Journal of Biologically Active Products from Nature最新文献_第10页

In Vivo Analysis of Pongamia pinnata (L.) Pierre on Glucose, Lipid and Liver in Diabetic Rats 五倍子对糖尿病大鼠血糖、血脂和肝脏的体内分析

Journal of Biologically Active Products from Nature Pub Date : 2021-07-04 DOI: 10.1080/22311866.2021.1955740

A. Morajkar, Bharat Sharma, Kiran R Kharat

{"title":"In Vivo Analysis of Pongamia pinnata (L.) Pierre on Glucose, Lipid and Liver in Diabetic Rats","authors":"A. Morajkar, Bharat Sharma, Kiran R Kharat","doi":"10.1080/22311866.2021.1955740","DOIUrl":"https://doi.org/10.1080/22311866.2021.1955740","url":null,"abstract":"Abstract Pongamia pinnata (L.) and its various parts have been used as a traditional medicine in the treatment and prevention of several kinds of ailments such as piles, skin diseases, and wounds. This study reports in vivo effects of P. pinnata on glucose, lipid and liver in diabetic rats and its possible action mechanism. Stem bark extract of P. Pinnata was prepared using the soxhlet apparatus. Experimental induction of diabetes was carried out by giving a single dose of alloxan monohydrate. Plant extracts treatment was started on the 7th day of the alloxan treatment (i.e. Day 1) as a single dose in the morning and was continued for 3 months with respective groups. Blood was collected from the retro-orbital plexus at specific periodic intervals for three months for the purpose of biochemical investigation. In diabetic rats (DC), the Serum BSF, AST, ALT, TG, TC levels were significantly increased in correlation with Normal control (NC). Treatment with PPAlcExt produced significant reduction in levels of TG (76.06 mg/dl) as compared to DC (200.63 mg/dl), TC (54.6 mg/dl) as compared to DC (89.7 mg/dl), AST (293.28 U/L) as compared to DC (564.09 U/L), and ALT (74.5 U/L) as compared to DC (238.0 U/L). Treatment with PPAqExt and PPAlcExt showed remarkable recovery on all the parameters, while a highly significant reduction was achieved with PPAlcExt treatment. The results proved that hydroalcoholic bioactive phytochemical constituents from plants can be a good alternative to synthetic drugs, and can constitute a potentially novel approach for the treatment of diabetes.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46023134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Ascidians as Bioresources: An Anti-inflammatory Activity of Colonial Ascidians Eudistoma ovatum and Didemnum perlucidum 作为生物资源的海鞘:群居的卵形海鞘和透明海鞘的抗炎活性

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1919208

B. Kaleemullah Khan, L. Praba, H. Abdul Jaffar Ali

{"title":"Ascidians as Bioresources: An Anti-inflammatory Activity of Colonial Ascidians Eudistoma ovatum and Didemnum perlucidum","authors":"B. Kaleemullah Khan, L. Praba, H. Abdul Jaffar Ali","doi":"10.1080/22311866.2021.1919208","DOIUrl":"https://doi.org/10.1080/22311866.2021.1919208","url":null,"abstract":"Abstract Carrageenan-induced rat paw edema is a prominent inflammatory model to evaluate the anti-inflammatory effect of compounds of biological origin. In animals pretreated with Eudistoma ovatum (EO) and Didemnum perlucidum (DP) drugs, there was significant and dose-dependent inhibition of Carrageenan-induced posterior paw edema. A variety of antioxidant enzymes, such as Superoxide dismutase (SOD), Glutathione peroxidase (GPx), and Glutathione reductase (GRd) can scavenge and minimize the formation of reactive oxygen species (ROS). SOD protects cells against the damages of ROS. GPx in the presence of glutathione (GSH) accelerates the reduction of H2O2 or other organic hydroperoxides and serves as a second line of defense against hydroperoxides. The amount of platelets is affected by the increased plasma concentration of active proteins in the acute response to inflammation. Anti-inflammatory activity in carrageenan-induced paw edema in rat model was found in the extract of both ascidians E. ovatum and D. perlucidum. But the methanolic extract of E. ovatum showed more significant anti-inflammatory activity. The study includes the investigation on the effects of EO and DP on some oxidative parameters such as lipid peroxidation (LPO), SOD and GSH level, hematological parameters (RBC, WBC and Platelets, cytokines (IL 6 and TNF α), hepatic enzymes (Acid phosphatase - ACP and Alkaline phosphatase - ALP) and membrane-bound glycoproteins (hexose, hexosamine, sialic acid, and fucose). This study provided the finely tuned of the extracts in inflammatory diseases. Thus, a pharmacological basis is achieved for use of the ascidians against rheumatism and other associated diseases.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1919208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42383494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hedychium spicatum Sm.: Chemical Composition with Biological Activities of Methanolic and Ethylacetate Oleoresins from Rhizomes 五香扁豆：根状茎中甲醇和乙酸乙酯油树脂的化学组成及生物活性

