Journal of Cancer Survivorship最新文献

{"title":"Primary care providers and their needs caring for cancer survivors: a qualitative study.","authors":"Jean C Yi, Casey A Walsh, Eric J Chow, K Scott Baker, Jason A Mendoza, Allison Cole","doi":"10.1007/s11764-025-01852-y","DOIUrl":"https://doi.org/10.1007/s11764-025-01852-y","url":null,"abstract":"<p><strong>Purpose: </strong>To enhance survivorship care, we explored primary care providers' (PCPs) preferences and needs related to treatment summary and survivorship care plans (TS/SCPs) as a communication tool and PCPs' general thoughts related to barriers in managing the care of cancer survivors.</p><p><strong>Methods: </strong>We conducted semi-structured qualitative interviews via video with PCPs within primary care practice networks in the Pacific Northwest. A codebook was developed with the interview guide as a template. Directed content analysis was used to analyze PCP reported challenges, supports needed, and TS/SCP feedback.</p><p><strong>Results: </strong>Qualitative interviews were conducted with 18 PCPs. The majority were female (72%) and non-Hispanic White (94%), with 56% from urban areas and with varied amounts of time in clinical practice (median 4.5 years, range 0.5-47). PCPs reported common challenges caring for cancer survivors (e.g., unsure what surveillance is needed) and supports needed to improve care (e.g., further PCP education). PCPs also described preferred information to include in TS/SCPs (e.g., surveillance schedule) and format (e.g., in the electronic health record). They also reported that e-consultation could be useful in communication with other health care providers about any questions, CONCLUSIONS: PCPs want further education and support about cancer surveillance guidelines and managing long-term effects in survivors. Having TS/SCP information easy to find in the EHR was mentioned by the PCPs as something that would improve their care of cancer survivors.</p><p><strong>Implications for cancer survivors: </strong>Providing PCPs with more education and tools in the EHR could lead to improved care of cancer survivors.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of change and predictors of cognitive function in older adults receiving allogeneic hematopoietic cell transplantation using the Montreal cognitive assessment.","authors":"Thuy T Koll, Jillian Timperley, Moataz Ellithi, Vijaya R Bhatt, Hongying Dai, Marcia Free, Amelia L Nelson-Sheese, Patrick J Smith, Lauren Hill, Ernaya Johnson, Rebecca A Shelby, Caroline S Dorfman, Aaron T Zhao, Tanya M Wildes, Daniel L Murman, Alfred L Fisher, Anthony D Sung","doi":"10.1007/s11764-025-01835-z","DOIUrl":"10.1007/s11764-025-01835-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the pattern of change in cognitive function using the Montreal Cognitive Assessment (MoCA) in the context of physical function and identified risk factors for poor cognitive function post allogeneic HCT in adults ≥ 60 years.</p><p><strong>Materials and methods: </strong>This is a two-center prospective cohort study, measuring cognitive and physical function pre-HCT and 3 months post-HCT. A MoCA score of 26 and above is considered normal. We defined mild impairment as a MoCA score of 23-25, and < 23 as moderate impairment. The Sankey plot was generated to assess the transition of impairment status on the MoCA screen from pre-HCT to 3 months post-HCT. The association of predetermined clinical and demographic variables and 3-month cognitive function and cognitive categories was determined using linear mixed-effects model and ordinal logistic regression, respectively. Predetermined variables including physical function, age, gender, education, depressive symptoms, KPS, HCT-CI, disease type, and treatment intensity were used in multivariate analyses.</p><p><strong>Results: </strong>A total of 171 participants were identified. Pre-HCT, 84 (49%) had normal MoCA scores, 51 (30%) had mild, and 36 (21%) had moderate impairment scores. The prevalence of post-HCT mild impairment scores decreased, and moderate impairment scores nearly doubled. Female gender and pre-HCT functional mobility impairment predicted performance on the MoCA post-HCT above and beyond pre-HCT depressive symptoms, comorbid conditions, KPS, and transplant-related factors. Pre-HCT MoCA and functional mobility scores also predicted post-HCT cognitive categories (normal, mild and moderate impairment).