Journal of Cancer Survivorship最新文献

{"title":"Effects of live-remote exercise on quality of life and other health-related outcomes in cancer survivors: a randomised controlled trial.","authors":"Melissa Kotte, Kate A Bolam, Renske Altena, Prue Cormie, Yvonne Wengström, Sara Mijwel","doi":"10.1007/s11764-025-01845-x","DOIUrl":"https://doi.org/10.1007/s11764-025-01845-x","url":null,"abstract":"<p><strong>Purpose: </strong>Exercise following cancer treatment has been shown to improve health-related quality of life (HRQoL) and other important health outcomes, yet barriers to participation prevent many cancer survivors from exercising according to recommendations. Live-remote exercise methods could improve accessibility; however, evidence on their efficacy is limited. The EX-MED Cancer Sweden randomised controlled trial compared the effects of a 12-week live-remote online exercise intervention to usual care in adult cancer survivors.</p><p><strong>Methods: </strong>Two hundred adults who had completed curative treatment for breast, prostate, or colorectal cancer were randomised to a 12-week live-remote online exercise intervention or a usual care control group. Intervention effects on the primary outcome overall HRQoL (EORTC-QLQ-C30) and secondary outcomes cardiorespiratory fitness (CRF), muscle strength, physical function, body composition, and other patient-reported outcomes were determined by comparing changes from baseline to 3 (primary timepoint) and 6 months between groups.</p><p><strong>Results: </strong>No significant effect was observed on overall HRQoL. However, live-remote exercise resulted in significant improvements at 3 months on the physical functioning domain of HRQoL (p ≤ 0.001), five-times sit-to-stand (p = 0.003), and moderate-vigorous physical activity levels (p ≤ 0.001) as well as estimated VO_{2 max} (p = 0.045), and upper body strength (p = 0.010) at 3 and 6 months. No significant differences were observed between the groups on lower body strength, handgrip strength, fatigue, or the other functional domains or symptoms of the EORTC-QLQ-C30.</p><p><strong>Conclusions: </strong>A 12-week live-remote exercise intervention did not lead to improvements in overall HRQoL; however, it did result in significant benefits in physical function, CRF, and upper body strength in adults treated for breast, prostate, or colorectal cancer. These findings add to the limited evidence on the effects of virtually supervised exercise for cancer survivors.</p><p><strong>Implications for cancer survivors: </strong>EX-MED Cancer Sweden addresses common exercise barriers for cancer survivors while providing the benefits of supervised exercise.</p><p><strong>Trial registration: </strong>NCT05064670, Trial registered on October 1, 2021, https://clinicaltrials.gov/ct2/show/NCT05064670.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with cancer-related pain among Utah cancer survivors.","authors":"Rachel R Codden, Blessing S Ofori-Atta, Marjorie E Carter, Kimberly A Herget, Jennifer A Doherty, Anne C Kirchhoff, Morgan M Millar","doi":"10.1007/s11764-025-01840-2","DOIUrl":"10.1007/s11764-025-01840-2","url":null,"abstract":"<p><strong>Purpose: </strong>To identify clinical and sociodemographic factors associated with cancer-related pain among Utah cancer survivors 2-5 years after diagnosis.</p><p><strong>Methods: </strong>Participants include 2232 Utah cancer survivors diagnosed with invasive cancers at ages 18 + who responded to a probability-based sample survey administered by the Utah Cancer Registry from 2018 to 2023. Participants self-reported cancer-related pain status and methods of pain control. We calculated counts and percentages and used logistic regression to identify sociodemographic and clinical factors associated with cancer-related pain. All analyses were weighted to account for complex survey sample design and age-adjusted to the Utah cancer survivor population.</p><p><strong>Results: </strong>Twenty-two percent of survivors reported currently experiencing physical pain caused by their cancer or cancer treatment. Of those reporting pain, 24% reported their pain was not under control, 40% indicated their pain was under control with medication, and 36% reported it was under control without medication. The most frequently used pain control methods were nonopioid analgesics (49%) and physical activity (37%). In multivariable models, younger survivors, those either underweight or obese, survivors of breast cancer, and those facing material financial hardships were more likely to report cancer-related pain.</p><p><strong>Conclusion: </strong>Twenty-two percent of Utah cancer survivors experienced pain related to their cancer or cancer treatment. For some, this pain is well managed, but approximately a quarter have uncontrolled pain.</p><p><strong>Implications for cancer survivors: </strong>Cancer-related pain is not solely associated with clinical features, and the findings here can guide clinicians and researchers toward a better understanding of the needs of cancer survivors and tailor pain management treatments to this unique population.