Journal of Carbohydrate Chemistry最新文献_第3页

A comprehensive study of intravenous iron-carbohydrate nanomedicines: From synthesis methodology to physicochemical and pharmaceutical characterization 静脉注射铁碳水化合物纳米药物的综合研究:从合成方法到物理化学和药物表征

4区化学

Journal of Carbohydrate Chemistry Pub Date : 2023-11-01 DOI: 10.1080/07328303.2023.2272892

Ozra Tabasi, Mahdi Roohi Razlighi, Cavus Falamaki

{"title":"A comprehensive study of intravenous iron-carbohydrate nanomedicines: From synthesis methodology to physicochemical and pharmaceutical characterization","authors":"Ozra Tabasi, Mahdi Roohi Razlighi, Cavus Falamaki","doi":"10.1080/07328303.2023.2272892","DOIUrl":"https://doi.org/10.1080/07328303.2023.2272892","url":null,"abstract":"AbstractAdministration of intravenous iron is pivotal in the management of iron-deficiency anemia patients. In the past, parenteral iron was administrated as a ferric hydroxide complex that caused severe toxic reactions. The introduction of compounds containing iron in a core surrounded by a carbohydrate shell has circumvented this problem. Intravenous iron complexes, such as iron sucrose and iron carboxymaltose, consist of a polynuclear Fe (III)-oxyhydroxide/oxide core that is coated with a specific carbohydrate molecule. The carbohydrate shell stabilizes the insoluble iron core particles in colloidal suspension form and slows down the release of iron. Moreover, the carbohydrate shell chemistry differences influence the stability of the complex and iron release rate. In particular, this paper discusses the preparation method, physicochemical properties, and characteristics of iron sucrose, ferric derisomaltose, iron carboxymaltose, and ferumoxytol. These products differ in their physicochemical and clinical properties such as molecular weight distribution, particle size, zeta potential, free, and labile iron content, stability and release of iron in serum, and maximum tolerated dose. The first-generation of intravenous iron formulations were replaced with new intravenous iron dextran–free formulations, due to an elevated risk of anaphylactic reactions. Comparatively, the third-generation intravenous iron formulations, such as ferric derisomaltose, iron carboxymaltose, and ferumoxytol, allow higher doses of iron due to high complex stability and safety than the second generation formulations like iron sucrose.Keywords: Characterizationintravenous ironiron deficiencyiron formulationssynthesis Disclosure statementNo potential conflict of interest was reported by the author(s).Additional informationFundingNone.","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135325707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial cellulose-based hydrogels carrying Lewis X trisaccharides as a system for monitoring carbohydrate–carbohydrate interactions with the naked eye 细菌纤维素基水凝胶携带Lewis X三糖，作为肉眼监测碳水化合物-碳水化合物相互作用的系统

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2023-08-06 DOI: 10.1080/07328303.2023.2242927

Jiayu Dong, Katsunari Hiroki, M. Tobito, Keisuke Yoshida, Ai Tanabe, T. Shindo, Megu Gunji, Qintong Li, Teruaki Hasegawa

引用次数: 0

Advances in the synthesis of antiviral agents from carbohydrate-derived chiral pools 糖源性手性池合成抗病毒药物的研究进展

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2023.2189473

Anjali Sharma , Smritilekha Bera , Dhananjoy Mondal

引用次数: 0

New macrocycles incorporating glycolipids via copper-catalyzed triazole coupling 通过铜催化的三唑偶联结合糖脂的新大环

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2022.2039685

Nuha S. Kareem , Shaymaa A. Mohammed , May Jaleel Abed , Asaad H. Aneed , Hayder M. Kamal , N. Idayu Zahid , Karem J. Sabah

引用次数: 0

Highly stereoselective construction of 1,2-cis-D-quinovosamine glycosides for the synthesis of Pseudomonas aeruginosa O-antigen disaccharide 1,2-顺式- d -喹啉氨基糖苷的高立体选择性构建合成铜绿假单胞菌o抗原双糖

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2022.2055049

Hongli Hou , Guangzong Tian , Junjie Fu , Chunjun Qin , Guodong Chen , Xiaopeng Zou , Jing Hu , Jian Yin

