Journal of Cancer Survivorship最新文献

{"title":"Risky, protective, and screening health behaviours among childhood cancer survivors: A cross-sectional survey in Australia and New Zealand.","authors":"Lauren Ha, Christina Signorelli, Jordana K McLoone, Claire E Wakefield, Joseph E Alchin, Venkatesha Venkatesha, Richard J Cohn, Joanna E Fardell","doi":"10.1007/s11764-025-01858-6","DOIUrl":"https://doi.org/10.1007/s11764-025-01858-6","url":null,"abstract":"<p><strong>Purpose: </strong>Childhood cancer survivors are at risk of late effects. Engaging in health behaviours may reduce this risk. We aimed to investigate engagement in risky (alcohol consumption, smoking), protective (sun protection, physical activity, dental hygiene), and screening (cervical screening, skin examinations) behaviours between survivors and an age- and sex-matched control group.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey in childhood cancer survivors (aged 16 + years) who were 5 + years post-diagnosis, proxy report of parents of survivors (aged < 16 years) and age- and sex-matched non-cancer controls. We compared survivor responses to the Children's Oncology Group Long-Term Follow-Up Guidelines.</p><p><strong>Results: </strong>612 survivors (median age = 19, range = 7-61; 49% male) and 423 controls (median = 21, range = 0-45; 51.5% male) were included in our analysis. Survivors were more likely to smoke less (p < .001), floss less (p < .05), use sunscreen (p < .001), wear protective clothing (p < .001), stay in the shade less (p < .01), and engage in skin examinations (p < .001), compared to controls. Most survivors met alcohol (72%), smoking (93%) and sunscreen (66%) guidelines. Fewer survivors met guidelines for physical activity (31%), flossing (4%), wearing a hat for sun protection (40%), skin examinations (40%) and cervical screening (43%). Survivors who were older age, female sex and had higher income were associated with meeting all health behaviour guidelines.</p><p><strong>Conclusions: </strong>Many survivors do not meet protective and screening behaviour recommended guidelines.</p><p><strong>Implications for cancer survivors: </strong>Engagement in multiple positive health behaviours is critical for this population who are at increased risk of developing long-term health issues.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survivors' perspectives on cisplatin-induced ototoxicity and barriers to ototoxicity monitoring.","authors":"David S Lee, Lauren Mueller, Susan K Wong, Emma Y Travis, Marie-Ange Munyemana, Angela L Mazul, Katrina S McClannahan, Donna B Jeffe, Judith E Lieu","doi":"10.1007/s11764-025-01860-y","DOIUrl":"https://doi.org/10.1007/s11764-025-01860-y","url":null,"abstract":"<p><strong>Purpose: </strong>Cisplatin-based chemoradiation therapy (CRT) causes ototoxicity in survivors of head and neck (H&N) cancer, but rates of audiologic follow-up are poor. Our objective is to identify (1) QOL domains that are affected by treatment-related ototoxicity and (2) barriers to ototoxicity monitoring among survivors of H&N cancer to inform patient-centered interventions that reduce undiagnosed and untreated ototoxicity in survivorship.</p><p><strong>Methods: </strong>A qualitative study using semi-structured focus groups was conducted from March 2023 to September 2023 on survivors of H&N cancer treated with cisplatin-based CRT at a single tertiary care center. Inductive thematic analysis was used to identify themes related to the effect of ototoxicity on QOL and barriers to ototoxicity monitoring.</p><p><strong>Results: </strong>Seven focus groups ranging from 1 to 4 participants were conducted on 18 total participants (median age = 58 (range 45-67); 13 (72%) male; 16 (89%) white). Themes regarding ototoxicity and its effects on QOL included (1) social isolation, (2) emotional distress, (3) adaptive behaviors, and (4) that the impact is context-dependent. Themes regarding barriers to ototoxicity monitoring included (5) inconsistent referral to audiology; (6) the lack of patient education; (7) socioeconomic factors; and (8) hesitancy towards hearing aids.</p><p><strong>Conclusions: </strong>Treatment-related ototoxicity has long-term implications for poorer QOL in H&N cancer survivorship. However, the negative impact of ototoxicity changes over time and depends on multiple patient-related factors.