The Siberian Medical Journal最新文献

{"title":"THE RESULTS OF STEP-BY-STEP MYOCARDIAL REVASCULARIZATION IN PATIENTS WITH ACUTE CORONARY SYNDROME AND MULTIVESSEL CORONARY ARTERY DISEASE: EARLY PERFORMING CORONARY ARTERY BYPASS SURGERY AFTER STENTING USING BARE-METAL STENTS","authors":"A. V. Bocharov, L. V. Popov","doi":"10.29001/2073-8552-2019-34-2-84-88","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-84-88","url":null,"abstract":"Objective: To compare the long-term results of coronary artery bypass grafting performed in the early period after stenting for acute coronary syndrome by bare-metal stents with the results of coronary artery bypass grafting in patients with coronary heart disease.Material and Methods. The results of 24-month follow-up of step-by-step treatment of patients with acute coronary syndrome and multivessel lesion who received stenting of clinical-dependent artery with bare-metal stents as the first step and, then, underwent functional myocardial revascularization by aortocoronary bypass surgery within 90 days were analyzed. Results are presented as mean value and standard deviation (M±SD) in case of normal distribution and median with interquartile range in the form of 25 and 75 percentiles in case of non-normal distribution. The type of distribution of quantitative variables was assessed by the Lilliefors-corrected Kolmogorov–Smirnov test. Efficacy and safety assessments were carried out according to the criteria of non-inferiority in comparison with the literature data of myocardial revascularization by stenting. The differences were estimated using a two-way 95% confidence interval of the difference in adverse events based on the selected noninferiority design.Results. Surgical revascularization of the coronary bed in the early period after stenting of the clinically dependent artery using bare-metal stents in patients with acute coronary syndrome and multivessel lesion was equivalent to coronary artery bypass grafting, except for the rate of repeated revascularization.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115653031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE FUNCTIONAL PROPERTIES OF A BIOLOGICAL CASE FOR IMPLANTABLE CARDIAC DEVICES, IMPREGNATED WITH BIOACTIVE SUBSTANCES IN AN EXPERIMENT ON LARGE LABORATORY ANIMALS","authors":"E. A. Artukhina, V. Vaskovskiy, A. Venediktov, S. V. Evdokimov, S. S. Durmanov, I. A. Evtjushkin, V. Bazylev, A. Revishvil","doi":"10.29001/2073-8552-2019-34-2-118-128","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-118-128","url":null,"abstract":"Aim. The purpose of the experimental study was to determine the functional properties of the case with antibacterial and hemostatic preparations impregnated on it, to assess the biological safety and the effectiveness of using this medical device in an in vivo model on large laboratory animals (pigs).Material and Methods. The article presents the first results of an experimental study of a domestic extracellular collagen matrix-based biological case “Bio-NEST” for implantable cardiac devices, impregnated with bioactive substances, in an in vivo experiment on large laboratory animals. The experiment was conducted in three chronological stages to analyze and evaluate the safety, efficacy, and histological compatibility of the biological sheath during implantation and reimplantation of cardiac devices using bioactive substances (antibacterial, hemostatic, and their combinations) as well as under the conditions of the established model of infection with pathogenic microflora implant pocket.Results. Results of the study showed that the use of the experimental cover sample was safe for a laboratory animal. Experimental samples were biocompatible and did not cause inflammatory and immune responses. Implantation of cardiac devices in the sample of the case allowed preventing implant migration and development of infectious inflammation of the implant bed when the experimental cover was impregnated with a solution of rifampicin and aminocaproic acid.