Journal of Cerebral Blood Flow & Metabolism最新文献_第10页

Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity 细胞类型特异性神经元活动对小鼠体感觉皮层耗氧量和血流的影响

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-05-27 DOI: 10.1177/0271678X19882787

Matilda K Dahlqvist, K. Thomsen, D. Postnov, M. Lauritzen

{"title":"Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity","authors":"Matilda K Dahlqvist, K. Thomsen, D. Postnov, M. Lauritzen","doi":"10.1177/0271678X19882787","DOIUrl":"https://doi.org/10.1177/0271678X19882787","url":null,"abstract":"Gamma activity arising from the interplay between pyramidal neurons and fast-spiking parvalbumin (PV) interneurons is an integral part of higher cognitive functions and is assumed to contribute significantly to brain metabolic responses. Cerebral metabolic rate of oxygen (CMRO2) responses were evoked by optogenetic stimulation of cortical PV interneurons and pyramidal neurons. We found that CMRO2 responses depended on neuronal activation, but not on the power of gamma activity induced by optogenetic stimulation. This implies that evoked gamma activity per se is not energy demanding. Optogenetic stimulation of PV interneurons during somatosensory stimulation reduced excitatory neuronal activity but did not potentiate O2 consumption as previously hypothesized. In conclusion, our data suggest that activity-driven CMRO2 responses depend on neuronal excitation rather than the cerebral rhythmic activity they induce. Excitation of both excitatory and inhibitory neurons requires energy, but inhibition of cortical excitatory neurons by interneurons does not potentiate activity-driven energy consumption.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"34 1","pages":"2010 - 2025"},"PeriodicalIF":0.0,"publicationDate":"2019-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89979459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice 增加脑血流量可以改善阿尔茨海默病小鼠晚期的认知能力

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-05-17 DOI: 10.1177/0271678X19873658

O. Bracko, Brendah N. Njiru, Madisen A Swallow, Muhammad Ali, Mohammad Haft-Javaherian, C. Schaffer

{"title":"Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice","authors":"O. Bracko, Brendah N. Njiru, Madisen A Swallow, Muhammad Ali, Mohammad Haft-Javaherian, C. Schaffer","doi":"10.1177/0271678X19873658","DOIUrl":"https://doi.org/10.1177/0271678X19873658","url":null,"abstract":"Alzheimer’s disease is associated with a 20–30% reduction in cerebral blood flow. In the APP/PS1 mouse model of Alzheimer’s disease, inhibiting neutrophil adhesion using an antibody against the neutrophil specific protein Ly6G was recently shown to drive rapid improvements in cerebral blood flow that was accompanied by an improvement in performance on short-term memory tasks. Here, in a longitudinal aging study, we assessed how far into disease development a single injection of anti-Ly6G treatment can acutely improve short-term memory function. We found that APP/PS1 mice as old as 15–16 months had improved performance on the object replacement and Y-maze tests of spatial and working short-term memory, measured at one day after anti-Ly6G treatment. APP/PS1 mice at 17–18 months of age or older did not show acute improvements in cognitive performance, although we did find that capillary stalls were still reduced and cerebral blood flow was still increased by 17% in 21–22-months-old APP/PS1 mice given anti-Ly6G antibody. These data add to the growing body of evidence suggesting that cerebral blood flow reductions are an important contributing factor to the cognitive dysfunction associated with neurodegenerative disease. Thus, interfering with neutrophil adhesion could be a new therapeutic approach for Alzheimer’s disease.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"8 1","pages":"1441 - 1452"},"PeriodicalIF":0.0,"publicationDate":"2019-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87082346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models 两种C57BL/6小鼠脑缺血后脑侧支循环可塑性的探索性研究

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2019-02-07 DOI: 10.1177/0271678X19827251

Marco Foddis, K. Winek, K. Bentele, S. Mueller, S. Blumenau, Nadine Reichhart N, S. Crespo-Garcia, Dermot Harnett, Andranik Ivanov, A. Meisel, A. Joussen, O. Strauß, D. Beule, U. Dirnagl, C. Sassi

