Development and Evaluation of Sucrose Free Herbal Orally Disintegrating Tablets of Ginger

Abstract

The objective of the present study was to develop orally disintegrating tablets of dry ginger powder with sugar free ingredients. In the present research work, orally disintegrating tablets of ginger were prepared by wet granulation method. A total of eight formulations were prepared with different compositions. The formulated tablets were evaluated for post-compression parameters. FTIR spectroscopic studies revealed that there was no interaction between the dry ginger powder and other excipients used in the formulations. The disintegration time of the optimized formulation was less than 30 sec. The in vitro release study of optimized formulation showed more than 90% drug release at the end of 10 min. The optimized formulation B8 showed good in vitro and in vivo antimicrobial activity against Gram positive bacteria Staphylococcus aureus, Corynebacterium diphtheriae, Streptococcus pyogenes and Gram-negative bacteria Klebsiella pneumoniae. The formulation B8 was found to be stable for one month under accelerated stability condition.