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue and diabetes self-management among operable pancreatic cancer survivors with comorbid diabetes: comparative propensity analysis.","authors":"Hsuan-Ju Kuo, Yun-Jen Chou, Hui-Ying Yang, Shiow-Ching Shun","doi":"10.1007/s11764-025-01838-w","DOIUrl":"https://doi.org/10.1007/s11764-025-01838-w","url":null,"abstract":"<p><strong>Purpose: </strong>Operable pancreatic cancer survivors with diabetes experience fatigue and engage less in diabetes self-management, which could lead to worse health-related outcomes. However, little is known about the impact of having both diseases on aspects of fatigue and diabetes self-management. This study aimed to compare characteristics of fatigue and diabetes self-management between operable pancreatic cancer (OPC) survivors with diabetes and people who have diabetes without OPC.</p><p><strong>Methods: </strong>This is a cross-sectional study with a total of 207 participants with diabetes (57 OPC survivors and 150 without OPC). Fatigue and diabetes self-management were measured by the Fatigue Symptom Inventory and the Summary of Diabetes Self-Care Activities, respectively. Data were matched by age, gender, and diabetes treatment using propensity analysis. We used generalized estimating equations to compare the fatigue characteristics and diabetes self-management between the two groups.</p><p><strong>Results: </strong>The final analysis included 98 participants with diabetes (49 OPC survivors and 49 without OPC) after propensity score matching. OPC survivors with diabetes perceived higher fatigue interference in general daily activities, work activities, and enjoyment of life and performed fewer diet and foot self-management compared to people who had diabetes without OPC.</p><p><strong>Conclusions: </strong>OPC survivors with diabetes perceived more fatigue interference and engaged less in healthy eating and foot care. Future longitudinal studies should focus on examining the interplay between fatigue and diabetes self-management during the perioperative period.</p><p><strong>Implications for cancer survivors: </strong>Future interventions addressing perceived fatigue interference and barriers to daily healthy eating and foot care are crucial for OPC survivors with diabetes.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the right to be forgotten for childhood or breast cancer survivors: results of a quasi-experimental study in France.","authors":"Nicolas Bougas, Tienhan Sandrine Dabakuyo Yonli, Emerline Assogba, Nadia Haddy, Florent De Vathaire, Asmaa Janah, Morgane Michel, Aurelie Bourmaud, Hugo Jeanningros, Moreno Ursino, Renaud Debailly, Agnes Dumas","doi":"10.1007/s11764-025-01830-4","DOIUrl":"https://doi.org/10.1007/s11764-025-01830-4","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer survivors have reported difficulties in accessing loan-related insurance, in particular for a home loan. In France, a law called \"the Right To Be Forgotten\" (RTBF) was adopted in 2017 to counter this \"financial toxicity\" of cancer. Since then, eight other European countries have adopted or implemented legislation inspired by the French RTBF. Several patients' organizations in Europe have called for an extension of the RTBF across all European countries. The aim of this study was to evaluate the effects of the RTBF on the reduction of survivors experiencing difficulties in obtaining loan-related insurance after cancer in France.</p><p><strong>Method: </strong>A quasi-experimental study was conducted using different sources of recruitment to enroll breast and childhood cancer survivors (cases) and individuals without a history of cancer (controls). Difficulties in accessing loan-related insurance reported by cancer survivors and controls before and after the adoption of the law (2010-2022) were collected using an online questionnaire and compared between groups. Groups were matched using propensity scores on age, sex, the amount of insured capital, and health-related variables. The effect of the RTBF's adoption was estimated using a conditional logistic regression.</p><p><strong>Results: </strong>Out of 552 matched respondents (1:3 case-control ratio), difficulties in accessing loan-related insurance were reported by 65% of cases vs. 16% of controls before the RTBF and by 35% of cases vs. 15% of controls after the RTBF (P < .0001). The likelihood of experiencing difficulties in obtaining a loan was significantly decreased (β =  - 0.29; OR = 0.74; P = 0.01) after the RTBF. In subgroup analyses, the results remained significant solely for childhood cancer survivors.</p><p><strong>Conclusions: </strong>Despite a significant decrease in the proportion of cancer survivors experiencing difficulties after the adoption of the RTBF, there are possible difficulties in the law's implementation, dissemination, and usage, in particular for adult cancer survivors.</p><p><strong>Implications for cancer survivors: </strong>The RTBF may alleviate cancer survivors' difficulties in accessing loan-related insurance with a possible impact in decreasing the financial toxicity of cancer, both from a subjective and an objective point of view.