic value of delta apparent diffusion coefficient (dADC) values in distinguishing between type I and type II EOC and to explore its correlation with Ki-67 expression.</p><p><strong>Methods: </strong>A retrospective analysis included 95 patients (mean age: 51.6 ± 12.5 y; range: 17 to 73 y) diagnosed with EOC at our hospital from September 2021 to August 2023. Of these, 51 patients had type I EOC (low-grade serous carcinoma, clear cell carcinoma, endometrioid carcinoma, mucinous carcinoma, or borderline tumors), and 44 had type II EOC (high-grade serous carcinoma or high-grade endometrioid carcinoma). Bilateral lesions were observed in 16.8% of patients. Preoperative MRI, including diffusion-weighted imaging (DWI), serum CA125 levels, and postoperative immunohistochemical Ki-67 expression, were analyzed. Tumor staging was based on the 2021 FIGO criteria. Minimum ADC (minADC), maximum ADC (maxADC), and dADC values were calculated from the solid tumor components. Receiver operating characteristic (ROC) curves assessed diagnostic performance, and the correlation between dADC and Ki-67 expression was examined.</p><p><strong>Results: </strong>The maxADC and minADC of type II EOC were lower than those of type I, while dADC was higher than type I ( P <0.05). ROC curve analysis showed that the efficacy of dADC in distinguishing between type I and type II EOC was higher than that of minADC and maxADC ( P <0.05). When the dADC threshold was 0.31×10 -3 mm 2 /s, the area under the curve (AUC) was 0.982, with a sensitivity of 95.3% and specificity of 97.3%. Pearson correlation analysis showed a positive correlation between dADC and Ki-67 expression.</p><p><strong>Conclusion: </strong>dADC has a certain value in accurately distinguishing between type I and type II EOC preoperatively, and it can reflect the proliferative activity of tumor cells.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"714-720"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erkan Bilgin, Ezel Yaltirik Bilgin, Ahmet Bayrak, Şahap Törenek
{"title":"Effectiveness of CT Histogram Analysis to Differentiate Lung Metastases From Second Primary Lung Cancer to Decrease Need for Lung Biopsy.","authors":"Erkan Bilgin, Ezel Yaltirik Bilgin, Ahmet Bayrak, Şahap Törenek","doi":"10.1097/RCT.0000000000001742","DOIUrl":"10.1097/RCT.0000000000001742","url":null,"abstract":"<p><strong>Objective: </strong>Differentiating lung metastasis from second primary lung cancer is crucial for determining the appropriate treatment strategy. Lung biopsy, the gold standard for diagnosis, is an invasive procedure. This study aimed to evaluate the potential of CT histogram analysis as a noninvasive method for differentiating these 2 conditions in solitary pulmonary nodules.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on CT images of patients with solitary pulmonary nodule, confirmed to be either lung metastasis or second primary lung cancer histopathologically. Histogram analysis features of the lesion and perilesional area were extracted from the CT images and subjected to statistical analysis to identify significant differences between the 2 groups. The performance of histogram analysis was assessed using sensitivity, specificity, and area under the ROC curve.</p><p><strong>Results: </strong>The data of 26 (46%) patients whose lung biopsy pathology was determined as second primary lung cancer and 30 (54%) patients defined as lung metastasis were investigated. The second primary lung cancer's mean pathologic tumor diameter was statistically higher than the lung metastasis [25.3 (5.7) mm, 18.3(5.6) mm; P =0.003]. The mean skewness ( P =0.020) and entropy ( P =0.018) values in the second primary lung cancer were statistically significantly lower in the lesion area. There was a statistically significant difference in the mean measurement of SD ( P =0.001), skewness ( P <0.001), kurtosis ( P <0.001), and entropy ( P <0.001) values between the 2 groups in the perilesional area.</p><p><strong>Conclusion: </strong>CT histogram analysis shows promise as a noninvasive method for differentiating lung metastasis from second primary lung cancer in solitary pulmonary nodules.