The Siberian Medical Journal最新文献

{"title":"The association of glycemia level and myocardial functional indices in patients with coronary heart disease and type 2 diabetes mellitus","authors":"D. Kondratieva, S. Afanasiev, O. V. Budnikova, I. Vorozhtsova, S. Akhmedov, V. Shipulin","doi":"10.29001/2073-8552-2020-35-1-133-141","DOIUrl":"https://doi.org/10.29001/2073-8552-2020-35-1-133-141","url":null,"abstract":"Introduction. The strict control of glycemia does not always lead to positive effects associated with a decrease in cardiovascular complications. Moreover, the combined development of type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) makes it challenging to control glycemic levels adequately. Objective. To study the relationship between glycemia and functional myocardial parameters in patients with coronary artery disease and type 2 diabetes mellitus. Material and Methods. The study included patients with a diagnosis of chronic coronary artery disease associated with type 2 diabetes mellitus. We studied the echocardiography-based structural and functional parameters of the heart and the contractile properties of the myocardium in patients ex vivo depending on the level of glycated hemoglobin (НbА1с). The ex vivo studies were performed on trabeculae isolated from the right atrial appendage obtained during coronary artery bypass surgery. The contractile function of trabeculae was assessed based on an extrasystolic effect and a resting effect (post-rest reaction). Results. Patients were divided into two groups according to the HbA1c level: group 1 included patients with HbA1c less than 8%; group 2 comprised patients with HbA1c more than 8%. The main clinical baseline parameters were similar between the groups. The ejection fraction (EF) was higher, whereas the thickness of the left ventricular posterior wall (LVPW) was lower in patients of group 1 compared to the corresponding parameters of group 2. The ex vivo study of myocardial contractility showed that extrasystolic contractions occurred at earlier extrasystolic intervals in patients of group 2, suggesting higher excitability of the cardiomyocyte membranes. At the same time, post-extrasystolic contractions of trabeculae in patients of group 2 had significant potentiation. The amplitude of post-rest trabeculae contractions was potentiated at short rest periods in patients of both groups. However, post-rest contractions significantly increased with an increase in the duration of rest periods only in group 2. Post-rest inotropic response in patients of group 1 did not have any potentiation after long rest periods. Conclusions. The results of this study based on the contractility of isolated trabeculae showed that the increased HbA1c levels are better indicators of the myocardial functional state.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114552984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal obesity and other components of metabolic syndrome among the young population of Novosibirsk","authors":"Y. Ragino, V. I. Oblaukhova, D. Denisova, N. Kovalkova","doi":"10.29001/2073-8552-2020-35-1-167-176","DOIUrl":"https://doi.org/10.29001/2073-8552-2020-35-1-167-176","url":null,"abstract":"Objective. To study the prevalence of abdominal obesity (AO) and metabolic syndrome (MS) components among young adults in the city of Novosibirsk. Material and Methods. A cross-sectional study of the young population of Novosibirsk was performed in 2013–2017. A representative sample comprised 1,512 people aged 25–44 years. The study included 1,449 people (45.6% men) based on the presence of all criteria required to perform the analysis according to the goal. The following age groups were assigned for the study: group 1 comprised 25–34-year-old individuals; group 2 included 35–44-year-olds. According to the recommendations for diagnosis and treatment of MS (RSC, 2009), AO was detected when participants had a waist circumference greater than 94/80 cm in men/women; hypertriglyceridemia (hyper-TG) when triglycerides (TG) were ≥ 1.7 mmol/L; low-density lipoprotein (LDL) hypercholesterolemia (hyper-LDL) when LDL cholesterol was > 3.0 mmol/L; highdensity lipoprotein (LDL) hypocholesterolemia (hypo-HDL) when HDL cholesterol was < 1.0/1.2 mmol/L in men/women; hypertension (AH130/85) when blood pressure (BP) was ≥ 130/85 mmHg; and fasting hyperglycemia (hyper-Gl) when fasting plasma glucose was ≥ 6.1 mmol/L. Results. The prevalence rates of AO were 43.0% in men and 42.0% in women (p = 0.679); AН130/85 rates were 48.6% in men