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1923572

A. Rawat, O. Prakash, Ravendra Kumar, Sushila Arya, R. Srivastava

{"title":"Hedychium spicatum Sm.: Chemical Composition with Biological Activities of Methanolic and Ethylacetate Oleoresins from Rhizomes","authors":"A. Rawat, O. Prakash, Ravendra Kumar, Sushila Arya, R. Srivastava","doi":"10.1080/22311866.2021.1923572","DOIUrl":"https://doi.org/10.1080/22311866.2021.1923572","url":null,"abstract":"Abstract The current study deals with different biological activities and phytochemical composition of methanolic and ethyl acetate oleoresins from rhizomes of Hedychium spicatum Sm. Chemical analysis of Hedychium spicatum rhizome methanolic oleoresin (HSRMO) revealed the presence of curzerene (14.7 %), coronarin E (13.3 %), curdione (10.2 %) and linderazulene (6.0 %) as major phytoconstituents while Hedychium spicatum rhizome ethylacetate oleoresin (HSREO) was dominated by curcumol (13.0 %), curzerene (10.4 %) and isovelleral (9.7 %). The total phenolic content and flavonoid content in the oleoresins were found to be significantly high on the dry weight basis. In antioxidant assay, HSRMO and HSREO exhibited DPPH radical scavenging activity (IC50 = 52.4±0.6 mg/mL) and (IC50 = 55.3±0.1 mg/mL), metal chelating activity of Fe2+ (IC50 = 25.6±0.1 mg/mL) and (IC50 = 19.9±0.2 mg/mL) and reducing power activity (RP50 = 36.1±0.1 50 mg/mL) and (RP50 = 32.7±0.2 mg/mL) respectively. Both the oleoresins revealed significant in-vitro anti-inflammatory activity compared to diclofenac sodium. HSRMO and HSREO at 25 % dose levels exhibited 51.9 % and 68.5 % antifeeding activity against Spilosoma obliqua respectively. HSRMO and HSREO were also found to exhibit moderate to strong antifungal activity against Colletotrichum falcatum, Rhizoctonia solani, Sclerotinia sclerotiorum and Sclerotium rolfsii and exhibited significant anti-glycemic activity.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1923572","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43955055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Nobiletin a Biologically Active Phytoconstituent: Systematic Review Nobiletin一种生物活性植物成分：系统评价