</p><p><strong>Implications for cancer survivors: </strong>Monitoring programs might seek to develop protocols to routinely screen H&N cancer survivors for ototoxicity and provide referrals and patient education material to improve audiologic follow-up. Such protocols may decrease rates of undiagnosed and untreated hearing loss in this patient population.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective multi-institutional assessment of breast radiology and pathology report readability and a novel patient tool (MedEd) utilizing American literacy standards.","authors":"Samantha Greenseid, Gande Li, Olivia Mihulka, Arianna Vazquez, Alex Verosky, Salvador Rodriguez Franco, Samhita Bheemireddy, Madeline G Higgins, Sarah Leslie, Sarah Tevis, Kristin Rojas","doi":"10.1007/s11764-025-01842-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01842-0","url":null,"abstract":"<p><strong>Background: </strong>Health literacy is a critical factor in patient engagement and outcomes during cancer survivorship. With the 21st Century Cures Act, patients now receive immediate access to radiology and pathology reports, yet these documents often exceed the 6th-grade reading level recommended by the American Medical Association. While prior studies have examined general breast cancer materials, the readability of individualized clinical reports remains unexplored.</p><p><strong>Methods: </strong>In this multi-institutional retrospective study, 120 de-identified breast radiology and pathology reports from the University of Colorado and the University of Miami were analyzed across six report types. Readability was assessed using six validated indices. Additionally, 98 MedEd definitions and 96 MedEd-directed online patient education materials (OPEMs) were evaluated. MedEd is a Chrome plug-in designed to highlight key breast health terms and provide physician-curated definitions with links to vetted educational content.</p><p><strong>Results: </strong>Across institutions, most clinical reports exceeded a high school reading level, with surgical pathology reports being the least accessible. MedEd definitions and OPEMs demonstrated better readability but still surpassed the recommended 6th-grade level.</p><p><strong>Conclusions: </strong>Breast cancer-related reports and educational materials remain difficult for many survivors to comprehend. Improved design of patient-facing tools-potentially through AI integration and patient co-development-may enhance accessibility, empowerment, and shared decision-making.</p><p><strong>Implications for cancer survivors: </strong>This study underscores a critical gap between the readability of breast radiology and pathology reports and the literacy levels of many cancer survivors. As patients gain immediate access to these documents through electronic portals, the complexity of medical language can lead to confusion, anxiety, and disengagement from care. Survivors may be particularly vulnerable during post-treatment surveillance when understanding follow-up imaging and pathology is vital for shared decision-making. Tools like MedEd-while promising-must continue to evolve to meet national literacy standards. Simplifying medical reports and integrating patient-centered, Al-supported education tools can enhance survivors' comprehension, foster autonomy, and ultimately improve their confidence and outcomes throughout survivorship.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavior change techniques in physical activity and dietary interventions among adolescent and young adult cancer survivors: a systematic review and meta-analysis of randomized controlled trials.","authors":"Erin M Coffman, Susanna M Choi, Andrew B Smitherman, Erik A Willis, Stephanie L Martin, Deborah F Tate, Carmina G Valle","doi":"10.1007/s11764-025-01836-y","DOIUrl":"https://doi.org/10.1007/s11764-025-01836-y","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to synthesize the evidence from physical activity (PA) and dietary behavior change interventions designed specifically for adolescent and young adult (AYAs) cancer survivors. We identified study characteristics and behavior change techniques (BCTs), examined intervention effectiveness, and explored study characteristics and BCTs associated with effectiveness.