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127894936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT OF NONINVASIVE TOPICAL DIAGNOSTICS OF CARDIAC ARRHYTHMIAS","authors":"M. Khlynin, R. Batalov, N. V. Kiselev, I. F. Nam, V. Silivanov, S. A. Spisivtsev","doi":"10.29001/2073-8552-2019-34-2-9-20","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-9-20","url":null,"abstract":"Heart arrhythmias may accompany virtually any cardiac disease. The problem of the preprocedure topical diagnostics of various arrhythmias remains fundamentally important and relevant, which is confirmed by numerous algorithms aimed at non-invasive detection of the arrhythmogenic focus location. Today, many different methods are available for non-invasive topical diagnostics of the arrhythmogenic foci in both ventricular and atrial arrhythmias. A non-invasive imaging of cardiac electrophysiology (NICE), based on the solution of the inverse problem of the electrocardiography, is the most advanced new technology. The accuracy of NICE reaches 90%, however, it is still inferior in its capabilities to the “reference” method of the invasive intracardiac electrophysiological examination. Currently, the market presents devices for both invasive mapping and NICE. However, in the context of surgery, an integrated system of non-invasive electrophysiological mapping with invasive three-dimensional electroanatomic mapping is of high demand. The creation of hybrid systems will allow to visualize electrophysiological processes in the epi- and endocardial surface in the real time with very high accuracy and to carry out the radiofrequency catheter ablation of arrhythmias with the simultaneous reduction of the radiation load on the patient and medical personnel.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125246434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF THE NEW NAVIGATION SYSTEM “ASTROCARD” (RUSSIA) WITH THE ABILITY TO INTEGRATE THE COMPUTER MODEL OF THE LEFT ATRIUM FOR THE TREATMENT OF ATRIAL FIBRILLATION AND FLUTTER","authors":"M. V. Yashkov, E. A. Artukhina, A. Popov, V. A. Vasin, A. Revishvili","doi":"10.29001/2073-8552-2019-34-2-33-38","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-33-38","url":null,"abstract":"Aim. The first experience of the application of the integration algorithm for computed tomography of the heart with the navigation system “Astrocard” (Russia) when performing radiofrequency ablation in patients with atrial fibrillation and flutter.Material and Methods. A total of 31 patients with atrial fibrillation and two patients with atypical left atrial flutter were subjected to electroanatomical reconstruction of the left atrium and pulmonary veins with computed tomography of the heart. In patients with atrial fibrillation, an ablation scheme involved for antral isolation of the pulmonary veins. In patients with atypical left atrial flutter, linear ablation was applied in the area of slow conduction. The duration of the operation was 58±14.5 min, and the time of fluoroscopy was 33±8 min.Conclusion. The merge function of the “Astrocard” navigation mapping system (Russia) provided an accurate comparison of the electroanatomical map with the computed tomography of the heart, which allowed us to minimize the time of fluoroscopy and the time of operation.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131005178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIAC CONTRACTILITY MODULATION IN HEART FAILURE PATIENTS. FUNDAMENTAL MECHANISMS AND CLINICAL RESULTS","authors":"I. A. Ryabov, T. Chichkova, S. Mamchur, E. Khomenko","doi":"10.29001/2073-8552-2019-34-2-26-32","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-26-32","url":null,"abstract":"This review highlights the preclinical and clinical data about a relatively new electrophysiological method for chronic heart failure (CHF) treatment, cardiac contractility modulation (CCM). The review presents efficacy and safety data. An updated information about the capability of CCM to influence the molecular genetic apparatus of the cardiomyocytes is proposed. In addition, the review assesses prospects for application of CCM as a tool for reverse cardiac remodeling in patients with CHF.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121297650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INDICATIONS FOR IMPLANTATION AND EFFICIENCY OF CARDIOVERTER-DEFIBRILLATORS IN PATIENTS WITH DILATED CARDIOMYOPATHY","authors":"E. Solovyeva, O. Blagova, V. Sedov, E. Kogan, E. Zaklyazminskaya","doi":"10.29001/2073-8552-2019-34-2-54-62","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-54-62","url":null,"abstract":"Purpose. To assess the frequency and predictors of appropriate shocks of cardioverter-defibrillators in patients with dilated cardiomyopathy (DCM) syndrome and the impact on the total mortality and sudden cardiac death (SCD).Material and Methods. A total of 275 patients with DCM syndrome (average age of 46.8 ± 12.5 years; 185 males and 90 females) were observed. Inclusion criteria were left ventricular (LV) end-diastolic diameter (EDD) more than 5.5 cm and LV ejection fraction (EF) less than 50%. Patients with coronary artery stenosis more than 50% were excluded. Implantable cardioverter-defibrillator (ICD) (n=44) and cardiac resynchronization therapy defibrillator (CRT-D) (n=32) were implanted in 76 (27.6%) patients (53 males and 23 females, average