</p><p><strong>Conclusion: </strong>Our findings suggest that the pre-HCT MoCA screen can identify those at risk for cognitive impairment post-HCT and can help monitor cognitive function post-HCT.</p><p><strong>Implications for cancer survivors: </strong>Employing the widely used MoCA threshold for impairment (MoCA < 26) could fail to identify a subgroup requiring intervention and monitoring.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are guidelines guiding? A mixed methods study examining the integration of ASCO fertility discussion guidelines in practice among oncologists and adolescents and young adults at an NCI-designated Comprehensive Cancer Center.","authors":"Julia Stal, Serena Y Yi, Charleen I Roche, David R Freyer, Sue E Kim, Joel E Milam, Gino K In, Kimberly A Miller","doi":"10.1007/s11764-025-01850-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01850-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the integration of American Society of Clinical Oncology (ASCO) guidelines for fertility discussion in clinical practice.</p><p><strong>Methods: </strong>A concurrent triangulation mixed methods design was used. We recruited oncologists from an NCI-designated Comprehensive Cancer Center who treat adolescents and young adults (AYAs) at risk for infertility to participate in a semi-structured qualitative interview and conducted a thematic analysis. Simultaneously, self-report fertility-related data were collected from AYAs (age 18-39) diagnosed at the same institution via self-report survey and were analyzed using descriptive statistics.</p><p><strong>Results: </strong>Themes reported by oncologists (N = 12; 66.7% female, on average in practice for 14.3 years) included a lack of oncofertility-related training and limited knowledge surrounding fertility discussion guidelines. Those who were aware of guidelines stated that they informed their discussions. Oncologists' perceptions of fertility discussion guidelines were largely positive, though reservations were expressed. Discussions were primarily informed by patient needs and research/literature, but seldom by oncologists' explicit training or experience in oncofertility. Among AYAs (N = 58; 53.5% female, 35.1% Hispanic, on average 32.0 years at diagnosis), 82.3% had a fertility discussion, 62.6% of which occurred with their oncologist. Fertility discussions occurred at some visits (66.7%), and AYAs were very (39.4%) or moderately (27.3%) satisfied with counseling received. Components of ASCO guidelines most often discussed were the timing of preservation and consideration of individual factors in fertility preservation (66.7% each). Patient advocacy resources (33.3%) and informing them that their cancer history does not increase risk of cancer or birth defects in a child (30.3%) were least often discussed.</p><p><strong>Conclusion: </strong>Awareness of fertility discussion guidelines among oncologists was low, and more than half of AYAs reported only two components of ASCO guidelines were included in fertility discussions with their oncologists. Despite this, AYAs' overall satisfaction with discussions was moderate to high, suggesting adherence to all guideline components may not be necessary for AYAs to derive benefit. While oncologists reported largely positive perceptions of fertility discussion guidelines, several shared that the guidelines themselves may hinder implementation if they do not capture diverse patient scenarios and/or are outdated.</p><p><strong>Implications for cancer survivors: </strong>Findings suggest a need to improve oncologists' knowledge surrounding guidelines, refine recommendations to optimize oncofertility counseling, and subsequently improve their integration in practice to ensure AYAs are provided with desired and actionable information to support goal-concordant reproductive decisions.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body image of patients in follow-up for pediatric bone sarcoma: implications of tumor location and local therapy.","authors":"Hinke van der Hoek, Leonie G Tigelaar, Heleen Maurice-Stam, Laura R Beek, Jennifer van Dijk, Marjolein E M Langemeijer, Relinde W Slooff-Lentink, Alied M van der Aa-van Delden, W Peter Bekkering, Irene L B Oude Lansink, Christel D Rohrich, Jos A M Bramer, Michiel A J van de Sande, H W Bart Schreuder, Lianne M Haveman, Johannes H M Merks, Martha A Grootenhuis","doi":"10.1007/s11764-025-01847-9","DOIUrl":"https://doi.org/10.1007/s11764-025-01847-9","url":null,"abstract":"<p><strong>Purpose: </strong>Bone sarcomas often arise during adolescence, a crucial period for psychosocial development. Treatment requires local therapy, which frequently involves body-altering surgery. Therefore, we aim to evaluate this population's body image and perceived physical appearance, and explore its relationship with tumor location, surgery type for tumors around the knee, and psychological difficulties.