Journal of Cerebral Blood Flow & Metabolism最新文献_第2页

A systematic review and in silico analysis of studies investigating the ischaemic penumbra proteome in animal models of experimental stroke 对实验性中风动物模型缺血半影蛋白质组研究的系统综述和硅学分析

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-19 DOI: 10.1177/0271678x241248502

Joseph V Moxon, Cornea Pretorius, Alexandra F Trollope, Parul Mittal, Manuela Klingler-Hoffmann, Peter Hoffmann, Jonathan Golledge

{"title":"A systematic review and in silico analysis of studies investigating the ischaemic penumbra proteome in animal models of experimental stroke","authors":"Joseph V Moxon, Cornea Pretorius, Alexandra F Trollope, Parul Mittal, Manuela Klingler-Hoffmann, Peter Hoffmann, Jonathan Golledge","doi":"10.1177/0271678x241248502","DOIUrl":"https://doi.org/10.1177/0271678x241248502","url":null,"abstract":"Ischaemic stroke results in the formation of a cerebral infarction bordered by an ischaemic penumbra. Characterising the proteins within the ischaemic penumbra may identify neuro-protective targets and novel circulating markers to improve patient care. This review assessed data from studies using proteomic platforms to compare ischaemic penumbra tissues to controls following experimental stroke in animal models. Proteins reported to differ significantly between penumbra and control tissues were analysed in silico to identify protein-protein interactions and over-represented pathways. Sixteen studies using rat (n = 12), mouse (n = 2) or primate (n = 2) models were included. Heterogeneity in the design of the studies and definition of the penumbra were observed. Analyses showed high abundance of p53 in the penumbra within 24 hours of permanent ischaemic stroke and was implicated in driving apoptosis, cell cycle progression, and ATM- MAPK- and p53- signalling. Between 1 and 7 days after stroke there were changes in the abundance of proteins involved in the complement and coagulation pathways. Favourable recovery 1 month after stroke was associated with an increase in the abundance of proteins involved in wound healing. Poor recovery was associated with increases in prostaglandin signalling. Findings suggest that p53 may be a target for novel therapeutics for ischaemic stroke.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice 慢性睡眠片段会损害年轻野生型小鼠的大脑间隙清除能力

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-19 DOI: 10.1177/0271678x241230188

Saiyue Deng, Yusi Hu, Simiao Chen, Yang Xue, Di Yao, Qian Sun, Maiken Nedergaard, Wei Wang, Fengfei Ding

{"title":"Chronic sleep fragmentation impairs brain interstitial clearance in young wildtype mice","authors":"Saiyue Deng, Yusi Hu, Simiao Chen, Yang Xue, Di Yao, Qian Sun, Maiken Nedergaard, Wei Wang, Fengfei Ding","doi":"10.1177/0271678x241230188","DOIUrl":"https://doi.org/10.1177/0271678x241230188","url":null,"abstract":"Accumulating evidence shows that most chronic neurological diseases have a link with sleep disturbances, and that patients with chronically poor sleep undergo an accelerated cognitive decline. Indeed, a single-night of sleep deprivation may increase metabolic waste levels in cerebrospinal fluid. However, it remains unknown how chronic sleep disturbances in isolation from an underlying neurological disease may affect the glymphatic system. Clearance of brain interstitial waste by the glymphatic system occurs primarily during sleep, driven by multiple oscillators including arterial pulsatility, and vasomotion. Herein, we induced sleep fragmentation in young wildtype mice and assessed the effects on glymphatic activity and cognitive functions. Chronic sleep fragmentation reduced glymphatic function and impaired cognitive functions in healthy mice. A mechanistic analysis showed that the chronic sleep fragmentation suppressed slow vasomotion, without altering cardiac-driven pulsations. Taken together, results of this study document that chronic sleep fragmentation suppresses brain metabolite clearance and impairs cognition, even in the absence of disease.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review, meta-analysis, and meta-regression amalgamating the driven approaches used to quantify dynamic cerebral autoregulation 系统综述、荟萃分析和荟萃回归综合了用于量化动态大脑自动调节的驱动方法

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-18 DOI: 10.1177/0271678x241235878

Joel S Burma, Marc-Antoine Roy, Courtney M Kennedy, Lawrence Labrecque, Patrice Brassard, Jonathan D Smirl