and 20.9% in women (p < 0.0001); hyper-TG rates were 24.5% in men and 9.9% in women (p < 0.0001); hypo-HDL rates were 20.0% in men and 24.7% in women (p = 0.033); hyper-LDL rates were 60.3% in men and 50.3% in women (p = 0.0002); and hyper-Gl rates were 32.4% in men and 15.7% in women (p < 0.0001). An increase in age was associated with a significant increase in the frequencies of AO, AH130/85, hyper-LDL, and hyper-Gl in both men and women (age group 2 relative to group 1). A tendency to an increase in hyper-TG was observed in women. In terms of prevalence, men had the highest prevalence rate of hyper-LDL followed by AH130/85 (the second-highest rate) and AO (the third-highest rate). Women had the highest prevalence rate of hyper-LDL, followed by AO (the second-highest rate). According to the results of univariate analysis, AO was associated with all components of MS in both men and women. The frequency of MS (RSC, 2009) was 32.0% in men and 22.2% in women (p < 0.0001). Conclusions. Data obtained demonstrate the prognostically unfavorable situation in regard to cardiovascular pathology among young adults of Novosibirsk (especially among men), which requires prompt action to timely detect and correct the modifiable risk factors of this nosological entity.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114646511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure and proinflammatory marker dynamics after renal denervation in patients with resistant hypertension and various severity of coronary atherosclerosis","authors":"I. Zyubanova, V. Mordovin, S. Pekarskiy, T. Ripp, A. Falkovskaya, V. Lichikaki, E. Sitkova, E. Bukharova, A. Gusakova, A. Baev","doi":"10.29001/2073-8552-2020-35-1-28-37","DOIUrl":"https://doi.org/10.29001/2073-8552-2020-35-1-28-37","url":null,"abstract":"Introduction. Patients with resistant hypertension (RH) associated with coronary heart disease (CHD) and, in particular, with an unfavorable course of coronary atherosclerosis have the highest risk of cardiovascular complications. Tumor necrosis factor-alpha (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) were shown to play a role of independent predictors for the development of such complications. However, the changes in these markers and blood pressure (BP) due to renal denervation (RDN) have not been a subject of investigation in this patient group yet. Objectives. To study changes in BP and proinflammatory markers in patients with RH and CHD after RDN and to compare the indicators depending on the severity of coronary atherosclerosis. Material and Methods. The study analyzed case histories of 35 patients with RH and CHD who underwent a full clinical, instrumental, and laboratory examination before and one year after RDN. Results. We observed a reduction of average 24-hour blood pressure by 15 (0–21) / 7(–3–14) mmHg (p < 0.05), a decrease in TNF-α from 7.8 (6.3; 9.6) to 7.3 (6.8; 8.6) pg/mL (p = 0.044), and a downward trend of hs-CRP values from 2.4 (1.4; 6.0) to 1.8 (1.3; 3.6) mg/L (p = 0.186). Group of patients with unfavorable course of coronary atherosclerosis had higher levels of TNF-α initially (р = 0.040) and a year after RDN (р = 0.038), but no significant changes in BP were observed. Conclusions. Obtained data suggested that the antihypertensive effect of RDN was less pronounced in patients with an unfavorable course of coronary atherosclerosis.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122981363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rhythm and conduction disorders as manifestations of cardiotoxicity of anticancer treatment: myth or reality?","authors":"Y. Vasyuk, E. Shupenina, E. Novosel, I. S. Agapov","doi":"10.29001/2073-8552-2020-35-1-13-21","DOIUrl":"https://doi.org/10.29001/2073-8552-2020-35-1-13-21","url":null,"abstract":"Oncologic diseases are currently one of the leading causes of death. Modern anticancer therapy allows preserving life and social adaptation of cancer patients for many years. However, the use of anticancer drugs is limited due to their adverse and, in some cases, severe cardiotoxic effects such as coronary artery disease, toxic cardiomyopathy, chronic heart failure, arterial hypertension, and others. Heart rhythm and conduction disorders occur, on average, in 16–36% chemotherapy patients and atrial fibrillation is one of the most common arrhythmogenic manifestations of cardiotoxicity. Anthracyclines, alkylating agents, and monoclonal antibodies disrupt the ion pumps function, contribute to the excess release of calcium from the