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"759-763"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Image Findings and Background Characteristics of Extrapleural Air Collection: A Pneumothorax Mimicker.","authors":"Hiroki Nishinaka, Mami Oi, Takashi Hiroi, Sho Ishikawa, Hitomi Kawamura, Koji Tokunaga, Shigeaki Umeoka","doi":"10.1097/RCT.0000000000001747","DOIUrl":"10.1097/RCT.0000000000001747","url":null,"abstract":"<p><strong>Objective: </strong>The extrapleural space (EPS) is a potential space external to the thoracic cavity. Extrapleural air collection (EAC) refers to the accumulation of air within the EPS. Differentiating EAC from pneumothorax using imaging is challenging but crucial for accurate diagnosis and effective management. This retrospective study aimed to identify imaging and clinical findings that aid in distinguishing EAC from pneumothorax.</p><p><strong>Materials and methods: </strong>Two radiologists reviewed 2771 cases of pneumothorax identified in computed tomography reports, focusing on web-like linear septa within air collection around the lung (described as a web appearance). Twenty-two patients met the inclusion criteria. Additional imaging findings, including pneumomediastinum, dependent distribution (air localized dorsally relative to the ventral margin of the descending aorta), and perivascular distribution (air surrounding the internal thoracic artery), were evaluated. Patient background information was analyzed using medical records. We also investigated CT images of a control group to determine whether these imaging characteristics could be observed in age/sex-matched patients with typical pneumothorax.</p><p><strong>Results: </strong>Pneumomediastinum was observed in all cases. Dependent distribution and perivascular distribution were present in 59% (13/22) and 50% (11/22) of cases, respectively.Concurrent interstitial lung disease and steroid use were identified in 77% (17/22) and 73% (16/22) of patients, respectively. In contrast, pneumomediastinum, dependent distribution and perivascular distribution were present in 4.5% (1/22), 55% (12/22), and 0% (0/22) of cases in the control group. In particular, pneumomediastinum ( P =3.71×10 -10 ) and perivascular distribution ( P =1.53×10 -4 ) were statistically more frequent in EAC patients than in the control group.</p><p><strong>Conclusions: </strong>Pneumomediastinum is a critical diagnostic feature of EAC. Dependent distribution and perivascular distribution are valuable imaging findings for diagnosing EAC. Careful interpretation is warranted when pneumomediastinum is observed in patients with interstitial lung disease or those on steroid therapy.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"764-768"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tahsin Aybal, Onur Buğdayci, Erkin Aribal, Handan Kaya, Mustafa Ümit Uğurlu, Can Ilgin
{"title":"Evaluation of High-risk (B3) Breast Lesions on MRI: The Role of Diffusion-weighted Imaging and Texture Analysis Features in Predicting Upgrade to Malignancy.","authors":"Tahsin Aybal, Onur Buğdayci, Erkin Aribal, Handan Kaya, Mustafa Ümit Uğurlu, Can Ilgin","doi":"10.1097/RCT.0000000000001745","DOIUrl":"10.1097/RCT.0000000000001745","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential malignancy associated with high-risk breast lesions using breast magnetic resonance imaging (MRI) characteristics, apparent diffusion coefficient (ADC) measurements, and texture analysis parameters.</p><p><strong>Methods: </strong>This retrospective study included 40 patients with 41 lesions diagnosed as high-risk lesions after needle biopsy. All the patients underwent surgery. Based on the histopathologic results of the surgical excision, the patients were divided into 2 groups: those diagnosed with malignancy and those who were not. The MRI characteristics of the lesions were recorded. The ADC values of the lesions were measured. Textural analysis of the lesions was also performed.