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1920461

A. Singh, Jai B Kandpal, R. Sharma, H. Chitme

{"title":"Nobiletin a Biologically Active Phytoconstituent: Systematic Review","authors":"A. Singh, Jai B Kandpal, R. Sharma, H. Chitme","doi":"10.1080/22311866.2021.1920461","DOIUrl":"https://doi.org/10.1080/22311866.2021.1920461","url":null,"abstract":"Abstract Nobiletin is an abundant phytoconstituent having multiple pharmacological activities. Various citrus species like orange (Citrus sinensis), lemon (Citrus limon), grapefruit (Citrus paradisi) and tangerine (Citrus tangirina) having flavanones, flavones, flavon aglycon, and Polymethoxyflavones (Nobiletin & Tangeretin). Nobiletin (HMF); Hexamethoxyflavone {2-(3, 4)-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one}is extracted from non-edible orange peel rich in polymethoxyflavones (PMFs). Many are suggesting Nobiletin as chemo-sensitizing agent induces nuclear retention of tumor suppressor protein and Tyrosinase inhibitor, inhibiting hepatitis B virus replication. It is also proposed that 2-aryl-4H-chromen-4-one derivative may be effective in Chikungunya Virus, and other suggested multiple activities. Citrus species are traditionally used in Ayurveda as immune modulator which is effective in viral disease because of their antioxidant properties. To study the ability as drug of an independent phyto-active Nobiletin (HMF) is under consideration, HMF is lipophilic in nature, its physiochemical properties may by enhanced by increasing water solubility for more bioavailable, and prospective as a therapeutic agent or as broad-spectrum antiviral. Graphical abstract","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1920461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44215938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Review on Pharmacological, Anti-oxidant Activities and Phytochemical Constituents of a Novel Lichen Parmotrema Species 一种新型地衣的药理、抗氧化活性及植物化学成分研究进展

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1916596

S. Saha, Amrita Pal, Santanu Paul

{"title":"A Review on Pharmacological, Anti-oxidant Activities and Phytochemical Constituents of a Novel Lichen Parmotrema Species","authors":"S. Saha, Amrita Pal, Santanu Paul","doi":"10.1080/22311866.2021.1916596","DOIUrl":"https://doi.org/10.1080/22311866.2021.1916596","url":null,"abstract":"Abstract Increased resistance and side effects of synthetic pharmaceutical drugs have led to the exploration of bioactive compounds from alternative sources. Therefore, research on drug development from members of natural sources has gained much importance. Lichens are a unique association of fungi and algae, producing a wide array of secondary metabolites which has immense pharmacological activities. Lichen extracts have been used in traditional systems of medicines and are known to cure several diseases. Parmotrema is a large genus of foliose lichen belonging to the family Parmeliaceae. Parmeloid lichens are a diverse and ubiquitous group of lichens. Members of the Parmeliaceae family have been used in several traditional systems of medicines. One hundred and nine articles have been reported till date regarding pharmacological activities of Parmotrema species. Studies reveal that Parmotrema exhibits numerous biological activities ranging from anti-microbial, anti-fungal, anti-oxidative, and anti-proliferative properties. These properties can be attributed to the presence of pharmacologically active compounds like depsides, depsidones, phenolics, polysaccharides, lipids, diphenyl ethers, and dibenzofurans. The free radical scavenging activity and cytotoxicity specifically towards cancer cells infer that this lichen genus can have potential anti-cancer properties and should be extensively investigated for pharmaceutical purposes. This review dealt with the in-depth potentiality of this novel lichen Parmotrema species and its role in pharmacology. Graphical abstract","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1916596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48715902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In Vitro Antidiabetic and In Vivo Hypoglycaemic Activities and Toxicity of Canarium zeylanicum Bark Extracts 莪术皮提取物体外抗糖尿病和体内降糖活性及毒性研究

