Nathan T. Cannon, David L. Cooke, Jascha A. Wendelstein, Erik Lehman, Seth M. Pantanelli
{"title":"Impact of quality indicators on variability of keratometry measurements using a swept-source OCT based optical biometer","authors":"Nathan T. Cannon, David L. Cooke, Jascha A. Wendelstein, Erik Lehman, Seth M. Pantanelli","doi":"10.1097/j.jcrs.0000000000001550","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001550","url":null,"abstract":"Purpose: To characterize the variability of keratometry measurements on the IOLMaster 700, and relate it to device image quality indicators (QI). Setting: Two academic centers and one private practice. Design: Multicenter, retrospective consecutive case series. Methods: Measurements from three sites, obtained between December, 2015 and July, 2023 were included. Surgery-naïve phakic eyes with same-day sequential measurements on the same eye were identified. Repeat measurement pairs were grouped by IOLMaster QIs (success vs. warning), and changes in mean standard (∆Kmean) and total (∆TKmean) keratometry as well as standard (∆Kastig) and total (∆TKastig) astigmatism vectors were calculated. Results: Analysis was performed on 3,222 eyes of 1,890 patients. Measurement ‘success’ was associated with a smaller ΔKmean (0.09 ± 0.14 D) and ΔTKmean (0.11 ± 0.16 D) when compared to pairs in which both measurements had a ‘warning’ [0.25 ± 0.32 D and 0.14 ± 0.17 D, respectively; (p < 0.0001)]. A similarly smaller ∆Kastig (0.26 ± 0.28 D) and ∆TKastig (0.28 ± 0.30 D) was observed with measurement ‘success’ versus ‘warning’ [0.77 ± 0.79 D and 0.42 ± 0.41 D, respectively (p < 0.0001)]. Even when both measurements were successful, the proportion of measurement pairs that had a ∆Kastig > 0.50 D increased from 14% to 24% to 32% when Kmean standard deviation (SD) was ≥ 0.01, 0.05, and 0.10 D, respectively. Conclusions: When measurement quality is poor, total keratometry varies less than standard keratometry measurements. Clinicians may use the SD of Kmean/TKmean to estimate the repeatability of measurements and balance this against their tolerance for performing repeat measurements.","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siamak Zarei-Ghanavati, Yasaman Hadi, Abbas Habibi, Maryam Ashraf Khorasani, Sonia H. Yoo
{"title":"Cataract and Diabetes: a review of the literature","authors":"Siamak Zarei-Ghanavati, Yasaman Hadi, Abbas Habibi, Maryam Ashraf Khorasani, Sonia H. Yoo","doi":"10.1097/j.jcrs.0000000000001547","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001547","url":null,"abstract":"Cataracts can cause visual impairment in diabetic patients. Diabetes mellitus (DM) affects different parts of the eye and causes many complications and problems before, during and after intraocular surgeries. In this review, we will discuss the effects of diabetes on different aspects of cataract surgery and review the current management of diabetic cataracts. Careful preoperative examination of the patient’s ocular surface, cornea, iris and posterior segment, as well as the use of advanced phacoemulsification techniques, new intraocular lenses (IOLs) and the appropriate use of auxiliary medications such as non-steroidal anti-inflammatory drugs (NSAIDs) and anti-vascular endothelial growth factors (VEGFs) have improved the outcomes of cataract surgery in diabetic patients.","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keming Zhao, Linxi Wan, Xi Chen, Yiming Ye, Ying Yang, Jing Zhuang, Keming Yu
