Journal of clinical and experimental neuropsychology最新文献

{"title":"Age at menopause and subjective cognitive symptoms predict digital cognitive outcomes at the gynecological Well-Woman visit.","authors":"Teresa Facchetti, Jillian L Joyce, Sandra Rizer, Sarah E Tom, Karen Marder, Silvia Chapman, Mary L Rosser, Stephanie Cosentino","doi":"10.1080/13803395.2026.2707992","DOIUrl":"10.1080/13803395.2026.2707992","url":null,"abstract":"<p><strong>Introduction: </strong>Women are at increased risk for Alzheimer's Disease (AD). Growing evidence suggests that the menopausal transition may represent a vulnerable window for development of AD-related pathology. Yet, women are diagnosed with AD later than men. Conducting routine cognitive screenings and integrating information about both cognitive symptoms and age at menopause may help address sex-based disparities in detection and prevention. This study investigated whether subjective cognitive symptoms, in combination with age at menopause, were associated with performance on a digital cognitive task in postmenopausal women.</p><p><strong>Methods: </strong>183 postmenopausal women (mean age = 63.8, range = 45-85) were recruited after their Well-Woman visit. Participants completed the Screener for Cognitive Problems in Everyday Life (SCoPE) to assess subjective cognitive symptoms, followed by a sensitive measure of objective cognition: the Linus Health Digital Clock and Recall (DCR™). Information was also collected on age at menopause. We examined associations of subjective cognitive symptoms and age at menopause with digital cognitive performance, adjusting for age, education and depression. Model fit was evaluated using adjusted R², AIC, and BIC.</p><p><strong>Results: </strong>48.1% of women reported one or more cognitive symptoms on the SCoPE. On objective testing, 73.2% scored in the normal range, 20.8% in the borderline range, and 6.0% in the impaired range. SCoPE total score was negatively associated with objective cognitive performance in adjusted models (B = -.12, <i>p</i> = .03). Age at menopause showed a significant quadratic association with cognitive performance (B = -0.006, <i>p</i><.001). SCoPE total was not associated with DCR subtests, while age at menopause predicted both Delayed Recall and Clock Drawing.</p><p><strong>Conclusion: </strong>Subjective cognitive symptoms and age at menopause were associated with lower performance on a sensitive, objective cognitive test. Findings support routine cognitive screening and suggest that subjective cognitive symptoms as well as age at menopause are associated with cognitive function.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"696-707"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to special issue: the influence of menopause and other hormonal changes on neuropsychological functioning.","authors":"Erin Sullivan-Baca, Rachael L Ellison","doi":"10.1080/13803395.2026.2685008","DOIUrl":"https://doi.org/10.1080/13803395.2026.2685008","url":null,"abstract":"<p><strong>Background: </strong>Menopause has historically been viewed through the lens of hormonal influences on sex organs and reproduction, despite evidence of widespread systemic hormonal effects. When seen through a neuropsychological perspective, it is critical to understand that many sex hormones, including estrogen, progesterone, testosterone, luteinizing hormone, and anti-Mullerian hormone, directly influence brain functioning. With these considerations in mind, distinct changes in hormonal levels that affect women at different periods throughout their lifetime are a central consideration for neuropsychologists. Considering menopause specifically, the menopausal transition includes variations in estradiol and progesterone levels, leading to eventual cessation of ovarian function. Alongside vasomotor symptoms, urogenital symptoms, and mood symptoms, there is evidence to support both subjective and objective cognitive changes during menopause.</p><p><strong>Methodology & results: </strong>Overall, articles from the current special issue can broadly be divided into two categories: (1) research investigating subjective and/or objective cognitive functioning during periods of hormonal transitions, including midlife and (2) the influence of reproductive factors on long-term cognitive outcomes. Here, they are briefly overviewed, followed by a discussion on applications to clinical care.</p><p><strong>Conclusion: </strong>Overall, these articles in the present special issue address a dearth of research on the relationship between reproduction, female sex hormones, menopause, and other factors with women's neuropsychological functioning, and aim to provide a significant contribution to the field, as well as spark interest among clinicians and researchers alike to continue to pursue these understudied topics.