sarcoplasmic reticulum, cause more rapid development of spontaneous diastolic depolarization, and ultimately provoke the occurrence of atrial fibrillation. Some chemotherapy drugs, in particular, anthracyclines, tyrosine kinase inhibitors, and histone deacetylases disrupt the functioning of potassium channels, which leads to an increase in the action potential and prolongation of QT interval. Data on the effects of other classes of chemotherapy drugs on the heart conduction system are scarce and contradictory. Heart rhythm and conduction disorders caused by chemotherapy can lead to a dose reduction or discontinuation of anticancer drugs and require careful monitoring and a joint approach by doctors of several specialties in the management of these patients.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116559923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal denervation as a new nephroprotective strategy in diabetic patients with resistant hypertension","authors":"A. Falkovskaya, V. Mordovin, S. Pekarskiy, T. Ripp, M. Manukyan, V. Lichikaki, E. Sitkova, I. Zyubanova, A. Gusakova, A. Baev, T. Ryabova, N. Ryumshina","doi":"10.29001/2073-8552-2020-35-1-80-92","DOIUrl":"https://doi.org/10.29001/2073-8552-2020-35-1-80-92","url":null,"abstract":"Background. Diabetic patients with resistant hypertension (RHT) are characterized by a high rate of annual decline in estimated glomerular filtration rate (eGFR) (up to 14 mL/min/1.73 m2). The distal approach to sympathetic renal denervation (RD) reduces blood pressure (BP) to a greater extent compared with standard RD. However, the long-term effect of distal RD on the renal function remains unknown. Aim. The purpose of this study was to evaluate the long-term safety and nephroprotective efficacy profile of distal RD compared to conventional intervention in RHT patients with type 2 diabetes mellitus (T2DM) during a three-year follow-up. Material and Methods. Twenty seven patients (eight men) with true RHT and T2DM were included in a single-arm prospective interventional study (number NCT01499810 at ClinicalTrials.gov) (mean age of 61.6 ± 7.3 years; mean office (systolic/ diastolic) BP of 171.8 ± 21.9/87.7 ± 17.7 mmHg; mean eGFR of 72.1 ± 19.9 mL/min/1.73 m2; and glycosylated hemoglobin level (HbA1c) of 6.3 ± 1.1%). Patients were randomized into two comparable groups of distant (n = 13) and standard RD (n = 14). Office BP, ABPM, renal Doppler ultrasound, renal function (eGFR (CKD-EPI) and 24-hour urinary albumin excretion (UAE)), and kidney MRI were assessed at baseline and annually during a three-year follow-up. Nineteen patients completed a 36-month follow-up (8 patients were treated by distal RD and 11 patients received the conventional procedure). Results. The change in eGFR during three-year follow-up was insignificant in group of distal RD (−5.3 ± 0.4 mL/min/1.73 m2, p = 0.63) and was comparable with the corresponding value in conventional RD group (–6.7 ± 4.2 mL/min/1.73 m2, p = 0.3), (p = 0.7 for intergroup comparison) despite a more powerful decrease in 24-h systolic BP in the distal RD group relative to that in conventional RD group (–25.3 ± 15.3 vs. 4.4 ± 22 mmHg, p = 0.04). The degrees of annual decline in GFR did not differ between the distal RD group and conventional RD group (p = 0.9) and were –2.7 ± 2.4 mL/min/1.73 m2/year and –2.7 ± 4.0 mL/min/1.73 m2/year, respectively. No significant changes in renal blood flow, albuminuria, MRI-based kidney size, and the number of patients with albuminuria and renal dysfunction were found during the study. Conclusions. Distal RDN in diabetic patients with RHT had a three-year safety profile and nephroprotective efficacy similar to those when the standard method was used despite a more significant reduction of blood pressure. Both modes of RD are likely to slow the progression of renal dysfunction in these patients.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126055091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphism in folate cycle genes in patients with gout in the Russian population of Trans-Baikal Territory","authors":"N. Kushnarenko, M. Mishko, Tatyana A. Medvedeva","doi":"10.29001/2073-8552-2020-35-1-142-150","DOIUrl":"https://doi.org/10.29001/2073-8552-2020-35-1-142-150","url":null,"abstract":"Objective. To study the frequency distribution of genotypes and alleles of polymorphic loci of folate cycle genes (MTHFR C677T, MTHFR A1298G, MTR A2756G, MTRR A66G) in patients with gout and to evaluate their association with the risk of the disease. Material and Methods. 