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1916595

C. P. Liyanaarachchie, M. Gunatilake, L. Jayasinghe, B. Bandara

{"title":"In Vitro Antidiabetic and In Vivo Hypoglycaemic Activities and Toxicity of Canarium zeylanicum Bark Extracts","authors":"C. P. Liyanaarachchie, M. Gunatilake, L. Jayasinghe, B. Bandara","doi":"10.1080/22311866.2021.1916595","DOIUrl":"https://doi.org/10.1080/22311866.2021.1916595","url":null,"abstract":"Abstract Aqueous bark extract of Canarium zeylanicum (Retz.) Blume (Burseraceae) is an antidiabetic remedy in indigenous medicine. Its antidiabetic potential has not been scientifically evaluated. In this study, antidiabetic activity and toxicity of the bark of C. zeylanicum were evaluated using a selected in vitro and in vivo set of experiments. A hot water extract (HWE) and an organic solvent extract (OSE) of the bark and respective negative and positive controls were subjected to in vitro α-amylase- and α-glucosidase-inhibitory and brine shrimp lethality assays. In vivo hypoglycaemic activity and hepato- and nephro-toxicities were evaluated by twice daily administration of each extract and the controls to 8 groups (n=10) of normoglycaemic Wistar rats for 14 days. Data of in vivo studies were statistically analysed using Minitab 16 with P- <0.05. IC50 values of HWE, OSE and the positive control in the α-amylase-inhibitory assay were 65.3 ± 18.5, 8.4 ± 4.1 and 0.04 ± 0.1 µg/ml, respectively; corresponding IC50 values in the α-glucosidase-inhibitory assay were 2.9 ± 0.1, 21.6 ± 0.5 and 0.01 ± 0.0 µg/ml. Brine shrimp lethality assay revealed that the extracts were non-toxic. In vivo studies revealed that extracts possess hypoglycaemic activity with higher percentage reduction (38.2 ± 12.9) of fasting blood sugar by OSE, high glucose tolerance, and the extracts were neither hepatotoxic nor nephrotoxic. Lupeol is one of the counterparts for the antidiabetic actions while some active compounds could not be resolved further. Results indicate that C. zeylanicum is a potential source for developing effective non-toxic antidiabetic drugs.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1916595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44330607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stilbenes at Low Micromolar Concentrations Mitigate the NO, TNF-α, IL-1β and ROS Production in LPS-Stimulated Murine Macrophages 低微摩尔浓度二苯乙烯降低lps刺激小鼠巨噬细胞NO、TNF-α、IL-1β和ROS的产生

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1923571

Iris Aja-Perez, S. Krisa, R. Hornedo-Ortega, M. Ruiz-Larrea, J. Ruiz-Sanz, T. Richard, A. Courtois

{"title":"Stilbenes at Low Micromolar Concentrations Mitigate the NO, TNF-α, IL-1β and ROS Production in LPS-Stimulated Murine Macrophages","authors":"Iris Aja-Perez, S. Krisa, R. Hornedo-Ortega, M. Ruiz-Larrea, J. Ruiz-Sanz, T. Richard, A. Courtois","doi":"10.1080/22311866.2021.1923571","DOIUrl":"https://doi.org/10.1080/22311866.2021.1923571","url":null,"abstract":"Abstract Stilbenes, of which resveratrol is the most studied, were described as antioxidant and anti-inflammatory molecules. Presumably, other stilbenes have similar biological properties, but the evidence is poorly documented. Therefore, 20 stilbenes from resveratrol monomers to tetramers were screened as anti-inflammatory and antioxidant agents in a cellular model of LPS-stimulated murine macrophages. Piceatannol (monomer), ϵ-viniferin and δ-viniferin (dimers), hopeaphenol and isohopeaphenol (tetramers) were the most powerful compounds that inhibited NO and ROS generation upon LPS exposure. Among these compounds, hopeaphenol (5-10 µM) showed the highest efficiency. Nevertheless, ϵ-viniferin was the most powerful to inhibit TNF-α release whereas isohopeaphenol was the greatest to reduce IL-1β upon LPS stimulation. Thus, this work provided evidence that the chemical structure of stilbenes is highly relevant to the behavior of their activities. These results will allow the selection of potential bioactive stilbenes to develop further studies to elucidate their molecular mechanism of action. Graphical abstract","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1923571","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43448874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In vitro Antioxidant, Antimutagenic and Anti-hemolytic Potency of Allyl Isothiocyanate: A Natural Molecule 异硫氰酸烯丙酯天然分子的体外抗氧化、抗诱变和抗溶血作用