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":"48 7","pages":"623-629"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent, but not synergistic, associations of <i>APOE</i>ε4 and systemic inflammation on cognitive decline: findings from the Women's Health Initiative.","authors":"Hannah M Klinger, Gillian T Coughlan, Kathleen M Hayden, JoAnn E Manson, Robert A Wild, Su Yon Jung, Ramon Casanova, Longjian Liu, Aladdin H Shadyab, Jean Wactawski-Wende, Susan M Schembre, Simin Liu, Stephen R Rapp, Rebecca E Amariglio, Dorene M Rentz, Susan M Resnick, Suzanne Baker, Rachel F Buckley","doi":"10.1080/13803395.2025.2608340","DOIUrl":"10.1080/13803395.2025.2608340","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the risk factors that associate with early cognitive decline in Alzheimer's disease (AD) is important to identify high-risk individuals and initiate early intervention. Existing studies show that APOEε4, systemic inflammation, and diabetes may play roles in cognitive decline, but the extent to which these factors interact with each other remains unclear. Our objective was to examine the main effects and higher-order interactions between APOEε4, high sensitivity-C-reactive protein (hs-CRP) as a measure of systemic inflammation, and diabetes on domain-specific measures of cognitive function in two ancillary studies of post-menopausal women from the Women's Health Initiative (WHI).</p><p><strong>Method: </strong>We identified 2979 cognitively unimpaired women from the WHI Epidemiology of Cognitive Health Outcomes and the WHI Memory Study of Younger Women with cognitive follow-up of up to 13 years. Linear mixed-effects models examined the main and interactive effects of APOEε4, hs-CRP, and diabetes on longitudinal changes in the personal communication for Cognitive Status-modified Test (TICS-m), East Boston Memory Test (immediate and delayed; EBMT), Oral Trail Making Test (OTMT), Verbal Fluency Test (VF-A), Digit Span Test Backwards (DST-backward), and the California Verbal Learning Test (CVLT). All models were adjusted for baseline age, education, body mass index, the WHI randomization arm, and the cohort.</p><p><strong>Results: </strong>APOEε4 carriers had steeper cognitive decline in TICS-m, EBMT (immediate and delayed), VF-A, and CVLT scores relative to non-carriers. Higher levels of hs-CRP were associated with steeper cognitive decline in the DST-backwards scores. There was no association of diabetes or any evidence of interactive effects on cognitive decline in our study.</p><p><strong>Conclusions: </strong>In this large longitudinal study of post-menopausal women, our findings support the hypothesis that genetic risk and systemic inflammation independently influence cognitive decline, but there was no evidence of synergistic effects in postmenopausal women. Further research is needed to elucidate the mechanistic pathways underlying these associations with cognitive decline.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"747-757"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and characterizing cognitive profiles in midlife women: a latent profile analysis.","authors":"Hannah A Hagy, Amy M Bohnert, Zoe R Smith, Tracy De Hart, Pauline M Maki","doi":"10.1080/13803395.2026.2673085","DOIUrl":"10.1080/13803395.2026.2673085","url":null,"abstract":"<p><strong>Introduction: </strong>Due to sex differences in cognitive aging and dementia burden, there is increased focus on the role of the menopause transition on cognitive functioning across midlife. This study aimed to characterize cognitive profiles among midlife women and to examine the demographic, social, and health factors associated with profile membership.</p><p><strong>Method: </strong>Midlife women (<i>N</i> = 202; Age 40-60 years) from the Human Connectome Project - Aging completed NIH Toolbox cognitive and emotion measures. Latent profile analysis was used to identify cognitive profiles utilizing nine performance-based measures. Emergent profiles were then characterized in terms of demographic, cardiovascular and metabolic health indicators, and medication use (e.g. hormone therapy). Multinomial regression was then used to determine whether sleep, physical activity, depressive symptoms, and psychological stress varied by cognitive profile.</p><p><strong>Results: </strong>Four distinct cognitive profiles were identified, the most common reflecting strength in verbal learning and memory (43% of women) and the next most common reflecting weaknesses in those same domains (39%). Black race and elevated depressive and anxiety symptoms were associated with the latter profile. A third profile (12%) reflected weakness in executive function (e.g. divided attention, picture vocabulary, working memory, task switching). The fourth (6%) was a mixed group showing strengths in pattern recognition and picture vocabulary but weaknesses in verbal memory and inhibitory control.</p><p><strong>Conclusion: </strong>Midlife women show heterogeneity in cognitive performance, with nearly half showing a profile of strength in verbal memory. However, two menopause-relevant profiles emerged that were characterized by subtle weaknesses. One was in the domain of verbal memory and, consistent with earlier work, related to sadness and anxiety. The second was in executive function. Though less common, that vulnerability is notable given reports of attention-deficit hyperactivity disorder (ADHD)-like symptoms at menopause. Longitudinal studies are underway to determine the stability and predictors of cognitive profiles among midlife women.