80 patients (69 men and 11 women) with gout were examined. The diagnosis of gout was made according to the classification criteria ACR/EULAR, 2015. DNA isolated from white blood cells of whole peripheral blood was the material used in the genetic analyses. All patients were genotyped to detect polymorphisms of the MTHFR C677T, MTHFR A1298G, MTR A2756G, MTRR A66G gene loci. Statistical data processing was performed using the software package Statistiсa 10.0. Results. Genetic polymorphisms of the MTHFR C677T and MTR A2756G genes are involved in the development of gout in individuals of Russian ethnicity in the population of the Trans-Baikal Territory. Minor T allele (χ2 = 4.65, p = 0.03, OR = 1.83, CI95% = 1.05–3.17) and the T/T genotype (χ2 = 6.5, p = 0.01, OR = 5.94, CI95% = 1.3–27.00) of the C677T locus of the MTHFR gene, minor G allele (χ2 = 6.46, p = 0.01, OR = 2.38, CI95% = 1.2–4.69) and the A/G genotype of the MTR A2756G gene (χ2 = 5.78, p = 0.01, OR = 2.66, CI95% = 1.18–5.98 ) were identified as alleles and genotypes having increased risk for developing gout. While the C allele (χ2 = 4.65, p = 0.03, OR = 0.55, CI95% = 0.31–0.94) of the MTHFR C677T gene, and allele A (χ2 = 6.46, p = 0.01, OR = 0.42, CI95% = 0.21–0.83) and genotype A/A (χ2 = 7.58, p = 0.006, OR = 0.33, CI95% = 0.15–0.74) of the A2756G locus of the MTR gene were determined as genotypes and alleles having a protective effect. Conclusion. Significant differences were found in the frequency distribution of genotypes and alleles of the MTHFR C677T and MTR A2756G genes in gout patients compared with the control group. The presence of minor T allele and the T/T genotype of MTHFR C677T gene, the minor G allele and the A/G genotype of MTR A2756G gene was associated with an increased risk of gout. In contrast, the carriage of the C allele of MTHFR C677T gene, allele A and the genotype A/A of MTR A2756G gene had a potentially protective effect.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128173265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in left ventricular hypertrophy regression after renal denervation in patients with resistant hypertension","authors":"E. Sitkova, V. Mordovin, T. Ripp, S. Pekarskiy, T. Ryabova, А. Y. Falkovskaya, V. Lichikaki, I. Zyubanova, A. Baev, O. Mochula, V. Usov","doi":"10.29001/2073-8552-2019-34-4-128-135","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-4-128-135","url":null,"abstract":"Purpose . To study the regression of left ventricular hypertrophy (LVH) in men and women with resistant hypertension (RH) after renal denervation (RDN). Material and Methods . A total of 84 patients (50% men) with RH were enrolled in the study after signing informed consent. Renal denervation was performed in all patients. Initially and at 6 and 12 months after treatment, patients underwent careful examination. These analyses included office blood pressure (BP) measurement, transthoracic echocardiography (TTE) study with assessments of the left ventricular (LV) wall thickness and LV mass (LVM), and cardiac magnetic resonance (CMR) imaging. Results. Groups of men and women were comparable in regard to office BP, age, number of administered antihypertensive drugs, and the number of radiofrequency energy applications for RDN. The LVM in the male group was significantly higher than in women due to anatomy differences. According to echocardiography data, the rate of LVH was insignificantly higher in women: 90% in women versus 76% in men, χ 2 = 0.079. In the presence of a significant and comparable BP reduction, significant regression in the values interventricular wall thickness (by 4.4%, р =0.039) and LVM (by 9.5%, р =0.044) was found in men one year after RND according to data of echocardiography. According to CMR according to CMR, LVM decreased by 11.9% at six months ( р =0.039) and by 22.9% at 12 months ( р =0.026) after RND. However, no significant changes in LVM were found in women. The extent of LVM regression did not depend on the antihypertensive effect of RDN in either group. Conclusion. The frequency of LVH was insignificantly higher in women than in men: 90% in women versus 76% in men. One year after RDN, LVH significantly regressed in men, but not in women, and did not depend on degree of BP reduction.