Journal of Biologically Active Products from Nature最新文献_第3页

Asparagus gonoclados Baker (AGAF) Root Tubers Improve Glycemic Control and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats 芦笋根茎（AGAF）可改善链脲佐菌素诱导的糖尿病大鼠的血糖控制和高脂血症状况

Journal of Biologically Active Products from Nature Pub Date : 2023-07-04 DOI: 10.1080/22311866.2023.2262965

A. Rajasekhar, K. Peddanna, N. Vedasree, Yallanki Sireesha, C. ParthaSarathi, Nagoji Nagaraju, Chippada Appa Rao

引用次数: 0

Kaempferia attapeuensis Picheans. & Koonterm Growing Wild in Vietnam: Chemical Composition of Fresh Rhizomes Essential Oil and Its In vitro Antimicrobial Activity 在越南野生生长的 Kaempferia attapeuensis Picheans：新鲜根茎精油的化学成分及其体外抗菌活性

Journal of Biologically Active Products from Nature Pub Date : 2023-07-04 DOI: 10.1080/22311866.2023.2255161

Nguyen Xuan Ha, Dinh Thi Huyen Trang, N. An, Hoang Van Trung, Nguyen Hoang Tuan, Cao Hong Le, Dang Khoa Nguyen, Vo Mong Tham, Nguyen-Thi-Thu Hien, Hieu Tran-Trung

{"title":"Kaempferia attapeuensis Picheans. & Koonterm Growing Wild in Vietnam: Chemical Composition of Fresh Rhizomes Essential Oil and Its In vitro Antimicrobial Activity","authors":"Nguyen Xuan Ha, Dinh Thi Huyen Trang, N. An, Hoang Van Trung, Nguyen Hoang Tuan, Cao Hong Le, Dang Khoa Nguyen, Vo Mong Tham, Nguyen-Thi-Thu Hien, Hieu Tran-Trung","doi":"10.1080/22311866.2023.2255161","DOIUrl":"https://doi.org/10.1080/22311866.2023.2255161","url":null,"abstract":"Abstract Kaempferia is a genus of the Zingiberaceae family containing a rich resource of essential oils (EOs) with various important biological activities. In the present study, the chemical compositions and in vitro antimicrobial activity of the EO of Kaempferia attapeuensis Picheans. & Koonterm were reported for the first time. By the Gas Chromatography-Mass Spectrometry (GC/MS) analysis, a number of 46 compounds were identified in K. attapeuensis rhizomes EO (accounted for 90.61 % of the total content), among which germacrone (25.80%), camphene (18.63%) and α-pinene (10.57%) were the major components. In the in vitro antimicrobial assay, K. attapeuensis rhizomes EO exhibited promising activity against the growth of three Gram-positive bacteria strains (Enterococcus faecalis, Staphylococcus aureus, and Bacillus cereus), three Gram-negative bacteria strains (Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica) and the yeast strain (Candida albicans) with their MIC values all of 32 µg/mL. In general, the present investigation has provided the foundation for additional research on the chemical compositions and biological effects of K. attapeuensis. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139363100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Induction of Apoptosis and Cell Cycle Arrest by Ethyl Acetate Extract of Salsola kali and Flavonoid Constituents Analysis 草乌乙酸乙酯提取物诱导细胞凋亡和细胞周期停滞及黄酮类成分分析

Journal of Biologically Active Products from Nature Pub Date : 2023-07-04 DOI: 10.1080/22311866.2023.2259869