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"630-647"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations between reproductive history and late-life cognitive outcomes.","authors":"Sotiria Moza, Nikolaos Scarmeas, Georgios M Hadjigeorgiou, Efthimios Dardiotis, Mary Yannakoulia, Paraskevi Sakka, Mary H Kosmidis","doi":"10.1080/13803395.2026.2678869","DOIUrl":"10.1080/13803395.2026.2678869","url":null,"abstract":"<p><strong>Background: </strong>Reproductive factors have been associated with cognition in older women, yet findings have been inconsistent. Moreover, recent studies have also found similar associations in men.</p><p><strong>Objective: </strong>Examine the relationship between reproductive and cognitive factors in both sexes, controlling for multiple covariates.</p><p><strong>Methods: </strong>We analyzed data from 914 women with natural menopause (<i>M</i>^<i>AGE</i> = 72.65<i>±</i>5.57) and 811 men (<i>M</i>^<i>AGE</i> = 74.43<i>±</i>5.37) from the HELIAD study. Participants provided reproductive, medical, and social histories and had a comprehensive neuropsychological assessment, including Mild Cognitive Impairment and dementia diagnosis. Covariates included age, education, medical, genetic, lifestyle, and socioeconomic factors.</p><p><strong>Results: </strong>Controlling for age and education, in women, later menarche, earlier menopause, fewer menstrual years, shorter interpregnancy intervals, and menstrual regularity were associated with poorer cognitive outcomes. Earlier first childbirth (<25y), greater parity (especially, before 20y), and older age at fourth childbirth were linked to better cognition (<i>ORs:</i>.95-2.20). In men, older age at third and fourth child birth, having more children at ages 20-29 or 40+, the last child at >35y, and childlessness were associated with poorer cognition, while having the first child at >35y (language tasks) and having more children overall were associated with better cognition (<i>ORs</i>:1.37-2.20). After full-adjustment and Bonferroni correction, no associations remained.</p><p><strong>Conclusions: </strong>Reproductive patterns may affect cognition differentially based on sex. Moderate reproductive activity may be protective, whereas extreme patterns (e.g. very early/late childbirth, childlessness) may be linked to cognitive decline. These associations attenuate after statistical adjustment and correction, necessitating further controlled and longitudinal studies to clarify these relationships.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"708-731"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dysconnectivity in breast cancer patients undergoing hormone therapy.","authors":"Julie Petersen, Sonya V Gupta, Alexandra C Apple, Derin Cobia, Mehmet E Dokucu, Eric D Donnelly, William J Gradishar, Marko Mihailovic, James L Reilly, Joel L Voss, Lynne I Wagner, Sandra Weintraub, Lei Wang","doi":"10.1080/13803395.2026.2617353","DOIUrl":"10.1080/13803395.2026.2617353","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer patients undergoing adjuvant hormone therapy commonly report adverse effects that can lead to lower quality of life and treatment nonadherence. How hormone therapy, independent of other systemic therapies, may impact patient functioning is a relatively new area of research with few neuroimaging studies delineating the effects. Prior nonspecific neuropsychological findings and the multifaceted role of estrogen in the brain suggest potentially diffuse effects of hormone therapy. The current study examined intrinsic neural functional organization and cognitive correlates unique to breast cancer patients undergoing hormone therapy.</p><p><strong>Method: </strong>Resting state functional magnetic resonance imaging was acquired from 24 breast cancer patients undergoing hormone therapy and 32 healthy controls. Resting-state functional connectivity (rsFC) was calculated between brain regions. Fractional amplitude of low frequency fluctuations (fALFF) was computed within a rsFC-derived mask to describe the regional properties within sites of dysconnectivity. Objective measures of cognition were obtained using neuropsychological tests and correlated with rsFC.</p><p><strong>Results: </strong>Patients demonstrated extensive dysconnectivity relative to controls, largely characterized by parietal-occipital hypoconnectivity. Reduced rsFC occurred primarily between regions with increased fALFF. A modest relationship between rsFC and visual working memory was observed in breast cancer patients but not in controls.