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122907162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The analysis of circulatory system morbidity in adult population in the city of Voronezh","authors":"N. M. Kolyagina, T. A. Berezhnova, Y. Kulintsova","doi":"10.29001/2073-8552-2019-34-4-143-148","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-4-143-148","url":null,"abstract":"Aim. To analyze the incidence rates of certain cardiovascular diseases in the adult population of Voronezh. allow to rationally optimize the resources of the urban healthcare system to improve the availability and quality of medical care for adults with cardiovascular diseases at the pre-hospital stage.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117033959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the prevalence of atherogenic lipoprotein fractions and vital exhaustion in men of open population","authors":"M. Kayumova, A. Gakova, V. Gafarov","doi":"10.29001/2073-8552-2019-34-4-149-156","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-4-149-156","url":null,"abstract":"Aim. To elucidate the associations of the prevalence of hypertriglyceridemia (HTG) and high-density lipoprotein hypocholesterolemia (hypo-HDL-ChE) with the levels of vital exhaustion in an unorganized population of 25-64-year-old men in the moderately urbanized city of Western Siberia. Material and Methods . A single-stage epidemiological study was conducted in an unorganized population of the moderately urbanized city of Western Siberia (the model of Tyumen). A representative sample of 1,000 people (25-64-year-old men in four decades of life) was formed based on the electoral lists of the citizens with the response rate of 85.0%. Cardiological screening data were used to analyze the levels of triglycerides and HDL cholesterol. The results of vital exhaustion assessment (low, moderate, or high level) were evaluated by the psychosocial methods of the WHO MONICA-MOPSY program. Low level of vital exhaustion was considered a physiologically normal state. Results. In an open population of men residing in the moderately urbanized city of Western Siberia, the average levels of triglycerides and HDL cholesterol were examined in a wide diapason of ages ranging from 25 to 64 years. The prevalence rates of HTG and hypo-HDL-ChE were 10.5% and 4.3%, respectively. The study showed that the indicators did not form a consistent age trend in the population. The age-standardized indicator of vital exhaustion in men of the open population was 54.5% where 15.9% and 38.6% of men had high and moderate levels of vital exhaustion, respectively. The rate of high level of vital exhaustion at the age of 55-64 years exceeded the corresponding rate in the younger age categories by 2-4 times. In the open population of men aged 25-64, HTG was predominant in groups with the low levels of vital exhaustion whereas hypo-HDL-ChE was predominant in the groups with moderate vital exhaustion. Conclusions. The development and organization of preventive programs in the conditions of Siberian cities with a moderate degree of urbanization may be based on the data obtained from the single-stage epidemiological study characterizing the prevalence of dyslipidemia in the unorganized urban population of the Tyumen model and its associations with the levels of vital exhaustion.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134579873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends and challenges of population-based cardiology","authors":"Y. Anfinogenova, I. Trubacheva, V. Serebryakova, S. Popov","doi":"10.29001/2073-8552-2019-34-4-24-38","DOIUrl":"https://doi.org/10.29001/2073-8552-2019-34-4-24-38","url":null,"abstract":"This article aims to review international literature on the current trends and challenges of cardiovascular epidemiology, including the emergence of new risk factors. The transformative impact of omics technologies on epidemiology, advantages and limitations of meta-epidemiology, as well as the role of mobile technologies and electronic medical records in maintaining and improving the cardiovascular health of the population are reviewed. Emphasis is given to the importance of continuity between the results acquired in the epidemiological studies and the programs aimed at the improvement of community health. The authors conclude that critical events make a significant impact on cardiovascular health. These events include changes in the lifestyle of people living in the industrial society, globalization, migration processes, and + Анфиногенова Яна Джоновна, e-mail: cardio.intl@gmail.com.","PeriodicalId":153905,"journal":{"name":"The Siberian Medical Journal","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126174284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}