Journal of Biologically Active Products from Nature最新文献_第10页

Differential Effects of p-Coumaric Acid in relieving Doxorubicin induced Cardiotoxicity in Solid Tumour Bearing and Non-tumor Bearing Mice 对Coumaric Acid在减轻阿霉素诱导的实体瘤和非实体瘤小鼠心脏毒性中的差异作用

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1903997

S. M. Chacko, R. Dhanyakrishnan, K. G. Nevin

{"title":"Differential Effects of p-Coumaric Acid in relieving Doxorubicin induced Cardiotoxicity in Solid Tumour Bearing and Non-tumor Bearing Mice","authors":"S. M. Chacko, R. Dhanyakrishnan, K. G. Nevin","doi":"10.1080/22311866.2021.1903997","DOIUrl":"https://doi.org/10.1080/22311866.2021.1903997","url":null,"abstract":"Abstract The cardioprotective potential of p-coumaric acid (pCA) against Doxorubicin (Dox)-mediated cardiotoxicity in normal animals has been previously documented. The present study sought to examine the effect of pCA on the cardiotoxic and anti-tumor activity of Dox in non-tumor vs. Daltons Lymphoma Ascites (DLA) induced solid tumor model. Male Swiss Albino mice were pretreated and co-treated with pCA (100 mg/kg b.w.), after which Dox (16 mg/kg b.w. cumulative) was administered for a period of 28 days. Levels of serum cardiac diagnostic markers, lipid peroxidation products, and liver marker enzymes were significantly increased (P<0.05) in the Dox only treated groups. Partial restoration of the antioxidant system in the pCA pre/co-treated groups was observed. Cardiac damage was elevated in the Dox only tumor group; evident from changes in the heart/body weight ratio, haematological and biochemical analyses. Dox treated groups showed a significant reduction in tumor progression. pCA treatment did not appear to impede/enhance the efficacy of Dox-mediated anti-tumor activity in the tumor supergroup. This study leads us to conclude that pCA can be explored as a potent molecule to combat Dox-induced cardiotoxicity by the virtue of its proven antioxidant properties with no interference in the anti-tumor activity of Dox at the given dose.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"138 - 161"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1903997","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47906868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Antibacterial Potential of the Oleoresin, Leaf Crude Hydroalcoholic Extracts and Isolated Compounds of the Copaifera spp. Against Helicobacter pylori 黄花楸油树脂、叶粗水醇提取物及分离化合物对幽门螺杆菌的体外抑菌活性研究

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1914730

T. S. Moraes, Lucas Kozoski de Lima, R. Veneziani, S. Ambrósio, R. Santos, J. J. M. Silva, Gustavo Lima Ribeiro, J. Bastos, C. Martins

引用次数: 3

Cost-Effective in vitro Multiplication and Phenolic Profile of an Important Medicinal Orchid, Satyrium nepalense D. Don 重要药用兰花油桐的成本效益体外繁殖及酚类物质特性

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1911681

Deepak Singh, B. Mir, S. Babbar, S. Babbar

{"title":"Cost-Effective in vitro Multiplication and Phenolic Profile of an Important Medicinal Orchid, Satyrium nepalense D. Don","authors":"Deepak Singh, B. Mir, S. Babbar, S. Babbar","doi":"10.1080/22311866.2021.1911681","DOIUrl":"https://doi.org/10.1080/22311866.2021.1911681","url":null,"abstract":"Abstract In this study we report a cost-effective and reproducible protocol for large-scale multiplication of an important medicinal orchid, Satyrium nepalense through a four-step protocol, involving asymbiotic seed germination, multiplication of protocorm-like bodies (PLBs), development and multiplication of shoots, and finally in vitro rooting of the developed shoots. Out of various media tested for seed germination, Mitra’s medium supplemented with 0.1 % peptone (BM) supported the highest (79.19 %) seed germination. Eight-weekold protocorms were sub-cultured on BM alone and supplemented with different concentrations (1-8 μM) of BAP, KN, or TDZ. The highest number of shoots was developed on the medium containing 4 μM KN. Here we also observed that the highest number of shoots were produced from protocorms cultured on a 2 % isubgol gelled medium out of the seven different low-cost gelling agents used. Further, optimal elongation of shoots was observed on BM alone and 2 % guar gum, among the tested gelling agents. Elongated shoots were transferred for rooting on BM containing 0-2 μM of IAA, IBA, or NAA. The best rhizogenic response was observed on BM fortified with 0.5 μM IBA and isubgol (3 %). The rooted plantlets showed a 76 % survival rate on acclimatization after transfer to the potting mixture of sand and vermiculite (1:1). HPLC analysis of therapeutically important phenolic acids of leaves and tubers of in vitro regenerated and in vivo plants revealed the presence of higher levels of selected phenolic acids in in vitro tissues than those from their native habitat. This protocol could facilitate the conservation and propagation of this important medicinal orchid.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"162 - 182"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1911681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42839136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In silico and in vitro Study on the Inhibition of FtsZ Protein of Staphylococcus aureus by Active Compounds from Andrographis paniculata 穿心莲活性成分对金黄色葡萄球菌FtsZ蛋白抑制作用的体外及室内研究