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-perceived muscular strength and its correlation with physical, mental, and emotional health status in long-term breast cancer survivors: a cross-sectional study.","authors":"Francisco Álvarez-Salvago, Jose Medina-Luque, Maria Figueroa-Mayordomo, Clara Pujol-Fuentes, Sandra Atienzar-Aroca, José Daniel Jiménez-García, Palmira Gutiérrez-García, Cristina Estornut, Cristina Molina-García","doi":"10.1007/s11764-025-01819-z","DOIUrl":"https://doi.org/10.1007/s11764-025-01819-z","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to explore the association between different levels of self-perceived muscular strength and health status among long-term breast cancer survivors (LTBCSs), as well as to determine the factors that predict self-perceived muscular strength during this phase of long-term survivorship.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 80 LTBCSs, classified into three groups based on self-perceived muscular strength levels: very poor/poor (1-2), average (3), and good/very good (4-5). Variables analyzed, measured ≥ 5 years post-diagnosis, included other aspects of physical fitness, physical activity (PA) levels, pain, cancer-related fatigue (CRF), mood state, and health-related quality of life (HRQoL). ANOVA, Mann-Whitney U, and chi-square tests were performed, along with correlation and multiple regression analysis. Cohen's d was used to calculate effect sizes.</p><p><strong>Results: </strong>Among LTBCSs, 37.5% reported very poor/poor self-perceived muscular strength, 32.5% average, and 30% good/very good levels. Participants with lower self-perceived muscular strength exhibited declines in physical fitness, greater inactivity, higher pain levels, elevated CRF, mood disturbances, and reduced HRQoL (all p < 0.05). Regression analysis identified \"general physical fitness\" (β = 0.32; p = 0.01), \"cardiorespiratory endurance\" (β = 0.40; p < 0.01), \"global health status\" (β = 0.16; p = 0.04), and \"breast symptoms\" (β = - 0.16; p = 0.04) as significant predictors of higher self-perceived muscular strength (r² adjusted = .573).</p><p><strong>Conclusion: </strong>Good/very good levels of self-perceived muscular strength were observed in just 30% of LTBCSs. Those with lower self-perceived muscular strength exhibited more significant physical, mental, and emotional decline ≥ 5 years post-diagnosis. The combination of \"general physical fitness,\" \"cardiorespiratory endurance,\" \"global health status,\" and \"breast symptoms\" accounts for 57.3% of the variance in self-perceived muscular strength levels among LTBCSs.</p><p><strong>Implications for cancer survivors: </strong>Targeted interventions addressing self-perceived muscular strength could help mitigate long-term physical and emotional sequelae.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare experiences among Black and White sexual and gender minority cancer survivors: a qualitative study.","authors":"Deirdre A Shires, Leonardo Kattari, Forrest Hosea, Jen Hirsch, Megan Mulvaney, Alicia K Matthews, Hayley S Thompson","doi":"10.1007/s11764-023-01504-z","DOIUrl":"10.1007/s11764-023-01504-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to explore healthcare experiences of Black and White sexual and gender minority (SGM) cancer survivors across the cancer care continuum.</p><p><strong>Methods: </strong>This was a qualitative analysis of two focus groups and eight individual interviews completed as part of a larger initiative using a community-engaged research approach to reduce cancer disparities in marginalized communities. There was a total of 16 participants in the study (9 were White, 7 were Black) and data were collected between 2019 and 2020.</p><p><strong>Results: </strong>Three main themes emerged from the thematic analysis: strategically coming out, provider preferences, and health system challenges. Participants noted that they often came out through their support system, decided to come out based on the relevance of their SGM identity that they perceived, and expressed a desire for privacy. Lack of an accessible and competent PCP was tied to delayed cancer diagnosis and many participants voiced a preference for consistency when they found a provider they liked.</p><p><strong>Conclusions: </strong>Providers across specialties can address barriers for SGM patients by not making assumptions about patient sexual orientation or gender identity. Institutions should systematically collect sexual orientation and gender identity information. Primary care providers should be aware that due to resistance to switching from trusted providers, they may need to take greater initiative to facilitate cancer screenings for their patients when appropriate or take special care when making referrals to ensure they are using SGM-affirming providers.</p><p><strong>Implications for cancer survivors: </strong>SGM cancer survivors often benefit from a cultivating relationship with a trusted PCP or other provider.