Journal of Cerebral Blood Flow & Metabolism最新文献_第4页

Thanks to Reviewers 感谢审稿人

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-04-11 DOI: 10.1177/0271678X221076492

引用次数: 0

Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease 自由水扩散MRI检测早期脑血管疾病白质高信号周围的结构改变

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-04-11 DOI: 10.1177/0271678X221093579

C. Mayer, Felix L. Nägele, M. Petersen, B. Frey, U. Hanning, O. Pasternak, E. Petersen, C. Gerloff, G. Thomalla, B. Cheng

{"title":"Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease","authors":"C. Mayer, Felix L. Nägele, M. Petersen, B. Frey, U. Hanning, O. Pasternak, E. Petersen, C. Gerloff, G. Thomalla, B. Cheng","doi":"10.1177/0271678X221093579","DOIUrl":"https://doi.org/10.1177/0271678X221093579","url":null,"abstract":"In cerebral small vessel disease (CSVD), both white matter hyperintensities (WMH) of presumed vascular origin and the normal-appearing white matter (NAWM) contain microstructural brain alterations on diffusion-weighted MRI (DWI). Contamination of DWI-derived metrics by extracellular free-water can be corrected with free-water (FW) imaging. We investigated the alterations in FW and FW-corrected fractional anisotropy (FA-t) in WMH and surrounding tissue and their association with cerebrovascular risk factors. We analysed 1,000 MRI datasets from the Hamburg City Health Study. DWI was used to generate FW and FA-t maps. WMH masks were segmented on FLAIR and T1-weighted MRI and dilated repeatedly to create 8 NAWM masks representing increasing distance from WMH. Linear models were applied to compare FW and FA-t across WMH and NAWM masks and in association with cerebrovascular risk. Median age was 64 ± 14 years. FW and FA-t were altered 8 mm and 12 mm beyond WMH, respectively. Smoking was significantly associated with FW in NAWM (p = 0.008) and FA-t in WMH (p = 0.008) and in NAWM (p = 0.003) while diabetes and hypertension were not. Further research is necessary to examine whether FW and FA-t alterations in NAWM are predictors for developing WMH.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"61 1","pages":"1707 - 1718"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73681865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality 慢性睡眠质量差患者脑脊液示踪剂的淋巴增强改变

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-03-29 DOI: 10.1177/0271678X221090747

P. Eide, A. Pripp, Benedikte Berge, H. Hrubos-Strøm, G. Ringstad, L. Valnes

{"title":"Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality","authors":"P. Eide, A. Pripp, Benedikte Berge, H. Hrubos-Strøm, G. Ringstad, L. Valnes","doi":"10.1177/0271678X221090747","DOIUrl":"https://doi.org/10.1177/0271678X221090747","url":null,"abstract":"Chronic sleep disturbance is a risk factor for dementia disease, possibly due to impaired sleep-dependent clearance of toxic metabolic by-products. We compared enrichment of a cerebrospinal fluid (CSF) tracer within brain of patients reporting good or poor sleep quality, assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Tracer enrichment in a selection of brain regions was assessed using multiphase magnetic resonance imaging up to 48 hours after intrathecal administration of the contrast agent gadobutrol (0.5 ml of 1 mmol/ml) serving as tracer. Tracer enrichment differed between patients with good (PSQI ≤5) and poor (PSQI >5) sleep quality in a cohort of non-dementia individuals (n = 44; age 42.3 ± 14.5 years), and in patients with the dementia subtype idiopathic normal pressure hydrocephalus (n = 24; age 71.0 ± 4.9 years). Sleep impairment was associated with increased CSF tracer enrichment in several brain regions. Cortical brain volume as well as entorhinal cortex thickness was reduced in the oldest cohort and was correlated with the severity of sleep disturbance and the degree of cortical tracer enrichment. We suggest chronic sleep disturbance is accompanied by altered glymphatic function along enlarged perivascular spaces.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"7 1","pages":"1676 - 1692"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79080437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Cerebrovascular responses to somatomotor stimulation in Parkinson’s disease: A multivariate analysis 帕金森病患者对躯体运动刺激的脑血管反应:一项多变量分析

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-03-15 DOI: 10.1177/0271678X211065204