</p><p><strong>Methods: </strong>A comprehensive search of multiple databases was conducted (March 2024) for randomized controlled trials (RCTs) conducted among post-treatment cancer survivors diagnosed during adolescence or young adulthood (15-39 years), comparing PA or dietary outcomes. Two reviewers screened all studies, extracted data, and characterized interventions by BCTs. Analyses weighted effect sizes (Hedges g) by their inverse variance and combine them using multilevel random effects meta-analytic procedures. Random effects univariate regressions examined the association between study characteristics, BCTs, and effectiveness.</p><p><strong>Results: </strong>Fourteen RCTs (n = 1169) were included for review. All studies had multiple outcomes of interest, including PA; two included dietary components. There was a significant overall intervention effect on PA (0.378, 95% CI, 0.183-0.573; p = 0.002). Significant moderators were the type of PA outcome assessed, the use of two behavioral theories, and biofeedback. Other BCTs showed notable differences in effect size, though not significant.</p><p><strong>Discussion: </strong>Interventions improved PA outcomes in AYA cancer survivors. Most studies were pilot or feasibility trials, lasting three months. Future research should prospectively identify BCTs and examine their effects post-intervention. Interventions targeting both PA and dietary behaviors are lacking.</p><p><strong>Implications for cancer survivors: </strong>There is a need for behavioral interventions designed specifically to meet the unique needs of AYA cancer survivors and future studies should include PA and dietary components, larger and more diverse samples, and longer follow-up periods.</p><p><strong>Registration: </strong>PROSPERO (reference: CRD42022198889).</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of resilience in the association between stigma and psychosocial adjustment among young and middle-aged patients with lung cancer.","authors":"Ziyun Li, Shuangni Huang, Jiudi Zhong, June Zhang","doi":"10.1007/s11764-025-01853-x","DOIUrl":"https://doi.org/10.1007/s11764-025-01853-x","url":null,"abstract":"<p><strong>Purpose: </strong>This cross-sectional study aimed to examine the level of psychosocial adjustment among young and middle-aged patients with lung cancer, explore the influencing factors of psychosocial adjustment, and identify the mediating role of resilience between stigma and psychosocial adjustment.</p><p><strong>Methods: </strong>Between October 2022 and October 2023, data were collected using a self-designed demographic and disease-related questionnaire, the Psychosocial Adjustment to Illness Scale-Self-Report (PAIS-SR), Social Impact Scale (SIS), and Connor-Davidson Resilience Scale (CD-RISC). The sample comprised 245 patients with lung cancer recruited from a tertiary grade A cancer center in southern China. To analyze the data, hierarchical multiple regression analyses were used, and the mediation Model 4 of the PROCESS macro in SPSS was implemented.</p><p><strong>Results: </strong>Participants (42.9%) had moderate or severe psychosocial maladjustment. Financial stress, cancer stage, time since treatment completion, dyspnea, stigma, and resilience were included in the final regression model and explained 46.2% of the variance of psychosocial adjustment. The total and direct effects of stigma on psychosocial adjustment were significant, and a positive indirect effect was identified for stigma on psychosocial adjustment via resilience.</p><p><strong>Conclusions: </strong>Stigma had a negative impact on psychosocial adjustment among young and middle-aged lung cancer patients, while resilience had a partial mediating effect on the relationship between stigma and psychosocial adjustment.</p><p><strong>Implications for cancer survivors: </strong>Targeted psychosocial interventions should be developed to alleviate stigma, enhance psychological resilience, and ultimately support patients' reintegration into society and their return to normal life.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary care providers and their needs caring for cancer survivors: a qualitative study.","authors":"Jean C Yi, Casey A Walsh, Eric J Chow, K Scott Baker, Jason A Mendoza, Allison Cole","doi":"10.1007/s11764-025-01852-y","DOIUrl":"https://doi.org/10.1007/s11764-025-01852-y","url":null,"abstract":"<p><strong>Purpose: </strong>To enhance survivorship care, we explored primary care providers' (PCPs) preferences and needs related to treatment summary and survivorship care plans (TS/SCPs) as a communication tool and PCPs' general thoughts related to barriers in managing the care of cancer survivors.