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"779-788"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138487578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to work after cancer-the impact of working conditions: A Norwegian Register-based Study.","authors":"Giang Huong Le, Åsmund Hermansen, Espen Dahl","doi":"10.1007/s11764-023-01503-0","DOIUrl":"10.1007/s11764-023-01503-0","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to compare a cohort of cancer survivors with a cohort of cancer-free employees (1) with respect to employment prospects over a 15-year period and (2) with respect to the differential impact of working conditions on employment over this time period.</p><p><strong>Methods: </strong>The cancer cohort is retrieved from the Cancer Registry of Norway, while data on the non-cancer cohort are retrieved from register data managed by Statistics Norway. Job exposure matrices were used to remedy the lack of working-conditions information in the register data. We use nearest-neighbor matching to match the non-cancer cohort (the control group) to the cancer-survivor cohort (the treatment group). Cox regression analysis was applied to examine the relationships between working conditions, employment, and cancer. The results are reported separately for mechanical-job exposures and psychosocial exposures, as well as by gender.</p><p><strong>Results: </strong>Cancer survivors are more likely to experience reduced employment as compared to individuals without a history of cancer. Male cancer survivors in physically demanding occupations have an increased risk of reduced employment after being diagnosed with cancer. This does not apply to female cancer survivors. Regarding the impact of psychosocial exposures on employment, we find no differences over time between cancer survivors and the non-cancer population.</p><p><strong>Conclusions: </strong>Male cancer survivors in physically demanding occupations have an increased risk of reduced employment after being diagnosed with cancer, whereas this is not the case for female cancer survivors. Psychosocial exposures do not impact the relative risk of reduced employment over time.</p><p><strong>Implications for cancer survivors: </strong>We suggest that return to work after cancer should be considered a process rather than only the re-entry step of resuming work. Thus, it is important to provide long-term support for cancer survivors. We recommend providing more attention to working conditions, particularly in occupations that involve a high level of mechanical-job exposures.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"766-778"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective evaluation of quality of life, psychosocial distress, and functional outcomes two years after radical cystectomy and urinary diversion in 842 German bladder cancer patients.","authors":"Henning Bahlburg, Alina Reicherz, Moritz Reike, Peter Bach, Marius Cristian Butea-Bocu, Karl Heinrich Tully, Florian Roghmann, Joachim Noldus, Guido Müller","doi":"10.1007/s11764-024-01535-0","DOIUrl":"10.1007/s11764-024-01535-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate survival, health-related quality of life (HRQoL), psychosocial distress, and functional outcomes after radical cystectomy (RC) and urinary diversion for ileal neobladder (INB) or ileal conduit (IC) in a contemporary German cohort of bladder cancer patients.</p><p><strong>Methods: </strong>Patients undergoing inpatient rehabilitation after RC between April 2018 and December 2019 in one high-volume rehabilitation center were surveyed regarding HRQoL, psychosocial distress, and functional outcomes until two years after RC.</p><p><strong>Results: </strong>Eight-hundred forty-two patients (683 male, 159 female; 395 INB, 447 IC) were included. Patients with an IC suffered more often from locally advanced disease (≥ pT3; 41.4% vs. 24.1%, p < 0.001) and lymph node metastases (19.9% vs. 11.8%, p = 0.002), resulting in worse probability of survival (p < 0.001). Global HRQoL improved steadily during follow-up, but significant differences in subscales persisted between cohorts. Multivariable regression analysis identified IC, male sex, and patient age ≤ 59 years as independent predictors for persistent high psychosocial distress. Almost 42% of female patients reported severe urinary incontinence two years after RC. Most men reported severely diminished erectile function, even after nerve-sparing surgery.</p><p><strong>Conclusion: </strong>Global HRQoL two years after RC is comparable to the general German population. Female patients should be informed about worse continence rates. Conversely, men should be educated about erectile dysfunction. Aftercare should include psycho-oncologic counseling, especially for patients at risk.</p><p><strong>Implications for cancer survivors: </strong>Patients should be counseled on long-term functional outcomes and persistent psychosocial distress after RC. Closer cooperation between urologists and psycho-oncologists is needed.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1102-1110"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139642161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To understand the experiences, needs, and preferences for supportive care, among children and adolescents (0-19 years) diagnosed with cancer: a systematic review of qualitative studies.","authors":"C Paterson, P S Kavanagh, R Bacon, M Turner, M Moore, M Barratt, M Chau","doi":"10.1007/s11764-023-01508-9","DOIUrl":"10.1007/s11764-023-01508-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to understand the experiences, needs, and preferences for supportive care, among children and adolescents (0-19 years) diagnosed with cancer.