</p><p><strong>Results: </strong>Fourteen lesions (34.1%) were upgraded to malignancy. The median ADC mean values in the malignant group were 1.114 × 10 -3 versus 1.383×10 -3 mm 2 /s in the nonmalignant group, which was statistically significant ( P < 0.001). The cutoff value for the mean ADC was 1.163 ×10 -3 mm 2 /s. The sensitivity and specificity were 71.4% and 85.2%, respectively. Among the texture analysis parameters, kurtosis values obtained from images on the ADC map and the first subtracted dynamic contrast-enhanced (DCE) series and contrast values obtained from images on the second subtracted DCE series were found to be statistically significant ( P = 0.016, P = 0.019, and P = 0.045, respectively) between the malignant and nonmalignant groups.</p><p><strong>Conclusions: </strong>ADC measurements and texture analysis parameters provide useful diagnostic information for determining which high-risk breast lesions will progress to malignancy.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"721-728"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehrdad Mozafar, Mobina Amanollahi, Mohammad Sadeghi, Ali Rafati, Seyyed Sina Hejazian, Faraz Jelodar, Negar Khodadadi, Artemis Kohanfekr, Arash Kamali
{"title":"Baseline Brain Volumes Predict Future Brain Atrophy in Mild Cognitive Impairment: A Tensor-based Morphometry Study of the Alzheimer Continuum.","authors":"Mehrdad Mozafar, Mobina Amanollahi, Mohammad Sadeghi, Ali Rafati, Seyyed Sina Hejazian, Faraz Jelodar, Negar Khodadadi, Artemis Kohanfekr, Arash Kamali","doi":"10.1097/RCT.0000000000001744","DOIUrl":"10.1097/RCT.0000000000001744","url":null,"abstract":"<p><strong>Objective: </strong>Prognostic evaluation of patients with mild cognitive impairment (MCI) is of great importance, and magnetic resonance imaging, as a readily available modality, can play a pivotal role in this field.</p><p><strong>Methods: </strong>Using the Alzheimer Disease Neuroimaging Initiative database, we conducted a retrospective longitudinal study of the associations between volumetric brain magnetic resonance imaging and cognitive composite scores in all domains (memory, executive function, language, and visuospatial) with annual whole-brain atrophy based on tensor-based morphometry (TBM) scores among patients with MCI and healthy controls (HCs). The Reliable Change Index was further used to categorize patients into 2 groups including (1) patients with meaningful 1-year reliable cognitive changes [reliable change (RC) group] and (2) patients without (non-RC).</p><p><strong>Results: </strong>One hundred thirty-seven patients with MCI and 132 HCs were enrolled. The 2 groups showed no significant differences in age, sex, and apolipoprotein E4 expression ( P > 0.05). Based on the TBM score, patients with MCI had more significant 1-year brain volume loss than HCs ( P < 0.001). After multiple comparison corrections, the 1-year TBM atrophy score was positively correlated with baseline whole brain ( P = 0.03), hippocampus ( P < 0.0001), entorhinal ( P < 0.0001), and middle temporal ( P < 0.0001) volumes among MCI patients, indicating that lower volumes in these regions were associated with greater 1-year atrophy rates. Regression analyses showed a positive correlation between baseline and 1-year memory composite scores and annual brain atrophy rate in MCI patients ( P = 0.01, 0.04), demonstrating that lower cognitive scores were associated with a greater annual atrophy rate. However, the correlations no longer held significance after correction for multiple comparison ( P = 0.05, 0.17). MCI participants with RCs in language composite scores initially had significantly greater brain atrophy than those without ( P = 0.03, corrected P = 0.06). However, TBM scores showed no significant differences between RC and non-RC groups for other composite scores ( P > 0.05).</p><p><strong>Conclusions: </strong>Lower baseline volumes in multiple brain regions of MCI are associated with greater annual brain volume loss based on TBM, suggesting TBM as a potential imaging marker for conventional volumetric studies in MCI. Further research is needed to explore the link between cognitive scores and the application of Reliable Change Index in TBM imaging across the Alzheimer disease spectrum.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"816-824"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kalpana Kanal, David Zamora, Richard Harruff, Jeffrey Robinson, William Shuman, Dushyant Sahani, J Matthew Lacy, Nicole Yarid, Jonathan Medverd