{"title":"An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models","authors":"Marco Foddis, K. Winek, K. Bentele, S. Mueller, S. Blumenau, Nadine Reichhart N, S. Crespo-Garcia, Dermot Harnett, Andranik Ivanov, A. Meisel, A. Joussen, O. Strauß, D. Beule, U. Dirnagl, C. Sassi","doi":"10.1177/0271678X19827251","DOIUrl":"https://doi.org/10.1177/0271678X19827251","url":null,"abstract":"Brain collateral circulation is an essential compensatory mechanism in response to acute brain ischemia. To study the temporal evolution of brain macro and microcollateral recruitment and their reciprocal interactions in response to different ischemic conditions, we applied a combination of complementary techniques (T2-weighted magnetic resonance imaging [MRI], time of flight [TOF] angiography [MRA], cerebral blood flow [CBF] imaging and histology) in two different mouse models. Hypoperfusion was either induced by permanent bilateral common carotid artery stenosis (BCCAS) or 60-min transient unilateral middle cerebral artery occlusion (MCAO). In both models, collateralization is a very dynamic phenomenon with a global effect affecting both hemispheres. Patency of ipsilateral posterior communicating artery (PcomA) represents the main variable survival mechanism and the main determinant of stroke lesion volume and recovery in MCAO, whereas the promptness of external carotid artery retrograde flow recruitment together with PcomA patency, critically influence survival, brain ischemic lesion volume and retinopathy in BCCAS mice. Finally, different ischemic gradients shape microcollateral density and size.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"21 1","pages":"276 - 287"},"PeriodicalIF":0.0,"publicationDate":"2019-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87225567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans 人类常氧和严重急性缺氧状态下短跑运动时脑血流量、额叶氧合和动脉内血压

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2018-01-01 DOI: 10.1177/0271678X17691986

D. Curtelin, D. Morales‐Alamo, R. Torres-Peralta, P. Rasmussen, Marcos Martin‐Rincon, Mario Perez-Valera, C. Siebenmann, I. Perez-Suarez, E. Cherouveim, A. Sheel, C. Lundby, J. Calbet

{"title":"Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans","authors":"D. Curtelin, D. Morales‐Alamo, R. Torres-Peralta, P. Rasmussen, Marcos Martin‐Rincon, Mario Perez-Valera, C. Siebenmann, I. Perez-Suarez, E. Cherouveim, A. Sheel, C. Lundby, J. Calbet","doi":"10.1177/0271678X17691986","DOIUrl":"https://doi.org/10.1177/0271678X17691986","url":null,"abstract":"Cerebral blood flow (CBF) is regulated to secure brain O2 delivery while simultaneously avoiding hyperperfusion; however, both requisites may conflict during sprint exercise. To determine whether brain O2 delivery or CBF is prioritized, young men performed sprint exercise in normoxia and hypoxia (PIO2 = 73 mmHg). During the sprints, cardiac output increased to ∼22 L min−1, mean arterial pressure to ∼131 mmHg and peak systolic blood pressure ranged between 200 and 304 mmHg. Middle-cerebral artery velocity (MCAv) increased to peak values (∼16%) after 7.5 s and decreased to pre-exercise values towards the end of the sprint. When the sprints in normoxia were preceded by a reduced PETCO2, CBF and frontal lobe oxygenation decreased in parallel (r = 0.93, P < 0.01). In hypoxia, MCAv was increased by 25%, due to a 26% greater vascular conductance, despite 4–6 mmHg lower PaCO2 in hypoxia than normoxia. This vasodilation fully accounted for the 22 % lower CaO2 in hypoxia, leading to a similar brain O2 delivery during the sprints regardless of PIO2. In conclusion, when a conflict exists between preserving brain O2 delivery or restraining CBF to avoid potential damage by an elevated perfusion pressure, the priority is given to brain O2 delivery.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"60 1","pages":"136 - 150"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76121541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 58

