Journal of Bioanalysis & Biomedicine最新文献

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Ionizing Radiation and Lucanthone Enhance the IgG Content of Burkitt's Lymphoma Cells 电离辐射和Lucanthone增强Burkitt淋巴瘤细胞IgG含量
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593X.1000216
R. Bases, R. Lekhraj
{"title":"Ionizing Radiation and Lucanthone Enhance the IgG Content of Burkitt's Lymphoma Cells","authors":"R. Bases, R. Lekhraj","doi":"10.4172/1948-593X.1000216","DOIUrl":"https://doi.org/10.4172/1948-593X.1000216","url":null,"abstract":"Lucanthone, a thiaxanthenone, once widely used to treat schistosomiasis, induced 3.6 fold increases in immune globulin G (IgG) relative to immune globulin M (IgM) in CRL-1647 Burkitt’s lymphoma cells [1]. This increase persisted for many generations and was accompanied by 7 fold increases in cellular activation induced cytidine deaminase (AID) [1]. AID is a key factor in Ig class switching from IgM to IgG.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"304 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75212482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of Correlation between Neurological Diseases and Breath Hexanal 呼吸己醛与神经系统疾病的相关性研究
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593X.1000205
Hatice Akman, I. Bayrakli, S. Kutluhan
{"title":"Investigation of Correlation between Neurological Diseases and Breath Hexanal","authors":"Hatice Akman, I. Bayrakli, S. Kutluhan","doi":"10.4172/1948-593X.1000205","DOIUrl":"https://doi.org/10.4172/1948-593X.1000205","url":null,"abstract":"Breath analysis is a method that has the potential to be used as a non-invasive method for the diagnosis of diseases, in the planning of drug use, and in indicating the health status of the patient, and of which importance increases with each passing day. The aim of this study is to examine neurological diseases from breath hexanal. In our study, the breaths of a total of 29 individuals consisting of 9 multiple sclerosis patients, 8 Parkinson’s patients and 12 healthy individuals in the control group were examined by means of the thermal desorption gas chromatography mass spectroscopy method. According to the results obtained, hexanal molecule, known as the biomarker for lipid peroxidation, was observed in patients with a statistically significant difference compared to the control group with multiple sclerosis patients as p=0.048. No correlation was found between Parkinson’s patient and the control group.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"31 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87621922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
About Consumer Genomics, Genetic Data Privacy and Ethics 关于消费者基因组学,基因数据隐私和伦理
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593X.1000222
François Paillier
{"title":"About Consumer Genomics, Genetic Data Privacy and Ethics","authors":"François Paillier","doi":"10.4172/1948-593X.1000222","DOIUrl":"https://doi.org/10.4172/1948-593X.1000222","url":null,"abstract":"The massive and continuous drop in cost of DNA sequencing holds the promise of a precision medicine accessible to everyone. However, the adequate management of GDP requires new tools. Indeed, even though the relative standardisation of bioinformatics formats and analysis pipelines allow genetic analysts to build informative personalised genetic reports, the storage and reporting of these data requires new methods to respect the personal privacy preferences of each patient.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75137228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay between Stride Velocity, Stride Frequency and Stride Length in Human Gait Transition 步态转换中步幅速度、步频和步幅的相互作用
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593X.1000209
N. Doppelhammer, W. Baumgartner, Y. Vereshchaga
