Journal of Cancer Survivorship最新文献

{"title":"From pelvic radiation to social isolation: a qualitative study of survivors' experiences of chronic bowel symptoms after pelvic radiotherapy.","authors":"A Biran, C Dobson, C Rees, R Brooks-Pearson, A Cunliffe, L Durrant, J Hancock, H Ludlow, L Neilson, A Wilson, L Sharp","doi":"10.1007/s11764-023-01527-6","DOIUrl":"10.1007/s11764-023-01527-6","url":null,"abstract":"<p><strong>Purpose: </strong>We explored survivors' experiences of chronic bowel symptoms following pelvic radiotherapy, strategies employed in living with these symptoms, effects on daily activities, and roles at home and in the workplace.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 28 individuals (10 gynaecological, 14 prostate, four anal/rectal cancer survivors) who had completed pelvic radiotherapy at least six months prior to data collection and who had experience of bowel symptoms during this post-treatment period. Reflexive thematic analysis was undertaken.</p><p><strong>Results: </strong>We propose four themes describing a process leading from experience of symptoms to withdrawal from activities and roles. These are (1) losing control (the experience of unintended anal leakage or discharge); (2) experiencing embarrassment and fear (the experience of embarrassment or fear of embarrassment as a result of discharge becoming public); (3) managing and reacting (acting to reduce the likelihood of discharge or to prevent this becoming public); and (4) restriction and withdrawal (avoiding specific activities or situations so as to reduce or remove the risk of embarrassment). Returning to the workplace presented additional challenges across these themes.</p><p><strong>Conclusions: </strong>Impacts of chronic bowel symptoms can be severe. Survivors employ a variety of methods and strategies in living with their symptoms. Some of these support continued role fulfilment but some constitute a withdrawal from pre-treatment roles. Current healthcare provision and statutory protections fail to fully meet needs following pelvic radiotherapy.</p><p><strong>Implications for cancer survivors: </strong>There is a need to develop and implement evidence-based services and supported self-management programmes for survivors experiencing chronic bowel problems post-radiotherapy.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1019-1027"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139106188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of healthy lifestyle interventions addressing quality of life of cancer survivors in the post treatment phase.","authors":"Morgan Leske, Christina Galanis, Bogda Koczwara, Lisa Beatty","doi":"10.1007/s11764-023-01514-x","DOIUrl":"10.1007/s11764-023-01514-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study's primary aim was to investigate whether including a mental health component to healthy lifestyle interventions are associated with greater effects on quality of life (QoL) for post-treatment cancer survivors than addressing physical activity and/or nutrition alone.</p><p><strong>Methods: </strong>PsycINFO, Scopus, Medline, CINAHL, and Google Scholar were searched to identify randomised control trials of healthy lifestyle interventions for post-treatment cancer survivors, with a usual care or waitlist control, and measured QoL. Meta-analyses quantified the effects of interventions vs controls at post-treatment on total QoL, physical, emotional, and social well-being. Subgroup analyses compared interventions with vs without a mental health component, modes of delivery, and duration. The quality of the included studies was assessed using the Cochrane Risk of Bias 2.</p><p><strong>Results: </strong>Eighty-eight papers evaluating 110 interventions were included: 66 effect sizes were extracted for meta-analysis, and 22 papers were narratively synthesised. The pooled effect size demonstrated a small, significant effect of healthy lifestyle interventions in comparison to control for all QoL outcomes (total g = 0.32, p >.001; physical g = 0.19, p = 0.05; emotional g = 0.20, p >.001; social g = 0.18, p = 0.01). There was no significant difference between interventions with vs without a mental health component. Face-to-face delivered interventions were associated with greater total QoL and physical well-being compared to other modalities. Interventions delivered ≤12 weeks were associated with greater physical well-being than those delivered ≥13 weeks. Overall, studies had substantial levels of heterogeneity and 55.9% demonstrated high risk of bias.</p><p><strong>Conclusions: </strong>Participating in a healthy lifestyle intervention following cancer treatment improves QoL. Few trials addressed mental health or evaluated online or telephone modalities; future research should develop and evaluate interventions that utilise these features.</p><p><strong>Implications for cancer survivors: </strong>Brief healthy lifestyle interventions can be recommended for cancer survivors, particularly those interested in improving physical well-being.