</p><p><strong>Methods: </strong>We conducted semi-structured qualitative interviews via video with PCPs within primary care practice networks in the Pacific Northwest. A codebook was developed with the interview guide as a template. Directed content analysis was used to analyze PCP reported challenges, supports needed, and TS/SCP feedback.</p><p><strong>Results: </strong>Qualitative interviews were conducted with 18 PCPs. The majority were female (72%) and non-Hispanic White (94%), with 56% from urban areas and with varied amounts of time in clinical practice (median 4.5 years, range 0.5-47). PCPs reported common challenges caring for cancer survivors (e.g., unsure what surveillance is needed) and supports needed to improve care (e.g., further PCP education). PCPs also described preferred information to include in TS/SCPs (e.g., surveillance schedule) and format (e.g., in the electronic health record). They also reported that e-consultation could be useful in communication with other health care providers about any questions, CONCLUSIONS: PCPs want further education and support about cancer surveillance guidelines and managing long-term effects in survivors. Having TS/SCP information easy to find in the EHR was mentioned by the PCPs as something that would improve their care of cancer survivors.</p><p><strong>Implications for cancer survivors: </strong>Providing PCPs with more education and tools in the EHR could lead to improved care of cancer survivors.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of change and predictors of cognitive function in older adults receiving allogeneic hematopoietic cell transplantation using the Montreal cognitive assessment.","authors":"Thuy T Koll, Jillian Timperley, Moataz Ellithi, Vijaya R Bhatt, Hongying Dai, Marcia Free, Amelia L Nelson-Sheese, Patrick J Smith, Lauren Hill, Ernaya Johnson, Rebecca A Shelby, Caroline S Dorfman, Aaron T Zhao, Tanya M Wildes, Daniel L Murman, Alfred L Fisher, Anthony D Sung","doi":"10.1007/s11764-025-01835-z","DOIUrl":"10.1007/s11764-025-01835-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the pattern of change in cognitive function using the Montreal Cognitive Assessment (MoCA) in the context of physical function and identified risk factors for poor cognitive function post allogeneic HCT in adults ≥ 60 years.</p><p><strong>Materials and methods: </strong>This is a two-center prospective cohort study, measuring cognitive and physical function pre-HCT and 3 months post-HCT. A MoCA score of 26 and above is considered normal. We defined mild impairment as a MoCA score of 23-25, and < 23 as moderate impairment. The Sankey plot was generated to assess the transition of impairment status on the MoCA screen from pre-HCT to 3 months post-HCT. The association of predetermined clinical and demographic variables and 3-month cognitive function and cognitive categories was determined using linear mixed-effects model and ordinal logistic regression, respectively. Predetermined variables including physical function, age, gender, education, depressive symptoms, KPS, HCT-CI, disease type, and treatment intensity were used in multivariate analyses.</p><p><strong>Results: </strong>A total of 171 participants were identified. Pre-HCT, 84 (49%) had normal MoCA scores, 51 (30%) had mild, and 36 (21%) had moderate impairment scores. The prevalence of post-HCT mild impairment scores decreased, and moderate impairment scores nearly doubled. Female gender and pre-HCT functional mobility impairment predicted performance on the MoCA post-HCT above and beyond pre-HCT depressive symptoms, comorbid conditions, KPS, and transplant-related factors. Pre-HCT MoCA and functional mobility scores also predicted post-HCT cognitive categories (normal, mild and moderate impairment).</p><p><strong>Conclusion: </strong>Our findings suggest that the pre-HCT MoCA screen can identify those at risk for cognitive impairment post-HCT and can help monitor cognitive function post-HCT.</p><p><strong>Implications for cancer survivors: </strong>Employing the widely used MoCA threshold for impairment (MoCA < 26) could fail to identify a subgroup requiring intervention and monitoring.