{"title":"A systematic review, meta-analysis, and meta-regression amalgamating the driven approaches used to quantify dynamic cerebral autoregulation","authors":"Joel S Burma, Marc-Antoine Roy, Courtney M Kennedy, Lawrence Labrecque, Patrice Brassard, Jonathan D Smirl","doi":"10.1177/0271678x241235878","DOIUrl":"https://doi.org/10.1177/0271678x241235878","url":null,"abstract":"Numerous driven techniques have been utilized to assess dynamic cerebral autoregulation (dCA) in healthy and clinical populations. The current review aimed to amalgamate this literature and provide recommendations to create greater standardization for future research. The PubMed database was searched with inclusion criteria consisting of original research articles using driven dCA assessments in humans. Risk of bias were completed using Scottish Intercollegiate Guidelines Network and Methodological Index for Non-Randomized Studies. Meta-analyses were conducted for coherence, phase, and gain metrics at 0.05 and 0.10 Hz using deep-breathing, oscillatory lower body negative pressure (OLBNP), sit-to-stand maneuvers, and squat-stand maneuvers. A total of 113 studies were included, with 40 of these incorporating clinical populations. A total of 4126 participants were identified, with younger adults (18–40 years) being the most studied population. The most common techniques were squat-stands (n = 43), deep-breathing (n = 25), OLBNP (n = 20), and sit-to-stands (n = 16). Pooled coherence point estimates were: OLBNP 0.70 (95%CI:0.59–0.82), sit-to-stands 0.87 (95%CI:0.79–0.95), and squat-stands 0.98 (95%CI:0.98–0.99) at 0.05 Hz; and deep-breathing 0.90 (95%CI:0.81–0.99); OLBNP 0.67 (95%CI:0.44–0.90); and squat-stands 0.99 (95%CI:0.99–0.99) at 0.10 Hz. This review summarizes clinical findings, discusses the pros/cons of the 11 unique driven techniques included, and provides recommendations for future investigations into the unique physiological intricacies of dCA.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-transplantation of autologous treg cells: A groundbreaking cell therapy for brain diseases 自体 treg 细胞联合移植：治疗脑部疾病的开创性细胞疗法

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-17 DOI: 10.1177/0271678x241245633

Yue Cheng, Yueman Zhang, Peiying Li

引用次数: 0

Acute isometric and dynamic exercise do not alter cerebral sympathetic nerve activity in healthy humans 急性等长和动态运动不会改变健康人的大脑交感神经活动

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-13 DOI: 10.1177/0271678x241248228

Michael M Tymko, Audrey Drapeau, Maria Augusta Vieira-Coelho, Lawrence Labrecque, Sarah Imhoff, Geoff B Coombs, Stephan Langevin, Marc Fortin, Nathalie Châteauvert, Philip N Ainslie, Patrice Brassard

{"title":"Acute isometric and dynamic exercise do not alter cerebral sympathetic nerve activity in healthy humans","authors":"Michael M Tymko, Audrey Drapeau, Maria Augusta Vieira-Coelho, Lawrence Labrecque, Sarah Imhoff, Geoff B Coombs, Stephan Langevin, Marc Fortin, Nathalie Châteauvert, Philip N Ainslie, Patrice Brassard","doi":"10.1177/0271678x241248228","DOIUrl":"https://doi.org/10.1177/0271678x241248228","url":null,"abstract":"The impact of physiological stressors on cerebral sympathetic nervous activity (SNA) remains controversial. We hypothesized that cerebral noradrenaline (NA) spillover, an index of cerebral SNA, would not change during both submaximal isometric handgrip (HG) exercise followed by a post-exercise circulatory occlusion (PECO), and supine dynamic cycling exercise. Twelve healthy participants (5 females) underwent simultaneous blood sampling from the right radial artery and right internal jugular vein. Right internal jugular vein blood flow was measured using Duplex ultrasound, and tritiated NA was infused through the participants' right superficial forearm vein. Heart rate was recorded via electrocardiogram and blood pressure was monitored using the right radial artery. Total NA spillover increased during HG (P = 0.049), PECO (P = 0.006), and moderate cycling exercise (P = 0.03) compared to rest. Cerebral NA spillover remained unchanged during isometric HG exercise (P = 0.36), PECO after the isometric HG exercise (P = 0.45), and during moderate cycling exercise (P = 0.94) compared to rest. These results indicate that transient increases in blood pressure during acute exercise involving both small and large muscle mass do not engage cerebral SNA in healthy humans. Our findings suggest that cerebral SNA may be non-obligatory for exercise-related cerebrovascular adjustments.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140568727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure 下半身负压振荡诱发强迫振荡时脑压-血流关系的方向敏感性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-13 DOI: 10.1177/0271678x241247633

