Journal of Cerebral Blood Flow & Metabolism最新文献_第3页

Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease 成人莫亚莫亚病的血管周围空间弥散性降低和脑血流动力学紊乱

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-04 DOI: 10.1177/0271678x241245492

Shoko Hara, Junko Kikuta, Kaito Takabayashi, Koji Kamagata, Shihori Hayashi, Motoki Inaji, Yoji Tanaka, Masaaki Hori, Kenji Ishii, Tadashi Nariai, Toshiaki Taoka, Shinji Naganawa, Shigeki Aoki, Taketoshi Maehara

{"title":"Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease","authors":"Shoko Hara, Junko Kikuta, Kaito Takabayashi, Koji Kamagata, Shihori Hayashi, Motoki Inaji, Yoji Tanaka, Masaaki Hori, Kenji Ishii, Tadashi Nariai, Toshiaki Taoka, Shinji Naganawa, Shigeki Aoki, Taketoshi Maehara","doi":"10.1177/0271678x241245492","DOIUrl":"https://doi.org/10.1177/0271678x241245492","url":null,"abstract":"Moyamoya disease (MMD) causes cerebral arterial stenosis and hemodynamic disturbance, the latter of which may disrupt glymphatic system activity, the waste clearance system. We evaluated 46 adult patients with MMD and 33 age- and sex-matched controls using diffusivity along the perivascular space (ALPS) measured with diffusion tensor imaging (ALPS index), which may partly reflect glymphatic system activity, and multishell diffusion MRI to generate freewater maps. Twenty-three patients were also evaluated via 15O-gas positron emission tomography (PET), and all patients underwent cognitive tests. Compared to controls, patients (38.4 (13.2) years old, 35 females) had lower ALPS indices in the left and right hemispheres (1.94 (0.27) vs. 1.65 (0.25) and 1.94 (0.22) vs. 1.65 (0.19), P < 0.001). While the right ALPS index showed no correlation, the left ALPS index was correlated with parenchymal freewater ( ρ = −0.47, P < 0.001); perfusion measured with PET (cerebral blood flow, ρ = 0.70, P < 0.001; mean transit time, ρ = −0.60, P = 0.003; and oxygen extraction fraction, ρ = −0.52, P = 0.003); and cognitive tests (trail making test part B for executive function; ρ = −0.37, P = 0.01). Adult patients with MMD may exhibit decreased glymphatic system activity, which is correlated with the degree of hemodynamic disturbance, increased interstitial freewater, and cognitive dysfunction, but further investigation is needed.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140568815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in moyamoya disease RNF213变体和自噬功能障碍：莫亚莫亚病内皮功能障碍的关键环节

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-04-04 DOI: 10.1177/0271678x241245557

Hee Sun Shin, Geun Hwa Park, Eun Sil Choi, So Young Park, Da Sol Kim, Jaerak Chang, Ji Man Hong

{"title":"RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in moyamoya disease","authors":"Hee Sun Shin, Geun Hwa Park, Eun Sil Choi, So Young Park, Da Sol Kim, Jaerak Chang, Ji Man Hong","doi":"10.1177/0271678x241245557","DOIUrl":"https://doi.org/10.1177/0271678x241245557","url":null,"abstract":"Moyamoya disease (MMD) is closely associated with the Ring Finger Protein 213 ( RNF213), a susceptibility gene for MMD. However, its biological function remains unclear. We aimed to elucidate the role of RNF213 in the damage incurred by human endothelial cells under oxygen-glucose deprivation (OGD). We analyzed autophagy in peripheral blood mononuclear cells (PBMCs) derived from patients carrying either RNF213 wildtype (WT) or variant (p.R4810K). Subsequently, human umbilical vein endothelial cells (HUVECs) were transfected with RNF213 WT (HUVECWT) or p.R4810K (HUVECR4810K) and exposed to OGD for 2 h. Immunoblotting was used to analyze autophagy marker proteins, and endothelial function was analyzed by tube formation assay. Autophagic vesicles were observed using transmission electron microscopy. Post-OGD exposure, we administered rapamycin and cilostazol as potential autophagy inducers. The RNF213 variant group during post-OGD exposure (vs. pre-OGD) showed autophagy inhibition, increased protein expression of SQSTM1/p62 ( p < 0.0001) and LC3-II ( p = 0.0039), and impaired endothelial function ( p = 0.0252). HUVECR4810K during post-OGD exposure (versus pre-OGD) showed a remarkable increase in autophagic vesicles. Administration of rapamycin and cilostazol notably restored the function of HUVECR4810K and autophagy. Our findings support the pivotal role of autophagy impaired by the RNF213 variant in MMD-induced endothelial cell dysfunction.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140568812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional magnetic resonance imaging signal has sub-second temporal accuracy 功能磁共振成像信号具有亚秒级时间精度