Taha A.I. El Bassossy, Ahmed A. M. Abdelgawad, Mayada M. El-Azab

{"title":"Induction of Apoptosis and Cell Cycle Arrest by Ethyl Acetate Extract of Salsola kali and Flavonoid Constituents Analysis","authors":"Taha A.I. El Bassossy, Ahmed A. M. Abdelgawad, Mayada M. El-Azab","doi":"10.1080/22311866.2023.2259869","DOIUrl":"https://doi.org/10.1080/22311866.2023.2259869","url":null,"abstract":"Abstract In our previous study on Salsola kali, the ethyl acetate extract revealed an in vitro cytotoxic effect against the tumor cell lines (MCF-7, HepG2, and A549). Therefore, this study was conducted to identify phenolic and flavonoid components in this extract by LC-ESI-TOF/MS technique and explore the mechanism of the cytotoxic effect on the progression of the cell cycle and the induction of apoptosis by flow cytometry. Further, protein markers were evaluated as cytotoxicity mechanisms to confirm apoptosis initiation. LC-ESI-TOF/MS analysis identified eleven phenolics and forty-five flavonoid compounds from the ethyl acetate extract. Ethyl acetate extract induced G1 cell population arrest in HepG2 cells after 24 hours of exposure. The flow cytometry data confirmed that ethyl acetate primarily initiates cell death by starting early and late apoptotic manners. Induction of apoptosis by ethyl acetate extract was proved by a significant increase in cytochrome C, caspase 3, and Bax levels, while the level of antiapoptotic BCl2 was significantly decreased. Moreover, the Bax/BCl2 ratio was increased after treatment in a dose-dependent manner of ethyl acetate extract compared to that of the untreated group. These findings suggest that ethyl acetate extract may have a remarkable anticancer effect in HepG2 cells through cell cycle regulation and apoptosis. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139363125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Characterization of EDC/NHS Crosslinked Collagen Scaffold from the Scales of Cyprinus carpio (Common Carp) 鲤鱼鳞EDC/NHS交联胶原支架的制备及表征

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2240284

Ravneet Kaur, Aisha Jamal, Rishu, Harjot Kaur, Bandu Matiyal, Ravinder Kumar

{"title":"Preparation and Characterization of EDC/NHS Crosslinked Collagen Scaffold from the Scales of Cyprinus carpio (Common Carp)","authors":"Ravneet Kaur, Aisha Jamal, Rishu, Harjot Kaur, Bandu Matiyal, Ravinder Kumar","doi":"10.1080/22311866.2023.2240284","DOIUrl":"https://doi.org/10.1080/22311866.2023.2240284","url":null,"abstract":"Abstract Aquaculture is the fast-growing industry and, consequently, fish waste management is becoming a rising concern. Fish scale trash contains collagen as a biomaterial which offers excellent properties such as biocompatibility, biodegradability, porosity, low toxicity, cell adhesion and water absorption capacity which makes it suitable for biomedical research in the form of scaffolds. But the scaffolds have the limitation of having less stability. To overcome this shortcoming, collagen scaffolds can either be modified by chemical or physical treatments such as crosslinking with suitable polymers and dehydrothermal treatment, respectively. In the present study, extraction of fish collagen from the scales of Cyprinus carpio was performed followed by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) & N-hydroxysuccinimide (NHS). Comparative characterization was done by techniques such as ATR-FTIR, FESEM and TGA to analyse the chemical composition, surface morphology and thermal degradation of fish collagen scaffold (CS) with EDC/NHS crosslinked collagen scaffold (EDC/NHS-CS). Crosslinked collagen scaffold’s antimicrobial activity was also determined with agar well diffusion assay by using S. aureus strain of bacteria and cytotoxicity on mouse fibroblast cells (NIH/3T3) by MTT assay. Moreover, the biomedical industry wants to shift to sustainable approaches and fish collagen-based scaffolds may prove to be a potential source in tissue engineering. And thus, also help in the management of fish waste. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45483358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guided Analysis of Selected Ethnobotanical Acanthaceous Plants for Anti-Inflammatory Properties 民族植物棘科植物抗炎特性的导引分析