{"title":"Early Experience With Postmortem CT Imaging.","authors":"Kalpana Kanal, David Zamora, Richard Harruff, Jeffrey Robinson, William Shuman, Dushyant Sahani, J Matthew Lacy, Nicole Yarid, Jonathan Medverd","doi":"10.1097/RCT.0000000000001732","DOIUrl":"10.1097/RCT.0000000000001732","url":null,"abstract":"<p><strong>Objective: </strong>Postmortem computed tomography (PMCT) is a procedure fairly unfamiliar to many US radiologists. We embarked on a collaboration between the department of radiology and the medical examiner's office (MEO) with the purpose of introducing PMCT into the autopsy workflow and the goal of assisting forensic pathologist decision-making regarding the need for autopsy in determining cause of death.</p><p><strong>Methods: </strong>Establishing this service involved coordination, education, and extensive planning involving numerous professionals volunteering their time and effort. For the last 2 years, PMCT has been performed on cases requested by the MEO. Two emergency radiologists issued double-read reports detailing the PMCT findings, and the MEO completed a report detailing the PM examination process, which always included an external examination and often included an autopsy. Shared documentation summarized decedent and case information (eg, medical history), radiology primary findings and impressions, and the pathology report findings (including autopsy conclusions, when performed).</p><p><strong>Results: </strong>As of July 2024, 116 PMCT examinations have been performed, of which 64 (55.2%) underwent formal autopsy, 2 (1.7%) received limited autopsy, and 50 (43.1%) had no subsequent autopsy performed. MEO conducted external exam only when PMCT findings were conclusive for the cause of the death, demonstrating that CT had a role in supplanting the need for an autopsy. Indications for PMCT included Rule out trauma, assess extent of trauma, and family/religious objection. The manner of death for these cases was classified as accident, homicide, natural, suicide, traffic related, or undetermined.</p><p><strong>Conclusions: </strong>PMCT can be a valuable service to decedent families as well as to forensic pathologists who often operate in a limited resource environment. We anticipate that PMCT will become a standard discipline in forensic analysis. This service can often reduce the need for traditional autopsy and provides the potential to honor cultural sentiments and religious needs surrounding traditional autopsy. Establishing such a service requires the co-operation of many stakeholders, sometimes across institutional boundaries. PMCT broadens the experience of the radiologist and provides the potential for collaborative research and educational opportunities between radiology and the MEO. Lessons learned from this study may be useful for other jurisdictions implementing PMCT.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"785-792"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editors' Recognition of Reviewers' Service and Awards for Distinction for Reviewing in 2024.","authors":"","doi":"10.1097/RCT.0000000000001790","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001790","url":null,"abstract":"","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":"49 5","pages":"683-684"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spectral Shaping Computed Tomography Applications.","authors":"Julian Wong, Peter Kutschera, Kenneth K Lau","doi":"10.1097/RCT.0000000000001738","DOIUrl":"10.1097/RCT.0000000000001738","url":null,"abstract":"<p><p>Spectral shaping (also known as spectral filtration) has been utilized in some of the latest computed tomography (CT) systems. This technique involves using tin (Sn) or silver (Ag) filters, which selectively absorb low-energy photons. This review aims to demonstrate the utility of spectral shaping across a wide range of protocols and clinical situations. Spectral-shaped CT protocols using tin filters allow for the acquisition of diagnostic images and greatly reduce the radiation dose, metal artifacts, and photon starvation. These features make spectral shaping suitable for various clinical situations in diagnostic and interventional CT imaging.