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"940-956"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professionally led support groups for people living with advanced or metastatic cancer: a systematic scoping review of effectiveness and factors critical to implementation success within real-world healthcare and community settings.","authors":"Zhicheng Li, Kitty-Jean Laginha, Frances Boyle, Michele Daly, Fiona Dinner, Pia Hirsch, Kim Hobbs, Laura Kirsten, Carolyn Mazariego, Ros McAuley, Mary O'Brien, Amanda O'Reilly, Natalie Taylor, Lisa Tobin, Sophie Lewis, Andrea L Smith","doi":"10.1007/s11764-023-01515-w","DOIUrl":"10.1007/s11764-023-01515-w","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the effectiveness of professionally led support groups for people with advanced or metastatic cancer, and identify factors critical to implementation success within real-world settings.</p><p><strong>Methods: </strong>Databases (MEDLINE; PsychINFO; CINAHL) and grey literature were searched for empirical publications and evaluations. Articles were screened for eligibility and data systematically extracted, charted and summarised using a modified scoping review methodology. Implementation factors were mapped using Proctor's implementation framework and the Consolidated Framework for Implementation Research 2.0.</p><p><strong>Results: </strong>A total of 1691 publications were identified; 19 were eligible for inclusion (8 randomised controlled trials, 7 qualitative studies, 2 cohort studies, 2 mixed methods studies). Most (n=18) studies focused on tumour-specific support groups. Evidence supported professionally led support groups in reducing mood disturbances (n=5), distress (i.e. traumatic stress, depression) (n=4) and pain (n=2). Other benefits included social connectedness (n=6), addressing existential distress (n=5), information and knowledge (n=6), empowerment and sense of control (n=2), relationships with families (n=2) and communication with health professionals (n=2). Thirteen studies identified factors predicting successful adoption, implementation or sustainment, including acceptability (n=12; 63%), feasibility (n=6; 32%) and appropriateness (n=1; 5%). Key determinants of successful implementation included group leaders' skills/experience, mode of operation, travelling distance, group composition and membership and resourcing.</p><p><strong>Conclusions: </strong>Professionally led tumour-specific support groups demonstrate effectiveness in reducing mood disturbances, distress and pain among patients. Successful implementation hinges on factors such as leadership expertise, operational methods and resource allocation.</p><p><strong>Implications for cancer survivors: </strong>Professionally led support groups may fill an important gap in supportive care for people with advanced or metastatic cancer.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"957-977"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a dose-graded aerobic exercise regimen on cardiopulmonary fitness and physical performance in pediatric survivors of acute lymphoblastic leukemia: a randomized clinical trial.","authors":"Ragab K Elnaggar, Ahmad M Osailan, Mohammed F Elbanna, Amira M Abd-Elmonem","doi":"10.1007/s11764-024-01534-1","DOIUrl":"10.1007/s11764-024-01534-1","url":null,"abstract":"<p><strong>Purpose: </strong>To determine whether a 12-week supervised dose-graded aerobic exercise (D-GAE) training, when implemented in conjunction with traditional rehabilitation, could help pediatric survivors of acute lymphoblastic leukemia (ALL) enhance their cardiopulmonary capacity and improve their physical performance.</p><p><strong>Methods: </strong>Fifty-eight pediatric survivors of ALL (age 13.78 ± 2.47 years; boys 60.34%) were assigned at random to either undergo the D-GAE in addition to the traditional physical rehabilitation (D-GAE group; n = 29) or the traditional physical rehabilitation solely (control group; n = 29). The cardiopulmonary fitness (peak oxygen uptake (VO_2peak), ventilatory equivalent (VEq/VO₂), minute ventilation (V_E, L/min), oxygen pulse (O₂P), maximum heart rate (HR_max), 1-min heart rate recovery (HRR₁), and respiratory exchange ratio (RER)) and physical performance (6-min walk test (6-MWT), timed up and down stairs (TUDS), and 4 × 10-m shuttle run test (4 × 10mSRT)) were assessed on the pre- and post-intervention occasions.</p><p><strong>Results: </strong>The mixed-model ANOVA revealed a meaningful increase of VO_2peak (P = .002), V_E (P = .026), O₂P (P = .0009), HR_max (P = .004), and HRR₁ (P = .011), and reduction of VEq/VO₂ (P = .003) and RER (P = .003) in the D-GAE group compared with the control group. Besides, the analysis detected a favorable increase in the physical performance for the D-GAE group (6-MWT (P = .007), TUDS (P < .001), 4 × 10mSRT (P = .009)).</p><p><strong>Conclusion: </strong>A 12-week D-GAE program in conjunction with traditional rehabilitation holds promise in enhancing cardiopulmonary fitness and improving the physical performance of pediatric survivors of ALL. Clinicians and physical rehabilitation professionals can, therefore, integrate the D-GAE into the traditional rehabilitation protocols for such a patient population to optimize their cardiopulmonary fitness and physical function, while also facilitating a gradual transition to practice and adaption.