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are guidelines guiding? A mixed methods study examining the integration of ASCO fertility discussion guidelines in practice among oncologists and adolescents and young adults at an NCI-designated Comprehensive Cancer Center.","authors":"Julia Stal, Serena Y Yi, Charleen I Roche, David R Freyer, Sue E Kim, Joel E Milam, Gino K In, Kimberly A Miller","doi":"10.1007/s11764-025-01850-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01850-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the integration of American Society of Clinical Oncology (ASCO) guidelines for fertility discussion in clinical practice.</p><p><strong>Methods: </strong>A concurrent triangulation mixed methods design was used. We recruited oncologists from an NCI-designated Comprehensive Cancer Center who treat adolescents and young adults (AYAs) at risk for infertility to participate in a semi-structured qualitative interview and conducted a thematic analysis. Simultaneously, self-report fertility-related data were collected from AYAs (age 18-39) diagnosed at the same institution via self-report survey and were analyzed using descriptive statistics.</p><p><strong>Results: </strong>Themes reported by oncologists (N = 12; 66.7% female, on average in practice for 14.3 years) included a lack of oncofertility-related training and limited knowledge surrounding fertility discussion guidelines. Those who were aware of guidelines stated that they informed their discussions. Oncologists' perceptions of fertility discussion guidelines were largely positive, though reservations were expressed. Discussions were primarily informed by patient needs and research/literature, but seldom by oncologists' explicit training or experience in oncofertility. Among AYAs (N = 58; 53.5% female, 35.1% Hispanic, on average 32.0 years at diagnosis), 82.3% had a fertility discussion, 62.6% of which occurred with their oncologist. Fertility discussions occurred at some visits (66.7%), and AYAs were very (39.4%) or moderately (27.3%) satisfied with counseling received. Components of ASCO guidelines most often discussed were the timing of preservation and consideration of individual factors in fertility preservation (66.7% each). Patient advocacy resources (33.3%) and informing them that their cancer history does not increase risk of cancer or birth defects in a child (30.3%) were least often discussed.</p><p><strong>Conclusion: </strong>Awareness of fertility discussion guidelines among oncologists was low, and more than half of AYAs reported only two components of ASCO guidelines were included in fertility discussions with their oncologists. Despite this, AYAs' overall satisfaction with discussions was moderate to high, suggesting adherence to all guideline components may not be necessary for AYAs to derive benefit. While oncologists reported largely positive perceptions of fertility discussion guidelines, several shared that the guidelines themselves may hinder implementation if they do not capture diverse patient scenarios and/or are outdated.</p><p><strong>Implications for cancer survivors: </strong>Findings suggest a need to improve oncologists' knowledge surrounding guidelines, refine recommendations to optimize oncofertility counseling, and subsequently improve their integration in practice to ensure AYAs are provided with desired and actionable information to support goal-concordant reproductive decisions.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body image of patients in follow-up for pediatric bone sarcoma: implications of tumor location and local therapy.","authors":"Hinke van der Hoek, Leonie G Tigelaar, Heleen Maurice-Stam, Laura R Beek, Jennifer van Dijk, Marjolein E M Langemeijer, Relinde W Slooff-Lentink, Alied M van der Aa-van Delden, W Peter Bekkering, Irene L B Oude Lansink, Christel D Rohrich, Jos A M Bramer, Michiel A J van de Sande, H W Bart Schreuder, Lianne M Haveman, Johannes H M Merks, Martha A Grootenhuis","doi":"10.1007/s11764-025-01847-9","DOIUrl":"https://doi.org/10.1007/s11764-025-01847-9","url":null,"abstract":"<p><strong>Purpose: </strong>Bone sarcomas often arise during adolescence, a crucial period for psychosocial development. Treatment requires local therapy, which frequently involves body-altering surgery. Therefore, we aim to evaluate this population's body image and perceived physical appearance, and explore its relationship with tumor location, surgery type for tumors around the knee, and psychological difficulties.