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2024-03-21 DOI: 10.1177/0271678x241241136

Yi-Tien Li, Hsin-Ju Lee, Fa-Hsuan Lin

{"title":"Functional magnetic resonance imaging signal has sub-second temporal accuracy","authors":"Yi-Tien Li, Hsin-Ju Lee, Fa-Hsuan Lin","doi":"10.1177/0271678x241241136","DOIUrl":"https://doi.org/10.1177/0271678x241241136","url":null,"abstract":"Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood-oxygenation-level-dependent functional magnetic resonance imaging (fMRI) signals is confounded by local cerebral vascular reactivity (CVR), which varies across brain locations. Thus, detecting neuronal synchrony as well as inferring inter-regional causal modulation using fMRI signals can be biased. Here we used fast fMRI measurements sampled at 10 Hz to measure the fMRI latency difference between visual and sensorimotor areas when participants engaged in a visuomotor task. The regional fMRI timing was calibrated by subtracting the CVR latency measured by a breath-holding task. After CVR calibration, the fMRI signal at the lateral geniculate nucleus (LGN) preceded that at the visual cortex by 496 ms, followed by the fMRI signal at the sensorimotor cortex with a latency of 464 ms. Sequential LGN, visual, and sensorimotor cortex activations were found in each participant after the CVR calibration. These inter-regional fMRI timing differences across and within participants were more closely related to the reaction time after the CVR calibration. Our results suggested the feasibility of mapping brain activity using fMRI with accuracy in hundreds of milliseconds.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An intravascular perspective on hyper-acute neutrophil, T-cell and platelet responses: Similarities between human and experimental stroke 超急性中性粒细胞，t细胞和血小板反应的血管内视角:人类和实验中风的相似性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-06-08 DOI: 10.1177/0271678X221105764

G. Stoll, Michael K. Schuhmann, B. Nieswandt, Alexander M. Kollikowski, M. Pham

引用次数: 4

Post-mortem correlates of Virchow-Robin spaces detected on in vivo MRI 活体MRI检测到的Virchow-Robin空间的死后相关性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-05-17 DOI: 10.1177/0271678X211067455

L. Haider, S. Hametner, Verena Endmayr, S. Mangesius, Andrea Eppensteiner, J. Frischer, J. E. Iglesias, F. Barkhof, G. Kasprian

引用次数: 4

Validation, kinetic modeling, and test-retest reproducibility of [18F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice [18F]SynVesT-1用于小鼠突触囊泡糖蛋白2A PET成像的验证、动力学建模和重测再现性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-05-14 DOI: 10.1177/0271678X221101648

Daniele Bertoglio, Franziska Zajicek, Stef De Lombaerde, A. Miranda, S. Stroobants, Yuchuan Wang, C. Dominguez, I. Muñoz-Sanjuán, J. Bard, Longbin Liu, J. Verhaeghe, S. Staelens

{"title":"Validation, kinetic modeling, and test-retest reproducibility of [18F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice","authors":"Daniele Bertoglio, Franziska Zajicek, Stef De Lombaerde, A. Miranda, S. Stroobants, Yuchuan Wang, C. Dominguez, I. Muñoz-Sanjuán, J. Bard, Longbin Liu, J. Verhaeghe, S. Staelens","doi":"10.1177/0271678X221101648","DOIUrl":"https://doi.org/10.1177/0271678X221101648","url":null,"abstract":"Alterations in synaptic vesicle glycoprotein 2 A (SV2A) have been associated with several neuropsychiatric and neurodegenerative disorders. Therefore, SV2A positron emission tomography (PET) imaging may provide a unique tool to investigate synaptic density dynamics during disease progression and after therapeutic intervention. This study aims to extensively characterize the novel radioligand [18F]SynVesT-1 for preclinical applications. In C57Bl/6J mice (n = 39), we assessed the plasma profile of [18F]SynVesT-1, validated the use of a noninvasive image-derived input function (IDIF) compared to an arterial input function (AIF), performed a blocking study with levetiracetam (50 and 200 mg/kg, i.p.) to verify the specificity towards SV2A, examined kinetic models for volume of distribution (VT) quantification, and explored test-retest reproducibility of [18F]SynVesT-1 in the central nervous system (CNS). Plasma availability of [18F]SynVesT-1 decreased rapidly (13.4 ± 1.5% at 30 min post-injection). VT based on AIF and IDIF showed excellent agreement (r2 = 0.95, p < 0.0001) and could be reliably estimated with a 60-min acquisition. The blocking study resulted in a complete blockade with no suitable reference region. Test-retest analysis indicated good reproducibility (mean absolute variability <10%). In conclusion, [18F]SynVesT-1 is selective for SV2A with optimal kinetics representing a candidate tool to quantify CNS synaptic density non-invasively.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"110 1","pages":"1867 - 1878"},"PeriodicalIF":0.0,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86233193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Increased interictal synchronicity of respiratory related brain pulsations in epilepsy 癫痫患者呼吸相关脑搏动间期同步性增高