{"title":"Comparison of rotational stability of the Implantable Collamer Lens after using a vertical or horizontal implanting orientation","authors":"Keming Zhao, Linxi Wan, Xi Chen, Yiming Ye, Ying Yang, Jing Zhuang, Keming Yu","doi":"10.1097/j.jcrs.0000000000001545","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001545","url":null,"abstract":"Purpose: To compare rotational stability of the Implantable Collamer Lens (ICL) between horizontal and vertical implantation. Setting: Zhongshan Ophthalmic Center, China. Design: Prospective 1:1 matched design. Methods: 94 cases (185 eyes with a vertical elliptical ciliary sulcus) were included with a 1:1 matched design based on ciliary sulcus morphology, preset deviation angle, and vault. Follow-ups at 4 days, 1 month, 3 months, and 6 months post-surgery measured rotational angles using slit-lamp photography. Latent class trajectory modeling was employed to investigate the postoperative rotational angle trajectories. Results: Six months after surgery, both groups exhibited similar visual acuity and refractive outcomes. The horizontal group had a significantly greater rotation angle than the vertical group (F <jats:sub>group</jats:sub> = 13.638, <jats:italic toggle=\"yes\">P</jats:italic> < 0.001). Additionally, a statistically significant difference (<jats:italic toggle=\"yes\">P</jats:italic> = 0.004) in the average trajectories of rotational angles was observed. The vertical group displayed a greater presence in the low-stable trajectory subgroup while demonstrating a reduced presence in the moderate-increase and high-fluctuation trajectory subgroups compared to the horizontal group. The horizontal group had a 3.750 times higher risk of rotation angle ≥3° compared to the vertical group, which represented a statistically significant difference (95% CI: 1.346∼10.446). In both groups, a positive correlation between the preset deviation angle and the rotation angle was observed, with correlation coefficients of 0.320 (<jats:italic toggle=\"yes\">P</jats:italic> = 0.030) and 0.371 (<jats:italic toggle=\"yes\">P</jats:italic> = 0.011), respectively. Conclusions: Vertical ICL implantation showed better rotational stability than horizontal implantation in eyes with a vertical elliptical ciliary sulcus, offering guidance for ICL surgery.","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Objective quantification of posterior capsule opacification using swept-source anterior segment optical coherence tomography","authors":"Shuya Tao, Feiyan Liang, Shuxin Fan, Mingwei Wang, Yimeng Zhang, Xialin Liu, Chang He","doi":"10.1097/j.jcrs.0000000000001546","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001546","url":null,"abstract":"Purpose: To objectively quantify posterior capsule opacification (PCO) using swept-source anterior segment optical coherence tomography (SS-ASOCT) in pseudophakic eyes. Setting: Zhongshan Ophthalmic Center, Guangzhou, China Design: Prospective cross-sectional study. Methods: One hundred and eighty eyes with PCO (37 multifocal intraocular lenses [MfIOLs] and 143 monofocal intraocular lenses [MoIOLs]) were enrolled. The PCO Irregular Degree (PID), defined to evaluate the surface irregularity of PCO, the average and maximum thickness of PCO (AT-PCO, MT-PCO) were applied to quantify PCO based on SS-ASOCT (CASIA2) images. Corrected distance visual acuity (CDVA), high order aberrations (HOAs), modulation transfer function (MTF) and Strehl ratio were recorded. The associations between SS-ASOCT parameters and visual function parameters were assessed by Spearman’s correlation analysis. Results: PID, AT-PCO and MT-PCO showed significant correlations with CDVA, Strehl ratio and HOAs (CDVA: r = 0.702, 0.741, 0.736; Strehl ratio: r = -0.746, -0.719, -0.740; HOAs: r = 0.762, 0.734, 0.752). The correlations of these three parameters with Strehl ratio and HOAs were significantly higher than those of clinical PCO grading with Strehl ratio and HOAs (all P < 0.05). Particularly, PID demonstrated notable correlations with Strehl ratio and HOAs. In addition, patients with MfIOLs presented worse Strehl ratio and HOAs than those with MoIOLs after matching age, PID, AT-PCO and MT-PCO. Conclusions: This study provides a novel method for objectively quantifying PCO using successive cross-sectional SS-ASOCT images. AT-PCO, MT-PCO and PID are presented as new indicators to document PCO severity, with PID offering a unique perspective by considering the irregularity aspect of PCO.","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kamran M. Riaz, Jascha A. Wendelstein, Douglas D. Koch