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1908163

J. Selvaraj, V. Vishnu Priya, P. Vijayalakshmi, R. Ponnulakshmi

{"title":"In silico and in vitro Study on the Inhibition of FtsZ Protein of Staphylococcus aureus by Active Compounds from Andrographis paniculata","authors":"J. Selvaraj, V. Vishnu Priya, P. Vijayalakshmi, R. Ponnulakshmi","doi":"10.1080/22311866.2021.1908163","DOIUrl":"https://doi.org/10.1080/22311866.2021.1908163","url":null,"abstract":"Abstract Both organ systems, ranging from isolated skin infections to life-threatening systemic infections are implicated in the gram-positive bacterium Staphylococcus aureus, responsible for a wide range of human diseases. Filamentous temperature-sensitive protein Z (FtsZ) is a protein encoded by the FtsZ gene that assembles into a Z-ring at the potential site of the septum of bacterial cell division. Structurally, FtsZ is a eukaryotic tubulin homolog that has a low resemblance in sequence; that makes it possible to acquire FtsZ inhibitors without impacting the division of eukaryotic cells. Hence, in our research, we tried to test compounds from the Andrographis paniculata plant using molecular docking and dynamic simulations as an efficient inhibitor of the S. aureus FtsZ protein. We have picked Andrographolide, Neoandrographolide, Andrograpanin, and 14-deoxyandrographolide as the best inhibitor for the FtsZ protein based on the docking results. In terms of docking score and hydrogen bond interaction, Andrographolide exhibited very good results relative to all other compounds. So the docked Andrographolide-FtsZ protein complex has been further analysed through simulation of molecular dynamics. Results of MD simulations indicate that the compound was excellent at linking the target protein and preserving firm connexions throughout the protein backbone structures, creating very little negligible disruption. Finally, the in vitro antimicrobial activity findings of these four compounds also showed that selected compounds may serve as a potent S.aureus inhibitor.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"116 - 128"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1908163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46073797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of MITF Gene in Melanogenesis with Psoralea corylifolia, Zingiber officinale, Terminalia chebula, Punica granatum and Eclipta alba Based on Poly-Herbal Formulation 复方补骨脂、姜、樱桃、石榴、白唇黑色素生成中MITF基因的表达

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1908164

Shravan Kumar Ghali, Alokananda Chakraborty, Priyanka Pallapolu, T. Rafeeqi, Gulam Mohammed Husain, G. Javed, M. Waheed, M. H. Kazmi