Lawrence Labrecque, Marc-Antoine Roy, Shahrzad Soleimani Dehnavi, Mahmoudreza Taghizadeh, Jonathan D Smirl, Patrice Brassard

{"title":"Directional sensitivity of the cerebral pressure-flow relationship during forced oscillations induced by oscillatory lower body negative pressure","authors":"Lawrence Labrecque, Marc-Antoine Roy, Shahrzad Soleimani Dehnavi, Mahmoudreza Taghizadeh, Jonathan D Smirl, Patrice Brassard","doi":"10.1177/0271678x241247633","DOIUrl":"https://doi.org/10.1177/0271678x241247633","url":null,"abstract":"A directional sensitivity of the cerebral pressure-flow relationship has been described using repeated squat-stands. Oscillatory lower body negative pressure (OLBNP) is a reproducible method to characterize dynamic cerebral autoregulation (dCA). It could represent a safer method to examine the directional sensitivity of the cerebral pressure-flow relationship within clinical populations and/or during pharmaceutical administration. Therefore, examining the cerebral pressure-flow directional sensitivity during an OLBNP-induced cyclic physiological stress is crucial. We calculated changes in middle cerebral artery mean blood velocity (MCAv) per alterations to mean arterial pressure (MAP) to compute ratios adjusted for time intervals (ΔMCAvT/ΔMAPT) with respect to the minimum-to-maximum MCAv and MAP, for each OLBNP transition (0 to −90 Torr), during 0.05 Hz and 0.10 Hz OLBNP. We then compared averaged ΔMCAvT/ΔMAPT during OLBNP-induced MAP increases (INC) (ΔMCAvT/[Formula: see text]) and decreases (DEC) (ΔMCAvT/[Formula: see text]). Nineteen healthy participants [9 females; 30 ± 6 years] were included. There were no differences in ΔMCAvT/ΔMAPT between INC and DEC at 0.05 Hz. ΔMCAvT/[Formula: see text] (1.06 ± 0.35 vs. 1.33 ± 0.60 cm⋅s−1/mmHg; p = 0.0076) was lower than ΔMCAvT/[Formula: see text] at 0.10 Hz. These results support OLBNP as a model to evaluate the directional sensitivity of the cerebral pressure-flow relationship.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140568817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of lactate and ketone bodies in acute brain injury 乳酸和酮体在急性脑损伤中的神经保护作用

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-11 DOI: 10.1177/0271678x241245486

Guillaume Plourde, Hélène Roumes, Laurent Suissa, Lorenz Hirt, Émilie Doche, Luc Pellerin, Anne-Karine Bouzier-Sore, Hervé Quintard

{"title":"Neuroprotective effects of lactate and ketone bodies in acute brain injury","authors":"Guillaume Plourde, Hélène Roumes, Laurent Suissa, Lorenz Hirt, Émilie Doche, Luc Pellerin, Anne-Karine Bouzier-Sore, Hervé Quintard","doi":"10.1177/0271678x241245486","DOIUrl":"https://doi.org/10.1177/0271678x241245486","url":null,"abstract":"The goal of neurocritical care is to prevent and reverse the pathologic cascades of secondary brain injury by optimizing cerebral blood flow, oxygen supply and substrate delivery. While glucose is an essential energetic substrate for the brain, we frequently observe a strong decrease in glucose delivery and/or a glucose metabolic dysregulation following acute brain injury. In parallel, during the last decades, lactate and ketone bodies have been identified as potential alternative fuels to provide energy to the brain, both under physiological conditions and in case of glucose shortage. They are now viewed as integral parts of brain metabolism. In addition to their energetic role, experimental evidence also supports their neuroprotective properties after acute brain injury, regulating in particular intracranial pressure control, decreasing ischemic volume, and leading to an improvement in cognitive functions as well as survival. In this review, we present preclinical and clinical evidence exploring the mechanisms underlying their neuroprotective effects and identify research priorities for promoting lactate and ketone bodies use in brain injury.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shining a light on cerebral autoregulation: Are we anywhere near the truth? 揭示大脑自动调节：我们接近真相了吗？

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-11 DOI: 10.1177/0271678x241245488

Jordan D Bird, David B MacLeod, Donald E Griesdale, Mypinder S Sekhon, Ryan L Hoiland

引用次数: 0

Prediction of trends in unfavorable prognosis in patients with acute ischemic stroke according to low left ventricular ejection fraction levels 根据左心室射血分数低水平预测急性缺血性脑卒中患者的不良预后趋势