</p><p><strong>Implications for cancer survivors: </strong>The favorable outcomes of this study bolster the inclusion of D-GAE as a crucial element in the care and rehabilitation of pediatric survivors of ALL. By embracing these findings, healthcare professionals and oncologists can contribute to mitigating the long-term cardiopulmonary and physical complications associated with cancer treatments and fostering a state of enhanced well-being and increased physical activity among survivors.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1090-1101"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139546534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet and physical activity intervention preferences for young adult cancer survivors.","authors":"Sylvia L Crowder, Bihe Hu, Aasha I Hoogland, Lisa M Gudenkauf, Xiaoyin Li, Yvelise Rodriguez, Nathaly E Irizarry-Arroyo, Laura B Oswald, Brian D Gonzalez, Brent J Small, Andrew Galligan, Heather S L Jim, Marilyn Stern","doi":"10.1007/s11764-025-01832-2","DOIUrl":"https://doi.org/10.1007/s11764-025-01832-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Patient preferences for diet and physical activity interventions likely vary by patient age at cancer diagnosis, gender, and ethnicity. Efficacious multiple health behavior interventions to improve diet and physical activity in young adult cancer survivors are critically needed. This study aimed to collect data to inform preferences for diet and physical activity interventions for young adult cancer survivors that could be modified, if needed, based on gender and ethnicity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between May 2022 and April 2024, young adult cancer survivors between 20 and 30 years of age participated in an observational study to assess diet and physical activity habits and preferences. Participants completed a survey of diet and physical activity intervention preferences to be used for planning future intervention development. Descriptive statistics were calculated for multiple choice question responses. Intervention preferences for diet and physical activity were compared across self-reported gender (i.e., male vs. female) and race/ethnicity (i.e., Hispanic vs. other) using chi-square tests or Fisher's exact tests (α = 0.05). Responses to open-ended questions were recorded and verified via quality assurance checks by a coauthor.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Study participants (N = 88) completed the preferences survey. Participants' mean age at diagnosis was 23 years, 67% were female, 23% were from a racial/ethnic minority background, and common cancer types included thyroid (24%), lymphoid (19%), and sarcoma (15%). All participants had completed treatment at least 1 year prior to study enrollment (range 1-8 years). Overall, for a dietary intervention, most participants preferred remote-based (e.g., Zoom), one-on-one counseling with a registered dietitian beginning before treatment, and respondents expressed enthusiasm for free dietary coaching and virtual cooking classes. For a physical activity intervention, most participants preferred one-on-one, in-person sessions beginning before treatment, ideally within 1-15 miles from their home that would be free of charge. Participants reported interest in a variety of physical activities, including yoga, strength training, and cardiovascular-based activities (e.g., HIIT, interval training, swimming). There were few differences among gender and ethnicity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Results indicate that future diet and physical activity intervention development for young adult cancer survivors should focus on strategies to promote one-on-one telehealth dietary counseling and in-person physical activity training. Virtual cooking classes and cookbooks coupled with in-person fitness training were preferred methodologies for young adult cancer survivors in this study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Implications for cancer survivors: &lt;/strong&gt;Study results highlight an opportunity to design a combined diet and physical activity intervention healthy lifestyle program for you","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can't I continue to exercise here? Exploring experiences, barriers, and facilitators for physical therapists and survivors of cancer to promote exercise maintenance.","authors":"S C Agasi-Idenburg, M M J Joosten, M Hoedjes, L M Buffart, C S Kampshoff, M M Stuiver","doi":"10.1007/s11764-025-01767-8","DOIUrl":"https://doi.org/10.1007/s11764-025-01767-8","url":null,"abstract":"<p><strong>Purpose: </strong>Maintaining exercise behavior is crucial for cancer survivors, yet adherence to exercise recommendations remains low. This study explores the experiences and perspectives of community-working physical therapists and survivors of cancer regarding barriers and facilitators that support the maintenance of exercise behavior post-treatment.</p><p><strong>Methods: </strong>A qualitative, exploratory focus group design was employed, using purposive sampling to recruit oncology physical therapists and cancer survivors who had undergone physical therapy. The study assessed current physical therapy practices, barriers, and facilitators to exercise maintenance through thematic content analysis Braun and Clarke.