Sam C Barnes, R. Panerai, L. Beishon, M. Hanby, T. Robinson, V. Haunton

{"title":"Cerebrovascular responses to somatomotor stimulation in Parkinson’s disease: A multivariate analysis","authors":"Sam C Barnes, R. Panerai, L. Beishon, M. Hanby, T. Robinson, V. Haunton","doi":"10.1177/0271678X211065204","DOIUrl":"https://doi.org/10.1177/0271678X211065204","url":null,"abstract":"Parkinson’s disease (PD) is a common neurodegenerative disorder, yet little is known about cerebral haemodynamics in this patient population. Previous studies assessing dynamic cerebral autoregulation (dCA), neurovascular coupling (NVC) and vasomotor reactivity (VMR) have yielded conflicting findings. By using multi-variate modelling, we aimed to determine whether cerebral blood flow (CBF) regulation is impaired in PD patients. 55 healthy controls (HC) and 49 PD patients were recruited. PD subjects underwent a second recording following a period of abstinence from their anti-Parkinsonian medication. Continuous bilateral transcranial Doppler in the middle cerebral arteries, beat-to-beat mean arterial blood pressure (MAP; Finapres), heart rate (HR; electrocardiogram), and end-tidal CO2 (EtCO2; capnography) were measured. After a 5-min baseline period, a passive motor paradigm comprising 60 s of elbow flexion was performed. Multi-variate modelling quantified the contributions of MAP, ETCO2 and neural stimulation to changes in CBF velocity (CBFV). dCA, VMR and NVC were quantified to assess the integrity of CBF regulation. Neural stimulation was the dominant input. dCA, NVC and VMR were all found to be impaired in the PD population relative to HC (p < 0.01, p = 0.04, p < 0.01, respectively). Our data suggest PD may be associated with depressed CBF regulation. This warrants further assessment using different neural stimuli.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"98 1","pages":"1547 - 1558"},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90528214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue 乳酸受体HCAR1的激活下调了啮齿动物和人类脑组织中的神经元活性

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2022-03-03 DOI: 10.1177/0271678X221080324

M. Briquet, A. Rocher, Maxime Alessandri, Nadia Rosenberg, Haíssa de Castro Abrantes, Joel Wellbourne-Wood, Céline Schmuziger, V. Ginet, J. Puyal, E. Pralong, R. Daniel, S. Offermanns, J. Chatton

{"title":"Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue","authors":"M. Briquet, A. Rocher, Maxime Alessandri, Nadia Rosenberg, Haíssa de Castro Abrantes, Joel Wellbourne-Wood, Céline Schmuziger, V. Ginet, J. Puyal, E. Pralong, R. Daniel, S. Offermanns, J. Chatton","doi":"10.1177/0271678X221080324","DOIUrl":"https://doi.org/10.1177/0271678X221080324","url":null,"abstract":"Lactate can be used by neurons as an energy substrate to support their activity. Evidence suggests that lactate also acts on a metabotropic receptor called HCAR1, first described in the adipose tissue. Whether HCAR1 also modulates neuronal circuits remains unclear. In this study, using qRT-PCR, we show that HCAR1 is present in the human brain of epileptic patients who underwent resective surgery. In brain slices from these patients, pharmacological HCAR1 activation using a non-metabolized agonist decreased the frequency of both spontaneous neuronal Ca2+ spiking and excitatory post-synaptic currents (sEPSCs). In mouse brains, we found HCAR1 expression in different regions using a fluorescent reporter mouse line and in situ hybridization. In the dentate gyrus, HCAR1 is mainly present in mossy cells, key players in the hippocampal excitatory circuitry and known to be involved in temporal lobe epilepsy. By using whole-cell patch clamp recordings in mouse and rat slices, we found that HCAR1 activation causes a decrease in excitability, sEPSCs, and miniature EPSCs frequency of granule cells, the main output of mossy cells. Overall, we propose that lactate can be considered a neuromodulator decreasing synaptic activity in human and rodent brains, which makes HCAR1 an attractive target for the treatment of epilepsy.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"57 1","pages":"1650 - 1665"},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80225715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Thanks to Reviewers 感谢审稿人

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2021-02-25 DOI: 10.1159/000485431