{"title":"Expression of MITF Gene in Melanogenesis with Psoralea corylifolia, Zingiber officinale, Terminalia chebula, Punica granatum and Eclipta alba Based on Poly-Herbal Formulation","authors":"Shravan Kumar Ghali, Alokananda Chakraborty, Priyanka Pallapolu, T. Rafeeqi, Gulam Mohammed Husain, G. Javed, M. Waheed, M. H. Kazmi","doi":"10.1080/22311866.2021.1908164","DOIUrl":"https://doi.org/10.1080/22311866.2021.1908164","url":null,"abstract":"Abstract Pigmentation is an important physical characteristic of human beings due to the presence of a biopolymer molecule called melanin. Melanin pigment in the human skin and several other tissues were due to the activation and inhibition of different genes at the downstream signaling pathway like Tyrosinase-related protein 1 (TYRP1) and Tyrosinase-related protein 2 (TYRP2) and Microphthalmia-associated transcription factor (MITF) genes. In this study, we tried to deliver the molecular approach of TYRP1, TYRP2, and MITF by activating kinases in the process of Melanogenesis by treating with Unani formulations on the B16F10 murine melanoma cell line. RNA isolation of B16F10 cells was performed followed by cDNA conversion and expression studies at mRNA levels by RT-PCR method. To explore further western blot was performed at the protein level for the significant results which we obtained with UNIM regimes in the expression studies. The bioactive ingredient of UNIM-004 and UNIM-005 of Methanolic extracts up-regulates the expression and protein levels of the MITF gene which leads to the synthesis of melanin pigment in human beings. Therefore from this study, it indicates that the application and administration of UNIM-004 and UNIM-005 of methanolic extract will result in activating melanin in B16F10 cells by increasing mRNA expression levels in the MITF gene when compared with TYRP1and TYRP2 genes followed by Western blot experiment and found to be producing melanocytes in the progression of Melanogenesis in a dose-dependent manner at 10 μg and 100 μg concerning for to GAPDH control gene at mRNA expression level in Vitiligo patients.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"82 - 96"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1908164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45739114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bergenin Attenuates Sodium Selenite-Induced Hepatotoxicity via Improvement of Hepatic Oxidant-Antioxidant Balance in HepG2 Cells and ICR Mice Bergenin通过改善HepG2细胞和ICR小鼠肝脏氧化剂抗氧化平衡减轻亚硒酸钠诱导的肝毒性

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1908162

Yollada Sriset, W. Chatuphonprasert, K. Jarukamjorn

{"title":"Bergenin Attenuates Sodium Selenite-Induced Hepatotoxicity via Improvement of Hepatic Oxidant-Antioxidant Balance in HepG2 Cells and ICR Mice","authors":"Yollada Sriset, W. Chatuphonprasert, K. Jarukamjorn","doi":"10.1080/22311866.2021.1908162","DOIUrl":"https://doi.org/10.1080/22311866.2021.1908162","url":null,"abstract":"Abstract Bergenin is a C-glucoside derivative of gallic acid claimed to exhibit antioxidant and hepatoprotective activities. However, its effect on sodium selenite-induced oxidative damage has never been elucidated. We investigated the impact of bergenin on the oxidant-antioxidant balance in sodium selenite-induced oxidative stress in HepG2 cells and mouse livers. HepG2 cells were co-incubated with sodium selenite (10 μM) and either bergenin (75, 150, and 300 μM) or gallic acid (60 μM) for 24 h. Adult male ICR mice were orally administered sodium selenite (4 mg/kg/day) in combination with either bergenin (10, 50, and 250 mg/kg/day) or gallic acid (100 mg/kg/day) for 7 days. Sodium selenite injured HepG2 cells and mouse livers by disturbing the oxidant-antioxidant balance. Bergenin exerted protective effects against sodium selenite-induced oxidative stress in HepG2 cells. Moreover, bergenin attenuated sodium selenite-induced liver damage (nuclear pyknosis and necrotic areas) through a decrease in plasma aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase levels, and decreased production of reactive oxygen species, resulting in reduced lipid peroxidation in plasma and livers. Bergenin also restored hepatic antioxidant enzyme expression levels and activities (superoxide dismutase, catalase, and glutathione peroxidase) and reinstated hepatic glutathione homeostasis. Finally, bergenin returned cytochrome P450 2E1 mRNA expression to normal levels. In conclusion, bergenin reduced-sodium selenite induced liver damage by restoring the oxidant-antioxidant balance and reducing lipid peroxidation through multiple pathways.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"97 - 115"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1908162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48414421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Aroma Profile, Chemical Composition and Antiproliferative Activity of the Hydrodistilled Essential Oil of a Rare Salvia Species (Salvia greggii) 一种稀有鼠尾草(Salvia greggii)水蒸馏精油的香气特征、化学成分及抗增殖活性

Journal of Biologically Active Products from Nature Pub Date : 2021-03-04 DOI: 10.1080/22311866.2021.1906320