age of 48.9±12.9 years, LV EDD of 6.7±0.8 cm, and LV EF of 28.2±9.9%). A comparison group comprised 199 patients (72.4%) without devices (132 males and 67 females, average age of 46.0±12.3 years, LV EDD of 6.5±0.8 cm, and LV EF of 32.0±10.2%). The average follow-up was 27 (24; 30) months.Results. SCD in patients with DCM syndrome was recorded in 2.9% of cases; the total mortality rate was 18.9%; the rate of death + transplantation was 22.6%. The SCD, total mortality, and death+transplantation rates were 2.6% (4.6/0%), 23.7% (22.7/25.0%), and 32.9% (34.1/31.3%) in patients with devices (ICD/CRT-D) and 3.0%, 17.1%, and 16.6% in patients without devices, respectively. The rate of SCD+appropriate shocks (ASR) was significantly higher in study group: 26.3 vs 3.0% in comparison group (p<0.001). The nature of DCM syndrome was predominantly inflammatory (53%), primary (genetic) (19.6%), and multifactorial (25.1%). Genetic forms of DCM were represented by non-compaction cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy (ARVC), myopathies, and amyloidosis. The pathogenic mutations in the genes LMNA (n=1), DES (n=2), DSP (n=2), EMD (n=2), PKP2 (n=1), TTR (n=1), MUH7+MyBPC3 (n=1), and MyBPC3 (n=4) were detected. The ASR (ICD/CRT-D) rate was 23.7% (n=13/5). The only reliable predictor of ASR was the generic nature of DCM syndrome, identified in 100% of patients with shocks (in the presence of myocarditis in 77.8%/isolated in 22.2%) in comparison with 51.7% (29.3/22.4%) in patients without ASR (p<0.002, AUC 0.747, RR 1.66, 95% CI 0.711-3.885). Ventricular tachycardia (VT) was registered in 84% of patients with shocks (stable/unstable VT rates of 17/67%) vs 1.7/72%, in patients without shocks (р=0.06). In patients with shocks, low QRS voltage (39 vs 6.9%, р<0.05) and the absence of LV hypertrophy signs on the ECG (77.6 vs 58.6%, р>0.05) were registered more often. The average LV EF was higher in patients with ASR (34.4±9.7%) in comparison with patients without ASR (25.9±8.8%), р<0.005. Conclusions. The genetic nature of DCM syndrome is an important predictor of appropriate shocks and an independent selection criterion for ICD/CRT-D implantation. Age, NYHA class, and LV EF did not show prognostic signi","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130149573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TWO CASE REPORTS OF SUCCESSFUL CONSERVATIVE TREATMENT OF DISSECTING AORTIC ANEURYSM","authors":"А. Толмачева, Н. Г. Ложкина, В. А. Козик, Е. А. Стафеева, Е. А. Найдена, М. Х. Хасанова, И. Мукарамов, Б. Барбарич, О. М. Пархоменко, А. Д. Куимов, Anastasia A. Tolmacheva, N. G. Lozhkina, Valentina A. Kozik, E. A. Stafeeva, E. A. Najdena, Madina H. Hasanova, I. Mukaramov, V. Barbarich, Olga M. Parhomenko, A. Kuimov","doi":"10.29001/2073-8552-2019-34-2-113-117","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-113-117","url":null,"abstract":"The relevance of this topic is due to the difficulties of diagnosis and management of patients with aortic dissection and the need for the interaction between doctors of different specialties whereas exact algorithm with clearly defined time frame for surgical treatment and overall criteria for choosing between conservative and surgical tactics of treatment in these patients are not currently available. This article presents two clinical cases illustrating the differences in clinical and anamnestic parameters and complexity of treatment of patients with aortic dissection as well as the organization of team work of specialists for the purpose of personalized approach to management of patients with extremely high cardiovascular risk.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129121880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE COMPLEXITY OF THE TREATMENT OF CARDIAC ARRHYTHMIAS IN PREGNANT WOMEN. CASE OF RADIOFREQUENCY ABLATION OF ATRIAL TACHYCARDIA IN A PREGNANT WOMAN USING A THREE-DIMENSIONAL NONFLUOROSCOPIC NAVIGATION SYSTEM","authors":"А. Киргизова, А. А. Дедкова, В. Кистенева, M. A. Kirgizova, Anna A. Dedkova, I. Kisteneva, Sergey N. Krivolapov","doi":"10.29001/2073-8552-2019-34-2-106-112","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-106-112","url":null,"abstract":"Purpose. Pregnant women, due to physiological changes in the body, are more prone to cardiac arrhythmias, the frequency of which ranges from 5 to 18%. Paroxysmal supraventricular tachycardia (SVT) occurs in 14% of pregnant women with cardiac arrhythmias. In the treatment of cardiac arrhythmias, radiofrequency ablation (RFA) is currently preferred over antiarrhythmic drugs. However, RFA is associated with radiation exposure to the mother and fetus. The current level of development of arrhythmology provides a unique opportunity to eliminate cardiac arrhythmias without the use of fluoroscopic technologies, which completely excludes radiation exposure.Clinical case. The article presents a clinical case of a 17-year-old patient diagnosed with idiopathic paroxysmal atrial tachycardia successfully treated in Cardiology Research Institute, Tomsk NRMC. When admitted to the hospital, the patient was at 31 weeks of pregnancy.Conclusion. The described case shows the possibility and necessity of using non-fluoroscopic navigation systems when performing RFA in pregnant women. RFA using electroanatomic mapping allows to remove the burden of receiving antiarrhythmic therapy in pregnant women without the use of X-ray.