引用次数: 0

Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors 循环tPA通过涉及内皮NMDA受体的机制促进神经血管偶联

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2020-10-01 DOI: 10.1177/0271678X19883599

Antoine Anfray, Antoine Drieu, Vincent Hingot, Y. Hommet, Mervé Yetim, M. Rubio, T. Deffieux, M. Tanter, C. Orset, D. Vivien

{"title":"Circulating tPA contributes to neurovascular coupling by a mechanism involving the endothelial NMDA receptors","authors":"Antoine Anfray, Antoine Drieu, Vincent Hingot, Y. Hommet, Mervé Yetim, M. Rubio, T. Deffieux, M. Tanter, C. Orset, D. Vivien","doi":"10.1177/0271678X19883599","DOIUrl":"https://doi.org/10.1177/0271678X19883599","url":null,"abstract":"The increase of cerebral blood flow evoked by neuronal activity is essential to ensure enough energy supply to the brain. In the neurovascular unit, endothelial cells are ideally placed to regulate key neurovascular functions of the brain. Nevertheless, some outstanding questions remain about their exact role neurovascular coupling (NVC). Here, we postulated that the tissue-type plasminogen activator (tPA) present in the circulation might contribute to NVC by a mechanism dependent of its interaction with endothelial N-Methyl-D-Aspartate Receptor (NMDAR). To address this question, we used pharmacological and genetic approaches to interfere with vascular tPA-dependent NMDAR signaling, combined with laser speckle flowmetry, intravital microscopy and ultrafast functional ultrasound in vivo imaging. We found that the tPA present in the blood circulation is capable of potentiating the cerebral blood flow increase induced by the activation of the mouse somatosensorial cortex, and that this effect is mediated by a tPA-dependent activation of NMDAR expressed at the luminal part of endothelial cells of arteries. Although blood molecules, such as acetylcholine, bradykinin or ATP are known to regulate vascular tone and induce vessel dilation, our present data provide the first evidence that circulating tPA is capable of influencing neurovascular coupling (NVC).","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"23 1","pages":"2038 - 2054"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74466610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model 在小鼠缺血/再灌注脑卒中模型中，miR-98通过保护血脑屏障(BBB)减少内皮功能障碍，改善神经预后

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2020-10-01 DOI: 10.1177/0271678X19882264

David L Bernstein, Viviana Zuluaga-Ramirez, Sachin Gajghate, N. Reichenbach, B. Polyak, Y. Persidsky, Slava Rom

{"title":"miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model","authors":"David L Bernstein, Viviana Zuluaga-Ramirez, Sachin Gajghate, N. Reichenbach, B. Polyak, Y. Persidsky, Slava Rom","doi":"10.1177/0271678X19882264","DOIUrl":"https://doi.org/10.1177/0271678X19882264","url":null,"abstract":"Most neurological diseases, including stroke, lead to some degree of blood–brain barrier (BBB) dysfunction. A significant portion of BBB injury is caused by inflammation, due to pro-inflammatory factors produced in the brain, and by leukocyte engagement of the brain endothelium. Recently, microRNAs (miRNAs) have appeared as major regulators of inflammation-induced changes to gene expression in the microvascular endothelial cells (BMVEC) that comprise the BBB. However, miRNAs’ role during cerebral ischemia/reperfusion is still underexplored. Endothelial levels of miR-98 were significantly altered following ischemia/reperfusion insults, both in vivo and in vitro, transient middle cerebral artery occlusion (tMCAO), and oxygen–glucose deprivation (OGD), respectively. Overexpression of miR-98 reduced the mouse’s infarct size after tMCAO. Further, miR-98 lessened infiltration of proinflammatory Ly6CHI leukocytes into the brain following stroke and diminished the prevalence of M1 (activated) microglia within the impacted area. miR-98 attenuated BBB permeability, as demonstrated by changes to fluorescently-labeled dextran penetration in vivo and improved transendothelial electrical resistance (TEER) in vitro. Treatment with miR-98 improved significantly the locomotor impairment. Our study provides identification and functional assessment of miRNAs in brain endothelium and lays the groundwork for improving therapeutic approaches for patients suffering from ischemic attacks.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"10 1","pages":"1953 - 1965"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91026980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 82