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2240747

P. Somwong, Chomnapas Chuchote

{"title":"Guided Analysis of Selected Ethnobotanical Acanthaceous Plants for Anti-Inflammatory Properties","authors":"P. Somwong, Chomnapas Chuchote","doi":"10.1080/22311866.2023.2240747","DOIUrl":"https://doi.org/10.1080/22311866.2023.2240747","url":null,"abstract":"Abstract Acanthaceous plants have emerged as important therapeutic plants on a global scale, producing biologically active chemical compounds with larvicidal, antimicrobial, and cytotoxic properties. In traditional Thai medicine, the crude extracts of these plants, including Clinacanthus nutans, Justicia gendarussa, and Rhinacanthus nasutus, have been used to detoxify bug bites and some skin illnesses caused by fungus and viruses. This study argued for investigating acanthaceous plant extracts for alternate advantages such as anti-inflammation. The presence of anti-inflammatory components in extracts was examined using HPLC in order to evaluate their potential. Lupeol, a prospective anti-inflammatory triterpene found in medicinal plants, was employed as a chemical marker. The anti-inflammatory activities of extracts containing the active chemical were studied utilizing protein denaturation and inhibition of nitric oxide production in RAW 264.7 cells stimulated with LPS. Also, the extract of combined active plants was assessed. Lupeol was detected in the tested extracts in quantities ranging from 0.25 to 1.22% w/w. It was found in the highest concentration in the extract of Clinacanthus nutans and in the lowest concentration in the extract of Justicia gendarussa. All extracts of plants containing the active ingredient exhibited anti-inflammatory effects. Their IC50 values ranged between 0.87 and 29.28 mg/mL. The extract made from a combination of plants that contained lupeol demonstrated the most potent anti-inflammatory effect, with a 0.6-fold difference when compared to diclofenac. This research implied that investigating acanthaceous plant extracts containing this active agent might be more beneficial in the design of herbal recipes with anti-inflammatory characteristics. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41850808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

α-Amylase and α-Glucosidase Enzyme Inhibition, Molecular Docking, and Pharmacokinetic Studies of Natural Products from Dilenia indica L. Barks 双头莲天然产物α-淀粉酶和α-葡萄糖苷酶抑制、分子对接及药动学研究

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2234334

Pinku Gogoi, Amit Kumar, N. Dutta, Aparoop Das, G. Baishya

{"title":"α-Amylase and α-Glucosidase Enzyme Inhibition, Molecular Docking, and Pharmacokinetic Studies of Natural Products from Dilenia indica L. Barks","authors":"Pinku Gogoi, Amit Kumar, N. Dutta, Aparoop Das, G. Baishya","doi":"10.1080/22311866.2023.2234334","DOIUrl":"https://doi.org/10.1080/22311866.2023.2234334","url":null,"abstract":"Abstract The present study describes the isolation and structural elucidation of bioactive natural products from the hydro ethanol extract of Dilenia indica L. barks (DIHEEB) and their inhibitory activity against α-amylase and α-glucosidase enzymes. Some natural products including n-nonyl oleate (1), stigmasterol (2), β-sitotenone (3), betulin (4), and betulinic acid (5) were isolated from the DIHEEB extract. These natural products were characterized through IR, NMR, and mass spectroscopy. Among all these compounds, 4 and 5 have shown significant activity to inhibit α-glucosidase and α-amylase, which proves their anti-diabetic effect. The α-amylase and α-glucosidase inhibitory activity of 4 (α-amylase: IC50 68.79±1.6 μg/ml; α-glucosidase: IC50 69.19±1.8 μg/ml;) are very much comparable with known anti-diabetic drug acarbose (IC50 64.70±1.6 μg/ml). But compound 5 also shows a comparable extent of activity against α-amylase and α-glucosidase and it is also well established in the literature. Molecular docking and other in-silico properties were studied to elucidate the interactions and conformations of the isolated molecules with the target protein enzyme. With minimal conformational energy, 4 and 5 bind to the α-amylase (PDB ID: 4GQR) and α-glucosidase (PDB ID: 3A4A) enzymes, as proved by their respective docking score (-8.2 and -9.4 kcal/mol) and having different types of binding interactions. Also, the pharmacokinetics (PK), drug-likeness scores (DLS), and well permeability properties were studied along with no violation of Lipinski’s rule. Both in vitro and in silico results suggest that D. indica could be a potential source of anti-diabetic formulations. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44991108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosinase Inhibition Activities of Depsides Isolated from Ramalina Species 拉玛林种分离物对酪氨酸酶的抑制作用