</p><p><strong>Conclusions: </strong>This study is the first to examine whole-brain rsFC in breast cancer patients undergoing hormone therapy. We found robust hypoconnectivity in patients, which demonstrated modest relationships with cognition. Identifying the pattern by which breast cancer and hormone therapy affect brain networks may aid in the development of therapeutic options for patients experiencing negative effects of hormone therapy, thus improving quality of life for cancer survivors. Further, the detection of abnormal brain function may help characterize treatment-associated neural changes that are not captured by standard cognitive measures.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"673-695"},"PeriodicalIF":2.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the diagnostic label: Data-driven characterisation of cognitive and mental health profiles in a transdiagnostic sample of neurodivergent adults.","authors":"Karin Madericova, Joel B Talcott","doi":"10.1080/13803395.2026.2703682","DOIUrl":"https://doi.org/10.1080/13803395.2026.2703682","url":null,"abstract":"<p><p>Neurodiverse diagnoses (NDs) have been largely conceptualised as distinct categories with clear-cut diagnostic boundaries. However, converging research evidence is showing that this conventional approach may inadequately capture the individual variation and overlaps that are commonly observed in population studies. This study extended emerging quantitative research frameworks for understanding diagnostic complexity, adopting a transdiagnostic dimensional approach toward characterising the cognitive and mental health dimensions associated with NDs. A cohort of 175 adults with suspected or previously diagnosed neurodiverse conditions was recruited using convenience sampling. Cognitive domains of executive function, language, attention, processing speed, and memory were assessed using the National Institute of Health (NIH) Cognition Toolbox<i>©</i>. A battery consisting of the Extended Strengths and Weaknesses Assessment of Normal Behavior (E-SWAN), Strengths and Difficulties Questionnaire (SDQ), and Emotion Regulation Skills Questionnaire (ERSQ) was administered to provide additional proxy measures of mental health. Cluster analyses revealed that the sample of neurodivergent adults was best represented by three data-driven clusters, none of which mapped coherently onto traditional diagnostic labels. In contrast, these transdiagnostic groups were best characterised by a combination of strengths and weaknesses along two multivariate dimensions: 1) cognitive flexibility and processing speed, and 2) language, memory, emotional wellbeing, and behavioral regulation. This study provides novel, data-driven evidence to support the emerging dimensional structure of NDs, and highlights several component processes which may contribute to the complexity associated with neurodiversity in adults. These findings may be used to inform future assessment and/or support strategies for neurodivergent adults, beyond those framed by strictly categorical approaches.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"1-22"},"PeriodicalIF":2.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of The Cognitive Estimation Test (BiTAHT) in healthy population and evaluation of reliability in individuals with multiple sclerosis.","authors":"Filiz Dilek, Erol Yıldırım, Aysun Ünal","doi":"10.1080/13803395.2026.2673080","DOIUrl":"10.1080/13803395.2026.2673080","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive estimation is a component of executive functions, involving judgment, reasoning, often impaired in neurological disorders. This study aimed to develop the Bilişsel Tahmin Testi (BiTAHT) for the Turkish population and to evaluate its reliability and validity in patients with Multiple Sclerosis (pwMS).</p><p><strong>Method: </strong>The study was conducted in four sequential phases. In the first phase, 56 preliminary estimation items were generated based on a review of existing Cognitive Estimation Tests and expert feedback. In the second phase, the items were evaluated for clarity, linguistic appropriateness, and feasibility through pilot testing with a small sample. In the third phase, BiTAHT was administered to 1,112 healthy participants, and statistical analyses including percentile calculation and item-level outlier removal were used to refine the test and develop two parallel forms (BiTAHT-A and BiTAHT-B). In the final phase, reliability and validity were assessed by administering BiTAHT to 54 pwMS and 80 controls. The final version comprised six estimation categories: quantity, weight, length, duration, area, and equivalent.</p><p><strong>Results: </strong>Each parallel form contained 13 estimation items. PwMS performed significantly worse than healthy controls in the quantity, weight, length, and equivalent categories, but not in duration or area. In the development sample, BiTAHT scores varied by age, gender, and education with low effect sizes, while no associations were found in validation groups (54 pwMS, 80 controls) (<i>p</i> > .05). İnternal consistency was moderate when the two forms were combined.