Inhibition of stress fiber formation preserves blood–brain barrier after intracerebral hemorrhage in mice 抑制应激纤维形成可保护小鼠脑出血后血脑屏障

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2018-01-01 DOI: 10.1177/0271678X16679169

A. Manaenko, Peng Yang, Derek Nowrangi, Enkhjargal Budbazar, R. Hartman, A. Obenaus, W. Pearce, John H. Zhang, Jiping Tang

{"title":"Inhibition of stress fiber formation preserves blood–brain barrier after intracerebral hemorrhage in mice","authors":"A. Manaenko, Peng Yang, Derek Nowrangi, Enkhjargal Budbazar, R. Hartman, A. Obenaus, W. Pearce, John H. Zhang, Jiping Tang","doi":"10.1177/0271678X16679169","DOIUrl":"https://doi.org/10.1177/0271678X16679169","url":null,"abstract":"Intracerebral hemorrhage (ICH) represents the deadliest subtype of all strokes. The development of brain edema, a consequence of blood–brain barrier (BBB) disruption, is the most life-threatening event after ICH. Pathophysiological conditions activate the endothelium, one of the components of BBB, inducing rearrangement of the actin cytoskeleton. Upon activation, globular actin assembles into a filamentous actin resulting in the formation of contractile actin bundles, stress fibers. The contraction of stress fibers leads to the formation of intercellular gaps between endothelial cells increasing the permeability of BBB. In the present study, we investigated the effect of ICH on stress fiber formation in CD1 mice. We hypothesized that ICH-induced formation of stress fiber is triggered by the activation of PDGFR-β and mediated by the cortactin/RhoA/LIMK pathway. We demonstrated that ICH induces formation of stress fibers. Furthermore, we demonstrated that the inhibition of PDGFR-β and its downstream reduced the number of stress fibers, preserving BBB and resulting in the amelioration of brain edema and improvement of neurological functions in mice after ICH.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"18 1","pages":"102 - 87"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78124811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia – The PREDICT study 中风引起的免疫抑制和吞咽困难独立预测中风相关肺炎——predict研究

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2017-12-01 DOI: 10.1177/0271678X16671964

S. Hoffmann, H. Harms, L. Ulm, D. Nabavi, B. Mackert, I. Schmehl, G. Jungehulsing, J. Montaner, A. Bustamante, M. Hermans, F. Hamilton, Jos Göhler, U. Malzahn, C. Malsch, P. Heuschmann, C. Meisel, A. Meisel

{"title":"Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia – The PREDICT study","authors":"S. Hoffmann, H. Harms, L. Ulm, D. Nabavi, B. Mackert, I. Schmehl, G. Jungehulsing, J. Montaner, A. Bustamante, M. Hermans, F. Hamilton, Jos Göhler, U. Malzahn, C. Malsch, P. Heuschmann, C. Meisel, A. Meisel","doi":"10.1177/0271678X16671964","DOIUrl":"https://doi.org/10.1177/0271678X16671964","url":null,"abstract":"Stroke-associated pneumonia is a frequent complication after stroke associated with poor outcome. Dysphagia is a known risk factor for stroke-associated pneumonia but accumulating evidence suggests that stroke induces an immunodepressive state increasing susceptibility for stroke-associated pneumonia. We aimed to confirm that stroke-induced immunodepression syndrome is associated with stroke-associated pneumonia independently from dysphagia by investigating the predictive properties of monocytic HLA-DR expression as a marker of immunodepression as well as biomarkers for inflammation (interleukin-6) and infection (lipopolysaccharide-binding protein). This was a prospective, multicenter study with 11 study sites in Germany and Spain, including 486 patients with acute ischemic stroke. Daily screening for stroke-associated pneumonia, dysphagia and biomarkers was performed. Frequency of stroke-associated pneumonia was 5.2%. Dysphagia and decreased monocytic HLA-DR were independent predictors for stroke-associated pneumonia in multivariable regression analysis. Proportion of pneumonia ranged between 0.9% in the higher monocytic HLA-DR quartile (≥21,876 mAb/cell) and 8.5% in the lower quartile (≤12,369 mAb/cell). In the presence of dysphagia, proportion of pneumonia increased to 5.9% and 18.8%, respectively. Patients without dysphagia and normal monocytic HLA-DR expression had no stroke-associated pneumonia risk. We demonstrate that dysphagia and stroke-induced immunodepression syndrome are independent risk factors for stroke-associated pneumonia. Screening for immunodepression and dysphagia might be useful for identifying patients at high risk for stroke-associated pneumonia.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"15 1","pages":"3671 - 3682"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84698731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 130