{"title":"Interplay between Stride Velocity, Stride Frequency and Stride Length in Human Gait Transition","authors":"N. Doppelhammer, W. Baumgartner, Y. Vereshchaga","doi":"10.4172/1948-593X.1000209","DOIUrl":"https://doi.org/10.4172/1948-593X.1000209","url":null,"abstract":"This paper presents the results of studying human gait transition outside the laboratory setting on a treadmill by means of wearable sensor technology. Combined inertial measurement and pressure sensor units embedded in footwear were employed to analyze the movement of the lower limbs during walk-run and run-walk transitions. Experimental data from 20 subjects was used to study three parameters - stride velocity, stride length and stride frequency. We focused on seven strides centered around the transition stride, that is, the stride in-between walking and running that has only a single floating phase. Three subjects underwent additional testing on a treadmill to capture the differences in kinematics between the two environments. The stride frequency varied least with both a subject’s individual transition behavior and the environment. The former can be concluded from the standard deviations evaluated for each stride, which were lower for stride frequency than for velocity and length. The latter was derived by comparing the results from within and outside the laboratory: Stride frequency shifted similarly in both cases, mainly within 2-4 strides, to the attractor of the new gait. Velocity profiles differed, with acceleration being more uniform and much lower on the treadmill. Stride lengths were inversely proportional: In the walk-run transition, when the belt of the treadmill was sped up, stride lengths decreased. In the run-walk transition, when the belt was slowed down, stride lengths increased. This phenomenon is attributable mainly to the dominant nature of the stride frequency, which forces changes in stride length in order to fulfill the velocity constraint. A non-laboratory environment lacks such a constraint, thus giving rise to free transition behavior. Stride frequency, being easy to measure, is well suited to analyzing and defining gait in a practical context.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"26 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87402603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Prevalence and Factors Affecting the Development of Active-TB among HIV-Positive Patients at Shashemene Referral Hospital, Shashemene, West Arsi, Ethiopia 埃塞俄比亚西阿尔西沙什梅内沙什梅内转诊医院艾滋病毒阳性患者中活动性结核病的患病率及影响因素
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593x.1000215
H. Ayeno
{"title":"Prevalence and Factors Affecting the Development of Active-TB among HIV-Positive Patients at Shashemene Referral Hospital, Shashemene, West Arsi, Ethiopia","authors":"H. Ayeno","doi":"10.4172/1948-593x.1000215","DOIUrl":"https://doi.org/10.4172/1948-593x.1000215","url":null,"abstract":"AFB: Acid Fast Bacilli; AIDS: Acquired Immune Deficiency Syndrome; AOR: Adjusted Odds Ratio; ART: Anti-Retroviral Therapy; AU: Ambo University; AUERB: Ambo University Electoral Review Board; CD4: Cluster of Differentiation 4; COR: Crude Odds Ratio; EPTB: Extra Pulmonary Tuberculosis; FMOH: Federal minister of Health; HBC: High Burden Countries; HIV: Human Immunodeficiency Virus; MDRTB: Multi Drug Resistance Tuberculosis; OPD: Outpatient Department; PTB: Pulmonary Tuberculosis; PLWHIV: People Living with Human Immune-deficiency Virus; RVI: Retro Viral Illness; SPSS: Statistical Package of Social Science; SRH: Shashemene Referral Hospital; TB: Tuberculosis; WHO: World Health Organization.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90236247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Study the Interaction between Gold Nanoparticles and Bovine Serum Albumin: Spectroscopic Approach 金纳米颗粒与牛血清白蛋白相互作用的光谱研究
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593X.1000203
H. Alsamamra, Ibrahim Hawwarin, S. Abu-Sharkh, M. Abuteir
{"title":"Study the Interaction between Gold Nanoparticles and Bovine Serum Albumin: Spectroscopic Approach","authors":"H. Alsamamra, Ibrahim Hawwarin, S. Abu-Sharkh, M. Abuteir","doi":"10.4172/1948-593X.1000203","DOIUrl":"https://doi.org/10.4172/1948-593X.1000203","url":null,"abstract":"Interaction between gold nanoparticles of 40 & 60 nm with BSA has been investigated using UV-absorption spectrophotometry, fluorescence spectroscopy and FT-IR spectroscopy. UV-absorption spectrophotometry showed an increase in the absorption intensity with increasing the molecular ratios of gold nanoparticles of both sizes to BSA, it is found that the value of the binding constant is estimated to be 0.888 × 104 M-1 for gold nanoparticles (40 nm)- BSA complexes, and 1.16 × 104 M-1 for gold nanoparticles (60 nm)-BSA complexes. FT-IR spectroscopy analysis showed that intensities of gold nanoparticles of both sizes-BSA complexes decrease as the concentration increased.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"101 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91224136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Detection of Anti-dermatophytic Active Molecule Range of Secondary Metabolites from Non Polar to Polar Solvents 100 Extracts of Ethnic Plants 100种少数民族植物非极性和极性溶剂提取物次生代谢产物抗皮肤真菌活性分子范围的检测