</p><p><strong>Methods: </strong>A qualitative systematic review has been reported according to PRISMA guidelines. A comprehensive search was conducted across multiple databases (APA PsycINFO, CINAHL, and Medline) and citation searches. Studies were screened according to pre-determined inclusion and exclusion criteria. Methodological quality was evaluated. Findings were extracted in relation to the context of interest of experiences, needs, and preferences of supportive care. Each finding was accompanied by a qualitative verbatim illustration representing the participant's voice.</p><p><strong>Results: </strong>4449 publications were screened, and 44 studies were included. Cancer populations represented in the included studies included lymphoma, leukaemia, brain cancer, sarcomas, and neuroblastoma. Two overarching synthesised findings were identified as (1) coping, caring relationships, communication, and impact of the clinical environment, and (2) experiences of isolation, fear of the unknown, restricted information, and changing self. Children and adolescents articulated that cancer care would be enhanced by developing a sense of control over their body and healthcare, being involved in communication and shared decision-making, and ensuring the clinical environment is age-appropriate. Many experienced a sense of disconnection from the rest of the world (including peers, school, and experiences of prejudice and bullying), and a lack of tailored support and information were identified as key unmet care needs that require further intervention.</p><p><strong>Conclusions: </strong>Children and adolescent who are diagnosed with cancer are a unique and understudied group in oncological survivorship research, with the slowest progress in improvement of care over time. This review will facilitate the development of future interventions and promote the importance of tailored support for children and adolescents at all stages of the cancer journey.</p><p><strong>Implications for cancer survivors: </strong>Children and adolescents continue to experience a range of difficulties despite routine contact with cancer healthcare professionals. Children and adolescents should be carefully assessed about their individual circumstances and preferences for support given the clear implications from this review that \"one size\" does not fit all.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"846-870"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical late effects of treatment among survivors of childhood cancer in low- and middle-income countries: a systematic review.","authors":"Kevin A Wong, Alexandra Moskalewicz, Paul C Nathan, Sumit Gupta, Avram Denburg","doi":"10.1007/s11764-023-01517-8","DOIUrl":"10.1007/s11764-023-01517-8","url":null,"abstract":"<p><strong>Purpose: </strong>Physical late effects of treatment are well-documented among childhood cancer survivors in high-income countries, but whether prevalence and risk factors are comparable in low- and middle-income countries (LMICs) is unclear. We conducted a systematic review to assess physical late effect outcomes among childhood cancer survivors in LMICs.</p><p><strong>Methods: </strong>Five health sciences databases were searched from inception to November 2022 in all languages. We included observational studies conducted in LMICs that evaluated physical late effects of treatment in childhood cancer survivors. Mean or median cohort follow-up must have been ≥ 5 years from original cancer diagnosis.</p><p><strong>Results: </strong>Sixteen full articles and five conference abstracts were included. Studies were conducted in lower-middle (n = 12, 57%) or upper-middle income (n = 9, 43%) countries; nearly half (n = 9, 43%) were conducted in India. Five cohorts (24%) were comprised entirely of 5-year survivors. Subsequent malignant neoplasms were reported in 0-11% of survivors (n = 10 studies). Hypothyroidism and metabolic syndrome prevalence ranged from 2-49% (n = 4 studies) and 4-17% (n = 5 studies), respectively. Gonadal dysfunction ranged from 3-47% (n = 4 studies). Cardiac dysfunction ranged from 1-16% (n = 3 studies). Late effects of the musculoskeletal and urinary systems were least investigated.</p><p><strong>Conclusions: </strong>Substantial knowledge gaps exist in LMIC childhood cancer survivorship. No low-income country data were found. In middle-income countries, late effects were defined and assessed variably and limited by selection bias and small sample sizes.</p><p><strong>Implications for cancer survivors: </strong>Survivors in LMICs can experience physical late effects of treatment, though additionally systematically collected data from survivor cohorts are needed to fill knowledge gaps.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1-17"},"PeriodicalIF":3.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139110985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}