</p><p><strong>Methods: </strong>Patients treated for pediatric bone sarcoma in the lower extremity, pelvis, or upper extremity and ≥ 2 years post-diagnosis completed the Perceived Physical Appearance Scale of the PedsQL Cancer Module (PedsQL-CM-PPA; 0 = worse,100 = good), Body Image Scale (BIS; 0 = good, 30 = worse, cut-off ≥ 10), and Emotion Thermometers (ET). The relationship with tumor location and surgery type for tumors around the knee was assessed by linear regression analyses controlled for age, sex, and time since local therapy. Pearson correlations evaluated associations with psychological difficulties (ET).</p><p><strong>Results: </strong>Patients (n = 132, 47% female) were on average 20.5 years old and 7.8 years after local therapy. Mean PedsQL-CM-PPA score was 72.0 (SD = 23.0), with amputation patients scoring higher (81.8; p = 0.02), while rotationplasty patients (70.8) and those after limb-sparing surgery (65.9) scored similarly. Mean BIS score was 8.4 (SD = 6.8), with 37% scoring ≥ 10. BIS scores did not differ between groups. PedsQL-CM-PPA and BIS scores significantly correlated with psychosocial difficulties.</p><p><strong>Conclusion: </strong>Body image, perceived physical appearance, and their relationship with psychological difficulties should be carefully addressed in counseling during shared decision-making for local therapy options and follow-up care. Since these outcomes are influenced by more than just medical factors, patient preferences and personal factors should be central to these discussions.</p><p><strong>Implications for cancer survivors: </strong>Body image concerns and perceived physical appearance may persist long after treatment and are not solely related to surgery type. Addressing these issues in follow-up care is essential to support survivors' long-term well-being.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life of long-term adolescent and young adult (AYA) cancer survivors compared to a matched normative population: results of the SURVAYA study.","authors":"Silvie H M Janssen, Carla Vlooswijk, Rhodé M Bijlsma, Suzanne E J Kaal, Jan Martijn Kerst, Jacqueline M Tromp, Monique E M M Bos, Tom van der Hulle, Roy I Lalisang, Janine Nuver, Mathilde C M Kouwenhoven, Winette T A van der Graaf, Olga Husson","doi":"10.1007/s11764-025-01818-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01818-0","url":null,"abstract":"<p><strong>Purpose: </strong>Health-related quality of life (HRQoL) is a commonly assessed patient-reported outcome that might be especially relevant for the adolescent and young adult (AYA) cancer survivor population. However, limited data is available regarding the HRQoL of long-term AYA cancer survivors compared to a matched normative population and associated factors.</p><p><strong>Methods: </strong>AYA cancer survivors (18-39 years at initial diagnosis; 5-20 years post-diagnosis), identified by the Netherlands Cancer Registry (NCR), were invited for participation in the SURVAYA questionnaire study. Participants self-reported their socio-demographics, health-related conditions, healthcare use, positive life outlook, and HRQoL (EORTC QLQ-C30). An age- and sex-matched normative population was randomly composed. Clinical data were retrieved from the NCR.</p><p><strong>Results: </strong>A total of 3745 AYAs (on average 32 years old at diagnosis, 12 years post-diagnosis) and 517 peers without cancer (normative population) were included. All functioning scales showed significant differences, with AYA cancer survivors scoring lower: cognitive (77.9 vs. 92.2), role (83.2 vs. 91.3), social (87.9 vs. 93.6), physical (91.5 vs. 94.3), and emotional functioning (79.5 vs. 83.4). No significant difference was observed in global QoL. Female sex, lower educational attainment, older age at diagnosis, several tumor types, radiotherapy, chemotherapy, higher stage, more health-related conditions, and more healthcare visits were negatively associated with several HRQoL scales.