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2236052

B. Marasini, J. Yue, Erendra Manandhar, Rejina Rai, Uddav Khadka, M. Manandhar, S. Shyaula

{"title":"Tyrosinase Inhibition Activities of Depsides Isolated from Ramalina Species","authors":"B. Marasini, J. Yue, Erendra Manandhar, Rejina Rai, Uddav Khadka, M. Manandhar, S. Shyaula","doi":"10.1080/22311866.2023.2236052","DOIUrl":"https://doi.org/10.1080/22311866.2023.2236052","url":null,"abstract":"Abstract Three depsides, namely sekikaic acid (1), homosekikaic acid (2), and 4′-O-demethylsekikaic acid (3) were isolated from acetone fraction of Ramalina spp. The structures were characterized by using spectroscopic techniques like 1H NMR, 13C NMR, ESI MS and IR. The quantitative determinations of these compounds were conducted by reversed phase high performance liquid chromatography with photodiode array detector (LC-PDA). The developed assay method could be considered as a suitable quality control method for Ramalina spp. The content on percentage dry basis of these compounds were 1.39%, 0.98% and 0.58% for compound 1, 2 and 3, respectively. It is the first time report for tyrosinase inhibition activity for depsides. All of these compounds exhibited inhibition for tyrosinase enzyme with the IC50 values 110.3±3.5, 90.1±1.4, and 206.4±5.1 µg/mL by the compounds 1, 2 and 3, respectively. The structure activity relationship of despides showed that the methoxy group at ring A might have enhanced the inhibitory activity. Therefore, these compounds may have their potential use in cosmetics with further studies. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45743924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of in vitro Simulated Poultry Digestion on Bioaccessibility of Quercetin 3-D-galactoside and Antioxidants from Moringa oleifera Leaf Extracts 体外模拟家禽消化对辣木叶提取物槲皮素、三维半乳糖苷及抗氧化剂生物可及性的影响

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2230177

Nguyen Van Quan, M. A. Hossen, T. Xuan

{"title":"Effect of in vitro Simulated Poultry Digestion on Bioaccessibility of Quercetin 3-D-galactoside and Antioxidants from Moringa oleifera Leaf Extracts","authors":"Nguyen Van Quan, M. A. Hossen, T. Xuan","doi":"10.1080/22311866.2023.2230177","DOIUrl":"https://doi.org/10.1080/22311866.2023.2230177","url":null,"abstract":"Abstract The use of Moringa oleifera leaves as a poultry feed has been recognized worldwide, thanks to its multi-beneficial properties for broiler quality and production. However, research on the absorption and bioaccessibility of antioxidant compounds in this material is still limited. This study aims to investigate the effect of simulated poultry digestion on the bioaccessibility of quercetin 3-D-galactoside (Q3G) from Moringa leaf extracts and its antioxidant capacity via an in vitro model. Initially, a bio-guided fractionation procedure was employed to isolate Q3G and co-occurring antioxidants from Moringa leaves using column chromatography. The identification of Q3G and major phytocompounds within the potent active samples was carried out using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/ MS). The findings revealed that Q3G is predominantly present in the ethyl acetate extract of Moringa leaves, with the highest concentration recorded as 1.3 mg/g of dry weight. Via a simulated poultry digestion model, the bioaccessibility of Q3G in the small intestinal stage was calculated to have the highest proportion of 67.1%. Significantly, the change in Q3G content was in accordance with the tendency for antioxidant activity of the Q3G-included fractions throughout the digestion. The correlation analysis suggested that Q3G has an important role in the antioxidant capacity of Moringa leaf extracts. To the best of our knowledge, this study represents a pioneering attempt to investigate the bioaccessibility and antioxidant activity of Q3G and Q3G-included extracts from Moringa leaves, utilizing an in vitro poultry digestion model. The findings establish a crucial foundation for future research and development endeavors that aim to produce antioxidant supplements enriched with Q3G from natural sources for applications in poultry production. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46103513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Investigation on Antidiabetic and Antioxidant Assessments of Partially Purified Fractions of Cassia siamea and Butea monosperma: Indigenous Myanmar Medicinal Plant 缅甸本土药用植物决明子和单精子丁茶部分纯化部位抗糖尿病和抗氧化作用的体外研究