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"777-784"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Computed Tomography Combined With Real-time Ultrasound-guided Percutaneous Needle Biopsy of Peripleural Lung Nodules.","authors":"Yingzhen Chen, Jun Liu, Jingjing Ji, Yanjun Zhao","doi":"10.1097/RCT.0000000000001739","DOIUrl":"10.1097/RCT.0000000000001739","url":null,"abstract":"<p><strong>Background: </strong>Ultrasound is rarely used for lung biopsy because the ultrasound window is too narrow to capture puncture points and perform whole imaging of lesions. The present study examined the usefulness of computed tomography (CT) combined with real-time ultrasound-guided percutaneous needle biopsy for peripleural lesions in clinical practice.</p><p><strong>Methods: </strong>In total, 59 patients with peripleural lesions who had undergone CT combined with ultrasound-guided percutaneous biopsy and 70 patients who had undergone conventional CT-guided biopsy at the Radiology Department of Wuxi NO.2 People's Hospital between January 2017 and June 2023 were enrolled. The operation duration, machine room occupation duration, number of CT-guided scans, radiation dose absorbed from the CT scans, and puncture-related complications were compared between the 2 groups of patients.</p><p><strong>Results: </strong>The operation duration (CT: 31.21 ± 7.99 min vs. CT + ultrasound: 22.20 ± 5.14 min, P < 0.001) and room occupation duration (43.17 ± 7.94 vs. 32.78 ± 5.15 min, P < 0.001) were significantly shorter and the number of CT-guided scans (3.31 ± 0.84 vs. 2.22 ± 0.42 times, P < 0.01) and the radiation dose absorbed from the CT scans were significantly lower (3.89 ± 1.07 vs. 2.56 ± 0.64 mSv, P < 0.001) in the CT combined with ultrasound group than in the conventional CT-guided puncture group. The results were significant after adjusting for age, sex, lesion thickness, and puncture depth.</p><p><strong>Conclusions: </strong>CT combined with real-time ultrasound-guided biopsy may be a useful biopsy technique for peripleural lesions in general hospitals.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"751-758"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amine El Kandoussi, Steven J Staffa, Emre Ömeroğlu, Yin P Hung, Fabian Bauer, Santiago Lozano-Calderon, Connie Y Chang
{"title":"Triangular Margin: Reliable Imaging Feature of Fibrous Dysplasia in Long Bones?","authors":"Amine El Kandoussi, Steven J Staffa, Emre Ömeroğlu, Yin P Hung, Fabian Bauer, Santiago Lozano-Calderon, Connie Y Chang","doi":"10.1097/RCT.0000000000001731","DOIUrl":"10.1097/RCT.0000000000001731","url":null,"abstract":"<p><strong>Objective: </strong>To determine the utility of a triangular margin as an imaging diagnostic feature for fibrous dysplasia.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed all surgically biopsied or managed benign and malignant bone tumors by a single orthopedic oncologist over 19 years (2003 to 2022). A musculoskeletal radiologist and an orthopedic oncologist, both with >10 years of experience, retrospectively evaluated all imaging in consensus. Groups were compared using the χ 2 test.</p><p><strong>Results: </strong>There were a total of 152 subjects [mean age 49±21 (range 7.8 to 91) years]; 80 (53%) females and 72 (47%) males. There were 52 subjects with fibrous dysplasia, 31 subjects with other benign bone tumors, and 69 subjects with malignant bone tumors. The sensitivity and specificity of a triangular margin for distinguishing fibrous dysplasia from other benign or malignant bone tumors were 74% and 96% on radiographs, 73% and 100% on CT, and 78% and 91% on MRI, respectively. The triangular margin was more prevalent in fibrous dysplasia (85%) versus benign (16%) and malignant (1.6%) primary bone tumors in all 3 modalities ( P <0.001). Multivariate analysis of the aggregated imaging data suggests that if a lesion has a triangular margin, it is 14 times more likely to be a fibrous dysplasia than another benign bone tumor ( P =0.012).</p><p><strong>Conclusions: </strong>The presence of a triangular margin could increase a radiologist's confidence that a bone tumor is fibrous dysplasia.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"793-799"},"PeriodicalIF":1.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}