Neurobehavioral testing in subarachnoid hemorrhage: A review of methods and current findings in rodents 蛛网膜下腔出血的神经行为测试:对啮齿动物方法和最新发现的回顾

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2017-11-01 DOI: 10.1177/0271678X16665623

Nefize Turan, B. Miller, R. A. Heider, M. Nadeem, I. Sayeed, D. Stein, G. Pradilla

{"title":"Neurobehavioral testing in subarachnoid hemorrhage: A review of methods and current findings in rodents","authors":"Nefize Turan, B. Miller, R. A. Heider, M. Nadeem, I. Sayeed, D. Stein, G. Pradilla","doi":"10.1177/0271678X16665623","DOIUrl":"https://doi.org/10.1177/0271678X16665623","url":null,"abstract":"The most important aspect of a preclinical study seeking to develop a novel therapy for neurological diseases is whether the therapy produces any clinically relevant functional recovery. For this purpose, neurobehavioral tests are commonly used to evaluate the neuroprotective efficacy of treatments in a wide array of cerebrovascular diseases and neurotrauma. Their use, however, has been limited in experimental subarachnoid hemorrhage studies. After several randomized, double-blinded, controlled clinical trials repeatedly failed to produce a benefit in functional outcome despite some improvement in angiographic vasospasm, more rigorous methods of neurobehavioral testing became critical to provide a more comprehensive evaluation of the functional efficacy of proposed treatments. While several subarachnoid hemorrhage studies have incorporated an array of neurobehavioral assays, a standardized methodology has not been agreed upon. Here, we review neurobehavioral tests for rodents and their potential application to subarachnoid hemorrhage studies. Developing a standardized neurobehavioral testing regimen in rodent studies of subarachnoid hemorrhage would allow for better comparison of results between laboratories and a better prediction of what interventions would produce functional benefits in humans.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"78 1","pages":"3461 - 3474"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90572113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Collateral status and tissue outcome after intra-arterial therapy for patients with acute ischemic stroke 急性缺血性脑卒中患者动脉内治疗后侧枝状态和组织预后

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2017-11-01 DOI: 10.1177/0271678X16678874

A. Boers, Ivo G. H. Jansen, O. Berkhemer, A. Yoo, Hester F. Lingsma, C. Slump, Y. Roos, R. V. van Oostenbrugge, D. Dippel, A. van der Lugt, W. V. van Zwam, H. Marquering, C. Majoie