Journal of Bioanalysis & Biomedicine Pub Date : 2018-01-01 DOI: 10.4172/1948-593X.1000220
P. ShivakumarSingh, G. Vidyasagar
{"title":"Detection of Anti-dermatophytic Active Molecule Range of Secondary Metabolites from Non Polar to Polar Solvents 100 Extracts of Ethnic Plants","authors":"P. ShivakumarSingh, G. Vidyasagar","doi":"10.4172/1948-593X.1000220","DOIUrl":"https://doi.org/10.4172/1948-593X.1000220","url":null,"abstract":"Ethnic plants and there is in position association with their potentiality. Mainstream of the secondary metabolites are the fundamental therapeutics. Typically these ascertains in superior plants are pleasing all the time additional remarkable in medicine conniving. The present report, 100 diverse solvent extort of 20 ethnic plants from HK region were detected for their foremost ingredients of secondary metabolites. From each plant five extracts were successively extracted from non-polar to polar manner (gradually the polarity increased) for the revealing of secondary metabolites. Deliberate for the screening of secondary metabolites the decisive factor investigations commencement with bunch prudent for alkaloids dragendroff’s, tannin for ferric chloride, phenolics for lead acetate, glycoside for keller-killiani test, flavonoids for NaoH and saponins for foam test. The apparent sites of secondary metabolites in the seam of non-polar to polar have been sensible. The paramount discovery of alkaloids, tannins recognized at non-polar range while in centre polar flavonoids; tannins have been noticed. Glycosides and saponins completely establish at far above the argument polar. The outcome of the in attending report will be incredibly much positive for remoteness of varied group of resultant metabolites in amass the time, chemicals, vigour consumption in active portion drug design.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"21 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84665913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial Activity of Biosynthesized Silver Nanoparticles against E. coli and B. subtilis 生物合成纳米银对大肠杆菌和枯草芽孢杆菌的抑菌活性研究
Journal of Bioanalysis & Biomedicine Pub Date : 2017-12-26 DOI: 10.4172/1948-593X.1000197
S. Al-Thawadi, Alaa Shukralla A. Rasool, K. Youssef
{"title":"Antimicrobial Activity of Biosynthesized Silver Nanoparticles against E. coli and B. subtilis","authors":"S. Al-Thawadi, Alaa Shukralla A. Rasool, K. Youssef","doi":"10.4172/1948-593X.1000197","DOIUrl":"https://doi.org/10.4172/1948-593X.1000197","url":null,"abstract":"Silver nanoparticles (AgNPs) are used increasingly in medical and agricultural sectors for disease management, due to their antimicrobial activity. In the current study, Biosynthesized AgNPs produced from a previous study (AgNPs1, AgNPs2 and AgNPs3) were used to test their toxicity on gram negative (E. coli) and gram positive (B. subtilis) bacteria. These nanoparticles (NPs) were examined by scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDS) and X-ray diffraction (XRD). SEM micrographs show that AgNPs1 were almost spherical monodispersed while AgNPs2 were aggregated. More aggregations appeared in AgNPs3. Peaks of AgNPs are obvious in the EDS which were confirmed further by XRD peaks ascertaining the precipitation of AgNPs. Toxicity effect of AgNPs was tested by exposing E. coli and B. subtilis to AgNPs1, AgNPs2 and AgNPs3 during their growth. Bacterial growth was followed by OD at 600 nm. Unexpectedly, an enhancement effect was proven in the presence of AgNPs1 for both bacterial strains, whereas an inhibition effect of bacterial growth was proven in the presence of AgNPs2 and AgNPs3. AgNPs3 were selected to test their minimum toxicity effect against E. coli and B. subtilis which shown to be 10 mg.L-1. To our knowledge, this study was the first study to show bacterial growth enhancement effect for AgNPs. The reasons for this enhancement need further investigation.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"64 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86042831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Development and Evaluation of Sucrose Free Herbal Orally Disintegrating Tablets of Ginger 无糖生姜口腔崩解片的研制与评价