</p><p><strong>Conclusions: </strong>AYA cancer survivors face worse HRQoL compared to peers in all functioning domains, but it is most pronounced in cognitive functioning. This study underlines the need for timely cancer survivorship care to regain, improve, and ensure the quality of life of current and future AYA cancer survivors.</p><p><strong>Clinical trial registration: </strong>NCT05379387.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and factors associated with clinically important levels of fatigue, pain, and insomnia in survivors of cancer: a population-based cross-sectional study.","authors":"Anne Katrine Graudal Levinsen, Susanne Oksbjerg Dalton, Erik Jakobsen, Ismail Gögenur, Michael Borre, Robert Zachariae, Peter Christensen, Søren Laurberg, Peter de Nully Brown, Lisbet Rosenkrantz Hölmich, Christoffer Johansen, Susanne K Kjær, Lonneke van de Poll-Franse, Trille Kristina Kjaer","doi":"10.1007/s11764-025-01851-z","DOIUrl":"https://doi.org/10.1007/s11764-025-01851-z","url":null,"abstract":"<p><strong>Purpose: </strong>To identify risk factors and patient characteristics in survivors who report clinically important fatigue, pain, and insomnia.</p><p><strong>Methods: </strong>Cross-sectional study including 39,374 survivors of breast, prostate, lung, colon, rectum cancer, melanoma, and lymphoma diagnosed at age 40 or older between Jan 2010 and Dec 2019. Prevalences and odds ratios (ORs) with 95% confidence intervals (CI) for clinically important fatigue, pain, and insomnia by sociodemographic, clinical, and lifestyle factors were calculated.</p><p><strong>Results: </strong>Among all survivors, 42% reported clinically important fatigue, pain, or insomnia, and 21% reported concurring symptoms. Prevalences were highest in women, survivors of breast and lung cancer, with short education, low income, comorbidity, obesity, and smokers. Adjusted analyses showed increased odds in women (OR fatigue 1.46, 95% CI 1.39-1.54; OR pain 1.62, 95% CI 1.55-1.70; OR insomnia 2.11, 95% CI 1.99-2.24), survivors with comorbidity (OR fatigue 2.97, 95% CI 2.78-3.18; OR pain 2.13, 95% CI 2.00-2.27; OR insomnia 1.67, 95% CI 1.55-1.80), smokers (OR fatigue 1.96, 95% CI 1.80-2.13; OR pain 1.67, 95% CI 1.55-1.81; OR insomnia 1.46, 95% CI 1.33-1.60), and survivors with obesity (OR fatigue 1.92, 95% CI 1.80-2.06; OR pain 2.21, 95% CI 2.08-2.35; OR insomnia 1.32, 95% CI 1.22-1.42).</p><p><strong>Conclusions: </strong>Clinically important fatigue, pain, or insomnia are common in survivors of cancer, and two in five report two or all three late effects. Report of these symptoms is associated with social and clinical vulnerability factors.</p><p><strong>Implication for cancer survivors: </strong>Management of survivorship care requires targeted consideration of the complexity and overall impact of these late effects.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Let's talk about risk\": co-designing a pathway to assess, communicate and act on individual risk of long-term toxicities after breast cancer.","authors":"Maria Alice Franzoi, Carlota Santolaya, Elise Martin, Leonor Fasse, Pascal Rouby, Marie Sophie Minot-This, Antonio Di Meglio, Ines Vaz-Luis","doi":"10.1007/s11764-025-01826-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01826-0","url":null,"abstract":"<p><strong>Purpose: </strong>Survivors of breast cancer (BC) may endure significant and persistent post-treatment burdens that negatively impact overall quality of life. We previously developed risk prediction algorithms to identify individual patient profiles at increased risk for long-term toxicities. To prepare for the implementation of these risk algorithms in routine care, we performed a study to assess preferences, catalysts, and barriers concerning communication of individual risk of long-term BC toxicities. The goal was to co-design a pathway for risk assessment, communication, and management starting at diagnosis.