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1916594

Sakshi Bhushan, S. Rajput, D. Sharma, Tajinder Kaur, M. Dhar, Saroj Arora

{"title":"In vitro Antioxidant, Antimutagenic and Anti-hemolytic Potency of Allyl Isothiocyanate: A Natural Molecule","authors":"Sakshi Bhushan, S. Rajput, D. Sharma, Tajinder Kaur, M. Dhar, Saroj Arora","doi":"10.1080/22311866.2021.1916594","DOIUrl":"https://doi.org/10.1080/22311866.2021.1916594","url":null,"abstract":"Abstract The cruciferous vegetables are richest sources of isothiocyanates and among them, allyl isothiocyanate (AITC) is one of the major constituents. It has been known to possess various activities of therapeutic interest. Keeping this in view, the present study was planned to investigate antioxidant capacity of AITC using Cupric Reducing Antioxidant Capacity (CUPRAC) Assay, 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) assay, β-Carotene bleaching (BCB) assay and superoxide anion scavenging assay. The antimutagenic potency of AITC was determined by modifying Vibrio harveyi bioluminescence assay against direct acting mutagen 4-nitro-o-phenylenediamine (NPD) and indirect acting mutagens 2-acetylaminofluorene (2-AAF), 7,12-Dimethylbenz[a]anthracene (DMBA) in presence and absence of S9. Furthermore, the antihemolytic activity was evaluated using hemolysis assay. Among the different activities carried out, it was observed that AITC exhibited efficient antimutagenic potential against direct acting mutagen NPD and indirect acting mutagens 2-AAF and DMBA in the presence as well as absence of S9 fraction in Vibrio harveyi bioluminescence assay. Overall, our results established the efficiency of AITC to act as strong antimutagenic agent, efficient anti-hemolytic agent and mild antioxidant agent thus, making AITC an interesting candidate to be further explored for drug discovery.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1916594","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47074699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seeds of Ornamental Tree Barringtonia asiatica as a Potential Source of Efficacious Antimicrobials 作为有效抗菌剂潜在来源的观赏树种亚洲白荆种子

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1916593

R. Paramasamy, M. Weerasekera, S. Ekanayake

{"title":"Seeds of Ornamental Tree Barringtonia asiatica as a Potential Source of Efficacious Antimicrobials","authors":"R. Paramasamy, M. Weerasekera, S. Ekanayake","doi":"10.1080/22311866.2021.1916593","DOIUrl":"https://doi.org/10.1080/22311866.2021.1916593","url":null,"abstract":"Abstract Microorganisms are the major cause of disease in human mucosal and deep tissue infections. Due to the development of resistance to existing drugs by microbes, discovering new antimicrobial agents is of paramount importance. Present study aimed at demonstrating growth inhibition of ATCC and clinical isolates of selected fungal and bacterial strains with a fraction (MPLCBA-3) isolated from crude methanolic extract (CME) with medium pressure liquid chromatography and CME of Barringtonia asiatica seed kernel. Both CME and MPLCBA-3 inhibited the growth of ATCC Candida strains studied except C. tropicalis. However, CME inhibited the growth of majority of clinical isolates of C. tropicalis. All clinical isolates of C. albicans and C. glabrata were inhibited by both fractions. Both CME and MPLCBA-3 were not active against most of the clinical isolates of C. parapsilosis at the given concentration. In the antibacterial study Staphylococcus aureus (ATCC) growth was inhibited (11 mm) by CME and Pseudomonas aeruginosa (ATCC) (14 mm) by MPLCBA-3 fraction. However, both fractions were not effective against Enterococcus faecalis, Escherichia coli, and their clinical isolates. MIC values of MPLCBA-3 reached 150, 200 and 250 ppm with C. albicans, C. parapsilosis, and C. glabrata respectively. Thus, CME and MPLCBA-3 fraction demonstrated potent antifungal activity at 33 and 50 times lower concentrations compared to positive control fluconazole but low antibacterial activity.","PeriodicalId":15364,"journal":{"name":"Journal of Biologically Active Products from Nature","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/22311866.2021.1916593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49111056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory Effects and Caspase 3 Activation Activity of Natural Compounds from Anemarrhena Asphodeloides (Bunge) Rhizomes in Vietnam 越南知母根状茎天然化合物的抑制作用和胱天冬酶3激活活性

Journal of Biologically Active Products from Nature Pub Date : 2021-05-04 DOI: 10.1080/22311866.2021.1919207

M. Truong, Mai Lan Huong, N. Anh, S. Shen, P. Khang

引用次数: 0