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-05-14 DOI: 10.1177/0271678X221099703

Janne Kananen, Matti Järvelä, V. Korhonen, Timo Tuovinen, N. Huotari, L. Raitamaa, H. Helakari, T. Väyrynen, V. Raatikainen, M. Nedergaard, H. Ansakorpi, J. Jacobs, P. LeVan, V. Kiviniemi

{"title":"Increased interictal synchronicity of respiratory related brain pulsations in epilepsy","authors":"Janne Kananen, Matti Järvelä, V. Korhonen, Timo Tuovinen, N. Huotari, L. Raitamaa, H. Helakari, T. Väyrynen, V. Raatikainen, M. Nedergaard, H. Ansakorpi, J. Jacobs, P. LeVan, V. Kiviniemi","doi":"10.1177/0271678X221099703","DOIUrl":"https://doi.org/10.1177/0271678X221099703","url":null,"abstract":"Respiratory brain pulsations have recently been shown to drive electrophysiological brain activity in patients with epilepsy. Furthermore, functional neuroimaging indicates that respiratory brain pulsations have increased variability and amplitude in patients with epilepsy compared to healthy individuals. To determine whether the respiratory drive is altered in epilepsy, we compared respiratory brain pulsation synchronicity between healthy controls and patients. Whole brain fast functional magnetic resonance imaging was performed on 40 medicated patients with focal epilepsy, 20 drug-naïve patients and 102 healthy controls. Cerebrospinal fluid associated respiratory pulsations were used to generate individual whole brain respiratory synchronization maps, which were compared between groups. Finally, we analyzed the seizure frequency effect and diagnostic accuracy of the respiratory synchronization defect in epilepsy. Respiratory brain pulsations related to the verified fourth ventricle pulsations were significantly more synchronous in patients in frontal, periventricular and mid-temporal regions, while the seizure frequency correlated positively with synchronicity. The respiratory brain synchronicity had a good diagnostic accuracy (ROCAUC = 0.75) in discriminating controls from medicated patients. The elevated respiratory brain synchronicity in focal epilepsy suggests altered physiological effect of cerebrospinal fluid pulsations possibly linked to regional brain water dynamics involved with interictal brain physiology.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"59 1","pages":"1840 - 1853"},"PeriodicalIF":0.0,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78867267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats 颞叶脑转录组分析揭示了新生大鼠生发基质出血后的关键病理事件

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-05-01 DOI: 10.1177/0271678X221098811

Juan Song, Gisela Nilsson, Yiran Xu, Aura Zelco, Eridan Rocha-Ferreira, Yafeng Wang, Xiaoli Zhang, Shan Zhang, J. Ek, H. Hagberg, Changlian Zhu, Xiaoyang Wang

{"title":"Temporal brain transcriptome analysis reveals key pathological events after germinal matrix hemorrhage in neonatal rats","authors":"Juan Song, Gisela Nilsson, Yiran Xu, Aura Zelco, Eridan Rocha-Ferreira, Yafeng Wang, Xiaoli Zhang, Shan Zhang, J. Ek, H. Hagberg, Changlian Zhu, Xiaoyang Wang","doi":"10.1177/0271678X221098811","DOIUrl":"https://doi.org/10.1177/0271678X221098811","url":null,"abstract":"Germinal matrix hemorrhage (GMH) is a common complication in preterm infants and is associated with high risk of adverse neurodevelopmental outcomes. We used a rat GMH model and performed RNA sequencing to investigate the signaling pathways and biological processes following hemorrhage. GMH induced brain injury characterized by early hematoma and subsequent tissue loss. At 6 hours after GMH, gene expression indicated an increase in mitochondrial activity such as ATP metabolism and oxidative phosphorylation along with upregulation of cytoprotective pathways and heme metabolism. At 24 hours after GMH, the expression pattern suggested an increase in cell cycle progression and downregulation of neurodevelopmental-related pathways. At 72 hours after GMH, there was an increase in genes related to inflammation and an upregulation of ferroptosis. Hemoglobin components and genes related to heme metabolism and ferroptosis such as Hmox1, Alox15, and Alas2 were among the most upregulated genes. We observed dysregulation of processes involved in development, mitochondrial function, cholesterol biosynthesis, and inflammation, all of which contribute to neurodevelopmental deterioration following GMH. This study is the first temporal transcriptome profile providing a comprehensive overview of the molecular mechanisms underlying brain injury following GMH, and it provides useful guidance in the search for therapeutic interventions.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"138 1","pages":"1632 - 1649"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88698955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The lateral entorhinal cortex is a hub for local and global dysfunction in early Alzheimer’s disease states 外侧内嗅皮层是早期阿尔茨海默病状态中局部和全局功能障碍的中心