{"title":"Depth of Field or Depth of Focus?","authors":"Kamran M. Riaz, Jascha A. Wendelstein, Douglas D. Koch","doi":"10.1097/j.jcrs.0000000000001548","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001548","url":null,"abstract":"","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. John Shammas, David L. Cooke, Kamran M. Riaz, Rahul Tonk, Maya C. Shammas, Adam Bleeker, Abdelrahman M. Anter, Sanjana Suraneni, Sebastian Leal
{"title":"Updating the No-History Method in Intraocular Lens Power Calculation After Myopic Laser Vision Correction","authors":"H. John Shammas, David L. Cooke, Kamran M. Riaz, Rahul Tonk, Maya C. Shammas, Adam Bleeker, Abdelrahman M. Anter, Sanjana Suraneni, Sebastian Leal","doi":"10.1097/j.jcrs.0000000000001508","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001508","url":null,"abstract":"PURPOSE: To describe the Shammas-Cooke formula, an updated no-history (NH) formula for IOL calculation in eyes with prior myopic laser vision correction (M-LVC), and to compare the results to the Shammas PL, Haigis-L and Barrett True-K NH formulas. SETTING: Bascom Palmer Eye Institute (BPEI), The Lennar Foundation Medical Center, University of Miami, Miami, Florida, USA; Dean A. McGee Eye Institute (DMEI), University of Oklahoma, Oklahoma City, Oklahoma, USA; and private practice, Lynwood, California, USA and St Joseph, Michigan, USA. DESIGN: Retrospective observational study. METHODS: We analyzed two large series of cataractous eyes with prior M-LVC. The training set (BPEI series of 330 eyes) was used to derive the new corneal power conversion equation to be used in the novel Shammas-Cooke formula, and the testing set (165 eyes of 165 patients in the DMEI series) to compare the updated formula to three other M-LVC NH formulas on the ASCRS calculator: Shammas PL, Haigis-L and Barrett True-K NH. RESULTS: Mean prediction error was 0.09±0.56, -0.44±0.61, -0.47±0.59 and -0.18±0.56 D, and the mean absolute error was 0.43, 0.60, 0.61 and 0.45 D for the Shammas-Cooke, Shammas PL, Haigis-L and Barrett True-K NH. The percentage of eyes within ± 0.50 D was 66.7% versus 47.9%, 48.5% and 65.5%, respectively. CONCLUSION: The Shammas-Cooke formula performed better than the Shammas PL and Haigis-L (P<0.001 for both) and as well as the Barrett True-K NH formula (P=0.923).","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"137 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The six generations of the intraocular lens evolution","authors":"Liliana Werner","doi":"10.1097/j.jcrs.0000000000001476","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001476","url":null,"abstract":"","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas W. Samuelson, Mark D. Larson, Analisa Arosemena, George Tanaka, Erin Boese, Marshall Huang, Marc Mardelli, Rohit Krishna, David A. Crandall, Sylvia L. Groth, Zane N. Khademi, Daniel S. Petkovsek, Ang Li, Mary Qiu
{"title":"Open-angle glaucoma and Fuchs dystrophy","authors":"Thomas W. Samuelson, Mark D. Larson, Analisa Arosemena, George Tanaka, Erin Boese, Marshall Huang, Marc Mardelli, Rohit Krishna, David A. Crandall, Sylvia L. Groth, Zane N. Khademi, Daniel S. Petkovsek, Ang Li, Mary Qiu","doi":"10.1097/j.jcrs.0000000000001498","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001498","url":null,"abstract":"A 62-year-old woman with a history of moderate myopia, long-standing open-angle glaucoma (OAG), and Fuchs dystrophy in both eyes was referred for consultative care. She had prior trabeculectomy in 1984 and 1992 in the left and right eyes, respectively. She is 3 months post–Descemet-stripping endothelial keratoplasty (DSEK) in the left eye, now referred with uncontrolled intraocular pressure (IOP) despite maximum tolerated medical