</p><p><strong>Methods: </strong>Patients treated for pediatric bone sarcoma in the lower extremity, pelvis, or upper extremity and ≥ 2 years post-diagnosis completed the Perceived Physical Appearance Scale of the PedsQL Cancer Module (PedsQL-CM-PPA; 0 = worse,100 = good), Body Image Scale (BIS; 0 = good, 30 = worse, cut-off ≥ 10), and Emotion Thermometers (ET). The relationship with tumor location and surgery type for tumors around the knee was assessed by linear regression analyses controlled for age, sex, and time since local therapy. Pearson correlations evaluated associations with psychological difficulties (ET).</p><p><strong>Results: </strong>Patients (n = 132, 47% female) were on average 20.5 years old and 7.8 years after local therapy. Mean PedsQL-CM-PPA score was 72.0 (SD = 23.0), with amputation patients scoring higher (81.8; p = 0.02), while rotationplasty patients (70.8) and those after limb-sparing surgery (65.9) scored similarly. Mean BIS score was 8.4 (SD = 6.8), with 37% scoring ≥ 10. BIS scores did not differ between groups. PedsQL-CM-PPA and BIS scores significantly correlated with psychosocial difficulties.</p><p><strong>Conclusion: </strong>Body image, perceived physical appearance, and their relationship with psychological difficulties should be carefully addressed in counseling during shared decision-making for local therapy options and follow-up care. Since these outcomes are influenced by more than just medical factors, patient preferences and personal factors should be central to these discussions.</p><p><strong>Implications for cancer survivors: </strong>Body image concerns and perceived physical appearance may persist long after treatment and are not solely related to surgery type. Addressing these issues in follow-up care is essential to support survivors' long-term well-being.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life of long-term adolescent and young adult (AYA) cancer survivors compared to a matched normative population: results of the SURVAYA study.","authors":"Silvie H M Janssen, Carla Vlooswijk, Rhodé M Bijlsma, Suzanne E J Kaal, Jan Martijn Kerst, Jacqueline M Tromp, Monique E M M Bos, Tom van der Hulle, Roy I Lalisang, Janine Nuver, Mathilde C M Kouwenhoven, Winette T A van der Graaf, Olga Husson","doi":"10.1007/s11764-025-01818-0","DOIUrl":"https://doi.org/10.1007/s11764-025-01818-0","url":null,"abstract":"<p><strong>Purpose: </strong>Health-related quality of life (HRQoL) is a commonly assessed patient-reported outcome that might be especially relevant for the adolescent and young adult (AYA) cancer survivor population. However, limited data is available regarding the HRQoL of long-term AYA cancer survivors compared to a matched normative population and associated factors.</p><p><strong>Methods: </strong>AYA cancer survivors (18-39 years at initial diagnosis; 5-20 years post-diagnosis), identified by the Netherlands Cancer Registry (NCR), were invited for participation in the SURVAYA questionnaire study. Participants self-reported their socio-demographics, health-related conditions, healthcare use, positive life outlook, and HRQoL (EORTC QLQ-C30). An age- and sex-matched normative population was randomly composed. Clinical data were retrieved from the NCR.</p><p><strong>Results: </strong>A total of 3745 AYAs (on average 32 years old at diagnosis, 12 years post-diagnosis) and 517 peers without cancer (normative population) were included. All functioning scales showed significant differences, with AYA cancer survivors scoring lower: cognitive (77.9 vs. 92.2), role (83.2 vs. 91.3), social (87.9 vs. 93.6), physical (91.5 vs. 94.3), and emotional functioning (79.5 vs. 83.4). No significant difference was observed in global QoL. Female sex, lower educational attainment, older age at diagnosis, several tumor types, radiotherapy, chemotherapy, higher stage, more health-related conditions, and more healthcare visits were negatively associated with several HRQoL scales.</p><p><strong>Conclusions: </strong>AYA cancer survivors face worse HRQoL compared to peers in all functioning domains, but it is most pronounced in cognitive functioning. This study underlines the need for timely cancer survivorship care to regain, improve, and ensure the quality of life of current and future AYA cancer survivors.</p><p><strong>Clinical trial registration: </strong>NCT05379387.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}