</p><p><strong>Results: </strong>Six focus groups with 26 participants (12 cancer survivors and 14 physical therapists) revealed three main themes: (1) transition challenges from supervised therapy to independent exercise, (2) environmental constraints on exercise adherence, and (3) motivators and supportive factors to help independent exercise. Transition challenges included a lack of knowledge and skills, persistent symptoms, and psychological recovery. Environmental constraints involved prioritizing exercise over work and family and limited financial resources. Motivators and supportive factors included goal-setting, gradual reduction in physical therapy sessions, and building confidence in self-management among cancer survivors.</p><p><strong>Conclusions: </strong>Both physical therapists and cancer survivors experience challenges in concluding the treatment relationship. The identified facilitators for independent exercise can assist physical therapists in developing effective exercise programs that promote patient independence during and after physical therapy treatment.</p><p><strong>Implications for cancer survivors: </strong>Understanding these barriers and facilitators can help tailor interventions that enhance long-term exercise adherence, ultimately improving health outcomes and quality of life for cancer survivors.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk assessment and predictive modeling of suicide in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Patients.","authors":"Fan Wang","doi":"10.1007/s11764-025-01839-9","DOIUrl":"https://doi.org/10.1007/s11764-025-01839-9","url":null,"abstract":"<p><strong>Background: </strong>Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) predominantly affects older adults and is characterized by a prolonged disease course. While overall survival has improved, the psychosocial burden, including suicide risk, remains underexplored.​ METHODS: A retrospective cohort study was conducted using data from 95,517 patients diagnosed with CLL/SLL between 2000 and 2021 from the SEER 17 registry. LASSO regression was utilized for variable selection, followed by univariate and multivariate Cox proportional hazards and Fine-Gray competing risk analyses to identify independent predictors. A nomogram was developed based on significant predictors and validated using time-dependent receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA).​ RESULTS: The cohort's mean age was 69.2 years, with 21.6% aged ≥ 80 years and a male-to-female ratio of 1.5:1; 88.8% were White. Although the suicide rate was low (0.1%), multivariate analysis showed that male sex, non-married status, lower income, and White race were significantly associated with increased suicide risk. Advanced age (≥ 80) was significant in Cox but not in competing risk models. The nomogram demonstrated good predictive accuracy (AUC > 0.71 at 3, 5, and 10 years) and clinical utility.</p><p><strong>Conclusions: </strong>Sociodemographic factors, including sex, race, marital status, and income, are independently associated with suicide risk in CLL/SLL patients. The developed nomogram offers a practical, evidence-based tool for early identification of high-risk individuals, thereby facilitating targeted psychosocial interventions and improving survivorship care.</p><p><strong>Implications for cancer survivors: </strong>CLL/SLL survivors who are male, unmarried, or of lower socioeconomic status face heightened suicide risk, highlighting the critical need for tailored psychosocial support within survivorship care.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of web platform delivery of a physical activity program for breast cancer survivors: a randomized controlled trial.","authors":"Bernardine M Pinto, Madison Kindred, Shira Dunsiger, Sheryl Mitchell, Ashwin Patel, Danielle Ostendorf, Amy G Huebschmann","doi":"10.1007/s11764-025-01811-7","DOIUrl":"https://doi.org/10.1007/s11764-025-01811-7","url":null,"abstract":"<p><strong>Purpose: </strong>We previously demonstrated that a 3-month peer-delivered program (Moving Forward Together, MFT) significantly increased breast cancer survivors' moderate-to-vigorous PA (MVPA). To enhance MFT's scalability and reach, we adapted it to an existing web platform and developed webMFT. Our goal was to test the efficacy of webMFT on survivors' MVPA.</p><p><strong>Methods: </strong>In a randomized controlled trial, we trained ten peer coaches from cancer care organizations to deliver webMFT or MVPA Tracking to 61 breast cancer survivors (mean age = 58.10 years [SD = 8.55], 1.40 years post-diagnosis [SD = 0.50], 80% Stage 0-1 cancer) for 3 months. Both groups received a FitBit® tracker and behavioral supports of weekly synchronization reminders, physical activity (PA) tipsheets, and recommended PA goals. In addition, webMFT participants received weekly coaching calls tailored to their FitBit® data shared through the web platform. All participants wore an Actigraph accelerometer for 7 days at baseline and at post-intervention and completed quality of life (QOL), mood, fatigue and physical functioning questionnaires. We used mixed effects regression models to examine between-group differences on outcomes.</p><p><strong>Results: </strong>Both groups significantly increased their MVPA from baseline to 12 weeks but there were no significant between-group differences in change in MVPA (b = - 22.84, SE = 16.99, p = .18). There were significant between-group effects favoring webMFT in improved QOL at 12 weeks (b = 1.56, SE = 0.77, p = .04).