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-11 DOI: 10.1177/0271678x241247020

Dehao Yang, Jingyu Hu, Minyue Zhang, Yiqun Chen, Haobo Xie, Yining Jin, Zerui Jiang, Jiaqi Huang, Kun Li, Jiexi Huang, Yanchu Wang, Yiyun Weng, Guangyong Chen

{"title":"Prediction of trends in unfavorable prognosis in patients with acute ischemic stroke according to low left ventricular ejection fraction levels","authors":"Dehao Yang, Jingyu Hu, Minyue Zhang, Yiqun Chen, Haobo Xie, Yining Jin, Zerui Jiang, Jiaqi Huang, Kun Li, Jiexi Huang, Yanchu Wang, Yiyun Weng, Guangyong Chen","doi":"10.1177/0271678x241247020","DOIUrl":"https://doi.org/10.1177/0271678x241247020","url":null,"abstract":"As few studies have reported the impact of lower left ventricular ejection fraction (LVEF) on the prognosis of acute ischemic stroke (AIS) patients, we aimed to explore this through a retrospective cohort study and a meta-analysis. A total of 283 AIS patients receiving intravenous thrombolysis at the Third Affiliated Hospital of Wenzhou Medical University between 2016 and 2019 were enrolled and divided into three groups based on LVEF tertiles. The logistic regression model estimated the association between LVEF and the three-month AIS prognosis. After adjusting for confounding factors, patients in tertile 3 exhibited an increased risk of poor functional outcome and mortality [odds ratio (OR), 2.656 (95% CI: 1.443–4.889); OR, 7.586 (95% CI: 2.102–27.375)]. A systematic search of PubMed, EMBASE and Cochrane Library was performed. Our meta-analysis revealed that LVEF < 40% was significantly associated with poor functional outcome [OR 1.94 (95% CI: 1.08–3.50)], mortality [OR 3.69 (95% CI: 1.22–11.11)], as well as LVEF < 55% [OR 1.68 (95% CI: 1.22–2.32); 2.27 (95% CI: 1.30–3.96)], respectively. A decreased LVEF could predict an inferior prognosis for AIS; therefore, it could aid in clinical decision-making in this patient population.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140568857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study 帕金森病脑血管反应模式：可行性研究

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-05 DOI: 10.1177/0271678x241241895

Harm Jan van der Horn, Andrei A Vakhtin, Kayla Julio, Stephanie Nitschke, Nicholas Shaff, Andrew B Dodd, Erik Erhardt, John P Phillips, Sarah Pirio Richardson, Amanda Deligtisch, Melanie Stewart, Gerson Suarez Cedeno, Sanne K Meles, Andrew R Mayer, Sephira G Ryman

{"title":"Parkinson’s disease cerebrovascular reactivity pattern: A feasibility study","authors":"Harm Jan van der Horn, Andrei A Vakhtin, Kayla Julio, Stephanie Nitschke, Nicholas Shaff, Andrew B Dodd, Erik Erhardt, John P Phillips, Sarah Pirio Richardson, Amanda Deligtisch, Melanie Stewart, Gerson Suarez Cedeno, Sanne K Meles, Andrew R Mayer, Sephira G Ryman","doi":"10.1177/0271678x241241895","DOIUrl":"https://doi.org/10.1177/0271678x241241895","url":null,"abstract":"A mounting body of research points to cerebrovascular dysfunction as a fundamental element in the pathophysiology of Parkinson’s disease (PD). In the current feasibility study, blood-oxygen-level-dependent (BOLD) MRI was used to measure cerebrovascular reactivity (CVR) in response to hypercapnia in 26 PD patients and 16 healthy controls (HC), and aimed to find a multivariate pattern specific to PD. Whole-brain maps of CVR amplitude (i.e., magnitude of response to CO2) and latency (i.e., time to reach maximum amplitude) were computed, which were further analyzed using scaled sub-profile model principal component analysis (SSM-PCA) with leave-one-out cross-validation. A meaningful pattern based on CVR latency was identified, which was named the PD CVR pattern (PD-CVRP). This pattern was characterized by relatively increased latency in basal ganglia, sensorimotor cortex, supplementary motor area, thalamus and visual cortex, as well as decreased latency in the cerebral white matter, relative to HC. There were no significant associations with clinical measures, though sample size may have limited our ability to detect significant associations. In summary, the PD-CVRP highlights the importance of cerebrovascular dysfunction in PD, and may be a potential biomarker for future clinical research and practice.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140569295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0