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-04-25 DOI: 10.1177/0271678X221082016

F. Mandino, Ling Yun Yeow, Renzhe Bi, Lee Sejin, H. Bae, S. Baek, C. Lee, H. Mohammad, C. Horien, C. L. Teoh, Jasinda H. Lee, Mitchell KP Lai, Sangyong Jung, Yu Fu, M. Olivo, J. Gigg, J. Grandjean

{"title":"The lateral entorhinal cortex is a hub for local and global dysfunction in early Alzheimer’s disease states","authors":"F. Mandino, Ling Yun Yeow, Renzhe Bi, Lee Sejin, H. Bae, S. Baek, C. Lee, H. Mohammad, C. Horien, C. L. Teoh, Jasinda H. Lee, Mitchell KP Lai, Sangyong Jung, Yu Fu, M. Olivo, J. Gigg, J. Grandjean","doi":"10.1177/0271678X221082016","DOIUrl":"https://doi.org/10.1177/0271678X221082016","url":null,"abstract":"Functional network activity alterations are one of the earliest hallmarks of Alzheimer’s disease (AD), detected prior to amyloidosis and tauopathy. Better understanding the neuronal underpinnings of such network alterations could offer mechanistic insight into AD progression. Here, we examined a mouse model (3xTgAD mice) recapitulating this early AD stage. We found resting functional connectivity loss within ventral networks, including the entorhinal cortex, aligning with the spatial distribution of tauopathy reported in humans. Unexpectedly, in contrast to decreased connectivity at rest, 3xTgAD mice show enhanced fMRI signal within several projection areas following optogenetic activation of the entorhinal cortex. We corroborate this finding by demonstrating neuronal facilitation within ventral networks and synaptic hyperexcitability in projection targets. 3xTgAD mice, thus, reveal a dichotomic hypo-connected:resting versus hyper-responsive:active phenotype. This strong homotopy between the areas affected supports the translatability of this pathophysiological model to tau-related, early-AD deficits in humans.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"3 1","pages":"1616 - 1631"},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90159759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Genetic ablation of smooth muscle KIR2.1 is inconsequential to the function of mouse cerebral arteries 平滑肌KIR2.1基因消融对小鼠脑动脉功能影响不大

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-04-11 DOI: 10.1177/0271678X221093432

Paulina M Kowalewska, J. Fletcher, W. Jackson, S. Brett, Michelle S Kim, G. Mironova, Nadia Haghbin, David M. Richter, N. Tykocki, M. Nelson, D. Welsh

{"title":"Genetic ablation of smooth muscle KIR2.1 is inconsequential to the function of mouse cerebral arteries","authors":"Paulina M Kowalewska, J. Fletcher, W. Jackson, S. Brett, Michelle S Kim, G. Mironova, Nadia Haghbin, David M. Richter, N. Tykocki, M. Nelson, D. Welsh","doi":"10.1177/0271678X221093432","DOIUrl":"https://doi.org/10.1177/0271678X221093432","url":null,"abstract":"Cerebral blood flow is a finely tuned process dependent on coordinated changes in arterial tone. These changes are strongly tied to smooth muscle membrane potential and inwardly rectifying K+ (KIR) channels are thought to be a key determinant. To elucidate the role of KIR2.1 in cerebral arterial tone development, this study examined the electrical and functional properties of cells, vessels and living tissue from tamoxifen-induced smooth muscle cell (SMC)-specific KIR2.1 knockout mice. Patch-clamp electrophysiology revealed a robust Ba2+-sensitive inwardly rectifying K+ current in cerebral arterial myocytes irrespective of KIR2.1 knockout. Immunolabeling clarified that KIR2.1 expression was low in SMCs while KIR2.2 labeling was remarkably abundant at the membrane. In alignment with these observations, pressure myography revealed that the myogenic response and K+-induced dilation were intact in cerebral arteries post knockout. At the whole organ level, this translated to a maintenance of brain perfusion in SMC KIR2.1−/− mice, as assessed with arterial spin-labeling MRI. We confirmed these findings in superior epigastric arteries and implicated KIR2.2 as more functionally relevant in SMCs. Together, these results suggest that subunits other than KIR2.1 play a significant role in setting native current in SMCs and driving arterial tone.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"36 1","pages":"1693 - 1706"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87813567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4