I. Abaza, Nour H Aboalhaija, Alhasan Alsalman, Wamidh H. Talib, F. Afifi

{"title":"Aroma Profile, Chemical Composition and Antiproliferative Activity of the Hydrodistilled Essential Oil of a Rare Salvia Species (Salvia greggii)","authors":"I. Abaza, Nour H Aboalhaija, Alhasan Alsalman, Wamidh H. Talib, F. Afifi","doi":"10.1080/22311866.2021.1906320","DOIUrl":"https://doi.org/10.1080/22311866.2021.1906320","url":null,"abstract":"Abstract The present study deals with the gas chromatography/mass spectrometry (GC/ MS) analysis of the aroma profile of different aerial organs obtained by solid-phase microextraction (SPME) and that of the hydro distilled essential oil of the fresh leaves and flowers of Salvia greggii A. Gray grown in Jordan. Oxygenated sesquiterpenes dominated the hydrodistilled oils of the leaves and flowers with guaiol (35.60 % and 31.92 %, respectively) and patchouli alcohol (16.30 % and 16.88 %, respectively) as the main constituents. Alpha-pinene, camphene, limonene, and γ-terpinene were detected as the major hydrocarbon monoterpenes and 1,8-cineol, camphor, and isobornyl acetate as the major oxygenated monoterpenes. The antiproliferative activity of the leaf essential oil was screened on MCF-7 and HCT116 cell lines. The essential oil exhibited a promising dosedependent inhibition of cell growth with low IC50’s (MCF-7: 35.35 μg/mL; HCT116: 23.57 μg/mL) with a high safety profile against the normal Vero cell line compared to the positive control Doxorubicin.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"129 - 137"},"PeriodicalIF":0.0,"publicationDate":"2021-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1906320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59980274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Gymnemic Acid-Rich Fraction from Gymnema Sylvestre Leaves Ameliorates Post Prandial Hyperglycaemia in In-vitro and In-vivo Studies 在体外和体内研究中，从金合欢叶中提取的富含金合欢酸的组分对印度洋地黄高血糖后的改善作用

Journal of Biologically Active Products from Nature Pub Date : 2021-01-02 DOI: 10.1080/22311866.2021.1895886

J. Ahamad, K. J. Naquvi, S. Amin, S. Mir

{"title":"Gymnemic Acid-Rich Fraction from Gymnema Sylvestre Leaves Ameliorates Post Prandial Hyperglycaemia in In-vitro and In-vivo Studies","authors":"J. Ahamad, K. J. Naquvi, S. Amin, S. Mir","doi":"10.1080/22311866.2021.1895886","DOIUrl":"https://doi.org/10.1080/22311866.2021.1895886","url":null,"abstract":"Abstract Gymnemic acids are triterpenoid glycosides with gymnemagenin as common aglycone found in Gymnema sylvestre (Gurmar). G. sylvestre is often used in herbal formulations because of its beneficial actions in diabetes, hyperlipidemia, and gastric problems. The purpose of the present study is to evaluate gymnemic acid-rich fraction of G. sylvestre in in-vitro and in-vivo model to control postprandial hyperglycemia. The gymnemic acid-rich fraction of G. sylvestre (GARF) was prepared by ultrasonic-assisted extraction using methanol-water (81:19 v/v) at a temperature of 49°C for 50 min using a solid-to-solvent ratio of 1:12.5 g/ml and gymnemic acid content was determined by validated High-performance thin-layer chromatography (HPTLC) densitometric method. The GARF effect was evaluated in the in-vitro model on α-amylase and α-glucosidase enzymes, while the antihyperglycemic effect was studied in carbohydrate-challenged and diabetic rats induced by Streptozotocin (STZ). In vitro studies show that GARF produces dose-dependent enzyme inhibition with IC50 values of 4.34 ± 0.81 mg/ml and 8.78 ± 1.22 mg/ml, respectively. In-vivo studies of normal and diabetic rats showed that GARF treatment (200 mg/kg b.w., p.o.), causes a significant (p < 0.01) blood glucose reduction effect in both models. The current study provides a scientific basis for the use of G. sylvestre in the management of diabetes mellitus.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"32 - 41"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1895886","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41892811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chemical Composition and in-vitro Antimicrobial Activity of Leaf Essential Oils of Senecio pedunculatus Edgew. and Nepeta coerulescens Maxim 长柄荆芥叶精油的化学成分及体外抗菌活性研究和Nepeta coerulescens Maxim