</p><p><strong>Methods: </strong>A co-design study was performed using a participatory research framework and qualitative methods. Two phases of focus groups (FG) were conducted to assess the perspective of patients and providers through an iterative process of Exploration, Consultation, Prioritization, Integration and Co-design. Discussions were guided by four main questions: Who should communicate the risk? When should the risk be communicated? How should the risk be communicated? What information should be communicated, and care proposed?. FG discussions were recorded, pseudo-anonymized, transcribed and evaluated through a thematic content analysis. Results were reported following the consolidated criteria for reporting qualitative research (COREQ).</p><p><strong>Results: </strong>Six FG were conducted between July 2022 and August 2023, with a total of 28 participants (8 patients and 20 providers). Results revealed a strong willingness to discuss the risk of long-term toxicities, particularly for patients who would present with a higher risk of toxicities. However, this willingness was contingent on the implementation of supportive care pathways that offer personalized communication strategies and risk mitigation approaches tailored to each patient's need.</p><p><strong>Conclusions: </strong>This study found that both patients and providers are interested in, and willing to engage in, the assessment, communication and mitigation of long-term toxicities from the time of diagnosis. To address this need in routine care, a tailored pathway was co-designed and will undergo formal testing in a hybrid Type 3 effectiveness/implementation clinical trial (NCT06479057).</p><p><strong>Implications for cancer survivors: </strong>This study assessed the needs, preferences and expectations of patients and providers for implementing a care pathway to assess, communicate and mitigate the risk of long-term toxicities after breast cancer treatment using risk prediction algorithms.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Employing skin self-examination and fear of cancer recurrence management in early-stage melanoma follow-up: evaluation of the MELACARE intervention in a randomised controlled trial.","authors":"Sara Mølgaard Hansen, Christoffer Johansen, Nadine A Kasparian, Mia Klinten Grand, Pernille Envold Bidstrup, Lisbet Rosenkrantz Hölmich","doi":"10.1007/s11764-025-01841-1","DOIUrl":"https://doi.org/10.1007/s11764-025-01841-1","url":null,"abstract":"<p><strong>Purpose: </strong>The MELACARE intervention aimed to evaluate a nurse-led follow-up program incorporating skin self-examination (SSE) education and psychosocial support to address fear of cancer recurrence (FCR) in early-stage melanoma survivors. This study assessed the MELACARE intervention's impact on FCR, psychological well-being, SSE performance, and healthcare usage compared to standard physician-led follow-up.</p><p><strong>Methods: </strong>A two-group randomised controlled trial was conducted at Herlev and Gentofte Hospital, Denmark. Participants included 153 patients with surgically treated melanoma (stages IA-IIA). Patients were randomised to either the MELACARE intervention (n = 78) or a control group provided treatment as usual (n = 75). The intervention involved nurse-led sessions focusing on SSE techniques and metacognitive strategies. Outcomes included FCR (primary), distress, anxiety, depression, health-related quality of life (HRQoL), patient activation, and SSE frequency and confidence (secondary) at 6 months.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov (NCT05253872).</p><p><strong>Results: </strong>At 6 months, the mean of the primary outcome FCR was lower in the intervention compared to the control groups, but the difference was not statistically significant (- 0.86 [- 3.34;1.62]). Intervention patients reported higher HRQoL (18% [3;32]) and patient activation (0.43 [0.15;0.71]) as the only significant secondary outcomes. Confidence in SSE was higher in the intervention group, with most performing SSE at recommended intervals.</p><p><strong>Conclusions: </strong>The MELACARE intervention may improve HRQoL and patient activation but did not reduce FCR. High fidelity of delivery and patient adherence highlight its potential utility.</p><p><strong>Implications for cancer survivors: </strong>The MELACARE approach empowers melanoma survivors through structured SSE education and psychosocial support. Future analyses will investigate long-term safety and efficacy.