引用次数: 0

The structural diversity of natural glycosphingolipids (GSLs) 天然鞘糖脂的结构多样性

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2022.2063308

Zhongwu Guo

{"title":"The structural diversity of natural glycosphingolipids (GSLs)","authors":"Zhongwu Guo","doi":"10.1080/07328303.2022.2063308","DOIUrl":"10.1080/07328303.2022.2063308","url":null,"abstract":"<div><p>Glycosphingolipids (GSLs) are a subclass of glycolipids made of a glycan and a ceramide that, in turn, is composed of a sphingoid base moiety and a fatty acyl group. GSLs represent the vast majority of glycolipids in eukaryotes, and as an essential component of the cell membrane, they play an important role in many biological and pathological processes. Therefore, they are useful targets for the development of novel diagnostic and therapeutic methods for human diseases. Since sphingosine was first described by J. L. Thudichum in 1884, several hundred GSL species, not including their diverse lipid forms that can further amplify the number of individual GSLs by many folds, have been isolated from natural sources and structurally characterized. This review tries to provide a comprehensive survey of the major GSL species, especially those with distinct glycan structures and modification patterns, and the ceramides with unique modifications of the lipid chains, that have been discovered to date. In particular, this review is focused on GSLs from eukaryotic species. This review has listed 251 GSL glycans with different linkages, 127 glycans with unique modifications, 46 sphingoids, and 43 fatty acyl groups. It should be helpful for scientists who are interested in GSLs, from isolation and structural analyses to chemical and enzymatic syntheses, as well as their biological studies and applications.</p></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10427639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Design and synthesis of 4-azido-phosphatidylinositol as a potential probe for metabolic engineering of glycosylphosphatidylinositol on cells 设计与合成4-叠氮-磷脂酰肌醇作为糖基磷脂酰肌醇在细胞上代谢工程的潜在探针

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2022.2077358

Kendall C. Craig , Zhongwu Guo

引用次数: 2

Arabinogalactan from Ixeris chinensis (Thunb.) Nakai as a stabilizer to decorate SeNPs and enhance their anti-hepatocellular carcinoma activity via the mitochondrial pathway 阿拉伯半乳聚糖(阿拉伯语:Ixeris chinensis)Nakai作为一种稳定剂，通过线粒体途径修饰SeNPs并增强其抗肝癌活性

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2022.2105860

Hongyan Li , Yifan Wang , Yan Chen , Shuxin Wang , Yifan Zhao , Jinyuan Sun

{"title":"Arabinogalactan from Ixeris chinensis (Thunb.) Nakai as a stabilizer to decorate SeNPs and enhance their anti-hepatocellular carcinoma activity via the mitochondrial pathway","authors":"Hongyan Li , Yifan Wang , Yan Chen , Shuxin Wang , Yifan Zhao , Jinyuan Sun","doi":"10.1080/07328303.2022.2105860","DOIUrl":"10.1080/07328303.2022.2105860","url":null,"abstract":"<div><p>Arabinogalactan (ICPA) was isolated from the medicinal plant <em>Ixeris chinensis</em> (Thunb.) Nakai, and was used as the reducing agent to stabilize selenium nanoparticles (SeNPs). ICPA-decorated SeNPs (ICPA-SeNPs) were synthesized with Na<sub>2</sub>SeO<sub>3</sub> and ICPA, and their average diameter was 82.6±2.5 nm. ICPA-SeNPs had good dispersity in phosphate-buffered saline (PBS) with a hydrodynamic size of 156.2±2.8 nm. They were stable in PBS solution with a zeta potential of −24.8±0.6 mV. The anti-hepatoma activity of ICPA-SeNPs was investigated <em>in vitro</em>. ICPA-SeNPs significantly suppressed the growth of SMMC-7721 and HepG2 hepatoma cells. They entered SMMC-7721 cells via energy- and caveolae-dependent endocytosis. ICPA-SeNPs were able to increase reactive oxygen species levels, reduce mitochondrial membrane potential, and increase caspase-3 expression in SMMC-7721 cells, which led to the apoptosis of SMMC-7721 cells. They also arrested the cell cycle of SMMC-7721 cells in the S phase. These findings indicate that ICPA could enhance the stability of SeNPs and inhibit SMMC-7721 cell proliferation via the mitochondrial pathway. ICPA-SeNPs could be developed as an antitumor agent for hepatocellular carcinoma treatment.</p></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49111345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigations to mechanism and applications of the glycosylation protocol employing 8-methyltosylaminoethynyl-1-naphthyl (MTEAN) glycoside donors 8-甲基甲酰基氨基乙基-1-萘基(MTEAN)糖苷供体糖基化机制及应用研究

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2022.2045021

Si-Yu Zhou , Hui-Juan Liu , Qing-Ju Zhang , Jin-Xi Liao , De-Yong Liu , Ming-Dong Li , Jian-Song Sun

引用次数: 1

A novel synthesis of tetrahydrocortisone 3-glucuronide 四氢化可的松3-葡萄糖醛酸盐的新合成方法

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2022-01-01 DOI: 10.1080/07328303.2021.2023559

Yan Zhang , Suqing Zhang , Rui Li , Jingshan Shen , Xiangrui Jiang , Haji A. Aisa

引用次数: 0