Journal of Biologically Active Products from Nature Pub Date : 2021-01-02 DOI: 10.1080/22311866.2021.1887762

Navadha Bhatt, N. Joshi, Kapil Ghai

{"title":"Chemical Composition and in-vitro Antimicrobial Activity of Leaf Essential Oils of Senecio pedunculatus Edgew. and Nepeta coerulescens Maxim","authors":"Navadha Bhatt, N. Joshi, Kapil Ghai","doi":"10.1080/22311866.2021.1887762","DOIUrl":"https://doi.org/10.1080/22311866.2021.1887762","url":null,"abstract":"Abstract When talking of herbal medicines, one of the most important herbal families is the Lamiaceae family that includes a varied range of plants with biological and medicinal interests. Medicinal properties of the Lamiaceae species are mainly because of the high content of volatile components. Another family that possesses a good number of plants for our health care system is Compositae. Plant species in Compositae and Lamiaceae family are widely being used to cure various diseases. The present study aims to study the composition and in vitro antimicrobial activity of the leaf essential oil of Senecio pedunculatus Edgew.of the Compositae family and compare the results with Nepeta coerulescens Maxim. of Lamiaceae family, both having caryophyllene oxide as the major constituent in their leaf essential oil. The antifungal activity of the essential oil could be due to the presence of caryophyllene oxide since it is well known as a preservative in food, drugs, and cosmetics, had been tested in vitro as an antifungal against dermatophytes. Essential oils of the leaves of Senecio pedunculatus and Nepeta coerulescens contained 23.5 % and 29.3 % caryophyllene oxide, respectively, as the major constituent. The leaf essential oil of Senecio pedunculatus showed mild activity against one or more pathogens on Petri plate assay based on the zone of inhibition and MIC values. The essential oil was most effective against Bacillus subtilis and least effective against Staphylococus aureus. Among fungal strains, the essential oil was most effective against Aspergillus flavus. The Nepeta coerulescens leaf essential oil was most effective against Staphylococus aureus and least effective against Salmonella enterica. Among fungal strains, the essential oil was equally effective against Aspergillus flavus and Candida albicans.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"1 - 10"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1887762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47691837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chemopreventive Efficacy of Green Tea, Ocimum gratissimum and their Combination Against Benzo[a]pyrene Induced Preneoplastic Lung Lesions in Murine Model 绿茶、茴香及其联合用药对苯并[a]芘致小鼠肿瘤前肺病变的化学预防作用

Journal of Biologically Active Products from Nature Pub Date : 2021-01-02 DOI: 10.1080/22311866.2021.1894236

Sumaya Farooq, A. Sehgal

{"title":"Chemopreventive Efficacy of Green Tea, Ocimum gratissimum and their Combination Against Benzo[a]pyrene Induced Preneoplastic Lung Lesions in Murine Model","authors":"Sumaya Farooq, A. Sehgal","doi":"10.1080/22311866.2021.1894236","DOIUrl":"https://doi.org/10.1080/22311866.2021.1894236","url":null,"abstract":"Abstract Green tea is a popular drink containing a rich profile of polyphenolic compounds responsible for its various health benefits. The clinical reports suggested limited efficacy of green tea in preventing lung cancer. The previous study based on chemical and ex-vivo antioxidant models demonstrated that aqueous infusion of green tea with Ocimum gratissimum illustrated high antioxidant potential and strong synergism. The aim of this study was to test the cytotoxic potential of green tea (GT), O. gratissimum (OG) and their combination (GT+OG) on A549 lung cancer cell line. Moreover, to elucidate the in vivo cancer preventive potential, these infusions were tested against benzo(a)pyrene [B(a)P] brought pulmonary preneoplastic lesions in mice. GT+OG and GT, showed higher cytotoxic activity at a lower concentration as compared to OG whereas at higher doses these extracts were equally effective. The oral intake of GT+OG revealed the highest plasma antioxidant capacity followed by GT and OG compared to carcinogen [B(a)P] treated group. The lung histopathological examination demonstrated a similar reduction in hyperplastic zones for all infusions. Consequently, green tea, O. gratissimum and their combination can act as a plausible chemopreventive agent against the production of pulmonary tumorigenesis.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":"11 1","pages":"22 - 31"},"PeriodicalIF":0.0,"publicationDate":"2021-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1894236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47617965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1