Journal of Bioanalysis & Biomedicine Pub Date : 2017-12-11 DOI: 10.4172/1948-593X.1000195
Achhra Cv, P.T.N. Ha
{"title":"Development and Evaluation of Sucrose Free Herbal Orally Disintegrating Tablets of Ginger","authors":"Achhra Cv, P.T.N. Ha","doi":"10.4172/1948-593X.1000195","DOIUrl":"https://doi.org/10.4172/1948-593X.1000195","url":null,"abstract":"The objective of the present study was to develop orally disintegrating tablets of dry ginger powder with sugar free ingredients. In the present research work, orally disintegrating tablets of ginger were prepared by wet granulation method. A total of eight formulations were prepared with different compositions. The formulated tablets were evaluated for post-compression parameters. FTIR spectroscopic studies revealed that there was no interaction between the dry ginger powder and other excipients used in the formulations. The disintegration time of the optimized formulation was less than 30 sec. The in vitro release study of optimized formulation showed more than 90% drug release at the end of 10 min. The optimized formulation B8 showed good in vitro and in vivo antimicrobial activity against Gram positive bacteria Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus pyogenes and Gram-negative bacteria Klebsiella pneumoniae. The formulation B8 was found to be stable for one month under accelerated stability condition.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"5 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86320852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association of Biochemical Parameters with Renal Functions of End Stage Renal Disease (ESRD) Patients of Bangladesh 孟加拉国终末期肾病(ESRD)患者的生化参数与肾功能的关系
Journal of Bioanalysis & Biomedicine Pub Date : 2017-12-11 DOI: 10.4172/1948-593X.1000196
S. Hossain, Khondokar Md Akter-Uz-Zaman, M. Amin, Rubel Ahammed, E. Haque, Ibrahim, L. Hakim, Dos Mohammad, Alamgir Kabir, Saiful Islam Arman, Ummay Hanni, Mohammad Safiqul Islam
{"title":"Association of Biochemical Parameters with Renal Functions of End Stage Renal Disease (ESRD) Patients of Bangladesh","authors":"S. Hossain, Khondokar Md Akter-Uz-Zaman, M. Amin, Rubel Ahammed, E. Haque, Ibrahim, L. Hakim, Dos Mohammad, Alamgir Kabir, Saiful Islam Arman, Ummay Hanni, Mohammad Safiqul Islam","doi":"10.4172/1948-593X.1000196","DOIUrl":"https://doi.org/10.4172/1948-593X.1000196","url":null,"abstract":"Biochemical parameters are greatly influenced by genetic, physiological and environmental factors. Regional data is essential to establish a relationship between End stage renal disease (ESRD) and biochemical parameters. In Bangladesh, there is not any established research data on biochemical parameters of ESRD patient. The present study was a case control study with 500 ESRD patients and equal number of healthy volunteers (controls). Sociodemographic, anthropometric and clinical data of both patients and controls were collected. Serum biochemical parameters were analyzed by laboratory test. Statistical software package SPSS were used for independent sample t-test and Pearson’s correlation test. Our study found that serum creatinine, blood urea nitrogen (BUN) and serum uric acid were significantly higher (p<0.05) and serum potassium were significantly lower in ESRD patient as compared to control subjects (p<0.05). But serum chloride, serum sodium and serum calcium level were in the normal range. Pearson correlation analysis reveals that serum creatinine and serum chloride was inversely correlated with GFR (glomerular filtration rate) in both patient and control groups. This study explored that ESRD patients have higher level of serum creatinine, BUN and serum uric acid but lower level of serum potassium than normal patient. Routine investigation of serum biochemical parameters may help to prevent ESRD complication.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"32 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85996164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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