</p><p><strong>Conclusions: </strong>Adapting the efficacious MFT intervention for web delivery did not result in significant improvements in MVPA vs. MVPA Tracking. This raises questions as to whether the efforts undertaken to adapt and deliver the program through the web platform were justified as compared to MVPA Tracking with behavioral supports.</p><p><strong>Implications for cancer survivors: </strong>Promoting PA does not require web delivery of coaching-using physical activity trackers with weekly reminders and resources is also effective.</p><p><strong>Trial registration: </strong>This trial was registered in Clinicaltrials.gov on 6/8/2022 (NCT05409664).</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived stigmatization in cancer patients during the first year after diagnosis: the role of socioeconomic status.","authors":"Jochen Ernst, Anne-Kathrin Köditz, Ute Goerling, Tanja Zimmermann, Beate Hornemann, Franziska Springer, Anja Mehnert-Theuerkauf","doi":"10.1007/s11764-025-01834-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01834-0","url":null,"abstract":"<p><strong>Purpose: </strong>Stigmatization in cancer patients leads to poorer health-related outcomes. The effect of socioeconomic status (SES) on stigmatization has not been investigated. We therefore aim to investigate, which differences in stigmatization in cancer patients regarding SES exist up to one year after diagnosis and which medical and demographic characteristics are associated with stigmatization.</p><p><strong>Methods: </strong>Patients with different solid cancer diagnoses were assessed within two months after diagnosis (t1) and at a 12-month follow-up (t2). Stigmatization was assessed using the Social Impact Scale (SIS), which comprises four dimensions: isolation, rejection, shame and financial insecurity. An SIS-total score can be computed. Bivariate and multiple regression analysis were performed.</p><p><strong>Results: </strong>Six hundred-eighty patients completed the assessments (mean age 60.4; 51.2% male; most prevalent cancers: prostate (21.0%), skin (17.1%), breast (16.2%)). Stigmatization at t1 was moderate in all dimensions, independent of SES. It decreased at t2, especially in patients with middle or high SES (p < 0.001). Low SES was identified as a risk factor for stigmatization at t2 (p = 0.036 - p < 0.001). Other predictors include stigmatization at t1 as well as distress, disease stage and cancer diagnosis, e.g. lung cancer. The predictors explained 27-43% of the variance in stigmatization in the four dimensions resp. in the SIS-total score.</p><p><strong>Conclusion: </strong>Stigmatization after cancer diagnosis was dependent of SES. Reasons may be fewer social and economic resources, lower health literacy and insufficient consideration of the specific needs of this patient group in the healthcare system.</p><p><strong>Implication for cancer survivors: </strong>Patients with low SES should receive greater attention in the medical care system and in scientific research to identify and mitigate possible burdens and subsequent problems.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to work after neoadjuvant versus adjuvant immunotherapy in stage III melanoma patients.","authors":"J M Lijnsvelt, Z Lievense, E A C Albers, M Lopez-Yurda, L V van de Poll-Franse, C U Blank","doi":"10.1007/s11764-025-01825-1","DOIUrl":"https://doi.org/10.1007/s11764-025-01825-1","url":null,"abstract":"<p><strong>Purpose: </strong>Neoadjuvant immunotherapy in stage III melanoma has recently been shown to improve event-free and distant metastasis-free survival compared to adjuvant therapy. Pathologic response allows for subsequent personalization of surgery and omission/application of adjuvant therapy. We addressed the question whether neoadjuvant therapy allows an earlier and more to a more extent return to work in this curatively treated patient population.</p><p><strong>Methods: </strong>In this single-center retrospective analysis of patients participating at the Netherlands, we interviewed via the telephone 88 stage III melanoma patients treated with neoadjuvant versus adjuvant immunotherapy in regards of their stopping work during therapy, and when returning partially or fully to work.</p><p><strong>Results: </strong>Six, 12, and 24 months post start of therapy at least partially worked 80% versus 61%, 84% versus 73%, and 91% versus 82% in the neoadjuvant versus adjuvant groups. Full return to work was observed at 6 months in 52% versus 48%, at 1 year in 71% versus 52%, and at 2 years 82% versus 62%, respectively. Return to work (RTW) started in general in both groups after finishing the systemic therapies.</p><p><strong>Conclusions: </strong>Our data suggest that the manner of therapy (neoadjuvant versus adjuvant) and potentially its treatment duration might be major factors influencing the timing and extent of RTW.</p><p><strong>Implications for cancer survivors: </strong>A faster and full RTW is not only of importance for the patient's well-being and QoL, but has also a significant financial impact on patients and their families.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}