{"title":"Collateral status and tissue outcome after intra-arterial therapy for patients with acute ischemic stroke","authors":"A. Boers, Ivo G. H. Jansen, O. Berkhemer, A. Yoo, Hester F. Lingsma, C. Slump, Y. Roos, R. V. van Oostenbrugge, D. Dippel, A. van der Lugt, W. V. van Zwam, H. Marquering, C. Majoie","doi":"10.1177/0271678X16678874","DOIUrl":"https://doi.org/10.1177/0271678X16678874","url":null,"abstract":"Intra-arterial therapy (IAT) for ischemic stroke aims to save brain tissue. Collaterals are thought to contribute to prolonged penumbra sustenance. In this study, we investigate the effect of collateral status on brain tissue salvage with IAT. In 500 patients randomized between IAT and standard care, collateral status was graded from 0 (absent) to 3 (good). Final infarct volumes (FIV) were calculated on post-treatment CT. FIVs were compared between treatment groups per collateral grade. Multivariable linear regression with interaction terms was performed to study whether collaterals modified IAT effect on FIV. Four-hundred-forty-nine patients were included in the analysis. Median FIV for the IAT group was significantly lower with 54.5 mL (95% IQR: 21.8–145.0) than for the controls with 81.8 mL (95% IQR: 40.0–154.0) (p = 0.020). Treatment effect differed across collateral grades, although there was no significant interaction (unadjusted p = 0.054; adjusted p = 0.105). For grade 3, IAT resulted in a FIV reduction of 30.1 mL (p = 0.024). For grade 2 and 1, this difference was, respectively, 28.4 mL (p = 0.028) and 28.4 mL (p = 0.29). For grade 0, this was 88.6 mL (p = 0.28) in favour of controls. IAT saves substantially more brain tissue as compared to standard care. We observed a trend of increasing effect of IAT with higher collateral grades.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"1 1","pages":"3589 - 3598"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89686151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Inhibition of fatty acid amide hydrolase by BIA 10-2474 in rat brain BIA 10-2474对大鼠脑脂肪酸酰胺水解酶的抑制作用

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2017-11-01 DOI: 10.1177/0271678X16668890

J. Tong, R. Mizrahi, S. Houle, S. Kish, I. Boileau, J. Nobrega, P. Rusjan, Alan A. Wilson

引用次数: 10

Crossed cerebellar diaschisis in acute ischemic stroke: Impact on morphologic and functional outcome 急性缺血性脑卒中的交叉小脑缺血:对形态学和功能结果的影响

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2017-11-01 DOI: 10.1177/0271678X16686594

W. Kunz, W. Sommer, C. Höhne, M. Fabritius, Felix Schuler, F. Dorn, A. Othman, F. Meinel, Louisa von Baumgarten, M. Reiser, B. Ertl-Wagner, K. Thierfelder

{"title":"Crossed cerebellar diaschisis in acute ischemic stroke: Impact on morphologic and functional outcome","authors":"W. Kunz, W. Sommer, C. Höhne, M. Fabritius, Felix Schuler, F. Dorn, A. Othman, F. Meinel, Louisa von Baumgarten, M. Reiser, B. Ertl-Wagner, K. Thierfelder","doi":"10.1177/0271678X16686594","DOIUrl":"https://doi.org/10.1177/0271678X16686594","url":null,"abstract":"Crossed cerebellar diaschisis (CCD) is the phenomenon of hypoperfusion and hypometabolism of the contralateral cerebellar hemisphere caused by dysfunction of the related supratentorial region. Our aim was to analyze its influence on morphologic and functional outcome in acute ischemic stroke. Subjects with stroke caused by a large vessel occlusion of the anterior circulation were selected from an initial cohort of 1644 consecutive patients who underwent multiparametric CT including whole-brain CT perfusion. Two experienced readers evaluated the posterior fossa in terms of CCD absence (CCD−) or presence (CCD+). A total of 156 patients formed the study cohort with 102 patients (65.4%) categorized as CCD− and 54 (34.6%) as CCD+. In linear and logistic regression analyses, no significant association between CCD and final infarction volume (β = −0.440, p = 0.972), discharge mRS ≤ 2 (OR = 1.897, p = 0.320), or 90-day mRS ≤ 2 (OR = 0.531, p = 0.492) was detected. CCD+ patients had larger supratentorial cerebral blood flow deficits (median: 164 ml vs. 115 ml; p = 0.001) compared to CCD−patients. Regarding complications, CCD was associated with a higher rate of parenchymal hematomas (OR = 4.793, p = 0.035). In conclusion, CCD is frequently encountered in acute ischemic stroke caused by large vessel occlusion of the anterior circulation. CCD was associated with the occurrence of parenchymal hematoma in the ipsilateral cerebral infarction but did not prove to significantly influence patient outcome.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"104 1","pages":"3615 - 3624"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76042141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26