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2239763

M. Thida, Hay Mar Aung, Zar Kyi Win, Nwe Nwe Htay, T. S. Moe

{"title":"In vitro Investigation on Antidiabetic and Antioxidant Assessments of Partially Purified Fractions of Cassia siamea and Butea monosperma: Indigenous Myanmar Medicinal Plant","authors":"M. Thida, Hay Mar Aung, Zar Kyi Win, Nwe Nwe Htay, T. S. Moe","doi":"10.1080/22311866.2023.2239763","DOIUrl":"https://doi.org/10.1080/22311866.2023.2239763","url":null,"abstract":"Abstract This study aimed to evaluate the antidiabetic and antioxidant potentials of fractions from Cassia siamea and Butea monosperma. The water, hexane, dichloromethane, and ethyl acetate fractions of tested plants was determined their bioactivities by hemolysis, antiglycation, alpha-glucosidase and dipeptidyl peptidase-IV (DPP-IV) inhibition, glucose uptake by yeast cells, DPPH radical scavenging, and total phenolic content determination assays. Non-hemolytic effects of all fractions were shown by < 20% on RBCs. The best inhibition activities for AGE formation of water and hexane fractions from C. siamea were shown in IC50 values (mg/mL) of 0.17 and 0.14, respectively. For B. monosperma, the EtOAc fraction exhibited the best inhibitory effect with an IC50 value of 0.10 mg/mL. The water and ethyl acetate fractions of C. siamea strongly inhibited α-glucosidase, and their IC50 values were 0.16 mg/mL and 0.17 mg/mL, respectively. Ethyl acetate fractions of B. monosperma significantly inhibited α-glucosidase, with a respective IC50 value of 0.14 mg/mL. DPP-IV inhibitory activities for water, hexane, and ethyl acetate fractions of C. siamea revealed with IC50 values of 0.11, 0.09, and 0.18 mg/mL, respectively and those of B. monosperma were 0.23, 0.13, and 0.24 mg/mL, respectively. The glucose uptake effect observed in the water and ethyl acetate fractions of B. monosperma was better than that observed in the fractions of C. siamea at tested glucose concentrations (5-25 mM). In addition, all tested fractions were very active in antioxidant capacity. This study indicated that the water fraction of C. siamea and ethyl acetate fraction of B. monosperma exhibited the best antidiabetic potential with high antioxidant power. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43800335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carob (Ceratonia siliqua L.): A Comprehensive Review on Traditional Uses, Chemical Composition, Pharmacological Effects and Toxicology (2002-2022) 角豆(Ceratonia silqua L.):传统用途、化学成分、药理作用和毒理学的综合综述(2002-2022)

Journal of Biologically Active Products from Nature Pub Date : 2023-05-04 DOI: 10.1080/22311866.2023.2237481

Mohammadine Moumou, I. Mokhtari, D. Milenkovic, S. Amrani, H. Harnafi

{"title":"Carob (Ceratonia siliqua L.): A Comprehensive Review on Traditional Uses, Chemical Composition, Pharmacological Effects and Toxicology (2002-2022)","authors":"Mohammadine Moumou, I. Mokhtari, D. Milenkovic, S. Amrani, H. Harnafi","doi":"10.1080/22311866.2023.2237481","DOIUrl":"https://doi.org/10.1080/22311866.2023.2237481","url":null,"abstract":"Abstract Carob (Ceratonia siliqua L.) is an evergreen tree widely cultivated in the Mediterranean contour thanks to its nutritional and economic value. Carob fruit (pods) and leaf preparations are used in traditional medicine as gastro-protective, anti-diarrheal, analgesic, laxative, hypocholesterolemic and anti-diabetic agents. Recent studies indicated that carob pods contain a variety of nutritional elements, including high amounts of carbohydrates, proteins (in seeds), and an appreciable amount of dietary fiber but low-fat content. Phytochemicals present in all parts of the plant are phenolic acids, flavonoids, hydrolysable and condensed tannins and volatile compounds, together with the functional sugar D-pinitol found in pods. These compounds were associated with many in vitro and in vivo pharmacological activities, including antioxidant, gastroprotective, anti-inflammatory, hypoglycemic, hypolipidemic, cardioprotective, anti-proliferative and cytotoxic activities. Clinical trials demonstrated a beneficial effect of carob fiber on cholesterolemia and the in vivo toxicological studies reported the safety of carob pulp and seeds, besides the low toxicity of leaves. This study aims to review the recent knowledge about the ethnopharmacological uses, nutritional and bioactive compounds available in Ceratonia siliqua, besides pharmacological effects and toxicity of carob pulp (unripe and ripe), seeds and leaves. GRAPHICAL ABSTRACT","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46668551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0