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a physical activity intervention on sleep among cancer survivors in a randomized controlled trial within the Cancer Prevention Study-3 cohort.","authors":"Charlie Zhong, Mariah Landry, Scott Whalen, Amber Grant, Ananya G Reddy, Sidney M Donzella, Anita R Peoples, Alpa V Patel, Erika Rees-Punia","doi":"10.1007/s11764-025-01837-x","DOIUrl":"https://doi.org/10.1007/s11764-025-01837-x","url":null,"abstract":"<p><strong>Purpose: </strong>Poor sleep is a long-term sequela of cancer and its treatment. Moderate-to-vigorous physical activity (MVPA) is associated with improved health outcomes among cancer survivors and has been suggested as a nonpharmacological method to improving sleep. We evaluated the efficacy of a MVPA intervention to improve sleep among cancer survivors.</p><p><strong>Methods: </strong>We conducted a randomized controlled trial among 415 cancer survivors embedded within the Cancer Prevention Study-3 cohort. Survivors were randomized to a year-long, web-based MVPA program. MVPA was assessed via hip-worn actigraphy at baseline, 3 months, 6 months, and 1 year. We evaluated sleep through the SATED sleep health questionnaire, PROMIS Sleep Disturbance Scale, and device-measured duration and efficiency. An intent-to-treat (ITT) analysis was performed, and secondary analyses were conducted based on measured MVPA levels with generalized additive mixed-effects models.</p><p><strong>Results: </strong>Survivors reported similar sleep health and patterns to the general US population. We observed no significant changes to sleep between treatment groups in ITT models. Though not statistically significant, there appeared to be heterogeneity based on baseline sleep disturbance (moderate-to-severe sleep disturbance: β_SATED = 0.73 (95% CI - 0.09, 1.60) vs mild-to-normal sleep disturbance: β_SATED = - 0.26 (95% CI - 0.57, 0.05)). Participants that engaged in more MVPA at the end of the trial reported better sleep health (p-value = 0.04) and less sleep disturbances (p-value = 0.11).</p><p><strong>Conclusions: </strong>The MVPA intervention was more effective at improving sleep among survivors with sleep disturbances at baseline. Increasing MVPA improved sleep among cancer survivors IMPLICATIONS FOR CANCER SURVIVORS: Increasing MVPA among cancer survivors with sleep disturbances may be a viable strategy for improving sleep.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partnership and fatherhood outcomes in young men diagnosed with cancer: a nationwide register-based study.","authors":"Line Bentsen, Helle Pappot, Kirsten Tryde Macklon, Lone Schmidt, Ditte Vassard","doi":"10.1007/s11764-025-01849-7","DOIUrl":"https://doi.org/10.1007/s11764-025-01849-7","url":null,"abstract":"<p><strong>Purpose: </strong>A cancer diagnosis during young adulthood can impact identity, relationships, and family building. While young men with cancer face fertility risks, data on fatherhood and partnership outcomes remain limited. This study aimed to examine the hazard ratios (HRs) for fatherhood and partnership formation in young men diagnosed with cancer compared to age-matched comparisons.</p><p><strong>Methods: </strong>This nationwide register-based study, based on the DANAC II cohort, included men diagnosed with cancer at 18-39 years (1978-2016) and age-matched male comparisons. Cox regression models estimated HRs of fatherhood and partnership formation, adjusting for time of diagnosis or study entry, immigration status, and pre-diagnosis children.</p><p><strong>Results: </strong>Among 16,913 men with cancer and 1,353,040 comparisons, those with cancer had a lower HR of fatherhood (0.88 [95% confidence interval (CI) 0.86-0.91]), the lowest among men with lymphoma, central-nerve system (CNS), and gastrointestinal cancers. Fatherhood probabilities improved over time, with older men showing the greatest gains. Among men who were single at diagnosis or study entry, the HR for partnership formation was similar to the comparison group (1.03 [95% CI 0.99-1.07]), except for those with gastrointestinal or CNS cancers.</p><p><strong>Conclusions: </strong>Fatherhood HRs were generally lower than in comparisons, varying by cancer group, age, and diagnosis period. However, single men diagnosed with cancer typically formed partnerships similar to the comparisons.</p><p><strong>Implications for cancer survivors: </strong>The lower probability of fatherhood highlights the need for and importance of oncofertility counseling, timely fertility preservation referrals, and follow-up care tailored to cancer groups and age at diagnosis.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}