</p><p><strong>Conclusions: </strong>BiTAHT may be used to assess cognitive estimation abilities in Turkish adults and support future research on cultural validity. Although differences were observed between healthy controls and pwMS, these should not be interpreted as executive dysfunction. Future studies should evaluate test - retest reliability, expand validity evidence, and examine its utility in other neurological populations.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"537-545"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties and diagnostic utility of the Mini-Addenbrooke's Cognitive Examination (M-ACE) for detecting Major Neurocognitive Disorder in primary healthcare settings.","authors":"Felipe Salinas-López, Carlos Calderón, Oscar Véliz-García, Marcos Domic-Siede","doi":"10.1080/13803395.2026.2622925","DOIUrl":"10.1080/13803395.2026.2622925","url":null,"abstract":"<p><p>Major neurocognitive disorder (MND) is a significant public health concern and a leading cause of disability and dependency among older adults. It is characterized by a chronic and acquired decline in cognitive functioning. For early detection, screening tools such as the Mini-Addenbrooke's Cognitive Examination (M-ACE)-a brief version of the Addenbrooke's Cognitive Examination-III (ACE-III)-have been proposed. This study analyzed data from 1164 adult participants from Antofagasta, Chile, including both the general population and individuals diagnosed with MND. Analyses included reliability estimation, factorial structure assessment using Confirmatory Factor Analysis (CFA), Item Response Theory (IRT) modeling, and diagnostic utility evaluation. Results indicate excellent reliability (McDonald's Omega = 0.926), a robust unidimensional factor structure, and good model fit under IRT. Differential item functioning (DIF) analysis revealed that performance on the clock-drawing item varied significantly according to educational level. Regarding diagnostic accuracy (AUC = 0.924), a cutoff score of ≤25/30 was proposed for the full sample, yielding 98% sensitivity. Consequently, alternative cutoffs stratified by educational level were also established to optimize performance. Findings support the M-ACE as a valid and reliable tool for cognitive screening and initial assessment of cognitive impairment in adults. The relevance of the clock-drawing task for assessing visuospatial abilities is also discussed.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"522-536"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional assessment of telephone- and computer-administered instruments in detection of cognitive impairment.","authors":"A Aaltonen, T T Saari, M Urjansson, T Palviainen, T I Paajanen, FinnGen, A Palotie, H Runz, J Kaprio, V Julkunen, E Vuoksimaa","doi":"10.1080/13803395.2026.2661625","DOIUrl":"10.1080/13803395.2026.2661625","url":null,"abstract":"<p><strong>Objective: </strong>We investigated the associations of telephone- and computer-administered cognitive screening instruments for Alzheimer's disease with in-person measurement in a population-based sample of individuals without a prior diagnosis of dementia-causing neurodegenerative disease.</p><p><strong>Method: </strong>We studied 202 TWINGEN participants (126 female) who had in-person administered Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-nb) data. The participants were aged 65-85 years and of European ancestry. Telephone-administered instruments were telephone assessment for dementia (TELE) and modified version of Telephone Tnterview for Cognitive Status, and computer-administered instrument was web-based cCOG. We utilized correlation analyses, areas under the receiver operating characteristic curves (AUC) and hierarchical linear mixed-effects models in main analyses.</p><p><strong>Results: </strong>Screening instruments exhibited moderate to high correlations with CERAD-nb, with the strongest correlation between cCOG and CERAD-nb (<i>r</i> = .62). Despite exclusion criteria, 20 participants had cognitive impairment according to the CERAD-nb total score. When evaluating the instruments' ability to distinguish between participants with and without cognitive impairment, AUCs ranged from .65 (95% CI [.53, .78]) for TELE to .76 (95% CI [.67, .86]) for cCOG. All instruments predicted in-person CERAD-nb score in linear mixed-effects models, when controlling for demographic factors. Including both telephone- and computer-administered measures as predictors resulted in better accuracy compared to including only one modality as a predictor.</p><p><strong>Conclusions: </strong>Performance in telephone- and computer-administered cognitive screening instruments was associated with performance in in-person neuropsychological battery designed for early detection of Alzheimer's disease. The results indicate validity of the computerized and telephone-administered tests at the population level.</p>","PeriodicalId":15382,"journal":{"name":"Journal of clinical and experimental neuropsychology","volume":" ","pages":"582-593"},"PeriodicalIF":2.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}