therapy. Current medical therapy for IOP consists of acetazolamide 250 mg by mouth 2 times a day, brimonidine 2 times a day in the left eye, dorzolamide 2 times a day in the left eye, and timolol 2 times a day in the left eye. The patient has a history of presumed steroid response; however, her corneal surgeon has requested that the steroid be continued for the next several months because of the recent DSEK. The IOP in the left eye has ranged from the mid-20s to mid-30s since DSEK. The right eye has consistently had pressure in the low teens and below for many years without topical antihypertensive medications. Examination revealed stable visual acuity at 20/30 and 20/40 in the right and left eyes, respectively, IOP was 12 mm Hg in the right eye and 25 mm Hg in the left eye by Goldman applanation, irregular but reactive pupils without afferent defect, and full confrontational visual fields. Slitlamp examination showed superior low avascular bleb, moderate-to-severe guttae, and posterior chamber IOL in the right eye. The left eye showed superior low diffuse bleb, clear DSEK graft, quiet chamber, superonasal iridectomy, and posterior chamber IOL with an open posterior capsule. The conjunctiva was moderately scarred but a repeat trabeculectomy or Xen Gel stent (Abbvie) appeared possible. The angles were wide open in each eye. Fundus examination was normal aside from myopic, anomalous-appearing nerves with an approximate cup-to-disc ratio of 0.90 in both eyes. Humphrey visual field showed nonspecific changes on the right and moderate nasal defect on the left eye, stable to previous examinations dating back to 2018 (Figure 1 JOURNAL/jcrs/04.03/02158034-202407000-00018/figure1/v/2024-06-18T204902Z/r/image-tiff and Figure 2 JOURNAL/jcrs/04.03/02158034-202407000-00018/figure2/v/2024-06-18T204902Z/r/image-tiff ). Optical coherence tomography (OCT) of the retinal nerve fiber layer (RNFL) revealed moderated thinning in both eyes that was also stable to prior examinations (Figure 3 JOURNAL/jcrs/04.03/02158034-202407000-00018/figure3/v/2024-06-18T204902Z/r/image-tiff ). Her axial length measured 25.23 and 26.34 mm in the right and left eyes, respectively. Central corneal thickness was 553 μm in the right eye and 563 μm in the left eye before her DSEK procedure. What would be your approach to management of this patient's left eye, addressing the following: Rationale for your procedure of choice? Would you over-rule the corneal surgeon and stop the steroid in an attempt to obviate the need for glaucoma surgery? Does the age of onset of","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141510048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of prophylactic capsular tension ring implantation during cataract surgery in highly myopic eyes","authors":"Xiaoxin Hu, Jiao Qi, Kaiwen Cheng, Wenwen He, Keke Zhang, Chen Zhao, Yi Lu, Xiangjia Zhu","doi":"10.1097/j.jcrs.0000000000001495","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001495","url":null,"abstract":"Purpose: To assess the effectiveness of prophylactic capsular tension ring (CTR) implantation during cataract surgery in highly myopic eyes. Setting: EENT Hospital of Fudan University, Shanghai, China Design: Prospective cohort study. Methods: Consecutive highly myopic patients treated with cataract surgery were recruited and randomized to undergo CTR implantation or not. The outcomes compared between the two groups included axial lens position (ALP), intraocular lens (IOL) decentration and tilt, area of anterior capsule opening, severity of anterior capsular opacification (ACO), and posterior capsular opacification (PCO) at 1 year after surgery. Results: A total of 55 highly myopic eyes with CTRs implanted and 55 without were included in the analysis. At 1 year after surgery, no significant differences were detected between the CTR and non-CTR groups for the mean ALP, IOL decentration, or tilt (all P > 0.05). However, the CTR group