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129019484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLEXIBLE RINGS IN COMPARISON WITH RIGID RINGS IN THE TREATMENT OF FUNCTIONAL TRICUSPID INSUFFICIENCY: TWO DIFFERENT MODELS OF REVERSE REMODELING OF THE RIGHT HEART","authors":"M. Ovcharov, A. Bogachev-Prokofiev, D. A. Astapov, A. Pivkin, K. S. Malozemov, T. N. Podsosnikova, O. Malakhova, A. Karaskov","doi":"10.29001/2073-8552-2019-34-2-89-98","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-89-98","url":null,"abstract":"Objective. To compare the models of reverse remodeling of the right heart after the tricuspid valve repair with rigid or flexible rings.Material and Methods. During the period from September, 2016 to February, 2018, 308 patients who had indications for intervention on the mitral valve and concomitant tricuspid insufficiency without significant differences in clinical status were randomized into two groups. Patients of both groups underwent intervention on the mitral valve with concomitant tricuspid valve repair by a rigid ring (Rigid group, n=154) or a flexible ring (Flex group, n=154)Results. The perioperative mortality rates were 2.0% in the Rigid group and 2.5% in the Flex group (p=0.504). There was no difference in the pacemaker implantation rate (5.1% vs. 2.6%, p=0.238). Freedom from tricuspid insufficiency recurrence at 12 months follow-up was comparable (96.7% in the Rigid group vs 96.1% in the Flex group, p=0.521). The global systolic function of the right ventricle (fractional change in area, FAC; ejection fraction, EF) significantly increased in both groups (p<0.001 for both group) without significant intergroup differences (p=0.231 for FAC; p=0.156 for EF). Intergroup comparison of the regional systolic function (systolic excursion tricuspid valve, TAPSE; longitudinal velocity of the tricuspid valve, S’) showed that patients of the Flex group had significantly higher increases in the parameters (p<0.001 for TAPSE; p=0.002 for S’).Conclusion. Both types of the devises had low rates of recurrence of tricuspid insufficiency at the midterm follow-up and contributed to the restoration of the global systolic function of the right ventricle. However, the rigid rings due to their design fix the tricuspid valve annulus, which inevitably affects the regional systolic function. In perspective, the flexible rings can function without interfering with the restoration of the natural shape of the tricuspid valve annulus and its uniform contraction during the cardiac cycle, thus ensuring a significant increase in regional systolic function.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134548857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION OF ADRENOREACTIVITY WITH THE STAGE OF CHRONIC HEART FAILURE IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION","authors":"V. Aleksandrenko, T. Rebrova, S. Afanasiev, A. Garganeeva","doi":"10.29001/2073-8552-2019-34-2-79-83","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-2-79-83","url":null,"abstract":"Objective. To identify associations of beta-adrenoreactivity with stage of chronic heart failure (CHF) in patient with previousmyocardial infarction (MI).Material and Methods. A total of 50 patients with CHF underwent an analysis of adrenoreactivity based on the changes in red blood cellosmoresistance in the presence of adrenergic blocker to determine the activity of the sympathoadrenal system a year after MI.Results. Higher levels of beta-adrenoreactivity (β-ARM) were characteristic of patients with CHF of higher gradations: 61.8(47.5;74.8) с.u. in patients with stage IIA CHF versus 48.7 (39;65.2) с.u. in patients with stage I CHF, p=0.037.Conclusion. These results may suggest the diagnostic value of the indicator of adrenoreactivity and its possible use as a newbiomarker for assessing the severity of CHF in patients with previous myocardial infarction.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124293417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}