Hyaluronidase reduced edema after experimental traumatic brain injury 透明质酸酶减轻实验性创伤性脑损伤后水肿

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2020-10-01 DOI: 10.1177/0271678X19882780

Patricia M. Washington, Changhee Lee, M. K. Dwyer, E. Konofagou, S. Kernie, B. Morrison

{"title":"Hyaluronidase reduced edema after experimental traumatic brain injury","authors":"Patricia M. Washington, Changhee Lee, M. K. Dwyer, E. Konofagou, S. Kernie, B. Morrison","doi":"10.1177/0271678X19882780","DOIUrl":"https://doi.org/10.1177/0271678X19882780","url":null,"abstract":"Cerebral edema and the subsequent increased intracranial pressure are associated with mortality and poor outcome following traumatic brain injury. Previous in vitro studies have shown that the Gibbs-Donnan effect, which describes the tendency of a porous, negatively charged matrix to attract positive ions and water, applies to brain tissue and that enzymatic reduction of the fixed charge density can prevent tissue swelling. We tested whether hyaluronidase, an enzyme that degrades the large, negatively charged glycosaminoglycan hyaluronan, could reduce brain edema after traumatic brain injury. In vivo, intracerebroventricular injection of hyaluronidase after controlled cortical impact in mice reduced edema in the ipsilateral hippocampus at 24 h by both the wet-weight/dry-weight method (78.15 ± 0.65% vs. 80.4 ± 0.46%; p < 0.01) and T2-weighted magnetic resonance imaging (13.88 ± 3.09% vs. 29.23 ± 6.14%; p < 0.01). Hyaluronidase did not adversely affect blood–brain-barrier-integrity measured by dynamic contrast-enhanced magnetic resonance imaging, nor did hyaluronidase negatively affect functional recovery after controlled cortical impact measured with the rotarod or Morris water maze tasks. Reduction of fixed charge density by hyaluronidase was confirmed in cortical explants in vitro (5.46 ± 1.15 µg/mg vs. 7.76 ± 1.87 µg/mg; p < 0.05). These data demonstrate that targeting the fixed charge density with hyaluronidase reduced edema in an in vivo mouse model of traumatic brain injury.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"25 3-4","pages":"2026 - 2037"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72627745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Measurement of CMRO2 and its relationship with CBF in hypoxia with an extended calibrated BOLD method 用扩展的校准BOLD方法测量缺氧时cro2及其与CBF的关系

Journal of Cerebral Blood Flow & Metabolism Pub Date : 2020-10-01 DOI: 10.1177/0271678X19885124

Yaoyu Zhang, Yayan Yin, Huanjie Li, Jia-Hong Gao

{"title":"Measurement of CMRO2 and its relationship with CBF in hypoxia with an extended calibrated BOLD method","authors":"Yaoyu Zhang, Yayan Yin, Huanjie Li, Jia-Hong Gao","doi":"10.1177/0271678X19885124","DOIUrl":"https://doi.org/10.1177/0271678X19885124","url":null,"abstract":"Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) are physiological parameters that not only reflect brain health and disease but also jointly contribute to blood oxygen level-dependent (BOLD) signals. Nevertheless, unsolved issues remain concerning the CBF–CMRO2 relationship in the working brain under various oxygen conditions. In particular, the CMRO2 responses to functional tasks in hypoxia are less studied. We extended the calibrated BOLD model to incorporate CMRO2 measurements in hypoxia. The extended model, which was cross-validated with a multicompartment BOLD model, considers the influences of the reduced arterial saturation level and increased baseline cerebral blood volume (CBV) and deoxyhemoglobin concentration on the changes of BOLD signals in hypoxia. By implementing a pulse sequence to simultaneously acquire the CBV-, CBF- and BOLD-weighted signals, we investigated the effects of mild hypoxia on the CBF and CMRO2 responses to graded visual stimuli. Compared with normoxia, mild hypoxia caused significant alterations in both the amplitude and the trend of the CMRO2 responses but did not impact the corresponding CBF responses. Our observations suggested that the flow-metabolism coupling strategies in the brain during mild hypoxia were different from those during normoxia.","PeriodicalId":15356,"journal":{"name":"Journal of Cerebral Blood Flow & Metabolism","volume":"38 1","pages":"2066 - 2080"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79842963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3