had a significantly larger area of anterior capsule opening (23.62 ± 3.30 mm<jats:sup>2</jats:sup> vs. 21.85 ± 2.30 mm<jats:sup>2</jats:sup>, P = 0.003), and less severe ACO (P = 0.033) and PCO (PCO-3 mm: 0.06 ± 0.13 vs. 0.13 ± 0.20, P = 0.038; PCO-C: 0.15 ± 0.18 vs. 0.25 ± 0.26, P = 0.026) than the non-CTR group. The corrected distance visual acuity, prediction error, and high-order aberrations did not differ between the two groups (all P > 0.05). Conclusions: In highly myopic eyes, although prophylactic CTR implantation can reduce the severity of capsular contraction and opacification, it does not significantly affect postoperative IOL stability or visual outcomes.","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141194766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcony R. Santhiago, Lycia Pedral Sampaio, Danielle Arroyo, Steven E. Wilson, Majid Moshirfar, Norma Del Risco, Kayvon A. Moin, Margarita Cabanás, Ramón Ruiz, Fernando Llovet, Rohit Shetty, Zeid Nawas, Zaina Al-Mohtaseb, Stephen C. Pflugfelder, Allison J. Chen
{"title":"Addressing corneal opacity after herpes zoster infection","authors":"Marcony R. Santhiago, Lycia Pedral Sampaio, Danielle Arroyo, Steven E. Wilson, Majid Moshirfar, Norma Del Risco, Kayvon A. Moin, Margarita Cabanás, Ramón Ruiz, Fernando Llovet, Rohit Shetty, Zeid Nawas, Zaina Al-Mohtaseb, Stephen C. Pflugfelder, Allison J. Chen","doi":"10.1097/j.jcrs.0000000000001471","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001471","url":null,"abstract":"A 15-year-old boy was referred for corneal opacity evaluation. The patient had a previous herpes zoster virus (HZV) infection—varicella-zoster virus (VZV)—with ocular manifestation 1 year ago. After the infection, he developed a central corneal scar and decreased corrected distance visual acuity (CDVA) in the right eye. The slitlamp examination showed the right eye with central corneal opacity (involving anterior stroma), lacuna area between the haze, fluorescein negative, and no vascularization near the scar (Figure 1 JOURNAL/jcrs/04.03/02158034-202406000-00019/figure1/v/2024-05-21T162725Z/r/image-tiff ). The patient had been treated with oral valacyclovir and topical corticosteroids without any improvement of visual acuity or changes in opacity within the 1-year follow-up. His CDVA was 20/200 (−4.50 −0.75 × 25) in the right eye and counting fingers (−4.00) in the left eye. Intraocular pressure was 12 mm Hg in both eyes. Fundoscopy was normal in the right eye, but he had a macular scar in the left eye (diagnosed when he was 7 years). The left eye had no cornea signs. The patient has no comorbidity or previous surgeries. Considering this case, a corneal central scar in a 15-year-old boy, legally single eye only, and assuming it is an opacity in the anterior stroma, would you consider surgery for this patient? If so, which would you choose: Would you consider an excimer laser treatment of his ametropia while partially removing his opacity, a phototherapeutic keratectomy (PTK), or a PTK followed by a topography-guided treatment, femtosecond laser-assisted anterior lamellar keratoplasty (FALK), or deep anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (depending on the scar depth)? Would you consider prophylactic acyclovir during and after surgery? Would you consider any other surgical step to prevent delayed corneal healing-persistent epithelial defect? Before the surgical approach, would you consider treating this patient with topical losartan (a transforming growth factor [TGF]-β signaling inhibitor)? Would you first perform the surgery (which one) and then start the medication? Furthermore, if so, how long would you treat this patient? Would you consider treatment with another medication?","PeriodicalId":15233,"journal":{"name":"Journal of Cataract & Refractive Surgery","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141150929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}